Works by Leonard, Warren J.

Results: 68

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.

Published in:

Nature, 1982, v. 300, n. 5889, p. 267, doi. 10.1038/300267a0

By:

Leonard, Warren J.;
Depper, Joel M.;
Uchiyama, Takashi;
Smith, Kendall A.;
Waldmann, Thomas A.;
Greene, Warner C.

Publication type:

Article

New insights into the regulation of T cells by gamma(c) family cytokines.

Published in:

2009

By:

Rochman, Yrina;
Spolski, Rosanne;
Leonard, Warren J.

Publication type:

journal article

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation.

Published in:

Nature Reviews Immunology, 2005, v. 5, n. 9, p. 688, doi. 10.1038/nri1688

By:

Leonard, Warren J.;
Spolski, Rosanne

Publication type:

Article

Cytokines and immunodeficiency diseases.

Published in:

2001

By:

Leonard, Warren J.;
Leonard, W J

Publication type:

journal article

A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus.

Published in:

Science Immunology, 2016, v. 1, n. 5, p. 1, doi. 10.1126/sciimmunol.aaf8471

By:

West, Erin E.;
Spolski, Rosanne;
Kazemian, Majid;
Zu Xi Yu;
Kemper, Claudia;
Leonard, Warren J.

Publication type:

Article

Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02738

By:

Li, Peng;
Leonard, Warren J.

Publication type:

Article

Endothelial interleukin-21 receptor up-regulation in peripheral artery disease.

Published in:

Vascular Medicine, 2016, v. 21, n. 2, p. 99, doi. 10.1177/1358863X15621798

By:

Wang, Tao;
Cunningham, Alexis;
Houston, Kevin;
Sharma, Aditya M.;
Chen, Lingdan;
Dokun, Ayotunde O.;
Lye, R. John;
Spolski, Rosanne;
Leonard, Warren J.;
Annex, Brian H.

Publication type:

Article

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency.

Published in:

Nature Genetics, 1998, v. 20, n. 4, p. 394, doi. 10.1038/3877

By:

Puel, Anne;
Ziegler, Steven F.;
Buckley, Rebecca H.;
Leonard, Warren J.

Publication type:

Article

ROGUE: an R Shiny app for RNA sequencing analysis and biomarker discovery.

Published in:

BMC Bioinformatics, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s12859-023-05420-y

By:

Farrel, Alvin;
Li, Peng;
Veenbergen, Sharon;
Patel, Khushbu;
Maris, John M.;
Leonard, Warren J.

Publication type:

Article

IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection

Published in:

PLoS Pathogens, 2013, v. 9, n. 5, p. 1, doi. 10.1371/journal.ppat.1003362

By:

Schmitz, Iwana;
Schneider, Christoph;
Fröhlich, Anja;
Frebel, Helge;
Christ, Daniel;
Leonard, Warren J.;
Sparwasser, Tim;
Oxenius, Annette;
Freigang, Stefan;
Kopf, Manfred

Publication type:

Article

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Published in:

Nature Immunology, 2012, v. 13, n. 12, p. 1187, doi. 10.1038/ni.2449

By:

Ring, Aaron M;
Lin, Jian-Xin;
Feng, Dan;
Mitra, Suman;
Rickert, Mathias;
Bowman, Gregory R;
Pande, Vijay S;
Li, Peng;
Moraga, Ignacio;
Spolski, Rosanne;
Özkan, Engin;
Leonard, Warren J;
Garcia, K Christopher

Publication type:

Article

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Published in:

Nature Immunology, 2011, v. 12, n. 6, p. 551, doi. 10.1038/ni.2030

By:

Liao, Wei;
Lin, Jian-Xin;
Wang, Lu;
Li, Peng;
Leonard, Warren J

Publication type:

Article

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression.

Published in:

Nature Immunology, 2008, v. 9, n. 11, p. 1288, doi. 10.1038/ni.1656

By:

Liao, Wei;
Schones, Dustin E;
Oh, Jangsuk;
Cui, Yongzhi;
Cui, Kairong;
Roh, Tae-Young;
Zhao, Keji;
Leonard, Warren J

Publication type:

Article

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

Published in:

Nature Immunology, 2007, v. 8, n. 9, p. 967, doi. 10.1038/ni1488

By:

Zhou, Liang;
Ivanov, Ivaylo I;
Spolski, Rosanne;
Min, Roy;
Shenderov, Kevin;
Egawa, Takeshi;
Levy, David E;
Leonard, Warren J;
Littman, Dan R

Publication type:

Article

GA binding protein regulates interleukin 7 receptora-chain gene expression in T cells.

Published in:

Nature Immunology, 2004, v. 5, n. 10, p. 1036, doi. 10.1038/ni1117

By:

Hai-Hui Xue;
Bollenbacher, Julie;
Rovella, Valentina;
Tripuraneni, Radhika;
Yu-Bin Du;
Cheng-Yu Liu;
Williams, Ann;
McCoy, J. Philip;
Leonard, Warren J.

Publication type:

Article

TSLP: finally in the limelight.

Published in:

Nature Immunology, 2002, v. 3, n. 7, p. 605, doi. 10.1038/ni0702-605

By:

Leonard, Warren J.

Publication type:

Article

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.

Published in:

Nature Immunology, 2000, v. 1, n. 1, p. 59, doi. 10.1038/76923

By:

Pandey, Akhilesh;
Ozaki, Katsutoshi;
Baumann, Heinz;
Levin, Steven D.;
Puel, Anne;
Farr, Andrew G.;
Ziegler, Steven F.;
Leonard, Warren J.;
Lodish, Harvey F.

Publication type:

Article

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.65777

By:

Glassman, Caleb R.;
Su, Leon;
Majri-Morrison, Sonia S.;
Winkelmann, Hauke;
Fei Mo;
Peng Li;
Pérez-Cruz, Magdiel;
Ho, Peggy P.;
Koliesnik, Ievgen;
Nagy, Nadine;
Hnizdilova, Tereza;
Picton, Lora K.;
Kovar, Marek;
Bollyky, Paul;
Steinman, Lawrence;
Meyer, Everett;
Piehler, Jacob;
Leonard, Warren J.;
Garcia, K.Christopher

Publication type:

Article

TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state.

Published in:

Science Signaling, 2018, v. 11, n. 521, p. 1, doi. 10.1126/scisignal.aam8858

By:

Rochman, Yrina;
Dienger-Stambaugh, Krista;
Richgels, Phoebe K.;
Lewkowich, Ian P.;
Kartashov, Andrey V.;
Barski, Artem;
Khurana Hershey, Gurjit K.;
Leonard, Warren J.;
Singh, Harinder

Publication type:

Article

Enhanced T Cell Lymphoma in NOD.Stat5b Transgenic Mice Is Caused by Hyperactivation of Stat5b in CD8+ Thymocytes.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056600

By:

Chen, Bo;
Yi, Bing;
Mao, Rui;
Liu, Haitao;
Wang, Jinhua;
Sharma, Ashok;
Peiper, Stephen;
Leonard, Warren J.;
She, Jin-Xiong

Publication type:

Article

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin.

Published in:

2010

By:

Dumortier, Alexis;
Durham, André-Dante;
Piazza, Matteo Di;
Vauclair, Sophie;
Koch, Ute;
Ferrand, Gisèle;
Ferrero, Isabel;
Demehri, Shadmehr;
Song, Lynda Li;
Farr, Andrew G.;
Leonard, Warren J.;
Kopan, Raphael;
Miele, Lucio;
Hohl, Daniel;
Finke, Daniela;
Radtke, Freddy

Publication type:

Case Study

GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.

Published in:

FASEB Journal, 2008, v. 22, n. 1, p. 225, doi. 10.1096/fj.07-8573com

By:

Crook, Martin F.;
Olive, Michelle;
Hai-Hui Xue;
Langenickel, Thomas H.;
Boehm, Manfred;
Leonard, Warren J.;
Nabel, Elizabeth G.

Publication type:

Article

Comprehensive assembly of novel transcripts from unmapped human RNA-Seq data and their association with cancer.

Published in:

Molecular Systems Biology, 2015, v. 11, n. 8, p. n/a, doi. 10.15252/msb.156172

By:

Kazemian, Majid;
Ren, Min;
Lin, Jian‐Xin;
Liao, Wei;
Spolski, Rosanne;
Leonard, Warren J

Publication type:

Article

TSLP‐targeting therapy: Beyond allergy?

Published in:

Clinical & Translational Medicine, 2023, v. 13, n. 5, p. 1, doi. 10.1002/ctm2.1241

By:

Ebina‐Shibuya, Risa;
Leonard, Warren J.

Publication type:

Article

IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.

Published in:

2011

By:

Publicover, Jean;
Goodsell, Amanda;
Nishimura, Stephen;
Vilarinho, Silvia;
Zhi-en Wang;
Avanesyan, Lia;
Spolski, Rosanne;
Leonard, Warren J.;
Cooper, Stewart;
Baron, Jody L.;
Wang, Zhi-en

Publication type:

journal article

A new pipeline SPICE identifies novel JUN-IKZF1 composite elements.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.88833

By:

Peng Li;
Pulugulla, Sree;
Das, Sonali;
Jangsuk Oh;
Spolski, Rosanne;
Jian-Xin Lin;
Leonard, Warren J.

Publication type:

Article

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.

Published in:

PLoS Pathogens, 2017, v. 13, n. 8, p. 1, doi. 10.1371/journal.ppat.1006544

By:

Shin, Hyun Mu;
Kapoor, Varun N.;
Kim, Gwanghun;
Li, Peng;
Kim, Hang-Rae;
Suresh, M.;
Kaech, Susan M.;
Wherry, E. John;
Selin, Liisa K.;
Leonard, Warren J.;
Welsh, Raymond M.;
Berg, Leslie J.

Publication type:

Article

Targeting the GA Binding Protein β1L Isoform Does Not Perturb Lymphocyte Development and Function.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 13, p. 8

By:

Hai-Hui Xue;
Xuefang Jing;
Bollenbacher-Reilley, Julie;
Dong-Mei Zhao;
Haring, Jodie S.;
Baoli Yang;
Chengyu Liu;
Bishop, Gail A.;
Harty, John T.;
Leonard, Warren J.

Publication type:

Article

New insights into heterogeneity of peritoneal B-1a cells.

Published in:

Annals of the New York Academy of Sciences, 2015, v. 1362, n. 1, p. 68, doi. 10.1111/nyas.12791

By:

Wang, Hongsheng;
Lin, Jian‐xin;
Li, Peng;
Skinner, Jeff;
Leonard, Warren J.;
Morse, Herbert C.

Publication type:

Article

Interleukin-21: a double-edged sword with therapeutic potential.

Published in:

2014

By:

Spolski, Rosanne;
Leonard, Warren J

Publication type:

journal article

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.

Published in:

Oncogene, 2000, v. 19, n. 21, p. 2566, doi. 10.1038/sj.onc.1203523

By:

Lin, Jian-Xin;
Leonard, Warren J

Publication type:

Article

Biology of IL‐2 and its therapeutic modulation: Mechanisms and strategies.

Published in:

Journal of Leukocyte Biology, 2018, v. 103, n. 4, p. 643, doi. 10.1002/JLB.2RI0717-278R

By:

Mitra, Suman;
Leonard, Warren J.

Publication type:

Article

The basis for TCR‐mediated regulation of the IL‐2 receptor α chain gene: role of widely separated regulatory elements.

Published in:

EMBO Journal, 2002, v. 21, n. 12, p. 3051, doi. 10.1093/emboj/cdf321

By:

Kim, Hyoung‐Pyo;
Leonard, Warren J.

Publication type:

Article

The basis for TCR-mediated regulation of the IL-2 receptor a chain gene: role of widely separated regulatory elements.

Published in:

EMBO Journal, 2002, v. 21, n. 12, p. 3051, doi. 10.1093/emboj/cdf321

By:

Kim, Hyoung-pyo;
Leonard, Warren J.

Publication type:

Article

Interleukin-21 Receptor Gene Induction in Human T Cells Is Mediated by T-Cell Receptor-Induced Sp1 Activity.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 22, p. 9741, doi. 10.1128/MCB.25.22.9741-9752.2005

By:

Zheng Wu;
Hyoung-Pyo Kim;
Hai-Hui Xue;
Hong Liu;
Keji Zhao;
Leonard, Warren J.

Publication type:

Article

Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance.

Published in:

2021

By:

Toshihito Hirai;
Ramos, Teresa L.;
Po-Yu Lin;
Simonetta, Federico;
Su, Leon L.;
Picton, Lora K.;
Baker, Jeanette;
Jian-Xin Lin;
Peng Li;
Kinya Seo;
Lohmeyer, Juliane K.;
Wagers, Sara B.;
Mavers, Melissa;
Leonard, Warren J.;
Blazar, Bruce R.;
Garcia, K. Christopher;
Negrin, Robert S.;
Hirai, Toshihito;
Lin, Po-Yu;
Lin, Jian-Xin

Publication type:

journal article

Complex interactions of transcription factors in mediating cytokine biology in T cells.

Published in:

Immunological Reviews, 2014, v. 261, n. 1, p. 141, doi. 10.1111/imr.12199

By:

Li, Peng;
Spolski, Rosanne;
Liao, Wei;
Leonard, Warren J.

Publication type:

Article

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50925-6

By:

Lin, Jian-Xin;
Ge, Meili;
Liu, Cheng-yu;
Holewinski, Ronald;
Andresson, Thorkell;
Yu, Zu-Xi;
Gebregiorgis, Tesfay;
Spolski, Rosanne;
Li, Peng;
Leonard, Warren J.

Publication type:

Article

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Published in:

Nature Immunology, 2015, v. 16, n. 5, p. 544, doi. 10.1038/ni0515-544d

By:

Vasanthakumar, Ajithkumar;
Moro, Kazuyo;
Xin, Annie;
Liao, Yang;
Gloury, Renee;
Kawamoto, Shimpei;
Fagarasan, Sidonia;
Mielke, Lisa A;
Afshar-Sterle, Shoukat;
Masters, Seth L;
Nakae, Susumu;
Saito, Hirohisa;
Wentworth, John M;
Li, Peng;
Liao, Wei;
Leonard, Warren J;
Smyth, Gordon K;
Shi, Wei;
Nutt, Stephen L;
Koyasu, Shigeo

Publication type:

Article

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Published in:

Nature Immunology, 2015, v. 16, n. 3, p. 276, doi. 10.1038/ni.3085

By:

Vasanthakumar, Ajithkumar;
Moro, Kazuyo;
Xin, Annie;
Liao, Yang;
Gloury, Renee;
Kawamoto, Shimpei;
Fagarasan, Sidonia;
Mielke, Lisa A;
Afshar-Sterle, Shoukat;
Masters, Seth L;
Nakae, Susumu;
Saito, Hirohisa;
Wentworth, John M;
Li, Peng;
Liao, Wei;
Leonard, Warren J;
Smyth, Gordon K;
Shi, Wei;
Nutt, Stephen L;
Koyasu, Shigeo

Publication type:

Article

Cytokine mediators of Th17 function.

Published in:

European Journal of Immunology, 2009, v. 39, n. 3, p. 658, doi. 10.1002/eji.200839066

By:

Spolski, Rosanne;
Leonard, Warren J.

Publication type:

Article

Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor γ chain is required for IL-7 signal transduction.

Published in:

European Journal of Immunology, 1995, v. 25, n. 2, p. 399, doi. 10.1002/eji.1830250214

By:

Ziegler, Steven F.;
Morella, Karen K.;
Anderson, Dirk;
Kumaki, Noriko;
Leonard, Warren J.;
Cosman, David;
Baumann, Heinz

Publication type:

Article

Expression of interleukin-2 receptor γ on human monocytes: characterization of lineage specific post-translational modifications.

Published in:

European Journal of Immunology, 1995, v. 25, n. 1, p. 291, doi. 10.1002/eji.1830250148

By:

Epling-Burnette, P. K.;
Wei, Sheng;
Liu, Jin Hong;
Pericle, Federica;
Ussery, Dewayne;
Russell, Sarah M.;
Leonard, Warren J.;
Djeu, Julie Y.

Publication type:

Article

Interleukin (IL)-2 activation of p21.

Published in:

European Journal of Immunology, 1992, v. 22, n. 3, p. 817, doi. 10.1002/eji.1830220328

By:

Izquierdo, Manuel;
Downward, Julian;
Otani, Hiroki;
Leonard, Warren J.;
Cantrell, Doreen A.

Publication type:

Article

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01477-5

By:

Jian-Xin Lin;
Ning Du;
Peng Li;
Kazemian, Majid;
Gebregiorgis, Tesfay;
Spolski, Rosanne;
Leonard, Warren J.

Publication type:

Article

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.

Published in:

Nature Communications, 2015, v. 6, n. 8, p. 7988, doi. 10.1038/ncomms8988

By:

Wan, Chi-Keung;
Li, Peng;
Spolski, Rosanne;
Oh, Jangsuk;
Andraski, Allison B.;
Du, Ning;
Yu, Zu-Xi;
Dillon, Christopher P.;
Green, Douglas R.;
Leonard, Warren J.

Publication type:

Article

Molecular Models of STAT5A Tetramers Complexed to DNA Predict Relative Genome-Wide Frequencies of the Spacing between the Two Dimer Binding Motifs of the Tetramer Binding Sites.

Published in:

PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160339

By:

Sathyanarayana, Bangalore K.;
Li, Peng;
Lin, Jian-Xin;
Leonard, Warren J.;
Lee, Byungkook

Publication type:

Article

Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells.

Published in:

2006

By:

Ozaki, Katsutoshi;
Hishiya, Ai;
Hatanaka, Keiko;
Nakajima, Hideaki;
Wang, Gang;
Hwu, Patrick;
Kitamura, Toshio;
Ozawa, Keiya;
Leonard, Warren J;
Nosaka, Tetsuya

Publication type:

journal article

Role of Jak Kinases and STATs in Cytokine Signal Transduction.

Published in:

International Journal of Hematology, 2001, v. 73, n. 3, p. 271, doi. 10.1007/BF02981951

By:

Leonard, Warren J.

Publication type:

Article

Induction of Thymic Stromal Lymphopoietin Production by Xylene and Exacerbation of Picryl Chloride-Induced Allergic Inflammation in Mice.

Published in:

International Archives of Allergy & Immunology, 2012, v. 157, n. 2, p. 194, doi. 10.1159/000327545

By:

Satou, Nozomi;
Ishihara, Kenji;
Hiratsuka, Masahiro;
Tanaka, Hiroyuki;
Endo, Yasuo;
Saito, Saburo;
Iwakura, Yoichiro;
Leonard, Warren J.;
Hirasawa, Noriyasu

Publication type:

Article