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Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model.
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-75870-8
By:
- Allerton, Timothy D.;
- Stampley, James E.;
- Li, Zhen;
- Yu, Xiaoman;
- Quiariate, Heather;
- Doiron, Jake E.;
- White, Ginger;
- Wigger, Zach;
- Gartia, Manas Ranjan;
- Lefer, David J.;
- Soto, Paul;
- Irving, Brian A.
Publication type:
Article
An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.
Published in:
Angewandte Chemie, 2017, v. 129, n. 39, p. 11911, doi. 10.1002/ange.201704117
By:
- Zheng, Yueqin;
- Yu, Bingchen;
- Li, Zhen;
- Yuan, Zhengnan;
- Organ, Chelsea L.;
- Trivedi, Rishi K.;
- Wang, Siming;
- Lefer, David J.;
- Wang, Binghe
Publication type:
Article
The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure.
Published in:
Scientifica, 2014, p. 1, doi. 10.1155/2014/768607
By:
- Polhemus, David J.;
- Calvert, John W.;
- Butler, Javed;
- Lefer, David J.
Publication type:
Article
An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.
Published in:
Angewandte Chemie International Edition, 2017, v. 56, n. 39, p. 11749, doi. 10.1002/anie.201704117
By:
- Zheng, Yueqin;
- Yu, Bingchen;
- Li, Zhen;
- Yuan, Zhengnan;
- Organ, Chelsea L.;
- Trivedi, Rishi K.;
- Wang, Siming;
- Lefer, David J.;
- Wang, Binghe
Publication type:
Article
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
Published in:
Nature Medicine, 2000, v. 6, n. 9, p. 1004, doi. 10.1038/79510
By:
- Kureishi, Yasuko;
- Luo, Zhengyu;
- Shiojima, Ichiro;
- Bialik, Ann;
- Fulton, David;
- Lefer, David J.;
- Sessa, William C.;
- Walsh, Kenneth
Publication type:
Article
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.
Published in:
EMBO Journal, 2000, v. 19, n. 23, p. 6341, doi. 10.1093/emboj/19.23.6341
By:
- Bueno, Orlando F.;
- De Windt, Leon J.;
- Tymitz, Kevin M.;
- Witt, Sandra A.;
- Kimball, Thomas R.;
- Klevitsky, Raisa;
- Hewett, Timothy E.;
- Jones, Steven P.;
- Lefer, David J.;
- Chang-Fu Peng;
- Kitsis, Richard N.;
- Molkentin, Jeffery D.
Publication type:
Article
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.
Published in:
2005
By:
- Duranski, Mark R.;
- Greer, James J. M.;
- Dejam, Andre;
- Jaganmohan, Sathya;
- Hogg, Neil;
- Langston, William;
- Patel, Rakesh P.;
- Shaw-fang Yet;
- Xunde Wang;
- Kevil, Christopher G.;
- Gladwin, Mark T.;
- Lefer, David J.;
- Yet, Shaw-Fang;
- Wang, Xunde
Publication type:
journal article
A Fluorescent Probe for Fast and Quantitative Detection of Hydrogen Sulfide in Blood.
Published in:
Angewandte Chemie, 2011, v. 123, n. 41, p. 9846, doi. 10.1002/ange.201104236
By:
- Peng, Hanjing;
- Cheng, Yunfeng;
- Dai, Chaofeng;
- King, Adrienne L.;
- Predmore, Benjamin L.;
- Lefer, David J.;
- Wang, Binghe
Publication type:
Article
Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131735
By:
- Chi, Yuling;
- Jasmin, Jean-Francois;
- Seki, Yoshinori;
- Lisanti, Michael P.;
- Charron, Maureen J.;
- Lefer, David J.;
- Schuster, Victor L.
Publication type:
Article
Additive Beneficial Effects of Two Inhibitors of Vasoconstrictor Mediators in Acute Myocardial Ischemia1.
Published in:
Proceedings of the Society for Experimental Biology & Medicine, 1987, v. 185, n. 3, p. 262, doi. 10.3181/00379727-185-42542
By:
- Bitterman, Haim;
- Lefer, David J.;
- Lefer, Allan M.
Publication type:
Article
Coronary Vascular Actions of the Converting Enzyme Inhibitor, Enalapril1.
Published in:
Proceedings of the Society for Experimental Biology & Medicine, 1984, v. 175, n. 2, p. 211, doi. 10.3181/00379727-175-41790
By:
- Lefer, David J.;
- Lefer, Allan M.
Publication type:
Article
364 Beneficial Actions of SGLT2 Inhibition and H2S Therapy in Heart Failure with Preserved Ejection Fraction.
Published in:
2023
By:
- Doiron, Jake;
- Li, Zhen;
- Xia, Huijing;
- Lapenna, Kyle B.;
- Allerton, Timothy D.;
- Kapusta, Daniel R.;
- Lefer, David J.
Publication type:
Abstract
Review focus on inorganic nitrite and nitrate in cardiovascular health and disease.
Published in:
Cardiovascular Research, 2011, v. 89, n. 3, p. 489, doi. 10.1093/cvr/cvq409
By:
- Kevil, Christopher G.;
- Lefer, David J.
Publication type:
Article
Announcement: Review Focus on Inorganic Nitrite and Nitrate in Cardiovascular Health and Disease.
Published in:
Cardiovascular Research, 2010, v. 86, n. 2, p. NP, doi. 10.1093/cvr/cvq098
By:
- Kevil, Christopher G.;
- Lefer, David J.
Publication type:
Article
Announcement: Review Focus on Inorganic Nitrite and Nitrate in Cardiovascular Health and Disease.
Published in:
Cardiovascular Research, 2010, v. 86, n. 1, p. NP, doi. 10.1093/cvr/cvq071
By:
- Kevil, Christopher G.;
- Lefer, David J.
Publication type:
Article
Announcement: Review Focus on Inorganic Nitrite and Nitrate in Cardiovascular Health and Disease.
Published in:
Cardiovascular Research, 2010, v. 85, n. 4, p. NP, doi. 10.1093/cvr/cvq017
By:
- Kevil, Christopher G.;
- Lefer, David J.
Publication type:
Article
Protective ischaemia in patients: preconditioning and postconditioning.
Published in:
Cardiovascular Research, 2009, v. 83, n. 2, p. 234, doi. 10.1093/cvr/cvp129
By:
- Asger Granfeldt;
- David J. Lefer;
- Jakob Vinten-Johansen
Publication type:
Article
Myocardial protection by nitrite.
Published in:
Cardiovascular Research, 2009, v. 83, n. 2, p. 195, doi. 10.1093/cvr/cvp079
By:
- John W. Calvert;
- David J. Lefer
Publication type:
Article
Thrombopoietin emerges as a new haematopoietic cytokine that confers cardioprotection against acute myocardial infarction.
Published in:
2008
By:
- Calvert, John W.;
- Lefer, David J.
Publication type:
Editorial
HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells
Published in:
Cardiovascular Research, 2003, v. 57, n. 1, p. 253, doi. 10.1016/S0008-6363(02)00618-1
By:
- Skaletz-Rorowski, Adriane;
- Lutchman, Mohini;
- Kureishi, Yasuko;
- Lefer, David J.;
- Faust, Jerry R.;
- Walsh, Kenneth
Publication type:
Article
Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.
Published in:
Cardiovascular Research, 2001, v. 49, n. 2, p. 281, doi. 10.1016/S0008-6363(00)00247-9
By:
- Lefer, Allan M;
- Scalia, Rosario;
- Lefer, David J
Publication type:
Article
The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion.
Published in:
Cardiovascular Research, 1996, v. 32, n. 4, p. 743, doi. 10.1016/S0008-6363(96)00073-9
By:
- Lefer, Allan M.;
- Lefer, David J.
Publication type:
Article
Nitric Oxide Therapy Attenuates Heart Failure with Preserved Ejection Fraction.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2429
By:
- Koul, Kashyap;
- LaPenna, Kyle;
- Li, Zhen;
- Doiron, Jake;
- Wang, John;
- Sharp, Thomas E.;
- Lefer, David J.
Publication type:
Article
Role of S‐nitrosoglutathione reductase (GSNOR) Dysregulation and Nitrosative Stress in Heart Failure With Preserved Ejection Fraction.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2460
By:
- LaPenna, Kyle B.;
- Li, Zhen;
- Sharp, Thomas E.;
- Mose, Karl H.;
- Doiron, Jake E.;
- Xia, Huijing;
- Goodchild, Traci T.;
- Lefer, David J.
Publication type:
Article
CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.
Published in:
Nature Communications, 2015, v. 6, n. 8, p. 7792, doi. 10.1038/ncomms8792
By:
- Akahori, Hirokuni;
- Karmali, Vinit;
- Polavarapu, Rohini;
- Lyle, Alicia N.;
- Weiss, Daiana;
- Shin, Eric;
- Husain, Ahsan;
- Naqvi, Nawazish;
- Van Dam, Richard;
- Habib, Anwer;
- Choi, Cheol Ung;
- King, Adrienne L.;
- Pachura, Kimberly;
- Taylor, W. Robert;
- Lefer, David J.;
- Finn, Aloke V.
Publication type:
Article
Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol.
Published in:
2016
By:
- Neuman, Robert B.;
- Hayek, Salim S.;
- Poole, Joseph C.;
- Rahman, Ayaz;
- Menon, Vivek;
- Kavtaradze, Nino;
- Polhemus, David;
- Veledar, Emir;
- Lefer, David J.;
- Quyyumi, Arshed A.
Publication type:
journal article
Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future.
Published in:
Antioxidants, 2021, v. 10, n. 3, p. 485, doi. 10.3390/antiox10030485
By:
- LaPenna, Kyle B.;
- Polhemus, David J.;
- Doiron, Jake E.;
- Hidalgo, Hunter A.;
- Li, Zhen;
- Lefer, David J.;
- Testai, Lara;
- Calderone, Vincenzo
Publication type:
Article
Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy.
Published in:
Antioxidants, 2019, v. 8, n. 12, p. 638, doi. 10.3390/antiox8120638
By:
- Kar, Sumit;
- Shahshahan, Hamid R.;
- Hackfort, Bryan T.;
- Yadav, Santosh K.;
- Yadav, Roopali;
- Kambis, Tyler N.;
- Lefer, David J.;
- Mishra, Paras K.
Publication type:
Article
Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction.
Published in:
Journal of the American Heart Association, 2024, v. 13, n. 4, p. 1, doi. 10.1161/JAHA.123.032646
By:
- Doiron, Jake E.;
- Zhen Li;
- Xiaoman Yu;
- LaPenna, Kyle B.;
- Quiriarte, Heather;
- Allerton, Timothy D.;
- Koul, Kashyap;
- Malek, Andrew;
- Shah, Sanjiv J.;
- Sharp, Thomas E.;
- Goodchild, Traci T.;
- Kapusta, Daniel R.;
- Lefer, David J.
Publication type:
Article
Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.
Published in:
Journal of the American Heart Association, 2024, v. 13, n. 2, p. 1, doi. 10.1161/JAHA.123.032037
By:
- Fenwick, Axel J.;
- Jani, Vivek P.;
- Foster, D. Brian;
- Sharp, Thomas E.;
- Goodchild, Traci T.;
- LaPenna, Kyle;
- Doiron, Jake E.;
- Lefer, David J.;
- Hill, Joseph A.;
- Kass, David A.;
- Cammarato, Anthony
Publication type:
Article
Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.
Published in:
Journal of the American Heart Association, 2023, v. 12, n. 4, p. 1, doi. 10.1161/JAHA.122.028480
By:
- LaPenna, Kyle B.;
- Zhen Li;
- Doiron, Jake E.;
- Sharp III, Thomas E.;
- Huijing Xia;
- Moles, Karl;
- Koul, Kashyap;
- Wang, John S.;
- Polhemus, David J.;
- Goodchild, Traci T.;
- Patel, Ravi B.;
- Shah, Sanjiv J.;
- Lefer, David J.
Publication type:
Article
Endothelial Cell Cystathionine γ-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.
Published in:
2020
By:
- Xia, Huijing;
- Li, Zhen;
- Sharp, Thomas E 3rd;
- Polhemus, David J;
- Carnal, Jean;
- Moles, Karl H;
- Tao, Ya-Xiong;
- Elrod, John;
- Pfeilschifter, Josef;
- Beck, Karl-Friedrich;
- Lefer, David J
Publication type:
journal article
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Published in:
2020
By:
- Organ, Chelsea L.;
- Zhen Li;
- Sharp III, Thomas E.;
- Polhemus, David J.;
- Gupta, Nilaksh;
- Goodchild, Traci T.;
- Tang, W. H. Wilson;
- Hazen, Stanley L.;
- Lefer, David J.;
- Li, Zhen;
- Sharp, Thomas E 3rd
Publication type:
journal article
Combined Angiotensin Receptor-Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure.
Published in:
2018
By:
- Trivedi, Rishi K.;
- Polhemus, David J.;
- Li, Zhen;
- Yoo, Daniel;
- Koiwaya, Hiroshi;
- Scarborough, Amy;
- Goodchild, Traci T.;
- Lefer, David J.
Publication type:
journal article
Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2)-Dependent Signaling in Chronic Heart Failure.
Published in:
2016
By:
- Donnarumma, Erminia;
- Bhushan, Shashi;
- Bradley, Jessica M.;
- Otsuka, Hiroyuki;
- Donnelly, Erinn L.;
- Lefer, David J.;
- Islam, Kazi N.
Publication type:
journal article
Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop.
Published in:
2016
By:
- Ahluwalia, Amrita;
- Gladwin, Mark;
- Coleman, Gary D.;
- Hord, Norman;
- Howard, George;
- Kim‐Shapiro, Daniel B.;
- Lajous, Martin;
- Larsen, Filip J.;
- Lefer, David J.;
- McClure, Leslie A.;
- Nolan, Bernard T.;
- Pluta, Ryszard;
- Schechter, Alan;
- Wang, Chia‐Yih;
- Ward, Mary H.;
- Harman, Jane L.
Publication type:
journal article
Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability.
Published in:
2016
By:
- Donnarumma, Erminia;
- Ali, Murtuza J.;
- Rushing, Amanda M.;
- Scarborough, Amy L.;
- Bradley, Jessica M.;
- Organ, Chelsea L.;
- Islam, Kazi N.;
- Polhemus, David J.;
- Evangelista, Stefano;
- Cirino, Giuseppe;
- Jenkins, J. Stephen;
- Patel, Rajan A. G.;
- Lefer, David J.;
- Goodchild, Traci T.
Publication type:
journal article
Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI).
Published in:
2015
By:
- Islam, Kazi N.;
- Polhemus, David J.;
- Donnarumma, Erminia;
- Brewster, Luke P.;
- Lefer, David J.
Publication type:
journal article
Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
Published in:
British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4294, doi. 10.1111/bph.16493
By:
- Doiron, Jake E.;
- Xia, Huijing;
- Yu, Xiaoman;
- Nevins, Alexandra R.;
- LaPenna, Kyle B.;
- Sharp, Thomas E.;
- Goodchild, Traci T.;
- Allerton, Timothy D.;
- Elgazzaz, Mona;
- Lazartigues, Eric;
- Shah, Sanjiv J.;
- Li, Zhen;
- Lefer, David J.
Publication type:
Article
Effects of storage-aged red blood cell transfusions on endothelial function in hospitalized patients.
Published in:
2015
By:
- Neuman, Robert;
- Hayek, Salim;
- Rahman, Ayaz;
- Poole, Joseph C.;
- Menon, Vivek;
- Sher, Salman;
- Newman, James L.;
- Karatela, Sulaiman;
- Polhemus, David;
- Lefer, David J.;
- De Staercke, Christine;
- Hooper, Craig;
- Quyyumi, Arshed A.;
- Roback, John D.
Publication type:
journal article
Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.
Published in:
Transfusion, 2013, v. 53, n. 11, p. 2619, doi. 10.1111/trf.12111
By:
- Alexander, Jason T.;
- El‐Ali, Alexander M.;
- Newman, James L.;
- Karatela, Sulaiman;
- Predmore, Benjamin L.;
- Lefer, David J.;
- Sutliff, Roy L.;
- Roback, John D.
Publication type:
Article
Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS-Mediated Signaling.
Published in:
Diabetes, 2008, v. 57, n. 3, p. 696, doi. 10.2337/db07-1098
By:
- Calvert, John W.;
- Gundewar, Susheel;
- Jha, Saurabh;
- Greer, James J. M.;
- Bestermann, William H.;
- Tian, Rong;
- Lefer, David J.
Publication type:
Article
Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.
Published in:
2016
By:
- Jiang, Hong;
- Polhemus, David J.;
- Islam, Kazi N.;
- Torregrossa, Ashley C.;
- Li, Zhen;
- Potts, Amy;
- Lefer, David J.;
- Bryan, Nathan S.
Publication type:
journal article
Development of an NIH Consortium for PreclinicAl AssESsment of CARdioprotective Therapies (CAESAR): A Paradigm Shift in Studies of Infarct Size Limitation.
Published in:
Journal of Cardiovascular Pharmacology & Therapeutics, 2011, v. 16, n. 3/4, p. 332, doi. 10.1177/1074248411414155
By:
- Lefer, David J.;
- Bolli, Roberto
Publication type:
Article
Emerging roles for gasotransmitters.
Published in:
Experimental Physiology, 2011, v. 96, n. 9, p. 831, doi. 10.1113/expphysiol.2011.057422
By:
- Peers, Chris;
- Lefer, David J.
Publication type:
Article
Cytoprotective actions of hydrogen sulfide in ischaemia-reperfusion injury.
Published in:
Experimental Physiology, 2011, v. 96, n. 9, p. 840, doi. 10.1113/expphysiol.2011.059725
By:
- King, Adrienne L.;
- Lefer, David J.
Publication type:
Article
Developmental programming resulting from maternal obesity in mice: effects on myocardial ischaemia–reperfusion injury.
Published in:
Experimental Physiology, 2009, v. 94, n. 7, p. 805, doi. 10.1113/expphysiol.2009.047183
By:
- Calvert, John W.;
- Lefer, David J.;
- Gundewar, Susheel;
- Poston, Lucilla;
- Coetzee, William A.
Publication type:
Article
Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction.
Published in:
Frontiers in Physiology, 2019, p. 1, doi. 10.3389/fphys.2019.00598
By:
- Kar, Sumit;
- Shahshahan, Hamid R.;
- Kambis, Tyler N.;
- Yadav, Santosh K.;
- Li, Zhen;
- Lefer, David J.;
- Mishra, Paras K.
Publication type:
Article
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.
Published in:
Clinical Science, 2022, v. 136, n. 12, p. 973, doi. 10.1042/CS20220083
By:
- Whitehead, Anna K.;
- Fried, Nicholas D.;
- Zhen Li;
- Neelamegam, Kandasamy;
- Pearson, Charlotte S.;
- LaPenna, Kyle B.;
- Sharp, Thomas E.;
- Lefer, David J.;
- Lazartigues, Eric;
- Gardner, Jason D.;
- Xinping Yue
Publication type:
Article
Nitric oxide attenuates ischaemia-reperfusion (I/R) injury in the diabetic liver.
Published in:
Clinical Transplantation, 2004, v. 18, p. 7, doi. 10.1111/j.1399-0012.2004.00210
By:
- Rogers III, Hollis;
- Zibari, Gazi B.;
- Roberts, Jenifer;
- Turnage, Richard;
- Lefer, David J.
Publication type:
Article

Found: 57