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Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2018, v. 45, n. 6, p. 2233, doi. 10.1159/000488169
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- Publication type:
- Article
Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity'?
- Published in:
- Nature Reviews Drug Discovery, 2012, v. 11, n. 9, p. 730, doi. 10.1038/nrd3503-c1
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- Publication type:
- Article
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine.
- Published in:
- Pharmacology Research & Perspectives, 2015, v. 3, n. 5, p. 1, doi. 10.1002/prp2.160
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- Publication type:
- Article
Microwave-Assisted Synthesis of (±)-Mandelic Acid-d<sub>5</sub>, Optical Resolution, and Absolute Configuration Determination.
- Published in:
- Journal of Chemistry, 2013, p. 1, doi. 10.1155/2013/386238
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- Publication type:
- Article
Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 9, p. 1513, doi. 10.3390/pharmaceutics13091513
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- Publication type:
- Article
A Comparative Study of the Inhibitory Action of Berberine Derivatives on the Recombinant Protein FtsZ of E. coli.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5674, doi. 10.3390/ijms24065674
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- Publication type:
- Article
Camel (Camelus spp.) Urine Bioactivity and Metabolome: A Systematic Review of Knowledge Gaps, Advances, and Directions for Future Research.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 15024, doi. 10.3390/ijms232315024
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- Publication type:
- Article
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na<sup>+</sup> channels enhancing the antimyotonic activity in vivo.
- Published in:
- British Journal of Pharmacology, 2001, v. 134, n. 7, p. 1523, doi. 10.1038/sj.bjp.0704366
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- Publication type:
- Article
Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX.
- Published in:
- 1999
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- Publication type:
- journal article
Corrigendum: Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels.
- Published in:
- ChemMedChem, 2022, v. 17, n. 7, p. 1, doi. 10.1002/cmdc.202200131
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- Publication type:
- Article
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels.
- Published in:
- ChemMedChem, 2021, v. 16, n. 23, p. 3588, doi. 10.1002/cmdc.202100496
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- Publication type:
- Article
Xanthenylacetic Acid Derivatives Effectively Target Lysophosphatidic Acid Receptor 6 to Inhibit Hepatocellular Carcinoma Cell Growth.
- Published in:
- ChemMedChem, 2021, v. 16, n. 13, p. 2121, doi. 10.1002/cmdc.202100032
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- Publication type:
- Article
Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities.
- Published in:
- ChemMedChem, 2021, v. 16, n. 3, p. 578, doi. 10.1002/cmdc.202000692
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- Publication type:
- Article
Plotting intersections.
- Published in:
- Nature Methods, 2015, v. 12, n. 4, p. 281, doi. 10.1038/nmeth.3328
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- Publication type:
- Article
(S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate.
- Published in:
- Molbank, 2019, v. 2019, n. 1, p. M1049, doi. 10.3390/M1049
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- Publication type:
- Article
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones.
- Published in:
- Journal of Heterocyclic Chemistry, 2011, v. 48, n. 2, p. 261, doi. 10.1002/jhet.536
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- Publication type:
- Article
New doxorubicin nanocarriers based on cyclodextrins.
- Published in:
- Investigational New Drugs, 2017, v. 35, n. 5, p. 539, doi. 10.1007/s10637-017-0461-0
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- Publication type:
- Article
Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity.
- Published in:
- Chirality, 2015, v. 27, n. 3, p. 239, doi. 10.1002/chir.22419
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- Publication type:
- Article
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs.
- Published in:
- Chirality, 2010, v. 22, n. 3, p. 299, doi. 10.1002/chir.20741
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- Publication type:
- Article
The Crystal Structure of N-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-4-methoxy-N-methylbenzenesulfonamide.
- Published in:
- Journal of Chemical Crystallography, 2019, v. 49, n. 2, p. 87, doi. 10.1007/s10870-018-0739-x
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- Publication type:
- Article
hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation.
- Published in:
- Archiv der Pharmazie, 2023, v. 356, n. 10, p. 1, doi. 10.1002/ardp.202300116
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- Publication type:
- Article
Hydroxylated Analogs of Mexiletine as Tools for Structural-Requirements Investigation of the Sodium Channel Blocking Activity.
- Published in:
- Archiv der Pharmazie, 2010, v. 343, n. 6, p. 325, doi. 10.1002/ardp.200900218
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- Publication type:
- Article
Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2003, v. 367, n. 3, p. 318, doi. 10.1007/s00210-002-0669-0
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- Publication type:
- Article
Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce.
- Published in:
- Molecules, 2023, v. 28, n. 1, p. 373, doi. 10.3390/molecules28010373
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- Publication type:
- Article
Lubeluzole Repositioning as Chemosensitizing Agent on Multidrug-Resistant Human Ovarian A2780/DX3 Cancer Cells.
- Published in:
- Molecules, 2022, v. 27, n. 22, p. 7870, doi. 10.3390/molecules27227870
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- Publication type:
- Article
Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization.
- Published in:
- Molecules, 2022, v. 27, n. 21, p. 7471, doi. 10.3390/molecules27217471
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- Publication type:
- Article
Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs.
- Published in:
- Molecules, 2022, v. 27, n. 11, p. 3494, doi. 10.3390/molecules27113494
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- Publication type:
- Article
Did Ebola Survivors Use Plant Medicines, and if so, Which Ones?
- Published in:
- Phytotherapy Research, 2015, v. 29, n. 4, p. 632, doi. 10.1002/ptr.5279
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- Publication type:
- Article
Phytochemical, antioxidant and anti-α-glucosidase activity evaluations of Bergenia cordifolia.
- Published in:
- 2012
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- Publication type:
- journal article
Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia.
- Published in:
- Phytotherapy Research, 2012, v. 26, n. 6, p. 908, doi. 10.1002/ptr.3655
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- Publication type:
- Article
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres.
- Published in:
- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00155
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- Publication type:
- Article
Antiviral Properties of Moringa oleifera Leaf Extracts against Respiratory Viruses.
- Published in:
- Viruses (1999-4915), 2024, v. 16, n. 8, p. 1199, doi. 10.3390/v16081199
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- Publication type:
- Article
2-Arylazetidines as ligands for nicotinic acetylcholine receptors.
- Published in:
- Chemistry of Heterocyclic Compounds, 2017, v. 53, n. 3, p. 329, doi. 10.1007/s10593-017-2061-5
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- Publication type:
- Article
Targeting Penicillium expansum GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production.
- Published in:
- Biology (2079-7737), 2021, v. 10, n. 1, p. 21, doi. 10.3390/biology10010021
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- Publication type:
- Article
Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline‐deficient l‐amino acid‐defined diet prevents hepatocarcinogenesis in mice.
- Published in:
- Molecular Carcinogenesis, 2023, v. 62, n. 5, p. 577, doi. 10.1002/mc.23516
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- Publication type:
- Article
Repurposing therapeutic agents and herbal medicines to defeat viral nemesis.
- Published in:
- Drug Development Research, 2020, v. 81, n. 6, p. 641, doi. 10.1002/ddr.21668
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- Publication type:
- Article
Antipsychotics: 70 Years.
- Published in:
- Biomedicines, 2023, v. 11, n. 11, p. 3070, doi. 10.3390/biomedicines11113070
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- Publication type:
- Article
Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective.
- Published in:
- Biomedicines, 2023, v. 11, n. 2, p. 469, doi. 10.3390/biomedicines11020469
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- Publication type:
- Article
Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models.
- Published in:
- Biomedicines, 2021, v. 9, n. 5, p. 452, doi. 10.3390/biomedicines9050452
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- Publication type:
- Article
Antimicrobial and Antibiofilm Activities of Citrus Water-Extracts Obtained by Microwave-Assisted and Conventional Methods.
- Published in:
- Biomedicines, 2018, v. 6, n. 2, p. 70, doi. 10.3390/biomedicines6020070
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- Publication type:
- Article
Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin.
- Published in:
- Biomedicines, 2018, v. 6, n. 2, p. 39, doi. 10.3390/biomedicines6020039
- By:
- Publication type:
- Article
Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential.
- Published in:
- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2017.00907
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- Publication type:
- Article
The honest h index: when a research performance indicator turns into an oxymoron.
- Published in:
- 2013
- By:
- Publication type:
- Letter
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate.
- Published in:
- Chirality, 2006, v. 18, n. 4, p. 227, doi. 10.1002/chir.20240
- By:
- Publication type:
- Article
Stereospecific synthesis of para-hydroxymexiletine and sodium channel blocking activity evaluation.
- Published in:
- Chirality, 2004, v. 16, n. 2, p. 72
- By:
- Publication type:
- Article
Facile entry to (−)-( R)- and (+)-( S)-mexiletine.
- Published in:
- Chirality, 2000, v. 12, n. 3, p. 103, doi. 10.1002/(SICI)1520-636X(2000)12:3<103::AID-CHIR1>3.0.CO;2-X
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- Publication type:
- Article
Stereospecific synthesis and absolute configuration of mexiletine.
- Published in:
- Chirality, 1994, v. 6, n. 7, p. 590, doi. 10.1002/chir.530060713
- By:
- Publication type:
- Article
Stereoselectivity in central analgesic action of tocainide and its analogs.
- Published in:
- Chirality, 1993, v. 5, n. 3, p. 135, doi. 10.1002/chir.530050306
- By:
- Publication type:
- Article
Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function.
- Published in:
- Journal of Molecular Medicine, 2020, v. 98, n. 2, p. 179, doi. 10.1007/s00109-019-01862-1
- By:
- Publication type:
- Article
Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials.
- Published in:
- Molecules, 2021, v. 26, n. 13, p. 3891, doi. 10.3390/molecules26133891
- By:
- Publication type:
- Article