Works by Lee, Seunggeun

Results: 53

An efficient resampling method for calibrating single and gene-based rare variant association analysis in case-control studies.

Published in:

2016

By:

SEUNGGEUN LEE;
FUCHSBERGER, CHRISTIAN;
SEHEE KIM;
SCOTT, LAURA;
Lee, Seunggeun;
Kim, Sehee

Publication type:

journal article

Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease.

Published in:

2017

By:

Dokyoon Kim;
Basile, Anna O.;
Lisa Bang;
Horgusluoglu, Emrin;
Seunggeun Lee;
Ritchie, Marylyn D.;
Saykin, Andrew J.;
Kwangsik Nho;
Kim, Dokyoon;
Bang, Lisa;
Lee, Seunggeun;
Nho, Kwangsik

Publication type:

journal article

Integrating external controls in case–control studies improves power for rare‐variant tests.

Published in:

Genetic Epidemiology, 2022, v. 46, n. 3, p. 145, doi. 10.1002/gepi.22444

By:

Li, Yatong;
Lee, Seunggeun

Publication type:

Article

Novel score test to increase power in association test by integrating external controls.

Published in:

Genetic Epidemiology, 2021, v. 45, n. 3, p. 293, doi. 10.1002/gepi.22370

By:

Li, Yatong;
Lee, Seunggeun

Publication type:

Article

Meta‐MultiSKAT: Multiple phenotype meta‐analysis for region‐based association test.

Published in:

Genetic Epidemiology, 2019, v. 43, n. 7, p. 800, doi. 10.1002/gepi.22248

By:

Dutta, Diptavo;
Gagliano Taliun, Sarah A.;
Weinstock, Joshua S.;
Zawistowski, Matthew;
Sidore, Carlo;
Fritsche, Lars G.;
Cucca, Francesco;
Schlessinger, David;
Abecasis, Gonçalo R.;
Brummett, Chad M.;
Lee, Seunggeun

Publication type:

Article

Robust meta‐analysis of biobank‐based genome‐wide association studies with unbalanced binary phenotypes.

Published in:

Genetic Epidemiology, 2019, v. 43, n. 5, p. 462, doi. 10.1002/gepi.22197

By:

Dey, Rounak;
Nielsen, Jonas B.;
Fritsche, Lars G.;
Zhou, Wei;
Zhu, Huanhuan;
Willer, Cristen J.;
Lee, Seunggeun

Publication type:

Article

Multi‐SKAT: General framework to test for rare‐variant association with multiple phenotypes.

Published in:

Genetic Epidemiology, 2019, v. 43, n. 1, p. 4, doi. 10.1002/gepi.22156

By:

Dutta, Diptavo;
Scott, Laura;
Boehnke, Michael;
Lee, Seunggeun

Publication type:

Article

Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA).

Published in:

Genetic Epidemiology, 2017, v. 41, n. 8, p. 801, doi. 10.1002/gepi.22081

By:

He, Zihuai;
Lee, Seunggeun;
Zhang, Min;
Smith, Jennifer A.;
Guo, Xiuqing;
Palmas, Walter;
Kardia, Sharon L.R.;
Ionita‐Laza, Iuliana;
Mukherjee, Bhramar

Publication type:

Article

Improving power for rare-variant tests by integrating external controls.

Published in:

Genetic Epidemiology, 2017, v. 41, n. 7, p. 610, doi. 10.1002/gepi.22057

By:

Lee, Seunggeun;
Kim, Sehee;
Fuchsberger, Christian

Publication type:

Article

Evaluating the Calibration and Power of Three Gene-Based Association Tests of Rare Variants for the X Chromosome.

Published in:

Genetic Epidemiology, 2015, v. 39, n. 7, p. 499, doi. 10.1002/gepi.21935

By:

Ma, Clement;
Boehnke, Michael;
Lee, Seunggeun

Publication type:

Article

GEE-Based SNP Set Association Test for Continuous and Discrete Traits in Family-Based Association Studies.

Published in:

Genetic Epidemiology, 2013, v. 37, n. 8, p. 778, doi. 10.1002/gepi.21763

By:

Wang, Xuefeng;
Lee, Seunggeun;
Zhu, Xiaofeng;
Redline, Susan;
Lin, Xihong

Publication type:

Article

Kernel Machine SNP-Set Testing Under Multiple Candidate Kernels.

Published in:

Genetic Epidemiology, 2013, v. 37, n. 3, p. 267, doi. 10.1002/gepi.21715

By:

Wu, Michael C.;
Maity, Arnab;
Lee, Seunggeun;
Simmons, Elizabeth M.;
Harmon, Quaker E.;
Lin, Xinyi;
Engel, Stephanie M.;
Molldrem, Jeffrey J.;
Armistead, Paul M.

Publication type:

Article

Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies.

Published in:

Genetic Epidemiology, 2013, v. 37, n. 2, p. 142, doi. 10.1002/gepi.21699

By:

Barnett, Ian J.;
Lee, Seunggeun;
Lin, Xihong

Publication type:

Article

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease.

Published in:

BMC Medical Genomics, 2017, v. 10, p. 45, doi. 10.1186/s12920-017-0267-0

By:

Kwangsik Nho;
Sungeun Kim;
Horgusluoglu, Emrin;
Risacher, Shannon L.;
Li Shen;
Dokyoon Kim;
Seunggeun Lee;
Foroud, Tatiana;
Shaw, Leslie M.;
Trojanowski, John Q.;
Aisen, Paul S.;
Petersen, Ronald C.;
Jack, Clifford R.;
Weiner, Michael W.;
Green, Robert C.;
Toga, Arthur W.;
Saykin, Andrew J.

Publication type:

Article

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.

Published in:

Nature Genetics, 2011, v. 43, n. 6, p. 539, doi. 10.1038/ng.838

By:

Wright, Fred A.;
Strug, Lisa J.;
Doshi, Vishal K.;
Commander, Clayton W.;
Blackman, Scott M.;
Sun, Lei;
Berthiaume, Yves;
Cutler, David;
Cojocaru, Andreea;
Collaco, J. Michael;
Corey, Mary;
Dorfman, Ruslan;
Goddard, Katrina;
Green, Deanna;
Kent Jr., Jack W.;
Lange, Ethan M.;
Seunggeun Lee;
Weili Li;
Jingchun Luo;
Mayhew, Gregory M.

Publication type:

Article

Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction.

Published in:

BMC Bioinformatics, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12859-024-05664-2

By:

Zhuang, Yongwen;
Kim, Na Yeon;
Fritsche, Lars G.;
Mukherjee, Bhramar;
Lee, Seunggeun

Publication type:

Article

Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0126637

By:

He, Zihuai;
Payne, Erin K.;
Mukherjee, Bhramar;
Lee, Seunggeun;
Smith, Jennifer A.;
Ware, Erin B.;
Sánchez, Brisa N.;
Seeman, Teresa E.;
Kardia, Sharon L. R.;
Diez Roux, Ana V.

Publication type:

Article

To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice.

Published in:

Journal of the American Medical Informatics Association, 2024, v. 31, n. 7, p. 1479, doi. 10.1093/jamia/ocae098

By:

Salvatore, Maxwell;
Kundu, Ritoban;
Shi, Xu;
Friese, Christopher R;
Lee, Seunggeun;
Fritsche, Lars G;
Mondul, Alison M;
Hanauer, David;
Pearce, Celeste Leigh;
Mukherjee, Bhramar

Publication type:

Article

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32885-x

By:

Dey, Rounak;
Zhou, Wei;
Kiiskinen, Tuomo;
Havulinna, Aki;
Elliott, Amanda;
Karjalainen, Juha;
Kurki, Mitja;
Qin, Ashley;
FinnGen;
Lee, Seunggeun;
Palotie, Aarno;
Neale, Benjamin;
Daly, Mark;
Lin, Xihong

Publication type:

Article

Addressing overfitting bias due to sample overlap in polygenic risk scoring.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 4, p. 1, doi. 10.1002/alz.70109

By:

Jeong, Seokho;
Shivakumar, Manu;
Jung, Sang‐Hyuk;
Won, Hong‐Hee;
Nho, Kwangsik;
Huang, Heng;
Davatzikos, Christos;
Saykin, Andrew J.;
Thompson, Paul M.;
Shen, Li;
Kim, Young Jin;
Kim, Bong‐Jo;
Lee, Seunggeun;
Kim, Dokyoon

Publication type:

Article

Trans-ethnic meta-analysis of rare variants in sequencing association studies.

Published in:

2021

By:

Shi, Jingchunzi;
Boehnke, Michael;
Lee, Seunggeun

Publication type:

journal article

Heritability of the Fibromyalgia Phenotype Varies by Age.

Published in:

Arthritis & Rheumatology, 2020, v. 72, n. 5, p. 815, doi. 10.1002/art.41171

By:

Dutta, Diptavo;
Brummett, Chad M.;
Moser, Stephanie E.;
Fritsche, Lars G.;
Tsodikov, Alexander;
Lee, Seunggeun;
Clauw, Daniel J.;
Scott, Laura J.

Publication type:

Article

Rare variant association test in family-based sequencing studies.

Published in:

Briefings in Bioinformatics, 2017, v. 18, n. 6, p. 954, doi. 10.1093/bib/bbw083

By:

Xuefeng Wang;
Yu, Timothy W.;
Walsh, Christopher A.;
Xihong Lin;
Zhenyu Zhang;
Morris, Nathan;
Tianxi Cai;
Seunggeun Lee;
Chaolong Wang

Publication type:

Article

Scalable and Robust Regression Methods for Phenome-Wide Association Analysis on Large-Scale Biobank Data.

Published in:

Frontiers in Genetics, 2021, v. 11, p. 1, doi. 10.3389/fgene.2021.682638

By:

Bi, Wenjian;
Lee, Seunggeun

Publication type:

Article

MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17315-0

By:

Surakka, Ida;
Fritsche, Lars G.;
Zhou, Wei;
Backman, Joshua;
Kosmicki, Jack A.;
Lu, Haocheng;
Brumpton, Ben;
Nielsen, Jonas B.;
Gabrielsen, Maiken E.;
Skogholt, Anne Heidi;
Wolford, Brooke;
Graham, Sarah E.;
Chen, Y. Eugene;
Lee, Seunggeun;
Kang, Hyun Min;
Langhammer, Arnulf;
Forsmo, Siri;
Åsvold, Bjørn O.;
Styrkarsdottir, Unnur;
Holm, Hilma

Publication type:

Article

Family-based association tests for sequence data, and comparisons with population-based association tests.

Published in:

European Journal of Human Genetics, 2013, v. 21, n. 10, p. 1158, doi. 10.1038/ejhg.2012.308

By:

Ionita-Laza, Iuliana;
Lee, Seunggeun;
Makarov, Vladimir;
Buxbaum, Joseph D;
Lin, Xihong

Publication type:

Article

De-identification of clinical notes with pseudo-labeling using regular expression rules and pre-trained BERT.

Published in:

BMC Medical Informatics & Decision Making, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12911-025-02913-z

By:

An, Jiyong;
Kim, Jiyun;
Sunwoo, Leonard;
Baek, Hyunyoung;
Yoo, Sooyoung;
Lee, Seunggeun

Publication type:

Article

On cross-ancestry cancer polygenic risk scores.

Published in:

PLoS Genetics, 2021, v. 17, n. 9, p. 1, doi. 10.1371/journal.pgen.1009670

By:

Fritsche, Lars G.;
Ma, Ying;
Zhang, Daiwei;
Salvatore, Maxwell;
Lee, Seunggeun;
Zhou, Xiang;
Mukherjee, Bhramar

Publication type:

Article

Optimal tests for rare variant effects in sequencing association studies.

Published in:

Biostatistics, 2012, v. 13, n. 4, p. 762, doi. 10.1093/biostatistics/kxs014

By:

Lee, Seunggeun;
Wu, Michael C.;
Lin, Xihong

Publication type:

Article

An improved and explicit surrogate variable analysis procedure by coefficient adjustment.

Published in:

Biometrika, 2017, v. 104, n. 2, p. 303, doi. 10.1093/biomet/asx018

By:

SEUNGGEUN LEE;
WEI SUN;
WRIGHT, FRED A.;
FEI ZOU

Publication type:

Article

Convergence of sample eigenvalues, eigenvectors, and principal component scores for ultra-high dimensional data.

Published in:

Biometrika, 2014, v. 101, n. 2, p. 484, doi. 10.1093/biomet/ast064

By:

Lee, Seunggeun;
Zou, Fei;
Wright, Fred A.

Publication type:

Article

SPA<sub>GRM</sub>: effectively controlling for sample relatedness in large-scale genome-wide association studies of longitudinal traits.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-56669-1

By:

Xu, He;
Ma, Yuzhuo;
Xu, Lin-lin;
Li, Yin;
Liu, Yufei;
Li, Ying;
Zhou, Xu-jie;
Zhou, Wei;
Lee, Seunggeun;
Zhang, Peipei;
Yue, Weihua;
Bi, Wenjian

Publication type:

Article

Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 19, p. 4341, doi. 10.3390/jcm10194341

By:

Zhao, Zhangchen;
Salerno, Stephen;
Shi, Xu;
Lee, Seunggeun;
Mukherjee, Bhramar;
Fritsche, Lars G.

Publication type:

Article

Set-Based Tests for the Gene–Environment Interaction in Longitudinal Studies.

Published in:

Journal of the American Statistical Association, 2017, v. 112, n. 519, p. 966, doi. 10.1080/01621459.2016.1252266

By:

He, Zihuai;
Zhang, Min;
Lee, Seunggeun;
Smith, Jennifer A.;
Kardia, Sharon L. R.;
Roux, V. Diez;
Mukherjee, Bhramar

Publication type:

Article

Earlier Age at Type 2 Diabetes Diagnosis Is Associated With Increased Genetic Risk of Cardiovascular Disease.

Published in:

Diabetes Care, 2023, v. 46, n. 5, p. 1085, doi. 10.2337/dc22-2144

By:

Lee, Hyunsuk;
Choi, Jaewon;
Kim, Na Yeon;
Kim, Jong-Il;
Moon, Min Kyong;
Lee, Seunggeun;
Park, Kyong Soo;
Kwak, Soo Heon

Publication type:

Article

Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes.

Published in:

Human Heredity, 2019, v. 83, n. 6, p. 283, doi. 10.1159/000496867

By:

Yu, Youfei;
Xia, Lu;
Lee, Seunggeun;
Zhou, Xiang;
Stringham, Heather M.;
Boehnke, Michael;
Mukherjee, Bhramar

Publication type:

Article

Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes.

Published in:

Human Heredity, 2018, v. 83, n. 6, p. 283, doi. 10.1159/000496867

By:

Yu, Youfei;
Xia, Lu;
Lee, Seunggeun;
Zhou, Xiang;
Stringham, Heather M.;
Boehnke, Michael;
Mukherjee, Bhramar

Publication type:

Article

Quantification of Population Structure Using Correlated SNPs by Shrinkage Principal Components.

Published in:

Human Heredity, 2010, v. 70, n. 1, p. 9, doi. 10.1159/000288706

By:

Zou, Fei;
Lee, Seunggeun;
Knowles, Michael R.;
Wright, Fred A.

Publication type:

Article

Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09861-z

By:

Graham, Sarah E.;
Nielsen, Jonas B.;
Zawistowski, Matthew;
Zhou, Wei;
Fritsche, Lars G.;
Gabrielsen, Maiken E.;
Skogholt, Anne Heidi;
Surakka, Ida;
Hornsby, Whitney E.;
Fermin, Damian;
Larach, Daniel B.;
Kheterpal, Sachin;
Brummett, Chad M.;
Lee, Seunggeun;
Kang, Hyun Min;
Abecasis, Goncalo R.;
Romundstad, Solfrid;
Hallan, Stein;
Sampson, Matthew G.;
Hveem, Kristian

Publication type:

Article

Applying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis.

Published in:

Behavior Genetics, 2016, v. 46, n. 1, p. 89, doi. 10.1007/s10519-015-9734-6

By:

Ware, Erin;
Smith, Jennifer;
Mukherjee, Bhramar;
Lee, Seunggeun;
Kardia, Sharon;
Diez-Roux, Ana

Publication type:

Article

A novel random effect model for GWAS meta-analysis and its application to trans-ethnic meta-analysis.

Published in:

Biometrics, 2016, v. 72, n. 3, p. 945, doi. 10.1111/biom.12481

By:

Shi, Jingchunzi;
Lee, Seunggeun

Publication type:

Article

Test for Rare Variants by Environment Interactions in Sequencing Association Studies.

Published in:

Biometrics, 2016, v. 72, n. 1, p. 156, doi. 10.1111/biom.12368

By:

Lin, Xinyi;
Lee, Seunggeun;
Wu, Michael C.;
Wang, Chaolong;
Chen, Han;
Li, Zilin;
Lin, Xihong

Publication type:

Article

Set-based tests for genetic association in longitudinal studies.

Published in:

Biometrics, 2015, v. 71, n. 3, p. 606, doi. 10.1111/biom.12310

By:

He, Zihuai;
Zhang, Min;
Lee, Seunggeun;
Smith, Jennifer A.;
Guo, Xiuqing;
Palmas, Walter;
Kardia, Sharon L. R.;
Roux, Ana V. Diez;
Mukherjee, Bhramar

Publication type:

Article

Control of Population Stratification by Correlation-Selected Principal Components.

Published in:

Biometrics, 2011, v. 67, n. 3, p. 967, doi. 10.1111/j.1541-0420.2010.01520.x

By:

Lee, Seunggeun;
Wright, Fred A.;
Zou, Fei

Publication type:

Article

Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.

Published in:

PLoS Genetics, 2023, v. 19, n. 12, p. 1, doi. 10.1371/journal.pgen.1010907

By:

Fritsche, Lars G.;
Nam, Kisung;
Du, Jiacong;
Kundu, Ritoban;
Salvatore, Maxwell;
Shi, Xu;
Lee, Seunggeun;
Burgess, Stephen;
Mukherjee, Bhramar

Publication type:

Article

XPRS: a tool for interpretable and explainable polygenic risk score Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 4, p. 1, doi. 10.1093/bioinformatics/btaf143

By:

Kim, Na Yeon;
Lee, Seunggeun

Publication type:

Article

Incorporating family disease history and controlling case–control imbalance for population-based genetic association studies.

Published in:

Bioinformatics, 2022, v. 38, n. 18, p. 4337, doi. 10.1093/bioinformatics/btac459

By:

Zhuang, Yongwen;
Wolford, Brooke N;
Nam, Kisung;
Bi, Wenjian;
Zhou, Wei;
Willer, Cristen J;
Mukherjee, Bhramar;
Lee, Seunggeun

Publication type:

Article

Investigation of genetic variants and causal biomarkers associated with brain aging.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-27903-x

By:

Kim, Jangho;
Lee, Junhyeong;
Nam, Kisung;
Lee, Seunggeun

Publication type:

Article

NETMAGE: A human disease phenotype map generator for the network-based visualization of phenome-wide association study results.

Published in:

GigaScience, 2022, v. 11, p. 1, doi. 10.1093/gigascience/giac002

By:

Sriram, Vivek;
Shivakumar, Manu;
Jung, Sang-Hyuk;
Nam, Yonghyun;
Bang, Lisa;
Verma, Anurag;
Lee, Seunggeun;
Choe, Eun Kyung;
Kim, Dokyoon

Publication type:

Article

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence.

Published in:

American Journal of Epidemiology, 2018, v. 187, n. 2, p. 355, doi. 10.1093/aje/kwx243

By:

Gang Liu;
Mukherjee, Bhramar;
Seunggeun Lee;
Lee, Alice W.;
Wu, Anna H.;
Bandera, Elisa V.;
Jensen, Allan;
Rossing, Mary Anne;
Moysich, Kirsten B.;
Chang-Claude, Jenny;
Doherty, Jennifer A.;
Gentry-Maharaj, Aleksandra;
Kiemeney, Lambertus;
Gayther, Simon A.;
Modugno, Francesmary;
Massuger, Leon;
Goode, Ellen L.;
Fridley, Brooke L.;
Terry, Kathryn L.;
Cramer, Daniel W.

Publication type:

Article