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A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.
Published in:
PLoS Pathogens, 2024, v. 20, n. 10, p. 1, doi. 10.1371/journal.ppat.1012627
By:
- Ferreira, Letícia Tiburcio;
- Cassiano, Gustavo Capatti;
- Alvarez, Luis Carlos Salazar;
- Okombo, John;
- Calit, Juliana;
- Fontinha, Diana;
- Gil-Iturbe, Eva;
- Coyle, Rachael;
- Andrade, Carolina Horta;
- Sunnerhagen, Per;
- Bargieri, Daniel Youssef;
- Prudêncio, Miguel;
- Quick, Matthias;
- Cravo, Pedro V.;
- Lee, Marcus C. S.;
- Fidock, David A.;
- Costa, Fabio Trindade Maranhão
Publication type:
Article
Genomewide Analysis Reveals Novel Pathways Affecting Endoplasmic Reticulum Homeostasis, Protein Modification and Quality Control.
Published in:
Genetics, 2009, v. 182, n. 3, p. 757, doi. 10.1534/genetics.109.101105
By:
- Čopič, Alenka;
- Dorrington, Mariana;
- Pagant, Silvere;
- Barry, Justine;
- Lee, Marcus C. S.;
- Singh, Indira;
- Hartman, John L.;
- Miller, Elizabeth A.
Publication type:
Article
Efficient generation of mNeonGreen Plasmodium falciparum reporter lines enables quantitative fitness analysis.
Published in:
Frontiers in Cellular & Infection Microbiology, 2022, v. 12, p. 1, doi. 10.3389/fcimb.2022.981432
By:
- Hoshizaki, Johanna;
- Jagoe, Hannah;
- Lee, Marcus C. S.
Publication type:
Article
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.
Published in:
Nature Methods, 2012, v. 9, n. 10, p. 993, doi. 10.1038/nmeth.2143
By:
- Straimer, Judith;
- Lee, Marcus C S;
- Lee, Andrew H;
- Zeitler, Bryan;
- Williams, April E;
- Pearl, Jocelynn R;
- Zhang, Lei;
- Rebar, Edward J;
- Gregory, Philip D;
- Llinás, Manuel;
- Urnov, Fyodor D;
- Fidock, David A
Publication type:
Article
Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif.
Published in:
Molecular Microbiology, 2008, v. 68, n. 6, p. 1535, doi. 10.1111/j.1365-2958.2008.06250.x
By:
- Lee, Marcus C. S.;
- Moura, Pedro A.;
- Miller, Elizabeth A.;
- Fidock, David A.
Publication type:
Article
Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
Published in:
2023
By:
- Stadler, Eva;
- Maiga, Mohamed;
- Friedrich, Lukas;
- Thathy, Vandana;
- Demarta-Gatsi, Claudia;
- Dara, Antoine;
- Sogore, Fanta;
- Striepen, Josefine;
- Oeuvray, Claude;
- Djimdé, Abdoulaye A.;
- Lee, Marcus C. S.;
- Dembélé, Laurent;
- Fidock, David A.;
- Khoury, David S.;
- Spangenberg, Thomas
Publication type:
Correction Notice
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40974-8
By:
- Stadler, Eva;
- Maiga, Mohamed;
- Friedrich, Lukas;
- Thathy, Vandana;
- Demarta-Gatsi, Claudia;
- Dara, Antoine;
- Sogore, Fanta;
- Striepen, Josefine;
- Oeuvray, Claude;
- Djimdé, Abdoulaye A.;
- Lee, Marcus C. S.;
- Dembélé, Laurent;
- Fidock, David A.;
- Khoury, David S.;
- Spangenberg, Thomas
Publication type:
Article
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40974-8
By:
- Stadler, Eva;
- Maiga, Mohamed;
- Friedrich, Lukas;
- Thathy, Vandana;
- Demarta-Gatsi, Claudia;
- Dara, Antoine;
- Sogore, Fanta;
- Striepen, Josefine;
- Oeuvray, Claude;
- Djimdé, Abdoulaye A.;
- Lee, Marcus C. S.;
- Dembélé, Laurent;
- Fidock, David A.;
- Khoury, David S.;
- Spangenberg, Thomas
Publication type:
Article
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Published in:
Molecular Microbiology, 2016, v. 101, n. 3, p. 381, doi. 10.1111/mmi.13397
By:
- Ng, Caroline L.;
- Siciliano, Giulia;
- Lee, Marcus C. S.;
- de Almeida, Mariana J.;
- Corey, Victoria C.;
- Bopp, Selina E.;
- Bertuccini, Lucia;
- Wittlin, Sergio;
- Kasdin, Rachel G.;
- Le Bihan, Amélie;
- Clozel, Martine;
- Winzeler, Elizabeth A.;
- Alano, Pietro;
- Fidock, David A.
Publication type:
Article
Correction: A manually curated annotation characterises genomic features of P. falciparum lncRNAs.
Published in:
2023
By:
- Hoshizaki, Johanna;
- Adjalley, Sophie H.;
- Thathy, Vandana;
- Judge, Kim;
- Berriman, Matthew;
- Reid, Adam J.;
- Lee, Marcus C. S.
Publication type:
Correction Notice
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Published in:
Nature Communications, 2017, v. 8, n. 2, p. 14574, doi. 10.1038/ncomms14574
By:
- Sonoiki, Ebere;
- Ng, Caroline L.;
- Lee, Marcus C. S.;
- Guo, Denghui;
- Zhang, Yong-Kang;
- Zhou, Yasheen;
- Alley, M. R. K.;
- Ahyong, Vida;
- Sanz, Laura M.;
- Lafuente-Monasterio, Maria Jose;
- Dong, Chen;
- Schupp, Patrick G.;
- Gut, Jiri;
- Legac, Jenny;
- Cooper, Roland A.;
- Gamo, Francisco-Javier;
- DeRisi, Joseph;
- Freund, Yvonne R.;
- Fidock, David A.;
- Rosenthal, Philip J.
Publication type:
Article
A broad analysis of resistance development in the malaria parasite.
Published in:
Nature Communications, 2016, v. 7, n. 6, p. 11901, doi. 10.1038/ncomms11901
By:
- Corey, Victoria C.;
- Lukens, Amanda K.;
- Istvan, Eva S.;
- Lee, Marcus C. S.;
- Franco, Virginia;
- Magistrado, Pamela;
- Coburn-Flynn, Olivia;
- Sakata-Kato, Tomoyo;
- Fuchs, Olivia;
- Gnädig, Nina F.;
- Goldgof, Greg;
- Linares, Maria;
- Gomez-Lorenzo, Maria G.;
- De Cózar, Cristina;
- Lafuente-Monasterio, Maria Jose;
- Prats, Sara;
- Meister, Stephan;
- Tanaseichuk, Olga;
- Wree, Melanie;
- Zhou, Yingyao
Publication type:
Article
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Published in:
Science Translational Medicine, 2017, v. 9, n. 387, p. 1, doi. 10.1126/scitranslmed.aad9735
By:
- Paquet, Tanya;
- Le Manach, Claire;
- González Cabrera, Diego;
- Younis, Yassir;
- Henrich, Philipp P.;
- Abraham, Tara S.;
- Lee, Marcus C. S.;
- Basak, Rajshekhar;
- Ghidelli-Disse, Sonja;
- Lafuente-Monasterio, María José;
- Bantscheff, Marcus;
- Ruecker, Andrea;
- Blagborough, Andrew M.;
- Zakutansky, Sara E.;
- Zeeman, Anne-Marie;
- White, Karen L.;
- Shackleford, David M.;
- Mannila, Janne;
- Morizzi, Julia;
- Scheurer, Christian
Publication type:
Article
Defining multiplicity of vector uptake in transfected Plasmodium parasites.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-67791-z
By:
- Carrasquilla, Manuela;
- Adjalley, Sophie;
- Sanderson, Theo;
- Marin-Menendez, Alejandro;
- Coyle, Rachael;
- Montandon, Ruddy;
- Rayner, Julian C.;
- Pance, Alena;
- Lee, Marcus C. S.
Publication type:
Article
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.
Published in:
British Journal of Pharmacology, 2023, v. 180, n. 15, p. 1899, doi. 10.1111/bph.16144
By:
- Armstrong, Jane F.;
- Campo, Brice;
- Alexander, Stephen P. H.;
- Arendse, Lauren B.;
- Cheng, Xiu;
- Davenport, Anthony P.;
- Faccenda, Elena;
- Fidock, David A.;
- Godinez‐Macias, Karla P.;
- Harding, Simon D.;
- Kato, Nobutaka;
- Lee, Marcus C. S.;
- Luth, Madeline R.;
- Mazitschek, Ralph;
- Mittal, Nimisha;
- Niles, Jacquin C.;
- Okombo, John;
- Ottilie, Sabine;
- Pasaje, Charisse Flerida A.;
- Probst, Alexandra S.
Publication type:
Article
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Published in:
Nature, 2015, v. 522, n. 7556, p. 315, doi. 10.1038/nature14451
By:
- Baragaña, Beatriz;
- Hallyburton, Irene;
- Lee, Marcus C. S.;
- Norcross, Neil R.;
- Grimaldi, Raffaella;
- Otto, Thomas D.;
- Proto, William R.;
- Blagborough, Andrew M.;
- Meister, Stephan;
- Wirjanata, Grennady;
- Ruecker, Andrea;
- Upton, Leanna M.;
- Abraham, Tara S.;
- Almeida, Mariana J.;
- Pradhan, Anupam;
- Porzelle, Achim;
- Martínez, María Santos;
- Bolscher, Judith M.;
- Woodland, Andrew;
- Norval, Suzanne
Publication type:
Article
Targeting Plasmodium PI(4)K to eliminate malaria.
Published in:
Nature, 2013, v. 504, n. 7479, p. 248, doi. 10.1038/nature12782
By:
- McNamara, Case W.;
- Lee, Marcus C. S.;
- Lim, Chek Shik;
- Lim, Siau Hoi;
- Roland, Jason;
- Nagle, Advait;
- Simon, Oliver;
- Yeung, Bryan K. S.;
- Chatterjee, Arnab K.;
- McCormack, Susan L.;
- Manary, Micah J.;
- Zeeman, Anne-Marie;
- Dechering, Koen J.;
- Kumar, T. R. Santha;
- Henrich, Philipp P.;
- Gagaring, Kerstin;
- Ibanez, Maureen;
- Kato, Nobutaka;
- Kuhen, Kelli L.;
- Fischli, Christoph
Publication type:
Article
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Published in:
Science Translational Medicine, 2023, v. 15, n. 686, p. 1, doi. 10.1126/scitranslmed.adc9249
By:
- Istvan, Eva S.;
- Guerra, Francisco;
- Abraham, Matthew;
- Huang, Kuo-Sen;
- Rocamora, Frances;
- Zhao, Haoshuang;
- Xu, Lan;
- Pasaje, Charisse;
- Kumpornsin, Krittikorn;
- Luth, Madeline R.;
- Cui, Haissi;
- Yang, Tuo;
- Palomo Diaz, Sara;
- Gomez-Lorenzo, Maria G.;
- Qahash, Tarrick;
- Mittal, Nimisha;
- Ottilie, Sabine;
- Niles, Jacquin;
- Lee, Marcus C. S.;
- Llinas, Manuel
Publication type:
Article
Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium.
Published in:
Briefings in Functional Genomics, 2019, v. 18, n. 5, p. 281, doi. 10.1093/bfgp/elz012
By:
- Lee, Marcus C S;
- Lindner, Scott E;
- Lopez-Rubio, Jose-Juan;
- Llinás, Manuel
Publication type:
Article
Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine.
Published in:
Journal of Infectious Diseases, 2023, v. 227, n. 10, p. 1121, doi. 10.1093/infdis/jiac469
By:
- Ward, Kurt E;
- Christensen, Peter;
- Racklyeft, Annie;
- Dhingra, Satish K;
- Chua, Adeline C Y;
- Remmert, Caroline;
- Suwanarusk, Rossarin;
- Matheson, Jessica;
- Blackman, Michael J;
- Kaneko, Osamu;
- Kyle, Dennis E;
- Lee, Marcus C S;
- Moon, Robert W;
- Snounou, Georges;
- Rénia, Laurent;
- Fidock, David A;
- Russell, Bruce;
- Bifani, Pablo
Publication type:
Article
Arresting malaria parasite egress from infected red blood cells.
Published in:
Nature Chemical Biology, 2008, v. 4, n. 3, p. 161, doi. 10.1038/nchembio0308-161
By:
- Lee, Marcus C. S.;
- Fidock, David A.
Publication type:
Article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Published in:
PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008482
By:
- Gnädig, Nina F.;
- Stokes, Barbara H.;
- Edwards, Rachel L.;
- Kalantarov, Gavreel F.;
- Heimsch, Kim C.;
- Kuderjavy, Michal;
- Crane, Audrey;
- Lee, Marcus C. S.;
- Straimer, Judith;
- Becker, Katja;
- Trakht, Ilya N.;
- Odom John, Audrey R.;
- Mok, Sachel;
- Fidock, David A.
Publication type:
Article
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.
Published in:
PLoS Pathogens, 2019, v. 15, n. 10, p. 1, doi. 10.1371/journal.ppat.1008086
By:
- Karpiyevich, Maryia;
- Adjalley, Sophie;
- Mol, Marco;
- Ascher, David B.;
- Mason, Bethany;
- van der Heden van Noort, Gerbrand J.;
- Laman, Heike;
- Ovaa, Huib;
- Lee, Marcus C. S.;
- Artavanis-Tsakonas, Katerina
Publication type:
Article
A manually curated annotation characterises genomic features of P. falciparum lncRNAs.
Published in:
BMC Genomics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s12864-022-09017-2
By:
- Hoshizaki, Johanna;
- Adjalley, Sophie H.;
- Thathy, Vandana;
- Judge, Kim;
- Berriman, Matthew;
- Reid, Adam J.;
- Lee, Marcus C. S.
Publication type:
Article

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