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Total Synthesis of (−)-Spiroleucettadine.
Published in:
Angewandte Chemie, 2017, v. 129, n. 46, p. 14855, doi. 10.1002/ange.201708110
By:
- Lamb, Richard A.;
- Aberle, Nicholas S.;
- Lucas, Nigel T.;
- Lessene, Guillaume;
- Hawkins, Bill C.
Publication type:
Article
BCL-2 family antagonists for cancer therapy.
Published in:
Nature Reviews Drug Discovery, 2008, v. 7, n. 12, p. 989, doi. 10.1038/nrd2658
By:
- Lessene, Guillaume;
- Czabotar, Peter E.;
- Colman, Peter M.
Publication type:
Article
Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.
Published in:
Cellular Microbiology, 2017, v. 19, n. 4, p. n/a, doi. 10.1111/cmi.12685
By:
- Stewart, Rebecca J.;
- Whitehead, Lachlan;
- Nijagal, Brunda;
- Sleebs, Brad E.;
- Lessene, Guillaume;
- McConville, Malcolm J.;
- Rogers, Kelly L.;
- Tonkin, Christopher J.
Publication type:
Article
Total Synthesis of (−)-Spiroleucettadine.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 46, p. 14663, doi. 10.1002/anie.201708110
By:
- Lamb, Richard A.;
- Aberle, Nicholas S.;
- Lucas, Nigel T.;
- Lessene, Guillaume;
- Hawkins, Bill C.
Publication type:
Article
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Published in:
Biochemical Journal, 2014, v. 457, n. 3, p. 369, doi. 10.1042/BJ20131270
By:
- MURPHY, James M.;
- LUCET, Isabelle S.;
- HILDEBRAND, Joanne M.;
- TANZER, Maria C.;
- YOUNG, Samuel N.;
- SHARMA, Pooja;
- LESSENE, Guillaume;
- ALEXANDER, Warren S.;
- BABON, Jeffrey J.;
- SILKE, John;
- CZABOTAR, Peter E.
Publication type:
Article
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.20352
By:
- Berger, Stephanie;
- Procko, Erik;
- Margineantu, Daciana;
- Lee, Erinna F.;
- Shen, Betty W.;
- Zelter, Alex;
- Silva, Daniel-Adriano;
- Chawla, Kusum;
- Herold, Marco J.;
- Garnier, Jean-Marc;
- Johnson, Richard;
- MacCoss, Michael J.;
- Lessene, Guillaume;
- Davis, Trisha N.;
- Stayton, Patrick S.;
- Stoddard, Barry L.;
- Fairlie, W. Douglas;
- Hockenbery, David M.;
- Baker, David
Publication type:
Article
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27032-x
By:
- Meng, Yanxiang;
- Davies, Katherine A.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Garnish, Sarah E.;
- Horne, Christopher R.;
- Luo, Cindy;
- Garnier, Jean-Marc;
- Liang, Lung-Yu;
- Cowan, Angus D.;
- Samson, Andre L.;
- Lessene, Guillaume;
- Sandow, Jarrod J.;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
Synthesis and Biological Evaluation of (−) and (+)‐Spiroleucettadine and Analogues.
Published in:
ChemMedChem, 2021, v. 16, n. 8, p. 1308, doi. 10.1002/cmdc.202000954
By:
- Badart, Michael P.;
- Barnes, Emma M.;
- Cording, Andrew P.;
- Gilmer, Selena C. L.;
- Billinghurst, Ian D.;
- Edupuganti, Veera V. Shivaji R.;
- Lessene, Guillaume;
- Bland, Abigail R.;
- Bower, Rebekah L.;
- Rana, Zohaib;
- Ferguson, Scott A.;
- Opel Reading, Helen K.;
- Cook, Gregory M.;
- Rosengren, Rhonda J.;
- Krause, Kurt L.;
- Gamble, Allan B.;
- Ashton, John C.;
- Hawkins, Bill C.
Publication type:
Article
BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage.
Published in:
EMBO Journal, 2020, v. 39, n. 24, p. 1, doi. 10.15252/embj.2020105561
By:
- Brinkmann, Kerstin;
- Waring, Paul;
- Glaser, Stefan P;
- Wimmer, Verena;
- Cottle, Denny L;
- Tham, Ming Shen;
- Nhu, Duong;
- Whitehead, Lachlan;
- Delbridge, Alex RD;
- Lessene, Guillaume;
- Smyth, Ian M;
- Herold, Marco J;
- Kelly, Gemma L;
- Grabow, Stephanie;
- Strasser, Andreas
Publication type:
Article
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Published in:
Nature Reviews Molecular Cell Biology, 2014, v. 15, n. 1, p. 49, doi. 10.1038/nrm3722
By:
- Czabotar, Peter E.;
- Lessene, Guillaume;
- Strasser, Andreas;
- Adams, Jerry M.
Publication type:
Article
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10363-1
By:
- Birkinshaw, Richard W.;
- Gong, Jia-nan;
- Luo, Cindy S.;
- Lio, Daisy;
- White, Christine A.;
- Anderson, Mary Ann;
- Blombery, Piers;
- Lessene, Guillaume;
- Majewski, Ian J.;
- Thijssen, Rachel;
- Roberts, Andrew W.;
- Huang, David C. S.;
- Colman, Peter M.;
- Czabotar, Peter E.
Publication type:
Article
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.
Published in:
PLoS Biology, 2024, v. 22, n. 5, p. 1, doi. 10.1371/journal.pbio.3002617
By:
- Yuan, Zheng;
- van Delft, Mark F.;
- Li, Mark Xiang;
- Sumardy, Fransisca;
- Smith, Brian J.;
- Huang, David C. S.;
- Lessene, Guillaume;
- Khakam, Yelena;
- Jin, Ruitao;
- He, Sitong;
- Smith, Nicholas A.;
- Birkinshaw, Richard W.;
- Czabotar, Peter E.;
- Dewson, Grant
Publication type:
Article
Dual drug targeting to kill colon cancers.
Published in:
Cancer Medicine, 2022, v. 11, n. 13, p. 2612, doi. 10.1002/cam4.4641
By:
- Corona, Silvia Paola;
- Walker, Francesca;
- Weinstock, Janet;
- Lessene, Guillaume;
- Faux, Maree;
- Burgess, Antony W.
Publication type:
Article
Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient.
Published in:
Proteomics, 2024, v. 24, n. 16, p. 1, doi. 10.1002/pmic.202300644
By:
- Emery‐Corbin, Samantha J.;
- Yousef, Jumana M.;
- Adhikari, Subash;
- Sumardy, Fransisca;
- Nhu, Duong;
- van Delft, Mark F.;
- Lessene, Guillaume;
- Dziekan, Jerzy;
- Webb, Andrew I.;
- Dagley, Laura F.
Publication type:
Article
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
Published in:
Cell Death & Disease, 2022, v. 13, n. 4, p. 1, doi. 10.1038/s41419-022-04740-w
By:
- Jacobsen, Annette V.;
- Pierotti, Catia L.;
- Lowes, Kym N.;
- Au, Amanda E.;
- Zhang, Ying;
- Etemadi, Nima;
- Fitzgibbon, Cheree;
- Kersten, Wilhelmus J. A.;
- Samson, André L.;
- van Delft, Mark F.;
- Huang, David C. S.;
- Sabroux, Hélène Jousset;
- Lessene, Guillaume;
- Silke, John;
- Murphy, James M.
Publication type:
Article
Defining the susceptibility of colorectal cancers to BH3-mimetic compounds.
Published in:
Cell Death & Disease, 2020, v. 11, n. 9, p. 1, doi. 10.1038/s41419-020-02815-0
By:
- Luo, Ming-Jie;
- Palmieri, Michelle;
- Riffkin, Chris D.;
- Sakthianandeswaren, Anuratha;
- Djajawi, Tirta Mario;
- Hirokawa, Yumiko;
- Shuttleworth, Victoria;
- Segal, David H.;
- White, Christine A.;
- Nhu, Duong;
- Lessene, Guillaume;
- Lee, Margaret;
- Gibbs, Peter;
- Huang, David C. S.;
- Sieber, Oliver M.;
- Gong, Jia-nan
Publication type:
Article
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04714-7
By:
- Petrie, Emma J.;
- Sandow, Jarrod J.;
- Jacobsen, Annette V.;
- Smith, Brian J.;
- Griffin, Michael D. W.;
- Lucet, Isabelle S.;
- Weiwen Dai;
- Young, Samuel N.;
- Tanzer, Maria C.;
- Wardak, Ahmad;
- Lung-Yu Liang;
- Cowan, Angus D.;
- Hildebrand, Joanne M.;
- Kersten, Wilhelmus J. A.;
- Lessene, Guillaume;
- Silke, John;
- Czabotar, Peter E.;
- Webb, Andrew I.;
- Murphy, James M.
Publication type:
Article
Simplified Silvestrol Analogues with Potent Cytotoxic Activity.
Published in:
ChemMedChem, 2014, v. 9, n. 7, p. 1556, doi. 10.1002/cmdc.201400024
By:
- Hawkins, Bill C.;
- Lindqvist, Lisa M.;
- Nhu, Duong;
- Sharp, Phillip P.;
- Segal, David;
- Powell, Andrew K.;
- Campbell, Michael;
- Ryan, Eileen;
- Chambers, Jennifer M.;
- White, Jonathan M.;
- Rizzacasa, Mark A.;
- Lessene, Guillaume;
- Huang, David C. S.;
- Burns, Christopher J.
Publication type:
Article
Structure-guided design of a selective BCL-XL inhibitor.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 6, p. 390, doi. 10.1038/nchembio.1246
By:
- Lessene, Guillaume;
- Czabotar, Peter E;
- Sleebs, Brad E;
- Zobel, Kerry;
- Lowes, Kym N;
- Adams, Jerry M;
- Baell, Jonathan B;
- Colman, Peter M;
- Deshayes, Kurt;
- Fairbrother, Wayne J;
- Flygare, John A;
- Gibbons, Paul;
- Kersten, Wilhelmus J A;
- Kulasegaram, Sanji;
- Moss, Rebecca M;
- Parisot, John P;
- Smith, Brian J;
- Street, Ian P;
- Yang, Hong;
- Huang, David C S
Publication type:
Article

Found: 19

Total Synthesis of (−)-Spiroleucettadine.

BCL-2 family antagonists for cancer therapy.

Analysis of Ca<sup>2</sup><sup>+</sup> mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules.

Total Synthesis of (−)-Spiroleucettadine.

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

Synthesis and Biological Evaluation of (−) and (+)‐Spiroleucettadine and Analogues.

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage.

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.

Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

Dual drug targeting to kill colon cancers.

Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient.

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds.

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Simplified Silvestrol Analogues with Potent Cytotoxic Activity.

Structure-guided design of a selective BCL-X<sub>L</sub> inhibitor.