Works by Leroy, Patrice

Results: 21

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.

Published in:

Archives of Toxicology, 2019, v. 93, n. 11, p. 3229, doi. 10.1007/s00204-019-02565-9

By:

Iskandar, Anita R.;
Zanetti, Filippo;
Marescotti, Diego;
Titz, Bjorn;
Sewer, Alain;
Kondylis, Athanasios;
Leroy, Patrice;
Belcastro, Vincenzo;
Torres, Laura Ortega;
Acali, Stefano;
Majeed, Shoaib;
Steiner, Sandro;
Trivedi, Keyur;
Guedj, Emmanuel;
Merg, Celine;
Schneider, Thomas;
Frentzel, Stefan;
Martin, Florian;
Ivanov, Nikolai V.;
Peitsch, Manuel C.

Publication type:

Article

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium.

Published in:

Clinical Medicine Insights: Circulatory, Respiratory & Pulmonary Medicine, 2017, n. 11, p. 1, doi. 10.1177/1179548417710928

By:

Talikka, Marja;
Martin, Florian;
Sewer, Alain;
Vuillaume, Grégory;
Leroy, Patrice;
Luettich, Karsta;
Chaudhary, Nveed;
Peck, Michael J.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.

Published in:

Journal of Applied Toxicology, 2022, v. 42, n. 10, p. 1701, doi. 10.1002/jat.4338

By:

Ee Tsin Wong;
Luettich, Karsta;
Cammack, Lydia;
Chin Suan Chua;
Sciuscio, David;
Merg, Celine;
Corciulo, Maica;
Piault, Romain;
Ashutosh, Kumar;
Smith, Cameron;
Leroy, Patrice;
Moine, Fabian;
Glabasnia, Anneke;
Diana, Pierrick;
Chia, Cecilia;
Ching Keong Tung;
Ivanov, Nikolai;
Hoeng, Julia;
Peitsch, Manuel;
Lee, Kyeonghee Monica

Publication type:

Article

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model.

Published in:

Journal of Applied Toxicology, 2021, v. 41, n. 10, p. 1598, doi. 10.1002/jat.4149

By:

Kogel, Ulrike;
Wong, Ee Tsin;
Szostak, Justyna;
Tan, Wei Teck;
Lucci, Francesco;
Leroy, Patrice;
Titz, Bjoern;
Xiang, Yang;
Low, Tiffany;
Wong, Sin Kei;
Guedj, Emmanuel;
Ivanov, Nikolai V.;
Schlage, Walter K.;
Peitsch, Manuel C.;
Kuczaj, Arkadiusz;
Vanscheeuwijck, Patrick;
Hoeng, Julia

Publication type:

Article

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

Published in:

Romanian Medical Journal, 2019, v. 66, n. 1, p. 70, doi. 10.1016/j.yrtph.2016.10.015

By:

Ee Tsin Wong;
Kogel, Ulrike;
Veljkovic, Emilija;
Martin, Florian;
Yang Xiang;
Boue, Stephanie;
Vuillaume, Gregory;
Leroy, Patrice;
Guedj, Emmanuel;
Rodrigo, Gregory;
Ivanov, Nikolai V.;
Hoeng, Julia;
Peitsch, Manuel C.;
PatrickVanscheeuwijck

Publication type:

Article

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model.

Published in:

Archives of Toxicology, 2020, v. 94, n. 6, p. 2163, doi. 10.1007/s00204-020-02769-4

By:

Reumann, Marie K.;
Schaefer, Jenny;
Titz, Bjoern;
Aspera-Werz, Romina H.;
Wong, Ee Tsin;
Szostak, Justyna;
Häussling, Victor;
Ehnert, Sabrina;
Leroy, Patrice;
Tan, Wei Teck;
Kuczaj, Arkadiusz;
Audretsch, Christof;
Springer, Fabian;
Badke, Andreas;
Augat, Peter;
Quentanilla-Fend, Leticia;
Martella, Manuela;
Lee, K. Monica;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.

Published in:

Archives of Toxicology, 2020, v. 94, n. 6, p. 2179, doi. 10.1007/s00204-020-02759-6

By:

Ho, Jenny;
Sciuscio, Davide;
Kogel, Ulrike;
Titz, Bjoern;
Leroy, Patrice;
Vuillaume, Gregory;
Talikka, Marja;
Martin, Elyette;
Pospisil, Pavel;
Lebrun, Stefan;
Xia, Wenhao;
Lee, Tom;
Chng, Yun Xuan;
Phillips, Blaine W.;
Veljkovic, Emilija;
Guedj, Emmanuel;
Xiang, Yang;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study.

Published in:

Biomarkers, 2025, v. 30, n. 2, p. 178, doi. 10.1080/1354750X.2025.2461069

By:

Ansari, S. Michael;
Leroy, Patrice;
de La Bourdonnaye, Guillaume;
Pouly, Sandrine;
Reese, Lindsay;
Haziza, Christelle

Publication type:

Article

A framework for in vitro systems toxicology assessment of e-liquids.

Published in:

Toxicology Mechanisms & Methods, 2016, v. 26, n. 6, p. 392, doi. 10.3109/15376516.2016.1170251

By:

Iskandar, Anita R.;
Gonzalez-Suarez, Ignacio;
Majeed, Shoaib;
Marescotti, Diego;
Sewer, Alain;
Xiang, Yang;
Leroy, Patrice;
Guedj, Emmanuel;
Mathis, Carole;
Schaller, Jean-Pierre;
Vanscheeuwijck, Patrick;
Frentzel, Stefan;
Martin, Florian;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD).

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 9, p. 1583, doi. 10.3390/ijms17091583

By:

Titz, Bjoern;
Luettich, Karsta;
Leroy, Patrice;
Boue, Stephanie;
Vuillaume, Gregory;
Vihervaara, Terhi;
Ekroos, Kim;
Martin, Florian;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.

Published in:

Toxicology Research, 2017, v. 6, n. 6, p. 930, doi. 10.1039/c7tx00152e

By:

Iskandar, Anita R.;
Martinez, Yannick;
Martin, Florian;
Schlage, Walter K.;
Leroy, Patrice;
Sewer, Alain;
Torres, Laura Ortega;
Majeed, Shoaib;
Merg, Celine;
Trivedi, Keyur;
Guedj, Emmanuel;
Frentzel, Stefan;
Mathis, Carole;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment.

Published in:

2019

By:

Iskandar, Anita R.;
Zanetti, Filippo;
Kondylis, Athanasios;
Martin, Florian;
Leroy, Patrice;
Majeed, Shoaib;
Steiner, Sandro;
Xiang, Yang;
Ortega Torres, Laura;
Trivedi, Keyur;
Guedj, Emmanuel;
Merg, Celine;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Doshi, Utkarsh;
Lee, Kyeonghee Monica;
McKinney, Willie J.;
Peitsch, Manuel C.;
Hoeng, Julia;
McKinney, Willie J Jr

Publication type:

journal article

3-D Nasal Cultures: Systems Toxicological Assessment of a Candidate Modified-Risk Tobacco Product.

Published in:

Altex, 2017, v. 34, n. 1, p. 23, doi. 10.14573/altex.1605041

By:

Iskandar, Anita R.;
Mathis, Carole;
Martin, Florian;
Leroy, Patrice;
Sewer, Alain;
Majeed, Shoaib;
Kuehn, Diana;
Trivedi, Keyur;
Grandolfo, Davide;
Cabanski, Maciej;
Guedj, Emmanuel;
Merg, Céline;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Published in:

Romanian Journal of Stomatology / Revista Romana de Stomatologie, 2019, v. 65, n. 2, p. 15, doi. 10.1016/j.fct.2016.12.027

By:

Zanetti, Filippo;
Titz, Bjoern;
Sewer, Alain;
Lo Sasso, Giuseppe;
Scotti, Elena;
Schlage, Walter K.;
Mathis, Carole;
Leroy, Patrice;
Majeed, Shoaib;
Torres, Laura Ortega;
Keppler, Brian R.;
Elamin, Ashraf;
Trivedi, Keyur;
Guedj, Emmanuel;
Martin, Florian;
Frentzel, Stefan;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Hoeng, Julia

Publication type:

Article

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis.

Published in:

Toxicological Sciences, 2016, v. 149, n. 2, p. 441, doi. 10.1093/toxsci/kfv244

By:

Titz, Bjoern;
Boué, Stéphanie;
Phillips, Blaine;
Talikka, Marja;
Vihervaara, Terhi;
Schneider, Thomas;
Nury, Catherine;
Elamin, Ashraf;
Guedj, Emmanuel;
Peck, Michael J.;
Schlage, Walter K.;
Cabanski, Maciej;
Leroy, Patrice;
Vuillaume, Gregory;
Martin, Florian;
Martin, Nikolai V.;
Veljkovic, Emilija;
Kim Ekroos;
Laaksonen, Reijo;
Vanscheeuwijck, Patrick

Publication type:

Article

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

Published in:

Toxicological Sciences, 2016, v. 149, n. 2, p. 411, doi. 10.1093/toxsci/kfv243

By:

Phillips, Blaine;
Veljkovic, Emilija;
Boué, Stéphanie;
Schlage, Walter K.;
Vuillaume, Gregory;
Martin, Florian;
Titz, Bjoern;
Leroy, Patrice;
Buettner, Ansgar;
Elamin, Ashraf;
Oviedo, Alberto;
Cabanski, Maciej;
León, Héctor De;
Guedj, Emmanuel;
Schneider, Thomas;
Talikka, Marja;
Ivanov, Nikolai V.;
Vanscheeuwijck, Patrick;
Peitsch, Manuel C.;
Julia Hoeng

Publication type:

Article

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Published in:

Toxicological Sciences, 2015, v. 147, n. 1, p. 207, doi. 10.1093/toxsci/kfv122

By:

Iskandar, Anita R.;
Yang Xiang;
Frentzel, Stefan;
Talikka, Marja;
Leroy, Patrice;
Kuehn, Diana;
Guedj, Emmanuel;
Martin, Florian;
Mathis, Carole;
Ivanov, Nikolai V.;
Peitsch, Manuel C.;
Julia Hoeng

Publication type:

Article

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe mice – a systems toxicology analysis.

Published in:

Inhalation Toxicology, 2016, v. 28, n. 5, p. 226, doi. 10.3109/08958378.2016.1150368

By:

Lo Sasso, Giuseppe;
Titz, Bjoern;
Nury, Catherine;
Boué, Stéphanie;
Phillips, Blaine;
Belcastro, Vincenzo;
Schneider, Thomas;
Dijon, Sophie;
Baumer, Karine;
Peric, Daruisz;
Dulize, Remi;
Elamin, Ashraf;
Guedj, Emmanuel;
Buettner, Ansgar;
Leroy, Patrice;
Kleinhans, Samuel;
Vuillaume, Gregory;
Veljkovic, Emilija;
Ivanov, Nikolai V.;
Martin, Florian

Publication type:

Article

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology.

Published in:

Inhalation Toxicology, 2015, v. 27, n. 9, p. 405, doi. 10.3109/08958378.2015.1046000

By:

Phillips, Blaine;
Esposito, Marco;
Verbeeck, Jan;
Boué, Stéphanie;
Iskandar, Anita;
Vuillaume, Gregory;
Leroy, Patrice;
Krishnan, Subash;
Kogel, Ulrike;
Utan, Aneli;
Schlage, Walter K.;
Bera, Monali;
Veljkovic, Emilija;
Hoeng, Julia;
Peitsch, Manuel C.;
Vanscheeuwijck, Patrick

Publication type:

Article

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.

Published in:

Toxicological Sciences, 2020, v. 178, n. 1, p. 138, doi. 10.1093/toxsci/kfaa132

By:

Titz, Bjoern;
Sewer, Alain;
Luettich, Karsta;
Wong, Ee Tsin;
Guedj, Emmanuel;
Nury, Catherine;
Schneider, Thomas;
Xiang, Yang;
Trivedi, Keyur;
Vuillaume, Grégory;
Leroy, Patrice;
Büttner, Ansgar;
Martin, Florian;
Ivanov, Nikolai V;
Vanscheeuwijck, Patrick;
Hoeng, Julia;
Peitsch, Manuel C

Publication type:

Article

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke.

Published in:

Toxicological Sciences, 2020, v. 178, n. 1, p. 44, doi. 10.1093/toxsci/kfaa131

By:

Wong, Ee Tsin;
Luettich, Karsta;
Krishnan, Subash;
Wong, Sin Kei;
Lim, Wei Ting;
Yeo, Demetrius;
Büttner, Ansgar;
Leroy, Patrice;
Vuillaume, Grégory;
Boué, Stéphanie;
Hoeng, Julia;
Vanscheeuwijck, Patrick;
Peitsch, Manuel C

Publication type:

Article

Works by Leroy, Patrice

Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology.

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium.

Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.

Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE<sup>−/−</sup> mouse model.

Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke.

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE–/– mouse model.

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis.

Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study.

A framework for in vitro systems toxicology assessment of e-liquids.

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD).

Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach.

A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment.

3-D Nasal Cultures: Systems Toxicological Assessment of a Candidate Modified-Risk Tobacco Product.

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study.

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe<sup>-/-</sup> Mice-An Integrative Systems Toxicology Analysis.

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe<sup>-/-</sup> Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts.

Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe mice – a systems toxicology analysis.

Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology.

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice.

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke.