Works matching AU Lehtiö, Lari

Results: 31

Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021).

Published in:

ChemistryOpen, 2021, v. 10, n. 10, p. 929, doi. 10.1002/open.202100215

By:

Korn, Patricia;
Classen, Arno;
Murthy, Sudarshan;
Guareschi, Riccardo;
Maksimainen, Mirko M.;
Lippok, Barbara E.;
Galera‐Prat, Albert;
Sowa, Sven T.;
Voigt, Catharina;
Rossetti, Giulia;
Lehtiö, Lari;
Bolm, Carsten;
Lüscher, Bernhard

Publication type:

Article

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10.

Published in:

ChemistryOpen, 2021, v. 10, n. 10, p. 939, doi. 10.1002/open.202100087

By:

Korn, Patricia;
Classen, Arno;
Murthy, Sudarshan;
Guareschi, Riccardo;
Maksimainen, Mirko M.;
Lippok, Barbara E.;
Galera‐Prat, Albert;
Sowa, Sven T.;
Voigt, Catharina;
Rossetti, Giulia;
Lehtiö, Lari;
Bolm, Carsten;
Lüscher, Bernhard

Publication type:

Article

Synthetically accessible de novo design using reaction vectors: Application to PARP1 inhibitors**.

Published in:

Molecular Informatics, 2024, v. 43, n. 4, p. 1, doi. 10.1002/minf.202300183

By:

Ghiandoni, Gian Marco;
Flanagan, Stuart R.;
Bodkin, Michael J.;
Nizi, Maria Giulia;
Galera‐Prat, Albert;
Brai, Annalaura;
Chen, Beining;
Wallace, James E. A.;
Hristozov, Dimitar;
Webster, James;
Manfroni, Giuseppe;
Lehtiö, Lari;
Tabarrini, Oriana;
Gillet, Valerie J.

Publication type:

Article

Managing macromolecular crystallographic data with a laboratory information management system.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2024, v. 80, n. 8, p. 580, doi. 10.1107/S2059798324005680

By:

Daniel, Edward;
Wierenga, Rik K.;
Lehtiö, Lari

Publication type:

Article

IceBear: an intuitive and versatile web application for research‐data tracking from crystallization experiment to PDB deposition.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2021, v. 77, n. 2, p. 151, doi. 10.1107/S2059798320015223

By:

Daniel, Ed;
Maksimainen, Mirko M.;
Smith, Neil;
Ratas, Ville;
Biterova, Ekaterina;
Murthy, Sudarshan N.;
Rahman, M. Tanvir;
Kiema, Tiila-Riikka;
Sridhar, Shruthi;
Cordara, Gabriele;
Dalwani, Subhadra;
Venkatesan, Rajaram;
Prilusky, Jaime;
Dym, Orly;
Lehtiö, Lari;
Koski, M. Kristian;
Ashton, Alun W.;
Sussman, Joel L.;
Wierenga, Rik K.

Publication type:

Article

Structural studies of tri-functional human GART.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 20, p. 7308, doi. 10.1093/nar/gkq595

By:

Welin, Martin;
Grossmann, Jörg Günter;
Flodin, Susanne;
Nyman, Tomas;
Stenmark, Pål;
Trésaugues, Lionel;
Kotenyova, Tetyana;
Johansson, Ida;
Nordlund, Pär;
Lehtiö, Lari

Publication type:

Article

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23800-x

By:

Obaji, Ezeogo;
Maksimainen, Mirko M.;
Galera-Prat, Albert;
Lehtiö, Lari

Publication type:

Article

Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers.

Published in:

BioEssays, 2022, v. 44, n. 1, p. 1, doi. 10.1002/bies.202100240

By:

Glumoff, Tuomo;
Sowa, Sven T.;
Lehtiö, Lari

Publication type:

Article

FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici.

Published in:

PLoS ONE, 2020, v. 15, n. 2, p. 1, doi. 10.1371/journal.pone.0223870

By:

Ashok, Yashwanth;
Maksimainen, Mirko M.;
Kallio, Tuija;
Kilpeläinen, Pekka;
Lehtiö, Lari

Publication type:

Article

Tankyrases as drug targets.

Published in:

FEBS Journal, 2013, v. 280, n. 15, p. 3576, doi. 10.1111/febs.12320

By:

Lehtiö, Lari;
Chi, Nai ‐ Wen;
Krauss, Stefan

Publication type:

Article

Structure of Streptococcus agalactiae serine/threonine phosphatase.

Published in:

FEBS Journal, 2007, v. 274, n. 12, p. 3128, doi. 10.1111/j.1742-4658.2007.05845.x

By:

Rantanen, Mika K.;
Lehtiö, Lari;
Rajagopal, Lakshmi;
Rubens, Craig E.;
Goldman, Adrian

Publication type:

Article

Structure and function of the 3-carboxy- cis, cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2.

Published in:

FEBS Journal, 2006, v. 273, n. 22, p. 5169, doi. 10.1111/j.1742-4658.2006.05512.x

By:

Halak, Sad;
Lehtiö, Lari;
Basta, Tamara;
Bürger, Sibylle;
Contzen, Matthias;
Stolz, Andreas;
Goldman, Adrian

Publication type:

Article

Multiple crystal forms of human MacroD2.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2020, v. 76, n. 10, p. 477, doi. 10.1107/S2053230X20011309

By:

Wazir, Sarah;
Maksimainen, Mirko M.;
Lehtiö, Lari

Publication type:

Article

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.

Published in:

Parasites & Vectors, 2016, v. 9, p. 1, doi. 10.1186/s13071-016-1461-1

By:

Schlesinger, Mariana;
Larrea, Salomé C. Vilchez;
Haikarainen, Teemu;
Narwal, Mohit;
Venkannagari, Harikanth;
Flawiá, Mirtha M.;
Lehtiö, Lari;
Villamil, Silvia H. Fernández

Publication type:

Article

Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 4, p. 1, doi. 10.1002/pro.4945

By:

Vela‐Rodríguez, Carlos;
Yang, Chunsong;
Alanen, Heli I.;
Eki, Rebeka;
Abbas, Tarek A.;
Maksimainen, Mirko M.;
Glumoff, Tuomo;
Duman, Ramona;
Wagner, Armin;
Paschal, Bryce M.;
Lehtiö, Lari

Publication type:

Article

The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: Co-evolution of structure and dynamics with the dehalogenation function.

Published in:

Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 9, p. 1855, doi. 10.1110/ps.0388503

By:

Kajander, Tommi;
Lehtiö, Lari;
Schlömann, Michael;
Goldman, Adrian

Publication type:

Article

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim

Published in:

FEBS Letters, 2008, v. 582, n. 25/26, p. 3590, doi. 10.1016/j.febslet.2008.09.028

By:

Herman, Maria Dolores;
Nyman, Tomas;
Welin, Martin;
Lehtiö, Lari;
Flodin, Susanne;
Trésaugues, Lionel;
Kotenyova, Tetyana;
Flores, Alex;
Nordlund, Pär

Publication type:

Article

para-Substituted 2-Phenyl-3,4-dihydroquinazolin-4-ones As Potent and Selective Tankyrase Inhibitors.

Published in:

ChemMedChem, 2013, v. 8, n. 12, p. 1978, doi. 10.1002/cmdc.201300337

By:

Haikarainen, Teemu;
Koivunen, Jarkko;
Narwal, Mohit;
Venkannagari, Harikanth;
Obaji, Ezeogo;
Joensuu, Päivi;
Pihlajaniemi, Taina;
Lehtiö, Lari

Publication type:

Article

High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-54123-8

By:

Dhakar, Saurabh S.;
Galera-Prat, Albert;
Lehtiö, Lari

Publication type:

Article

High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-54123-8

By:

Dhakar, Saurabh S.;
Galera-Prat, Albert;
Lehtiö, Lari

Publication type:

Article

Structural basis for DNA break recognition by ARTD2/PARP2.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 22, p. 12154, doi. 10.1093/nar/gky927

By:

Obaji, Ezeogo;
Haikarainen, Teemu;
Lehtiö, Lari

Publication type:

Article

Reconstitution of the DTX3L-PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly.

Published in:

Biochemical Journal, 2022, v. 479, n. 3, p. 289, doi. 10.1042/BCJ20210722

By:

Ashok, Yashwanth;
Vela-Rodríguez, Carlos;
Chunsong Yang;
Alanen, Heli I.;
Fan Liu;
Paschal, Bryce M.;
Lehtiö, Lari

Publication type:

Article

A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-69229-y

By:

Sowa, Sven T.;
Vela-Rodríguez, Carlos;
Galera-Prat, Albert;
Cázares-Olivera, Mariana;
Prunskaite-Hyyryläinen, Renata;
Ignatev, Alexander;
Lehtiö, Lari

Publication type:

Article

Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065404

By:

Haikarainen, Teemu;
Venkannagari, Harikanth;
Narwal, Mohit;
Obaji, Ezeogo;
Lee, Hao-Wei;
Nkizinkiko, Yves;
Lehtiö, Lari

Publication type:

Article

Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0046063

By:

Larrea, Salomé C. Vilchez;
Haikarainen, Teemu;
Narwal, Mohit;
Schlesinger, Mariana;
Venkannagari, Harikanth;
Flawiá, Mirtha M.;
Villamil, Silvia H. Fernández;
Lehtiö, Lari;
Francisco, Julio

Publication type:

Article

Comparative Structural Analysis of Lipid Binding START Domains.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0019521

By:

Thorsell, Ann-Gerd;
Wen Hwa Lee;
Persson, Camilla;
Siponen, Marina I.;
Nilsson, Martina;
Busam, Robert D.;
Kotenyova, Tetyana;
Schüler, Herwig;
Lehtiö, Lari

Publication type:

Article

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface.

Published in:

PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012907

By:

Nyman, Tomas;
Trésaugues, Lionel;
Welin, Martin;
Lehtiö, Lari;
Flodin, Susanne;
Persson, Camilla;
Johansson, Ida;
Hammarström, Martin;
Nordlund, Pär

Publication type:

Article

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008625

By:

Wisniewska, Magdalena;
Karlberg, Tobias;
Lehtiö, Lari;
Johansson, Ida;
Kotenyova, Tetyana;
Moche, Martin;
Herwig Schüler

Publication type:

Article

Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity.

Published in:

PEDS: Protein Engineering, Design & Selection, 2022, v. 35, p. 1, doi. 10.1093/protein/gzac006

By:

Galera-Prat, Albert;
Alaviuhkola, Juho;
Alanen, Heli I;
Lehtiö, Lari

Publication type:

Article

Characterization of the DNA dependent activation of human ARTD2/PARP2.

Published in:

Scientific Reports, 2016, p. 34487, doi. 10.1038/srep34487

By:

Obaji, Ezeogo;
Haikarainen, Teemu;
Lehtiö, Lari

Publication type:

Article

Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.

Published in:

Scientific Reports, 2016, p. 24213, doi. 10.1038/srep24213

By:

Haikarainen, Teemu;
Lehtiö, Lari

Publication type:

Article