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Design optimization for clinical trials in early-stage manifest Huntington's disease.
- Published in:
- 2017
- By:
- Publication type:
- journal article
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.
- Published in:
- Movement Disorders, 2015, v. 30, n. 3, p. 393, doi. 10.1002/mds.26118
- By:
- Publication type:
- Article
Diagnostic criteria for Huntington's disease based on natural history.
- Published in:
- Movement Disorders, 2014, v. 29, n. 11, p. 1335, doi. 10.1002/mds.26011
- By:
- Publication type:
- Article
Huntington's disease: A field on the move.
- Published in:
- 2014
- By:
- Publication type:
- Editorial
A systematic review and meta-analysis of clinical variables used in Huntington disease research.
- Published in:
- Movement Disorders, 2013, v. 28, n. 14, p. 1987, doi. 10.1002/mds.25663
- By:
- Publication type:
- Article
The structural involvement of the cingulate cortex in premanifest and early Huntington's disease.
- Published in:
- Movement Disorders, 2011, v. 26, n. 9, p. 1684, doi. 10.1002/mds.23747
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- Publication type:
- Article
Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats.
- Published in:
- Movement Disorders, 2008, v. 23, n. 12, p. 1794, doi. 10.1002/mds.21820
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- Publication type:
- Article
Cocaine- and amphetamine-regulated transcript is increased in Huntington disease.
- Published in:
- Movement Disorders, 2007, v. 22, n. 13, p. 1952, doi. 10.1002/mds.21447
- By:
- Publication type:
- Article
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.
- Published in:
- Scientific Reports, 2015, p. 12166, doi. 10.1038/srep12166
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- Publication type:
- Article
Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease.
- Published in:
- Frontiers in Neurology, 2017, p. 1, doi. 10.3389/fneur.2017.00519
- By:
- Publication type:
- Article
Medication Use in Early-HD Participants in TrackHD: an Investigation of its Effects on Clinical Performance.
- Published in:
- PLoS Currents, 2016, p. 280, doi. 10.1371/currents.hd.8060298fac1801b01ccea6acc00f97cb
- By:
- Publication type:
- Article
Phosphorylation of Huntingtin at Ser<sup>421</sup> in YAC128 Neurons Is Associated with Protection of YAC 128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 43, p. 14318, doi. 10.1523/JNEUROSCI.1589-10.2010
- By:
- Publication type:
- Article
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 8, p. 2414, doi. 10.1523/JNEUROSCI.5687-08.2009
- By:
- Publication type:
- Article
Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 7, p. 2193, doi. 10.1523/JNEUROSCI.5473-08.2009
- By:
- Publication type:
- Article
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease.
- Published in:
- Journal of Neuroscience, 2008, p. 2414, doi. 10.1523/JNEUROSCI.5687-08.2009
- By:
- Publication type:
- Article
Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.
- Published in:
- Journal of Neurochemistry, 2015, v. 135, n. 5, p. 1019, doi. 10.1111/jnc.13378
- By:
- Publication type:
- Article
Iron dysregulation in Huntington's disease.
- Published in:
- Journal of Neurochemistry, 2014, v. 130, n. 3, p. 328, doi. 10.1111/jnc.12739
- By:
- Publication type:
- Article
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
- Published in:
- Journal of Neurochemistry, 2013, v. 127, n. 6, p. 852, doi. 10.1111/jnc.12350
- By:
- Publication type:
- Article
Wild-type huntingtin protects neurons from excitotoxicity.
- Published in:
- Journal of Neurochemistry, 2006, v. 96, n. 4, p. 1121, doi. 10.1111/j.1471-4159.2005.03605.x
- By:
- Publication type:
- Article
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
- Published in:
- Journal of Neurochemistry, 2005, v. 95, n. 2, p. 553, doi. 10.1111/j.1471-4159.2005.03411.x
- By:
- Publication type:
- Article
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.
- Published in:
- Journal of Neurochemistry, 2005, v. 95, n. 1, p. 210, doi. 10.1111/j.1471-4159.2005.03357.x
- By:
- Publication type:
- Article
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
- Published in:
- Journal of Neurochemistry, 2005, v. 94, n. 4, p. 1087, doi. 10.1111/j.1471-4159.2005.03255.x
- By:
- Publication type:
- Article
Longitudinal Structural MRI in Neurologically Healthy Adults.
- Published in:
- 2020
- By:
- Publication type:
- journal article
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 3, p. 717, doi. 10.1093/hmg/ddt458
- By:
- Publication type:
- Article
Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease.
- Published in:
- Human Molecular Genetics, 2012, v. 21, n. 14, p. 3097, doi. 10.1093/hmg/dds132
- By:
- Publication type:
- Article
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 8, p. 1528, doi. 10.1093/hmg/ddq026
- By:
- Publication type:
- Article
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 8, p. 1438, doi. 10.1093/hmg/ddq018
- By:
- Publication type:
- Article
Expression analysis of novel striatal-enriched genes in Huntington disease.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 4, p. 609, doi. 10.1093/hmg/ddp527
- By:
- Publication type:
- Article
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
- Published in:
- Human Molecular Genetics, 2007, v. 16, n. 15, p. 1845, doi. 10.1093/hmg/ddm133
- By:
- Publication type:
- Article
Body weight is modulated by levels of full-length Huntingtin.
- Published in:
- Human Molecular Genetics, 2006, v. 15, n. 9, p. 1513, doi. 10.1093/hmg/ddl072
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- Publication type:
- Article
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.
- Published in:
- Human Molecular Genetics, 2005, v. 14, n. 24, p. 3823, doi. 10.1093/hmg/ddi407
- By:
- Publication type:
- Article
Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.
- Published in:
- Human Molecular Genetics, 2005, v. 14, n. 10, p. 1379, doi. 10.1093/hmg/ddi147
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- Publication type:
- Article
Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model.
- Published in:
- Nature Communications, 2013, v. 4, n. 12, p. 2906, doi. 10.1038/ncomms3906
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- Publication type:
- Article
Clinical utility gene card for: Huntington's disease.
- Published in:
- European Journal of Human Genetics, 2014, v. 22, n. 5, p. 1, doi. 10.1038/ejhg.2013.206
- By:
- Publication type:
- Article
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.
- Published in:
- Brain: A Journal of Neurology, 2023, v. 146, n. 11, p. 4532, doi. 10.1093/brain/awad275
- By:
- Publication type:
- Article
AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.
- Published in:
- Brain: A Journal of Neurology, 2023, v. 146, n. 6, p. 2298, doi. 10.1093/brain/awac458
- By:
- Publication type:
- Article
Testing a longitudinal compensation model in premanifest Huntington's disease.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Operationalizing compensation over time in neurodegenerative disease.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories.
- Published in:
- Movement Disorders Clinical Practice, 2019, v. 6, n. 7, p. 541, doi. 10.1002/mdc3.12808
- By:
- Publication type:
- Article
White matter predicts functional connectivity in premanifest Huntington's disease.
- Published in:
- Annals of Clinical & Translational Neurology, 2017, v. 4, n. 2, p. 106, doi. 10.1002/acn3.384
- By:
- Publication type:
- Article
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.
- Published in:
- Brain & Behavior, 2023, v. 13, n. 4, p. 1, doi. 10.1002/brb3.2940
- By:
- Publication type:
- Article
Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
- Published in:
- Nature Genetics, 2003, v. 35, n. 1, p. 76, doi. 10.1038/ng1219
- By:
- Publication type:
- Article
Depletion of wild-type huntingtin in mouse models of neurologic diseases.
- Published in:
- Journal of Neurochemistry, 2003, v. 87, n. 1, p. 101, doi. 10.1046/j.1471-4159.2003.01980.x
- By:
- Publication type:
- Article
Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease.
- Published in:
- Journal of the International Neuropsychological Society, 2016, v. 22, n. 6, p. 595, doi. 10.1017/S1355617716000321
- By:
- Publication type:
- Article
Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2013, v. 9, n. 2, p. 176, doi. 10.1016/j.jalz.2012.03.002
- By:
- Publication type:
- Article
The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2013, v. 9, n. 2, p. 189, doi. 10.1016/j.jalz.2012.03.003
- By:
- Publication type:
- Article
Progranulin deficiency leads to altered microglial function and neuroinflammation
- Published in:
- 2012
- By:
- Publication type:
- Abstract
Generation and characterization of a mouse model of progranulin deficiency
- Published in:
- 2010
- By:
- Publication type:
- Abstract
P3-377: A novel pathogenic pathway of immune activation detectable before cinical onset in Huntington's disease
- Published in:
- 2008
- By:
- Publication type:
- Abstract