Works matching AU Leitges, Michael

Results: 93

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control.

Published in:

PLoS Biology, 2013, v. 11, n. 6, p. 1, doi. 10.1371/journal.pbio.1001587

By:

Walser, Romy;
Burke, John E.;
Gogvadze, Elena;
Bohnacker, Thomas;
Zhang, Xuxiao;
Hess, Daniel;
Küenzi, Peter;
Leitges, Michael;
Hirsch, Emilio;
Williams, Roger L.;
Laffargue, Muriel;
Wymann, Matthias P.

Publication type:

Article

PKC-B controls I?B kinase lipid raft recruitment and activation in response to BCR signaling.

Published in:

Nature Immunology, 2002, v. 3, n. 8, p. 780, doi. 10.1038/ni823

By:

Su, Thomas T.;
Guo, Beichu;
Kawakami, Yuko;
Sommer, Karen;
Chae, Keun;
Humphries, Lisa A.;
Kato, Roberta M.;
Kang, Shin;
Patrone, Lisa;
Wall, Randolph;
Teitell, Michael;
Leitges, Michael;
Kawakami, Toshiaki;
Rawlings, David J.

Publication type:

Article

PKD3 deficiency causes alterations in microtubule dynamics during the cell cycle.

Published in:

Cell Cycle, 2016, v. 15, n. 14, p. 1844, doi. 10.1080/15384101.2016.1188237

By:

Zhang, Tianzhou;
Braun, Ursula;
Leitges, Michael

Publication type:

Article

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1.

Published in:

Cell Cycle, 2015, v. 14, n. 10, p. 1489, doi. 10.1080/15384101.2015.1032646

By:

Liou, Geou-Yarh;
Leitges, Michael;
Storz, Peter

Publication type:

Article

Regulation of B-cell survival by BAFF-dependent PKCd-mediated nuclear signalling.

Published in:

Nature, 2004, v. 431, n. 7007, p. 456, doi. 10.1038/nature02955

By:

Mecklenbräuker, Ingrid;
Kalied, Susan L.;
Leitges, Michael;
Mackay, Fabienne;
Tarakhovsky, Alexander

Publication type:

Article

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.

Published in:

Life Science Alliance, 2021, v. 4, n. 8, p. 1, doi. 10.26508/lsa.202000863

By:

Loza-Valdes, Angel;
Mayer, Alexander E.;
Kassouf, Toufic;
Trujillo-Viera, Jonathan;
Schmitz, Werner;
Dziaczkowski, Filip;
Leitges, Michael;
Schlosser, Andreas;
Sumara, Grzegorz

Publication type:

Article

A Protein Kinase Cε/Protein Kinase D3 Signalling Axis Modulates RhoA Activity During Cytokinesis.

Published in:

Biomedicines, 2025, v. 13, n. 2, p. 345, doi. 10.3390/biomedicines13020345

By:

Braun, Ursula;
Leitges, Michael

Publication type:

Article

Protein kinase C‐β‐dependent changes in the glucose metabolism of bone marrow stromal cells of chronic lymphocytic leukemia.

Published in:

Stem Cells, 2021, v. 39, n. 6, p. 819, doi. 10.1002/stem.3352

By:

Heydebrand, Franziska;
Fuchs, Maximilian;
Kunz, Meik;
Voelkl, Simon;
Kremer, Anita N.;
Oostendorp, Robert A. J.;
Wilke, Jochen;
Leitges, Michael;
Egle, Alexander;
Mackensen, Andreas;
Lutzny‐Geier, Gloria

Publication type:

Article

AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis.

Published in:

Nature Genetics, 2010, v. 42, n. 2, p. 175, doi. 10.1038/ng.519

By:

Louie, Carrie M.;
Caridi, Gianluca;
Lopes, Vanda S.;
Brancati, Francesco;
Kispert, Andreas;
Lancaster, Madeline A.;
Schlossman, Andrew M.;
Otto, Edgar A.;
Leitges, Michael;
Gröne, Hermann-Josef;
Lopez, Irma;
Gudiseva, Harini V.;
O'Toole, John F.;
Vallespin, Elena;
Ayyagari, Radha;
Ayuso, Carmen;
Cremers, Frans P. M.;
den Hollander, Anneke I.;
Koenekoop, Robert K.;
Dallapiccola, Bruno

Publication type:

Article

WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.

Published in:

2021

By:

Brandenburg, Julius;
Marwitz, Sebastian;
Tazoll, Simone C.;
Waldow, Franziska;
Kalsdorf, Barbara;
Vierbuchen, Tim;
Scholzen, Thomas;
Gross, Annette;
Goldenbaum, Svenja;
Hölscher, Alexandra;
Hein, Martina;
Linnemann, Lara;
Reimann, Maja;
Kispert, Andreas;
Leitges, Michael;
Rupp, Jan;
Lange, Christoph;
Niemann, Stefan;
Behrends, Jochen;
Goldmann, Torsten

Publication type:

journal article

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.

Published in:

2011

By:

Bezy, Olivier;
Tran, Thien T.;
Pihlajamäki, Jussi;
Suzuki, Ryo;
Emanuelli, Brice;
Winnay, Jonathan;
Mori, Marcelo A.;
Haas, Joel;
Biddinger, Sudha B.;
Leitges, Michael;
Goldfine, Allison B.;
Patti, Mary Elizabeth;
King, George L.;
Kahn, C. Ronald;
Pihlajamäki, Jussi

Publication type:

journal article

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

Published in:

2007

By:

Farese, Robert V;
Sajan, Mini P;
Yang, Hong;
Li, Pengfei;
Mastorides, Steven;
Gower, William R Jr;
Nimal, Sonali;
Choi, Cheol Soo;
Kim, Sheene;
Shulman, Gerald I;
Kahn, C Ronald;
Braun, Ursula;
Leitges, Michael

Publication type:

journal article

Response to Field.

Published in:

2006

By:

Turner, Jerrold R.;
Clayburgh, Daniel R.;
Musch, Mark W.;
Leitges, Michael;
Yang-Xin Fu

Publication type:

Letter

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 10, p. 2682, doi. 10.1172/JCI29218

By:

Clayburgh, Daniel R.;
Musch, Mark W.;
Leitges, Michael;
Yang-Xin Fu;
Turner, Jerrold R.

Publication type:

Article

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.

Published in:

2006

By:

Clayburgh, Daniel R.;
Musch, Mark W.;
Leitges, Michael;
Yang-Xin Fu;
Turner, Jerrold R.;
Fu, Yang-Xin

Publication type:

journal article

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

Published in:

Developmental Dynamics, 2008, v. 237, n. 6, p. spc1, doi. 10.1002/dvdy.21603

By:

Potok, Mary Anne;
Cha, Kelly B.;
Hunt, Andrea;
Brinkmeier, Michelle L.;
Leitges, Michael;
Kispert, Andreas;
Camper, Sally A.

Publication type:

Article

WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.

Published in:

Developmental Dynamics, 2008, v. 237, n. 4, p. 1006, doi. 10.1002/dvdy.21511

By:

Potok, Mary Anne;
Cha, Kelly B.;
Hunt, Andrea;
Brinkmeier, Michelle L.;
Leitges, Michael;
Kispert, Andreas;
Camper, Sally A.

Publication type:

Article

Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0163325

By:

Kim, Yun K.;
Yadava, Ramesh S.;
Mandal, Mahua;
Mahadevan, Karunasai;
Yu, Qing;
Leitges, Michael;
Mahadevan, Mani S.

Publication type:

Article

PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages.

Published in:

Cardiovascular Research, 2014, v. 104, n. 3, p. 467, doi. 10.1093/cvr/cvu213

By:

Szilagyi, Katka;
Meijer, Alexander B.;
Neele, Annette E.;
Verkuijlen, Paul;
Leitges, Michael;
Dabernat, Sandrine;
Förster-Waldl, Elisabeth;
Boztug, Kaan;
Belot, Alexandre;
Kuijpers, Taco W.;
Kraal, Georg;
de Winther, Menno P. J.;
van den Berg, Timo K.

Publication type:

Article

Transcriptome Profiling of Mouse Embryonic Fibroblast Spontaneous Immortalization: A Comparative Analysis.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 15, p. 8116, doi. 10.3390/ijms25158116

By:

Loaiza-Moss, Jocshan;
Braun, Ursula;
Leitges, Michael

Publication type:

Article

Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons.

Published in:

2003

By:

Pilz, Andreas;
Ramsauer, Katrin;
Heidari, Hamid;
Leitges, Michael;
Kovarik, Pavel;
Decker, Thomas

Publication type:

Report

12R-lipoxygenase deficiency disrupts epidermal barrier function.

Published in:

Journal of Cell Biology, 2007, v. 177, n. 1, p. 173, doi. 10.1083/jcb.200612116

By:

Epp, Nikolas;
Fürstenberger, Gerhard;
Müller, Karsten;
de Juanes, Silvia;
Leitges, Michael;
Hausser, Ingrid;
Thieme, Florian;
Liebisch, Gerhard;
Schmitz, Gerd;
Krieg, Peter

Publication type:

Article

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-? produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.

Published in:

Adipocyte, 2014, v. 3, n. 1, p. 19, doi. 10.4161/adip.26305

By:

Sajan, Mini P;
Jurzak, Michael J;
Samuels, Varman T;
Shulman, Gerald I;
Braun, Ursula;
Leitges, Michael;
Farese, Robert V

Publication type:

Article

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.

Published in:

Adipocyte, 2012, v. 1, n. 4, p. 203, doi. 10.4161/adip.20891

By:

Habegger, Kirk M.;
Matzke, Daniela;
Ottaway, Nickki;
Hembree, Jazzminn;
Holland, Jenna;
Raver, Christine;
Mansfeld, Johannes;
Müller, Timo D.;
Perez-Tilve, Diego;
Pfluger, Paul T.;
Lee, Sang Jun;
Diaz-Meco, Maria;
Moscat, Jorge;
Leitges, Michael;
Tschöp, Matthias H.;
Hofmann, Susanna M.

Publication type:

Article

Protein kinase C epsilon mediates angiotensin II-induced activation of β<sub>1</sub>-integrins in cardiac fibroblasts

Published in:

Cardiovascular Research, 2005, v. 67, n. 1, p. 50, doi. 10.1016/j.cardiores.2005.03.002

By:

Stawowy, Philipp;
Margeta, Christian;
Blaschke, Florian;
Lindschau, Carsten;
Spencer-Hänsch, Chantel;
Leitges, Michael;
Biagini, Giuseppe;
Fleck, Eckart;
Graf, Kristof

Publication type:

Article

Calcium-Dependent Isoforms of Protein Kinase C Mediate Glycine-Induced Synaptic Enhancement at the Calyx of Held.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 40, p. 13796, doi. 10.1523/JNEUROSCI.2158-12.2012

By:

YunXiang Chu;
Fioravante, Diasynou;
Thanawala, Monica;
Leitges, Michael;
Regehr, Wade G.

Publication type:

Article

Adaptive Regulation Maintains Posttetanic Potentiation at Cerebellar Granule Cell Synapses in the Absence of Calcium-Dependent PKC.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 38, p. 13004, doi. 10.1523/JNEUROSCI.0683-12.2012

By:

Fioravante, Diasynou;
Myoga, Michael H.;
Leitges, Michael;
Regehr, Wade G.

Publication type:

Article

Cholecystokinin Facilitates Glutamate Release by Increasing the Number of Readily Releasable Vesicles and Releasing Probability.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 15, p. 5136, doi. 10.1523/JNEUROSCI.5711-09.2010

By:

Pan-Yue Deng;
Zhaoyang Xiao;
Jha, Archana;
Ramonet, David;
Matsui, Toshimitsu;
Leitges, Michael;
Hee-Sup Shin;
Porter, James E.;
Geiger, Jonathan D.;
Lei, Saobo

Publication type:

Article

UV irradiation increases ROS production via PKCδ signaling in primary murine fibroblasts.

Published in:

Journal of Cellular Biochemistry, 2008, v. 105, n. 1, p. 194, doi. 10.1002/jcb.21817

By:

Bossi, Orit;
Gartsbein, Marina;
Leitges, Michael;
Kuroki, Toshio;
Grossman, Shlomo;
Tennenbaum, Tamar

Publication type:

Article

Involvement of atypical protein kinase C in the regulation of cardiac glucose and long-chain fatty acid uptake.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00361

By:

Habets, Daphna D.J.;
Luiken, Joost J. F. P.;
Ouwens, Margriet;
Coumans, Will A.;
Vergouwe, Monique;
Maarbjerg, Stine J.;
Leitges, Michael;
Bonen, Arend;
Richter, Erik A.;
Glatz, Jan F. C.

Publication type:

Article

Involvement of atypical protein kinase C in the regulation of cardiac glucose and long-chain fatty acid uptake.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00361

By:

Habets, Daphna D. J.;
Luiken, Joost J. F. P.;
Ouwens, Margriet;
Coumans, Will A.;
Vergouwe, Monique;
Maarbjerg, Stine J.;
Leitges, Michael;
Bonen, Arend;
Richter, Erik A.;
Glatz, Jan F. C.

Publication type:

Article

T cell‐intrinsic PKD3 fine‐tunes differentiation into CD8<sup>+</sup> central memory T cells and CD8 single positive thymocyte development.

Published in:

Immunology, 2024, v. 173, n. 1, p. 125, doi. 10.1111/imm.13804

By:

Koutník, Jiří;
Peer, Sebastian;
Humer, Dominik;
Sumara, Grzegorz;
Leitges, Michael;
Baier, Gottfried;
Siegmund, Kerstin

Publication type:

Article

Role of aPKC Isoforms and Their Binding Partners Par3 and Par6 in Epidermal Barrier Formation.

Published in:

Journal of Investigative Dermatology, 2007, v. 127, n. 4, p. 782, doi. 10.1038/sj.jid.5700621

By:

Helfrich, Iris;
Schmitz, Annika;
Zigrino, Paola;
Michels, Christian;
Haase, Ingo;
Bivic, André le;
Leitges, Michael;
Niessen, Carien M.

Publication type:

Article

Expression pattern of Protein Kinase C ε during mouse embryogenesis.

Published in:

BMC Developmental Biology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-213X-13-16

By:

Carracedo, Sergio;
Braun, Ursula;
Leitges, Michael

Publication type:

Article

Expression pattern of protein kinase C δ during mouse embryogenesis.

Published in:

BMC Developmental Biology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-213X-13-2

By:

Carracedo, Sergio;
Braun, Ursula;
Leitges, Michael

Publication type:

Article

Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce Tolerance.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 8, p. 1474, doi. 10.1128/MCB.01699-13

By:

Limnander, Andre;
Zikherman, Julie;
Lau, Tannia;
Leitges, Michael;
Weiss, Arthur;
Roose, Jeroen P.

Publication type:

Article

Protein Kinase Cζ Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 1, p. 104, doi. 10.1128/MCB.01294-08

By:

Galvez, Anita S.;
Duran, Angeles;
Linares, Juan F.;
Pathrose, Peterson;
Castilla, Elias A.;
Shadi Abu-Baker;
Leitges, Michael;
Diaz-Meco, Maria T.;
Moscat, Jorge

Publication type:

Article

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Published in:

Nature Immunology, 2011, v. 12, n. 5, p. 425, doi. 10.1038/ni.2016

By:

Limnander, Andre;
Depeille, Philippe;
Freedman, Tanya S;
Liou, Jen;
Leitges, Michael;
Kurosaki, Tomohiro;
Roose, Jeroen P;
Weiss, Arthur

Publication type:

Article

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation.

Published in:

Journal of Cell Biology, 2013, v. 202, n. 6, p. 887, doi. 10.1083/jcb.201307001

By:

Niessen, Michaela T.;
Scott, Jeanie;
Zielinski, Julia G.;
Vorhagen, Susanne;
Sotiropoulou, Panagiota A.;
Blanpain, Cédric;
Leitges, Michael;
Niessen, Carien M.

Publication type:

Article

A redundant role for PKC-ɛ in mast cell signaling and effector function.

Published in:

International Immunology, 2006, v. 18, n. 5, p. 767, doi. 10.1093/intimm/dxl012

By:

Eva Lessmann;
Michael Leitges;
Michael Huber

Publication type:

Article

PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.

Published in:

International Journal of Cancer, 2008, v. 123, n. 4, p. 769, doi. 10.1002/ijc.23560

By:

Cameron, Angus J.;
Procyk, Katarzyna J.;
Leitges, Michael;
Parker, Peter J.

Publication type:

Article

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Published in:

Nature Communications, 2015, v. 6, n. 2, p. 6200, doi. 10.1038/ncomms7200

By:

Liou, Geou-Yarh;
Döppler, Heike;
Braun, Ursula B.;
Panayiotou, Richard;
Scotti Buzhardt, Michele;
Radisky, Derek C.;
Crawford, Howard C.;
Fields, Alan P.;
Murray, Nicole R.;
Wang, Q. Jane;
Leitges, Michael;
Storz, Peter

Publication type:

Article

Decay-accelerating factor induction by tumour necrosis factor-α, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition.

Published in:

Immunology, 2003, v. 110, n. 2, p. 258, doi. 10.1046/j.1365-2567.2003.01733.x

By:

Ahmad, Saifur R.;
Lidington, Elaine A.;
Rieko Ohta, Elaine A.;
Noriko Okada, Elaine A.;
Robson, Michael G.;
Davies, Kevin A.;
Leitges, Michael;
Harris, Claire L.;
Haskard, Dorian O.;
Mason, Justin C.

Publication type:

Article

C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.

Published in:

Journal of Nephrology (JNonline), 2012, v. 25, n. 5, p. 738, doi. 10.5301/jn.5000053

By:

Xia Lu;
Na Li;
Shushakova, Nelli;
Schmitt, Roland;
Menne, Jan;
Susnik, Nathan;
Meier, Matthias;
Leitges, Michael;
Haller, Hermann;
Gueler, Faikah;
Rong, Song

Publication type:

Article

Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.

Published in:

Molecular Pain, 2015, v. 11, n. 1, p. 2, doi. 10.1186/1744-8069-11-1

By:

Valtcheva, Manouela V.;
Davidson, Steve;
Chengshui Zhao;
Leitges, Michael;
Gereau IV, Robert W.

Publication type:

Article

Protein kinase Cζ-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.

Published in:

Oncogene, 2002, v. 21, n. 22, p. 3620, doi. 10.1038/sj.onc.1205451

By:

Wheeler, Deric L.;
Reddig, Peter J.;
Dreckschmidt, Nancy E.;
Leitges, Michael;
Verma, Ajit K.

Publication type:

Article

The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.

Published in:

Neural Development, 2012, v. 7, n. 1, p. 39, doi. 10.1186/1749-8104-7-39

By:

Rabe, Tamara I.;
Griesel, Gundula;
Blanke, Stephen;
Kispert, Andreas;
Leitges, Michael;
van der Zwaag, Bert;
H. Burbach, J. Peter;
Varoqueaux, Fr‚d‚rique;
Mansouri, Ahmed

Publication type:

Article

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

Published in:

Nature Medicine, 2014, v. 20, n. 12, p. 1401, doi. 10.1038/nm.3740

By:

Baumann, Ursula;
Fernández-Sáiz, Vanesa;
Rudelius, Martina;
Lemeer, Simone;
Rad, Roland;
Knorn, Anna-Maria;
Slawska, Jolanta;
Engel, Katharina;
Jeremias, Irmela;
Li, Zhoulei;
Tomiatti, Viktoriya;
Illert, Anna-Lena;
Targosz, Bianca-Sabrina;
Braun, Martin;
Perner, Sven;
Leitges, Michael;
Klapper, Wolfram;
Dreyling, Martin;
Miething, Cornelius;
Lenz, Georg

Publication type:

Article

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.

Published in:

Nature Medicine, 2009, v. 15, n. 11, p. 1298, doi. 10.1038/nm.2052

By:

Geraldes, Pedro;
Hiraoka-Yamamoto, Junko;
Matsumoto, Motonobu;
Clermont, Allen;
Leitges, Michael;
Marette, Andre;
Aiello, Lloyd P;
Kern, Timothy S;
King, George L

Publication type:

Article

Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.

Published in:

EMBO Journal, 2008, v. 27, n. 16, p. 2181, doi. 10.1038/emboj.2008.149

By:

Joshi, Jayashree;
Fernandez-Marcos, Pablo J;
Galvez, Anita;
Amanchy, Ramars;
Linares, Juan F.;
Duran, Angeles;
Pathrose, Peterson;
Leitges, Michael;
Cañamero, Marta;
Collado, Manuel;
Salas, Clara;
Serrano, Manuel;
Moscat, Jorge;
Diaz-Meco, Maria T.

Publication type:

Article