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Membrane transport in the malaria parasite and its host erythrocyte.
Published in:
Biochemical Journal, 2014, v. 457, n. 1, p. 1, doi. 10.1042/BJ20131007
By:
- KIRK, Kiaran;
- LEHANE, Adele M.
Publication type:
Article
Protein kinase A negatively regulates Ca<sup>2+</sup> signalling in Toxoplasma gondii.
Published in:
PLoS Biology, 2018, v. 16, n. 9, p. 1, doi. 10.1371/journal.pbio.2005642
By:
- Uboldi, Alessandro D.;
- Wilde, Mary-Louise;
- McRae, Emi A.;
- Stewart, Rebecca J.;
- Dagley, Laura F.;
- Yang, Luning;
- Katris, Nicholas J.;
- Hapuarachchi, Sanduni V.;
- Coffey, Michael J.;
- Lehane, Adele M.;
- Botte, Cyrille Y.;
- Waller, Ross F.;
- Webb, Andrew I.;
- McConville, Malcolm J.;
- Tonkin, Christopher J.
Publication type:
Article
Efflux of a range of antimalarial drugs and ‘chloroquine resistance reversers’ from the digestive vacuole in malaria parasites with mutant PfCRT.
Published in:
Molecular Microbiology, 2010, v. 77, n. 4, p. 1039, doi. 10.1111/j.1365-2958.2010.07272.x
By:
- Lehane, Adele M.;
- Kirk, Kiaran
Publication type:
Article
A polymorphic drug pump in the malaria parasite.
Published in:
Molecular Microbiology, 2008, v. 70, n. 4, p. 775, doi. 10.1111/j.1365-2958.2008.06451.x
By:
- Saliba, Kevin J.;
- Lehane, Adele M.;
- Kirk, Kiaran
Publication type:
Article
Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.
Published in:
2016
By:
- van Schalkwyk, Donelly A.;
- Nash, Megan N.;
- Shafik, Sarah H.;
- Summers, Robert L.;
- Lehane, Adele M.;
- Smith, Peter J.;
- Martin, Rowena E.
Publication type:
journal article
Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter.
Published in:
Molecular Microbiology, 2015, v. 97, n. 2, p. 381, doi. 10.1111/mmi.13035
By:
- Petersen, Ines;
- Gabryszewski, Stanislaw J.;
- Johnston, Geoffrey L.;
- Dhingra, Satish K.;
- Ecker, Andrea;
- Lewis, Rebecca E.;
- Almeida, Mariana Justino;
- Straimer, Judith;
- Henrich, Philipp P.;
- Palatulan, Eugene;
- Johnson, David J.;
- Coburn‐Flynn, Olivia;
- Sanchez, Cecilia;
- Lehane, Adele M.;
- Lanzer, Michael;
- Fidock, David A.
Publication type:
Article
Diverse chemotypes disrupt ion homeostasis in the malaria parasite.
Published in:
Molecular Microbiology, 2014, v. 94, n. 2, p. 327, doi. 10.1111/mmi.12765
By:
- Lehane, Adele M.;
- Ridgway, Melanie C.;
- Baker, Eileen;
- Kirk, Kiaran
Publication type:
Article
¹H-NMR metabolite profiles of different strains of Plasmodium falciparum.
Published in:
Bioscience Reports, 2014, v. 34, n. 6, p. 685, doi. 10.1042/BSR20140134
By:
- Rongwei Teng;
- Lehane, Adele M.;
- Winterberg, Markus;
- Shafik, Sarah H.;
- Summers, Robert L.;
- Martin, Rowena E.;
- van Schalkwyk, Donelly A.;
- Junankar, Pauline R.;
- Kirk, Kiaran
Publication type:
Article
A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46500-5
By:
- Gilson, Paul R.;
- Kumarasingha, Rasika;
- Thompson, Jennifer;
- Zhang, Xinxin;
- Penington, Jocelyn Sietsma;
- Kalhor, Robabeh;
- Bullen, Hayley E.;
- Lehane, Adele M.;
- Dans, Madeline G.;
- de Koning-Ward, Tania F.;
- Holien, Jessica K.;
- Soares da Costa, Tatiana P.;
- Hulett, Mark D.;
- Buskes, Melissa J.;
- Crabb, Brendan S.;
- Kirk, Kiaran;
- Papenfuss, Anthony T.;
- Cowman, Alan F.;
- Abbott, Belinda M.
Publication type:
Article
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
Published in:
Nature Communications, 2016, v. 7, n. 5, p. 11553, doi. 10.1038/ncomms11553
By:
- Veiga, M. Isabel;
- Dhingra, Satish K.;
- Henrich, Philipp P.;
- Straimer, Judith;
- Gnädig, Nina;
- Uhlemann, Anne-Catrin;
- Martin, Rowena E.;
- Lehane, Adele M.;
- Fidock, David A.
Publication type:
Article
A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum.
Published in:
Nature Communications, 2015, v. 6, n. 3, p. 6721, doi. 10.1038/ncomms7721
By:
- Marchetti, Rosa V.;
- Lehane, Adele M.;
- Shafik, Sarah H.;
- Winterberg, Markus;
- Martin, Rowena E.;
- Kirk, Kiaran
Publication type:
Article
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite’s Chloroquine Resistance Transporter.
Published in:
PLoS Pathogens, 2016, v. 12, n. 7, p. 1, doi. 10.1371/journal.ppat.1005725
By:
- Richards, Sashika N.;
- Nash, Megan N.;
- Baker, Eileen S.;
- Webster, Michael W.;
- Lehane, Adele M.;
- Shafik, Sarah H.;
- Martin, Rowena E.
Publication type:
Article
Identifying the major lactate transporter of Toxoplasma gondii tachyzoites.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-86204-3
By:
- Zeng, Joy M.;
- Hapuarachchi, Sanduni V.;
- Shafik, Sarah H.;
- Martin, Rowena E.;
- Kirk, Kiaran;
- van Dooren, Giel G.;
- Lehane, Adele M.
Publication type:
Article
The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens.
Published in:
PLoS Pathogens, 2017, v. 13, n. 2, p. 1, doi. 10.1371/journal.ppat.1006180
By:
- Hapuarachchi, Sanduni V.;
- Cobbold, Simon A.;
- Shafik, Sarah H.;
- Dennis, Adelaide S. M.;
- McConville, Malcolm J.;
- Martin, Rowena E.;
- Kirk, Kiaran;
- Lehane, Adele M.
Publication type:
Article

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