Works by Leggio, Gian Marco

Results: 40

Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age‐related cognitive phenotype.

Published in:

Aging Cell, 2024, v. 23, n. 11, p. 1, doi. 10.1111/acel.14291

By:

Tropea, Maria Rosaria;
Melone, Marcello;
Li Puma, Domenica Donatella;
Vacanti, Valeria;
Aceto, Giuseppe;
Bandiera, Bruno;
Trovato, Roberta Carmela;
Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Palmeri, Agostino;
D'Ascenzo, Marcello;
Conti, Fiorenzo;
Grassi, Claudio;
Puzzo, Daniela

Publication type:

Article

Imputed expression of schizophrenia‐associated genes and cognitive measures in patients with schizophrenia.

Published in:

Molecular Genetics & Genomic Medicine, 2022, v. 10, n. 6, p. 1, doi. 10.1002/mgg3.1942

By:

Fabbri, Chiara;
Leggio, Gian Marco;
Drago, Filippo;
Serretti, Alessandro

Publication type:

Article

Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer’s disease.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1386224

By:

Munafò, Antonio;
Cantone, Anna Flavia;
Di Benedetto, Giulia;
Torrisi, Sebastiano Alfio;
Burgaletto, Chiara;
Bellanca, Carlo Maria;
Gaudio, Gabriella;
Broggi, Giuseppe;
Caltabiano, Rosario;
Leggio, Gian Marco;
Bernardini, Renato;
Cantarella, Giuseppina

Publication type:

Article

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00710

By:

Torrisi, Sebastiano Alfio;
Salomone, Salvatore;
Geraci, Federica;
Caraci, Filippo;
Bucolo, Claudio;
Drago, Filippo;
Leggio, Gian Marco

Publication type:

Article

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-β1.

Published in:

Frontiers in Pharmacology, 2016, v. 7, p. 1, doi. 10.3389/fphar.2016.00389

By:

Caraci, Filippo;
Tascedda, Fabio;
Merlo, Sara;
Benatti, Cristina;
Spampinato, Simona F.;
Munafò, Antonio;
Leggio, Gian Marco;
Nicoletti, Ferdinando;
Brunello, Nicoletta;
Drago, Filippo;
Sortino, Maria Angela;
Copani, Agata

Publication type:

Article

Increased Hippocampal CREB Phosphorylation in Dopamine D3 Receptor Knockout Mice Following Passive Avoidance Conditioning.

Published in:

Neurochemical Research, 2013, v. 38, n. 12, p. 2516, doi. 10.1007/s11064-013-1164-3

By:

D’Amico, Agata Grazia;
Scuderi, Soraya;
Leggio, Gian Marco;
Castorina, Alessandro;
Drago, Filippo;
D’Agata, Velia

Publication type:

Article

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System.

Published in:

Frontiers in Integrative Neuroscience, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00404

By:

Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Drago, Filippo;
Salomone, Salvatore

Publication type:

Article

Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 8, p. 2017, doi. 10.1038/npp.2014.51

By:

Leggio, Gian Marco;
Camillieri, Giovanni;
Platania, Chiara B M;
Castorina, Alessandro;
Marrazzo, Giuseppina;
Torrisi, Sebastiano Alfio;
Nona, Christina N;
D'Agata, Velia;
Nobrega, José;
Stark, Holger;
Bucolo, Claudio;
Le Foll, Bernard;
Drago, Filippo;
Salomone, Salvatore

Publication type:

Article

Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels.

Published in:

Neuropsychopharmacology, 2009, v. 34, n. 3, p. 593, doi. 10.1038/npp.2008.98

By:

Micale, Vincenzo;
Cristino, Luigia;
Tamburella, Alessandra;
Petrosino, Stefania;
Leggio, Gian Marco;
Drago, Filippo;
Di Marzo, Vincenzo

Publication type:

Article

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System.

Published in:

Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00404

By:

Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Drago, Filippo;
Salomone, Salvatore

Publication type:

Article

Retinal Protection and Distribution of Curcumin in Vitro and in Vivo.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00670

By:

Platania, Chiara B. M.;
Fidilio, Annamaria;
Lazzara, Francesca;
Piazza, Cateno;
Geraci, Federica;
Giurdanella, Giovanni;
Leggio, Gian Marco;
Salomone, Salvatore;
Drago, Filippo;
Bucolo, Claudio

Publication type:

Article

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.

Published in:

International Journal of Neuropsychopharmacology, 2013, v. 16, n. 4, p. 813, doi. 10.1017/S1461145712000612

By:

Tamburella, Alessandra;
Leggio, Gian Marco;
Micale, Vincenzo;
Navarria, Andrea;
Bucolo, Claudio;
Cicirata, Valentina;
Drago, Filippo;
Salomone, Salvatore

Publication type:

Article

Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites.

Published in:

Antioxidants, 2023, v. 12, n. 9, p. 1773, doi. 10.3390/antiox12091773

By:

Laudani, Samuele;
Godos, Justyna;
Di Domenico, Federica Martina;
Barbagallo, Ignazio;
Randazzo, Cinzia Lucia;
Leggio, Gian Marco;
Galvano, Fabio;
Grosso, Giuseppe

Publication type:

Article

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.1075746

By:

Fidilio, Annamaria;
Grasso, Margherita;
Caruso, Giuseppe;
Musso, Nicolò;
Begni, Veronica;
Privitera, Anna;
Torrisi, Sebastiano Alfio;
Campolongo, Patrizia;
Schiavone, Stefania;
Tascedda, Fabio;
Leggio, Gian Marco;
Drago, Filippo;
Riva, Marco Andrea;
Caraci, Filippo

Publication type:

Article

Ultra-Processed Food Consumption and Depressive Symptoms in a Mediterranean Cohort.

Published in:

Nutrients, 2023, v. 15, n. 3, p. 504, doi. 10.3390/nu15030504

By:

Godos, Justyna;
Bonaccio, Marialaura;
Al-Qahtani, Wahidah H.;
Marx, Wolfgang;
Lane, Melissa M.;
Leggio, Gian Marco;
Grosso, Giuseppe

Publication type:

Article

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer's Disease.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.809541

By:

Caruso, Giuseppe;
Grasso, Margherita;
Fidilio, Annamaria;
Torrisi, Sebastiano Alfio;
Musso, Nicolò;
Geraci, Federica;
Tropea, Maria Rosaria;
Privitera, Anna;
Tascedda, Fabio;
Puzzo, Daniela;
Salomone, Salvatore;
Drago, Filippo;
Leggio, Gian Marco;
Caraci, Filippo

Publication type:

Article

Epigenetic drugs for Alzheimer's disease: hopes and challenges.

Published in:

British Journal of Clinical Pharmacology, 2013, v. 75, n. 4, p. 1154, doi. 10.1111/j.1365-2125.2012.04443.x

By:

Caraci, Filippo;
Leggio, Gian Marco;
Drago, Filippo;
Salomone, Salvatore

Publication type:

Article

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 73, n. 4, p. 504, doi. 10.1111/j.1365-2125.2011.04134.x

By:

Salomone, Salvatore;
Caraci, Filippo;
Leggio, Gian Marco;
Fedotova, Julia;
Drago, Filippo

Publication type:

Article

Oral Echinacea purpurea Extract in Low-Grade, Steroid-Dependent, Autoimmune Idiopathic Uveitis: A Pilot Study.

Published in:

Journal of Ocular Pharmacology & Therapeutics, 2006, v. 22, n. 6, p. 431, doi. 10.1089/jop.2006.22.431

By:

Neri, Pier Giorgio;
Stagni, Edoardo;
Filippello, Massimo;
Camillieri, Giovanni;
Giovannini, Alfonso;
Leggio, Gian Marco;
Drago, Filippo

Publication type:

Article

The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8699, doi. 10.3390/ijms24108699

By:

Rivi, Veronica;
Benatti, Cristina;
Blom, Joan M. C.;
Pani, Luca;
Brunello, Nicoletta;
Drago, Filippo;
Papaleo, Francesco;
Caraci, Filippo;
Geraci, Federica;
Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Tascedda, Fabio

Publication type:

Article

Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7751, doi. 10.3390/ijms23147751

By:

Filippello, Agnese;
Di Mauro, Stefania;
Scamporrino, Alessandra;
Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Di Pino, Antonino;
Scicali, Roberto;
Di Marco, Maurizio;
Malaguarnera, Roberta;
Purrello, Francesco;
Piro, Salvatore

Publication type:

Article

High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6660, doi. 10.3390/ijms22136660

By:

Filippello, Agnese;
Di Mauro, Stefania;
Scamporrino, Alessandra;
Malaguarnera, Roberta;
Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Di Pino, Antonino;
Scicali, Roberto;
Purrello, Francesco;
Piro, Salvatore

Publication type:

Article

Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5157, doi. 10.3390/ijms22105157

By:

Maurel, Oriana Maria;
Torrisi, Sebastiano Alfio;
Barbagallo, Cristina;
Purrello, Michele;
Salomone, Salvatore;
Drago, Filippo;
Ragusa, Marco;
Leggio, Gian Marco;
Bocchio-Chiavetto, Luisella

Publication type:

Article

A New Human Blood–Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 5, p. 1636, doi. 10.3390/ijms21051636

By:

Fresta, Claudia G.;
Fidilio, Annamaria;
Caruso, Giuseppe;
Caraci, Filippo;
Giblin, Frank J.;
Marco Leggio, Gian;
Salomone, Salvatore;
Drago, Filippo;
Bucolo, Claudio

Publication type:

Article

Identification of Dysregulated microRNA Networks in Schwann Cell-Like Cultures Exposed to Immune Challenge: Potential Crosstalk with the Protective VIP/PACAP Neuropeptide System.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 4, p. 981, doi. 10.3390/ijms19040981

By:

Musumeci, Giuseppe;
Leggio, Gian Marco;
Marzagalli, Rubina;
Al-Badri, Ghaith;
Drago, Filippo;
Castorina, Alessandro

Publication type:

Article

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 10, p. 2076, doi. 10.3390/ijms18102076

By:

Platania, Chiara Bianca Maria;
Fisichella, Vincenzo;
Fidilio, Annamaria;
Geraci, Federica;
Lazzara, Francesca;
Leggio, Gian Marco;
Salomone, Salvatore;
Drago, Filippo;
Pignatello, Rosario;
Caraci, Filippo;
Bucolo, Claudio

Publication type:

Article

Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy.

Published in:

Journal of Diabetes Research, 2013, p. 1, doi. 10.1155/2013/432695

By:

Bucolo, Claudio;
Marrazzo, Giuseppina;
Platania, Chiara Bianca Maria;
Drago, Filippo;
Leggio, Gian Marco;
Salomone, Salvatore

Publication type:

Article

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1.

Published in:

Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00693

By:

Torrisi, Sebastiano Alfio;
Geraci, Federica;
Tropea, Maria Rosaria;
Grasso, Margherita;
Caruso, Giuseppe;
Fidilio, Annamaria;
Musso, Nicolò;
Sanfilippo, Giulia;
Tascedda, Fabio;
Palmeri, Agostino;
Salomone, Salvatore;
Drago, Filippo;
Puzzo, Daniela;
Leggio, Gian Marco;
Caraci, Filippo

Publication type:

Article

Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments.

Published in:

Pharmaceuticals (14248247), 2020, v. 13, n. 11, p. 365, doi. 10.3390/ph13110365

By:

Torrisi, Sebastiano Alfio;
Laudani, Samuele;
Contarini, Gabriella;
De Luca, Angelina;
Geraci, Federica;
Managò, Francesca;
Papaleo, Francesco;
Salomone, Salvatore;
Drago, Filippo;
Leggio, Gian Marco

Publication type:

Article

Homology Modeling of Dopamine D2 and D3 Receptors: Molecular Dynamics Refinement and Docking Evaluation.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0044316

By:

Platania, Chiara Bianca Maria;
Salomone, Salvatore;
Leggio, Gian Marco;
Drago, Filippo;
Bucolo, Claudio;
Yang Zhang

Publication type:

Article

Inhibition of D3 receptors restores synaptic plasticity and memory impairment in aged and Alzheimerʼs disease mouse models.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.075566

By:

Tropea, Maria Rosaria;
Melone, Marcello;
Vacanti, Valeria;
Gulisano, Walter;
Leggio, Gian Marco;
Conti, Fiorenzo;
Puzzo, Daniela

Publication type:

Article

Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 3, p. 418, doi. 10.3390/biom11030418

By:

Zingales, Veronica;
Torrisi, Sebastiano Alfio;
Leggio, Gian Marco;
Bucolo, Claudio;
Drago, Filippo;
Salomone, Salvatore;
Leo, Damiana

Publication type:

Article

Mechanism and Physiologic Significance of the Suppression of Cholesterol Esterification in Human Interstitial Fluid.

Published in:

Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00216

By:

Miller, Norman E.;
Olszewski, Waldemar L.;
Miller, Irina P.;
Nanjee, Mahmud N.;
Leggio, Gian Marco;
German, Nadezhda A.

Publication type:

Article

Effects of Topical Fucosyl-Lactose, a Milk Oligosaccharide, on Dry Eye Model: An Example of Nutraceutical Candidate.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00280

By:

Bucolo, Claudio;
Musumeci, Maria;
Salomone, Salvatore;
Romano, Giovanni Luca;
Leggio, Gian Marco;
Gagliano, Caterina;
Reibaldi, Michele;
Avitabile, Teresio;
Uva, Maurizio G.;
Musumeci, Salvatore;
Drago, Filippo;
Ibargoyen, Nora;
Eandi, Chiara

Publication type:

Article

Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors.

Published in:

Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00264

By:

Culhane, Kelly J.;
Yuting Liu;
Yingying Cai;
Yan, Elsa C. Y.;
Leggio, Gian Marco;
Bortolato, Andrea

Publication type:

Article

Absence of a significant pharmacokinetic interaction between atorvastatin and fenofibrate: a randomized, crossover, study of a fixed-dose formulation in healthy Mexican subjects.

Published in:

Frontiers in Pharmacology, 2015, v. 5, p. 1, doi. 10.3389/fphar.2015.00004

By:

Patiño-Rodríguez, Omar;
Martínez-Medina, Rosa María;
Torres-Roque, Irma;
Martínez-Delgado, Maricela;
Mares-García, América Susana;
Escobedo-Moratilla, Abraham;
Covarrubias-Pinedo, Amador;
Arzola-Paniagua, Angélica;
Herrera-Torres, José Luis;
Pérez-Urizar, José;
Ojo, Babatunde;
Leggio, Gian Marco

Publication type:

Article

Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00232

By:

Ermakov, Sergey;
Forster, Peter;
Pagidala, Jyotsna;
Miladinov, Marko;
Wang, Albert;
Baillie, Rebecca;
Bartlett, Derek;
Reed, Mike;
Leil, Tarek A.;
Benfenati, Emilio;
Leggio, Gian Marco

Publication type:

Article

Pharmacokinetic non-interaction analysis in a fixed-dose formulation in combination of atorvastatin and ezetimibe.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00261

By:

Patiño-Rodríguez, Omar;
Torres-Roque, Irma;
Martínez-Delgado, Maricela;
Escobedo-Moratilla, Abraham;
Pérez-Urizar, José;
Lohman, Rink-Jan;
Leggio, Gian Marco

Publication type:

Article

PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26757-z

By:

Prokop, Susanne;
Ábrányi-Balogh, Péter;
Barti, Benjámin;
Vámosi, Márton;
Zöldi, Miklós;
Barna, László;
Urbán, Gabriella M.;
Tóth, András Dávid;
Dudok, Barna;
Egyed, Attila;
Deng, Hui;
Leggio, Gian Marco;
Hunyady, László;
van der Stelt, Mario;
Keserű, György M.;
Katona, István

Publication type:

Article

In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist.

Published in:

Journal of Neurochemistry, 2009, v. 111, n. 2, p. 614, doi. 10.1111/j.1471-4159.2009.06356.x

By:

Leggio, Gian Marco;
Cathala, Adeline;
Neny, Maud;
Rouge-Pont, Françoise;
Drago, Filippo;
Piazza, Pier Vincenzo;
Spampinato, Umberto

Publication type:

Article