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Long-Term Glucocorticoid Exposure and Incident Cardiovascular Diseases—The Lifelines Cohort.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 10, p. 2520, doi. 10.1210/clinem/dgae081
By:
- Valk, Eline S van der;
- Mohseni, Mostafa;
- Iyer, Anand M;
- Hurk, Maartje J B van den;
- Lengton, Robin;
- Kuckuck, Susanne;
- Wester, Vincent L;
- Leenen, Pieter J M;
- Dik, Willem A;
- Visser, Jenny A;
- Kavousi, Maryam;
- Mirzaian, Mina;
- Berg, Sjoerd A A van den;
- Rossum, Elisabeth F C van
Publication type:
Article
Shear stress--induced changes in atherosclerotic plaque composition are modulated by chemokines.
Published in:
Journal of Clinical Investigation, 2007, v. 117, n. 3, p. 616, doi. 10.1172/JCI28180
By:
- Cheng, Caroline;
- Tempel, Dennie;
- van Haperen, Rien;
- de Boer, Hetty C.;
- Segers, Dolf;
- Huisman, Martin;
- Jan van Zonneveld, Anton;
- Leenen, Pieter J. M.;
- van der Steen, Anton;
- Serruys, Patrick W.;
- de Crom, Rini;
- Krams, Rob
Publication type:
Article
Monocyte adaptations in patients with obesity during a 1.5 year lifestyle intervention.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1022361
By:
- van der Valk, Eline S.;
- Mulder, Daniël S.;
- Kouwenhoven, Tessa;
- Nagtzaam, Nicole M. A.;
- van Rossum, Elisabeth F. C.;
- Dik, Willem A.;
- Leenen, Pieter J. M.
Publication type:
Article
UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells.
Published in:
International Immunology, 2000, v. 12, n. 11, p. 1531, doi. 10.1093/intimm/12.11.1531
By:
- Boonstra, André;
- van Oudenaren, Adri;
- Barendregt, Barbara;
- An, Liguo;
- Leenen, Pieter J. M.;
- Savelkoul, Huub F. J.
Publication type:
Article
Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation.
Published in:
PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129421
By:
- Baldeón R., Lucy;
- Weigelt, Karin;
- de Wit, Harm;
- Ozcan, Behiye;
- van Oudenaren, Adri;
- Sempértegui, Fernando;
- Sijbrands, Eric;
- Grosse, Laura;
- van Zonneveld, Anton-Jan;
- Drexhage, Hemmo A.;
- Leenen, Pieter J. M.
Publication type:
Article
Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115209
By:
- Baldeón R., Lucy;
- Weigelt, Karin;
- de Wit, Harm;
- Ozcan, Behiye;
- van Oudenaren, Adri;
- Sempértegui, Fernando;
- Sijbrands, Eric;
- Grosse, Laura;
- Freire, Wilma;
- Drexhage, Hemmo A.;
- Leenen, Pieter J. M.
Publication type:
Article
A Shift towards Pro-Inflammatory CD16+ Monocyte Subsets with Preserved Cytokine Production Potential after Kidney Transplantation.
Published in:
PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0070152
By:
- Vereyken, Elly J. F.;
- Kraaij, Marina D.;
- Baan, Carla C.;
- Rezaee, Farhad;
- Weimar, Willem;
- Wood, Kathryn J.;
- Leenen, Pieter J. M.;
- Rowshani, Ajda T.
Publication type:
Article
The Kinetics of Plasmacytoid Dendritic Cell Accumulation in the Pancreas of the NOD Mouse during the Early Phases of Insulitis.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0055071
By:
- Welzen-Coppens, Jojanneke M. C.;
- van Helden-Meeuwsen, Cornelia G.;
- Leenen, Pieter J. M.;
- Drexhage, Hem mo A.;
- Versnel, Marjan A.
Publication type:
Article
Myeloid I&kgr;Bα Deficiency Promotes Atherogenesis by Enhancing Leukocyte Recruitment to the Plaques.
Published in:
PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022327
By:
- Goossens, Pieter;
- Vergouwe, Monique N.;
- Gijbels, Marion J. J.;
- Curfs, Danielle M. J.;
- Van Woezik, Johannes H. G.;
- Hoeksema, Marten A.;
- Xanthoulea, Sofia;
- Leenen, Pieter J. M.;
- Rupec, Rudolf A.;
- Hofker, Marten H.;
- De Winther, Menno P. J.
Publication type:
Article
Synthetic Human Chorionic Gonadotropin-Related Oligopeptides Impair Early Innate Immune Responses to Listeria monocytogenes in Mice.
Published in:
Journal of Infectious Diseases, 2010, v. 201, n. 7, p. 1072, doi. 10.1086/651134
By:
- van der Zee, Marten;
- Dik, Willem A.;
- Kap, Yolanda S.;
- Dillon, Marilyn J.;
- Benner, Robbert;
- Leenen, Pieter J. M.;
- Khan, Nisar A.;
- Drevets, Douglas A.
Publication type:
Article
Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice.
Published in:
Journal of Orthopaedic Research, 2021, v. 39, n. 10, p. 2270, doi. 10.1002/jor.24958
By:
- Utomo, Lizette;
- Fahy, Niamh;
- Kops, Nicole;
- van Tiel, Sandra T.;
- Waarsing, Jan;
- Verhaar, Jan A. N.;
- Leenen, Pieter J. M.;
- van Osch, Gerjo J. V. M.;
- Bastiaansen‐Jenniskens, Yvonne M.
Publication type:
Article
Immunotherapy Added to Antibiotic Treatment Reduces Relapse of Disease in a Mouse Model of Tuberculosis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2017, v. 56, n. 2, p. 233, doi. 10.1165/rcmb.2016-0185OC
By:
- Mourik, Bas C.;
- Leenen, Pieter J. M.;
- de Knegt, Gerjo J.;
- Huizinga, Ruth;
- van der Eerden, Bram C. J.;
- Jinshan Wang;
- Krois, Charles R.;
- Napoli, Joseph L.;
- Bakker-Woudenberg, Irma A. J. M.;
- de Steenwinkel, Jurriaan E. M.
Publication type:
Article
Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell–macrophage lineage.
Published in:
Immunological Reviews, 2010, v. 234, n. 1, p. 213, doi. 10.1111/j.0105-2896.2009.00883.x
By:
- Egeler, R. Maarten;
- Van Halteren, Astrid G. S.;
- Hogendoorn, Pancras C. W.;
- Laman, Jon D.;
- Leenen, Pieter J. M.
Publication type:
Article
Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-56300-6
By:
- Mourik, Bas C.;
- de Steenwinkel, Jurriaan E. M.;
- de Knegt, Gerjo J.;
- Huizinga, Ruth;
- Verbon, Annelies;
- Ottenhoff, Tom H. M.;
- van Soolingen, Dick;
- Leenen, Pieter J. M.
Publication type:
Article
Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression.
Published in:
Neuro-Oncology, 2017, v. 19, n. 5, p. 648, doi. 10.1093/neuonc/now251
By:
- Changbin Zhu;
- Mustafa, Dana;
- Ping-pin Zheng;
- van der Weiden, Marcel;
- Sacchetti, Andrea;
- Brandt, Maarten;
- Chrifi, Ihsan;
- Tempel, Dennie;
- Leenen, Pieter J. M.;
- Duncker, Dirk Jan;
- Cheng, Caroline;
- Kros, Johan M.
Publication type:
Article
Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis.
Published in:
FASEB Journal, 2013, v. 27, n. 4, p. 1690, doi. 10.1096/fj.12-221143
By:
- Delhanty, Patric J. D.;
- Huisman, Martin;
- Baldeon-Rojas, Lucy Y.;
- van den Berge, Iris;
- Grefhorst, Aldo;
- Abribat, Thierry;
- Leenen, Pieter J. M.;
- Themmen, Axel P. N.;
- van der Lely, Aart-Jan
Publication type:
Article
Macrophages and Dendritic Cells Constitute a Major Subpopulation of Cells in the Mouse Dermis.
Published in:
Journal of Investigative Dermatology, 2004, v. 123, n. 5, p. 876, doi. 10.1111/j.0022-202X.2004.23427.x
By:
- Dupasquier, Marcel;
- Stoitzner, Patrizia;
- Oudenaren, Adri van;
- Romani, Nikolaus;
- Leenen, Pieter J. M.
Publication type:
Article
Differential Ultraviolet-B-Induced Immunomodulation in XPA, XPC, and CSB DNA Repair-Deficient Mice.
Published in:
Journal of Investigative Dermatology, 2001, v. 117, n. 1, p. 141, doi. 10.1046/j.0022-202X.2001.01390.x
By:
- Boonstra, André;
- van Oudenaren, Adri;
- Baert, Miranda;
- van Steeg, Harry;
- Leenen, Pieter J. M.;
- van der Horst, Gijsbertus T. J.;
- Hoeijmakers, Jan H. J.;
- Savelkoul, Huub F. J.;
- Garssen, Johan
Publication type:
Article
Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155.
Published in:
Immunity & Ageing, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12979-022-00281-0
By:
- Cassidy, Benjamin R.;
- Sonntag, William E.;
- Leenen, Pieter J. M.;
- Drevets, Douglas A.
Publication type:
Article
IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89625-2
By:
- Razawy, Wida;
- Alves, Celso H.;
- Koedam, Marijke;
- Asmawidjaja, Patrick S.;
- Mus, Adriana M. C.;
- Oukka, Mohamed;
- Leenen, Pieter J. M.;
- Visser, Jenny A.;
- van der Eerden, Bram C. J.;
- Lubberts, Erik
Publication type:
Article
Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.
Published in:
Frontiers in Immunology, 2017, v. 8, p. 1, doi. 10.3389/fimmu.2017.00294
By:
- Mourik, Bas C.;
- Lubberts, Erik;
- de Steenwinkel, Jurriaan E. M.;
- Ottenhoff, Tom H. M.;
- Leenen, Pieter J. M.
Publication type:
Article
CD16+ Monocytes and Skewed Macrophage Polarization toward M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
Published in:
Frontiers in Immunology, 2017, v. 8, p. 1, doi. 10.3389/fimmu.2017.00346
By:
- van den Bosch, Thierry P. P.;
- Caliskan, Kadir;
- Kraaij, Marina D.;
- Constantinescu, Alina A.;
- Manintveld, Olivier C.;
- Leenen, Pieter J. M.;
- von der Thüsen, Jan H.;
- Clahsen-van Groningen, Marian C.;
- Baan, Carla C.;
- Rowshani, Ajda T.
Publication type:
Article
Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1<sup>−/Δ7</sup> Mice.
Published in:
Frontiers in Immunology, 2016, v. 7, p. 1, doi. 10.3389/fimmu.2016.00408
By:
- Meijer, Ben;
- Hoogerland, Joanne A.;
- Mihailova, Violeta;
- van der Ploeg, Corine;
- Savelkoul, Huub F. J.;
- van Beek, Adriaan A.;
- Leenen, Pieter J. M.;
- Hendriks, Rudi W.;
- Sovran, Bruno;
- Wells, Jerry M.;
- Hugenholtz, Floor;
- Belzer, Clara;
- Boekschoten, Mark V.;
- de Vos, Paul;
- Nicoletti, Claudio;
- Vermeij, Wilbert P.;
- Hoeijmakers, Jan H. J.
Publication type:
Article
Intra‐articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice.
Published in:
British Journal of Pharmacology, 2022, v. 179, n. 11, p. 2771, doi. 10.1111/bph.15780
By:
- Ferrao Blanco, Mauricio N.;
- Bastiaansen Jenniskens, Yvonne M.;
- Kops, Nicole;
- Chavli, Athina;
- Narcisi, Roberto;
- Botter, Sander M.;
- Leenen, Pieter J. M.;
- van Osch, Gerjo J. V. M.;
- Fahy, Niamh
Publication type:
Article
The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function.
Published in:
PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170806
By:
- Kannegieter, Nynke M.;
- Hesselink, Dennis A.;
- Dieterich, Marjolein;
- Kraaijeveld, Rens;
- Rowshani, Ajda T.;
- Leenen, Pieter J. M.;
- Baan, Carla C.
Publication type:
Article
Classic and new mediators for in vitro modelling of human macrophages.
Published in:
Journal of Leukocyte Biology, 2021, v. 109, n. 3, p. 549, doi. 10.1002/JLB.1RU0620-018R
By:
- Luque‐Martin, Rosario;
- Mander, Palwinder K.;
- Leenen, Pieter J. M.;
- Winther, Menno P. J.
Publication type:
Article
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1<sup>−/Δ7</sup> mice.
Published in:
Journal of Leukocyte Biology, 2017, v. 101, n. 4, p. 811, doi. 10.1189/jlb.1HI0216-062RR
By:
- Beek, Adriaan A.;
- Hugenholtz, Floor;
- Meijer, Ben;
- Sovran, Bruno;
- Perdijk, Olaf;
- Vermeij, Wilbert P.;
- Brandt, Renata M. C.;
- Barnhoorn, Sander;
- Hoeijmakers, Jan H. J.;
- Vos, Paul;
- Leenen, Pieter J. M.;
- Hendriks, Rudi W.;
- Savelkoul, Huub F. J.
Publication type:
Article
Differentiation of Bone Marrow-Derived Endothelial Progenitor Cells Is Shifted into a Proinflammatory Phenotype by Hyperglycemia.
Published in:
Molecular Medicine, 2009, v. 15, n. 5/6, p. 152, doi. 10.2119/molmed.2009.00032
By:
- Loomans, Cindy J. M.;
- van Haperen, Rien;
- Duijs, Jacques M.;
- Verseyden, Caroline;
- de Crom, Rini;
- Leenen, Pieter J. M.;
- Drexhage, Hemmo A.;
- de Boer, Hetty C.;
- de Koning, Eelco J. P.;
- Rabelink, Ton J.;
- Staal, Frank J. T.;
- van Zonneveld, Anton Jan
Publication type:
Article
Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states.
Published in:
Diabetology & Metabolic Syndrome, 2017, v. 9, p. 1, doi. 10.1186/s13098-017-0239-8
By:
- Özcan, Behiye;
- Leenen, Pieter J. M.;
- Delhanty, Patric J. D.;
- Baldéon-Rojas, Lucy Y.;
- Neggers, Sebastian J.;
- van der Lely, Aart Jan
Publication type:
Article
Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D.
Published in:
Diabetology & Metabolic Syndrome, 2016, v. 8, p. 1, doi. 10.1186/s13098-015-0113-5
By:
- Rojas, Lucy Baldeón;
- Weigelt, Karin;
- de Wit, Harm;
- Ozcan, Behiye;
- Van Oudenaren, Adri;
- Sempértegui, Fernando;
- Sijbrands, Eric;
- Grosse, Laura;
- van Zonneveld, Anton-Jan;
- Drexhage, Hemmo A.;
- Leenen, Pieter J. M.
Publication type:
Article
MicroRNA-mediated down-regulation of M-CSF receptor contributes to maturation of mouse monocyte-derived dendritic cells.
Published in:
Frontiers in Immunology, 2013, p. 1, doi. 10.3389/fimmu.2013.00353
By:
- Riepsaame, Joey;
- van Oudenaren, Adri;
- den Broeder, Berlinda J. H.;
- van IJcken, Wilfred F. J.;
- Pothof, Joris;
- Leenen, Pieter J. M.
Publication type:
Article
Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells.
Published in:
European Journal of Immunology, 2009, v. 39, n. 12, p. 3538, doi. 10.1002/eji.200939530
By:
- Ribechini, Eliana;
- Leenen, Pieter J. M.;
- Lutz, Manfred B.
Publication type:
Article
NOD mice have a severly impaired ability to recruit leukocytes into sites of inflammation.
Published in:
European Journal of Immunology, 2005, v. 35, n. 1, p. 225, doi. 10.1002/eji.200425513
By:
- Bouma, Gerben;
- Nikolic, Tatjana;
- Coppens, Jojanneke M. C.;
- van Helden-Meeuwsen, Cornelia G.;
- Leenen, Pieter J. M.;
- Drexhage, Hemmo A.;
- Sozzani, Silvano;
- Versnel, Marjan A.
Publication type:
Article
A subfraction of B220.
Published in:
European Journal of Immunology, 2002, v. 32, n. 3, p. 686, doi. 10.1002/1521-4141(200203)32:3<686::AID-IMMU686>3.0.CO;2-I
By:
- Nikolic, Tatjana;
- Dingjan, Gemma M.;
- Leenen, Pieter J. M.;
- Hendriks, Rudolf W.
Publication type:
Article
Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31).
Published in:
European Journal of Immunology, 1997, v. 27, n. 2, p. 509, doi. 10.1002/eji.1830270223
By:
- Ling, Vincent;
- Luxenberg, Deborah;
- Wang, Jack;
- Nickbarg, Elliot;
- Leenen, Pieter J. M.;
- Neben, Steven;
- Kobayashi, Michiko
Publication type:
Article
High-level expression of the ER-MP58 antigen on mouse bone marrow hematopoietic progenitor cells marks commitment to the myeloid lineage.
Published in:
European Journal of Immunology, 1996, v. 26, n. 12, p. 2850, doi. 10.1002/eji.1830261208
By:
- De Bruijn, Marella F. T. R.;
- Ploemacher, Rob E.;
- Mayen, Angelique E. M.;
- Voerman, Jane S. A.;
- Slieker, Walentina A. T.;
- van Ewijk, Willem;
- Leenen, Pieter J. M.
Publication type:
Article
Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody.
Published in:
European Journal of Immunology, 1994, v. 24, n. 11, p. 2896, doi. 10.1002/eji.1830241147
By:
- Brekelmans, Pieter;
- Van Soest, Peter;
- Leenen, Pieter J. M.;
- van Ewijk, Willem
Publication type:
Article
Distinct mouse bone marrow macrophage precursors identified by differential expression of ER-MP12 and ER-MP20 antigens.
Published in:
European Journal of Immunology, 1994, v. 24, n. 10, p. 2279, doi. 10.1002/eji.1830241003
By:
- de Bruijn, Marella F. T. R.;
- Slieker, Walentina A. T.;
- van der Loo, Johannes C. M.;
- Voerman, Jane S. A.;
- van Ewijk, Willem;
- Leenen, Pieter J. M.
Publication type:
Article
The monoclonal antibody ER-BMDM1 recognizes a macrophage and dendritic cell differentiation antigen with aminopeptidase activity.
Published in:
European Journal of Immunology, 1992, v. 22, n. 6, p. 1567, doi. 10.1002/eji.1830220633
By:
- Leenen, Pieter J. M.;
- Melis, Marleen;
- Kraal, Georg;
- Hoogeveen, Andre T.;
- Ewijk, Willem Van
Publication type:
Article
Murine macrophage precursor characterization. I. Production, phenotype and differentiation of macrophage precursor hybrids.
Published in:
European Journal of Immunology, 1990, v. 20, n. 1, p. 15, doi. 10.1002/eji.1830200104
By:
- Leenen, Pieter J. M.;
- Slieker, Walentina A. T.;
- Melis, Marleen;
- van Ewijk, Willem
Publication type:
Article
Murine macrophage precursor characterization. II. Monoclonal antibodies against macrophage precursor antigens.
Published in:
European Journal of Immunology, 1990, v. 20, n. 1, p. 27, doi. 10.1002/eji.1830200105
By:
- Leenen, Pieter J. M.;
- Melis, Marleen;
- Slieker, Walentina A. T.;
- van Ewijk, Willem
Publication type:
Article
Brown Seaweed Food Supplementation: Effects on Allergy and Inflammation and Its Consequences.
Published in:
Nutrients, 2021, v. 13, n. 8, p. 2613, doi. 10.3390/nu13082613
By:
- Olsthoorn, Simone E. M.;
- Wang, Xi;
- Tillema, Berend;
- Vanmierlo, Tim;
- Kraan, Stefan;
- Leenen, Pieter J. M.;
- Mulder, Monique T.
Publication type:
Article
The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking Outside the Cell but Also Outside the Islet and Out of the Box.
Published in:
2016
By:
- Drexhage, Hemmo A.;
- Dik, Wim A.;
- Leenen, Pieter J. M.;
- Versnel, Marjan A.
Publication type:
journal article

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