Works by Leal, Lorna

Results: 33

Unintended HIV-1 Infection During Analytical Therapy Interruption.

Published in:

2020

By:

Ugarte, Ainoa;
Romero, Yolanda;
Tricas, Amparo;
Casado, Concepcion;
Lopez-Galindez, Cecilio;
Garcia, Felipe;
Leal, Lorna

Publication type:

Case Study

Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients.

Published in:

Infection, 2022, v. 50, n. 5, p. 1321, doi. 10.1007/s15010-022-01833-8

By:

Rico-Caballero, Verónica;
Fernández, Mariana;
Hurtado, Juan C.;
Marcos, M. Angeles;
Cardozo, Celia;
Albiach, Laia;
Agüero, Daiana;
Ambrosioni, Juan;
Bodro, Marta;
Chumbita, Mariana;
De la Mora, Lorena;
Garcia-Pouton, Nicole;
Gonzalez-Cordón, Ana;
Dueñas, Gerard;
Hernandez-Meneses, Marta;
Inciarte, Alexy;
Laguno, Montse;
Leal, Lorna;
Macaya, Irene;
Martínez, Miguel J.

Publication type:

Article

Altered T‐cell subset distribution in the viral reservoir in HIV‐1‐infected individuals with extremely low proviral DNA (LoViReTs).

Published in:

Journal of Internal Medicine, 2022, v. 292, n. 2, p. 308, doi. 10.1111/joim.13484

By:

Gálvez, Cristina;
Urrea, Víctor;
Garcia‐Guerrero, Maria del Carmen;
Bernal, Sílvia;
Benet, Susana;
Mothe, Beatriz;
Bailón, Lucía;
Dalmau, Judith;
Martinez, Andrea;
Nieto, Aroa;
Leal, Lorna;
García, Felipe;
Clotet, Bonaventura;
Martinez‐Picado, Javier;
Salgado, Maria

Publication type:

Article

Highly Efficient Autologous HIV-1 Isolation by Coculturing Macrophage With Enriched CD4<sup>+</sup> T Cells From HIV-1 Patients Cybersecurity in the Digital Age.

Published in:

Frontiers in Virology, 2022, p. 1, doi. 10.3389/fviro.2022.869431

By:

Xufre, Cristina;
González, Tanıá;
Leal, Lorna;
Trubey, Charles M.;
Lifson, Jeffrey D.;
Gatell, José Marıá;
Alcamı, José;
Climent, Núria;
García, Felipe;
Sánchez-Palomino, Sonsoles

Publication type:

Article

Adherence to a Supplemented Mediterranean Diet Drives Changes in the Gut Microbiota of HIV-1-Infected Individuals.

Published in:

Nutrients, 2021, v. 13, n. 4, p. 1141, doi. 10.3390/nu13041141

By:

Pastor-Ibáñez, Roque;
Blanco-Heredia, Juan;
Etcheverry, Florencia;
Sánchez-Palomino, Sonsoles;
Díez-Fuertes, Francisco;
Casas, Rosa;
Navarrete-Muñoz, María Ángeles;
Castro-Barquero, Sara;
Lucero, Constanza;
Fernández, Irene;
Leal, Lorna;
Benito, José Miguel;
Noguera-Julian, Marc;
Paredes, Roger;
Rallón, Norma;
Estruch, Ramón;
Torrents, David;
García, Felipe;
Barchitta, Martina

Publication type:

Article

Shared Care Unit: a new model of coordinating HIV care between Primary Settings and Hospital.

Published in:

International Journal of Integrated Care (IJIC), 2016, v. 16, n. 6, p. 1, doi. 10.5334/ijic.2748

By:

Barba, Olga;
Clusa, Thais;
Menacho, Ignacio;
Sequeira, Ethel;
Moreno, Laura;
Gonzalez, Eva;
Freixa, Xavier;
Cayuelas, Laia;
Muñoz, Susana;
Fernández, Emma;
Leal, Lorna;
García, Felipe;
Leon, Agathe

Publication type:

Article

Experience with the use of siltuximab in patients with SARS-CoV-2 infection.

Published in:

Revista Española de Quimioterapia, 2021, v. 34, n. 4, p. 337, doi. 10.37201/req/045.2021

By:

Meira, Fernanda;
Albiach, Laia;
Carbonell, Cristina;
Martín-Oterino, José-Ángel;
Martín-Ordiales, Mercedes;
Linares, Laura;
Macaya, Irene;
Agüero, Daiana;
Ambrosioni, Juan;
Bodro, Marta;
Cardozo, Celia;
Chumbita, Mariana;
De la Mora, Lorena;
García-Pouton, Nicole;
Garcia-Vidal, Carolina;
González-Cordón, Ana;
Hernández-Meneses, Marta;
Inciarte, Alexy;
Laguno, Montserrat;
Leal, Lorna

Publication type:

Article

Tocilizumab reduces the risk of ICU admission and mortality in patients with SARS-CoV-2 infection.

Published in:

Revista Española de Quimioterapia, 2021, v. 34, n. 3, p. 238, doi. 10.37201/req/037.2021

By:

Moreno-García, Estela;
Rico, Verónica;
Albiach, Laia;
Agüero, Daiana;
Ambrosioni, Juan;
Bodro, Marta;
Cardozo, Celia;
Chumbita, Mariana;
De la Mora, Lorena;
García-Pouton, Nicole;
Garcia-Vidal, Carolina;
González-Cordón, Ana;
Hernández-Meneses, Marta;
Inciarte, Alexy;
Laguno, Montse;
Leal, Lorna;
Linares, Laura;
Macaya, Irene;
Meira, Fernanda;
Mensa, Josep

Publication type:

Article

iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy.

Published in:

2019

By:

de Jong, Wesley;
Aerts, Joeri;
Allard, Sabine;
Brander, Christian;
Buyze, Jozefien;
Florence, Eric;
van Gorp, Eric;
Vanham, Guido;
Leal, Lorna;
Mothe, Beatriz;
Thielemans, Kris;
Plana, Montse;
Garcia, Félipe;
Gruters, Rob;
iHIVARNA consortium

Publication type:

journal article

Real-life experience with bictegravir/emtricitabine/tenofovir alafenamide in a large reference clinical centre.

Published in:

2022

By:

Ambrosioni, Juan;
Liévano, Jhon Rojas;
Berrocal, Leire;
Inciarte, Alexy;
de la Mora, Lorena;
González-Cordón, Ana;
Martínez-Rebollar, María;
Laguno, Montserrat;
Torres, Berta;
Ugarte, Ainoa;
Chivite, Iván;
Leal, Lorna;
Lazzari, Elisa de;
Miró, José M.;
Blanco, José L.;
Martinez, Esteban;
Mallolas, Josep;
Rojas Liévano, Jhon;
de Lazzari, Elisa

Publication type:

journal article

A randomized clinical trial comparing ritonavir-boosted lopinavir versus raltegravir each with tenofovir plus emtricitabine for post-exposure prophylaxis for HIV infection.

Published in:

2016

By:

Leal, Lorna;
León, Agathe;
Torres, Berta;
Inciarte, Alexy;
Lucero, Constanza;
Mallolas, Josep;
Laguno, Montserrat;
Martínez-Rebollar, María;
González-Cordón, Ana;
Manzardo, Christian;
Rojas, Jhon;
Pich, Judit;
Arnaiz, Joan A.;
Gatell, Josep M.;
García, Felipe;
RALPEP Study Group

Publication type:

journal article

A randomized clinical trial comparing ritonavir-boosted lopinavir versus maraviroc each with tenofovir plus emtricitabine for post-exposure prophylaxis for HIV infection.

Published in:

2016

By:

Leal, Lorna;
León, Agathe;
Torres, Berta;
Inciarte, Alexy;
Lucero, Constanza;
Mallolas, Josep;
Laguno, Montserrat;
Martínez-Rebollar, María;
González-Cordón, Ana;
Manzardo, Christian;
Rojas, Jhon;
Pich, Judit;
Arnaiz, Joan A.;
Gatell, Josep M.;
García, Felipe;
MARAVIPEP Study Group

Publication type:

journal article

Optimization and validation of an ELISA assay for the determination of antibody responses to CN54gp140 and AIDSVAX BE for use in the Phase IIb PrEPVacc vaccine trial.

Published in:

PLoS ONE, 2022, v. 17, n. 11, p. 1, doi. 10.1371/journal.pone.0275927

By:

Gombe, Ben;
Streatfield, Claire;
Leal, Lorna;
Opio, Solomon;
Joseph, Sarah;
Weber, Jonathan;
Hare, Jonathan;
Kaleebu, Pontiano;
Serwanga, Jennifer

Publication type:

Article

Virological Outcome Measures During Analytical Treatment Interruptions in Chronic HIV-1-Infected Patients.

Published in:

Open Forum Infectious Diseases, 2019, v. 6, n. 12, p. N.PAG, doi. 10.1093/ofid/ofz485

By:

Fehér, Csaba;
Leal, Lorna;
Plana, Montserrat;
Climent, Nuria;
Guardo, Alberto Crespo;
Martínez, Esteban;
Castro, Pedro;
Díaz-Brito, Vicens;
Mothe, Beatriz;
Quirós, Juan Carlos López Bernaldo De;
Gatell, Josep María;
Aloy, Patrick;
García, Felipe

Publication type:

Article

Monocytes Phenotype and Cytokine Production in Human Immunodeficiency Virus-1 Infected Patients Receiving a Modified Vaccinia Ankara-Based HIV-1 Vaccine: Relationship to Cd300 Molecules Expression.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00836

By:

Vitallé, Joana;
Zenarruzabeitia, Olatz;
Terrén, Iñigo;
Plana, Montserrat;
Guardo, Alberto C.;
Leal, Lorna;
Peña, José;
García, Felipe;
Borrego, Francisco

Publication type:

Article

Recreational Drug Use in People Living with HIV in Spain: Factors Associated with Drug Use and the Impact on Clinical Outcomes.

Published in:

AIDS & Behavior, 2021, v. 25, n. 12, p. 3883, doi. 10.1007/s10461-021-03271-3

By:

Castro-Granell, Vanessa;
Garin, Noé;
Jaén, Ángeles;
Casado, José Luis;
Leal, Lorna;
Cenoz, Santiago;
Fuster-RuizdeApodaca, María José

Publication type:

Article

In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?

Published in:

Viruses (1999-4915), 2021, v. 13, n. 3, p. 501, doi. 10.3390/v13030501

By:

Esteban, Ignasi;
Pastor-Quiñones, Carmen;
Usero, Lorena;
Plana, Montserrat;
García, Felipe;
Leal, Lorna;
Fleury, Herve J. A.

Publication type:

Article

High rates of long‐term progression in HIV‐1‐positive elite controllers.

Published in:

Journal of the International AIDS Society, 2021, v. 24, n. 2, p. 1, doi. 10.1002/jia2.25675

By:

Borrell, Maria;
Fernández, Irene;
Etcheverrry, Flor;
Ugarte, Ainoa;
Plana, Montserrat;
Leal, Lorna;
García, Felipe

Publication type:

Article

Protease inhibitor monotherapy is associated with a higher level of monocyte activation, bacterial translocation and inflammation.

Published in:

Journal of the International AIDS Society, 2014, v. 17, p. 1, doi. 10.7448/IAS.17.1.19246

By:

Torres, Berta;
Guardo, Alberto C.;
Leal, Lorna;
Leon, Agathe;
Lucero, Constanza;
Alvarez-Martinez, Míriam J.;
Martinez, Miguel J.;
Vila, Jordi;
Martínez-Rebollar, María;
González-Cordón, Ana;
M. Gatell, Josep;
Plana, Montserrat;
García, Felipe

Publication type:

Article

Assessment of Human SARS CoV-2-Specific T-Cell Responses Elicited In Vitro by New Computationally Designed mRNA Immunogens (COVARNA).

Published in:

Vaccines, 2024, v. 12, n. 1, p. 15, doi. 10.3390/vaccines12010015

By:

Esteban, Ignasi;
Pastor-Quiñones, Carmen;
Usero, Lorena;
Aurrecoechea, Elena;
Franceschini, Lorenzo;
Esprit, Arthur;
Gelpí, Josep Lluís;
Martínez-Jiménez, Francisco;
López-Bigas, Núria;
Breckpot, Karine;
Thielemans, Kris;
Leal, Lorna;
Gómez, Carmen Elena;
Sisteré-Oró, Marta;
Meyerhans, Andreas;
Esteban, Mariano;
Alonso, María José;
García, Felipe;
Plana, Montserrat

Publication type:

Article

The Combination of an mRNA Immunogen, a TLR7 Agonist and a PD1 Blocking Agent Enhances In-Vitro HIV T-Cell Immune Responses.

Published in:

Vaccines, 2023, v. 11, n. 2, p. 286, doi. 10.3390/vaccines11020286

By:

Usero, Lorena;
Leal, Lorna;
Gómez, Carmen Elena;
Miralles, Laia;
Aurrecoechea, Elena;
Esteban, Ignasi;
Torres, Berta;
Inciarte, Alexy;
Perdiguero, Beatriz;
Esteban, Mariano;
García, Felipe;
Plana, Montserrat

Publication type:

Article

Pulmonary Infection Caused by Mycobacterium malmoense in a Chronic HIV-Infected Individual Participating in a Therapeutic Vaccine Trial.

Published in:

2021

By:

Marques, Joana Silva;
Bodro, Marta;
Torres, Berta;
García, Felipe;
Martínez, José Antonio;
Leal, Lorna

Publication type:

Case Study

Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen.

Published in:

Vaccines, 2021, v. 9, n. 9, p. 959, doi. 10.3390/vaccines9090959

By:

Gómez, Carmen Elena;
Perdiguero, Beatriz;
Usero, Lorena;
Marcos-Villar, Laura;
Miralles, Laia;
Leal, Lorna;
Sorzano, Carlos Óscar S.;
Sánchez-Corzo, Cristina;
Plana, Montserrat;
García, Felipe;
Esteban, Mariano

Publication type:

Article

Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals.

Published in:

Vaccines, 2021, v. 9, n. 7, p. 799, doi. 10.3390/vaccines9070799

By:

Fehér, Csaba;
Pastor-lbáñez, Roque;
Leal, Lorna;
Plana, Montserrat;
Arnedo, Mireia;
van den Ham, Henk-Jan;
Andeweg, Arno C.;
Gruters, Rob A.;
Díez-Fuertes, Francisco;
Alcamí, José;
Aloy, Patrick;
García, Felipe

Publication type:

Article

Impact of Transcriptome and Gut Microbiome on the Response of HIV-1 Infected Individuals to a Dendritic Cell-Based HIV Therapeutic Vaccine.

Published in:

Vaccines, 2021, v. 9, n. 7, p. 694, doi. 10.3390/vaccines9070694

By:

Pastor-Ibáñez, Roque;
Díez-Fuertes, Francisco;
Sánchez-Palomino, Sonsoles;
Alcamí, Jose;
Plana, Montserrat;
Torrents, David;
Leal, Lorna;
García, Felipe

Publication type:

Article

Antiretroviral Therapy Interruption (ATI) in HIV-1 Infected Patients Participating in Therapeutic Vaccine Trials: Surrogate Markers of Virological Response.

Published in:

Vaccines, 2020, v. 8, n. 3, p. 442, doi. 10.3390/vaccines8030442

By:

Leal, Lorna;
Fehér, Csaba;
Richart, Valèria;
Torres, Berta;
García, Felipe

Publication type:

Article

Therapeutic Vaccine in Chronically HIV-1-Infected Patients: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial with HTI-TriMix †.

Published in:

Vaccines, 2019, v. 7, n. 4, p. 209, doi. 10.3390/vaccines7040209

By:

de Jong, Wesley;
Leal, Lorna;
Buyze, Jozefien;
Pannus, Pieter;
Guardo, Alberto;
Salgado, Maria;
Mothe, Beatriz;
Molto, Jose;
Moron-Lopez, Sara;
Gálvez, Cristina;
Florence, Eric;
Vanham, Guido;
van Gorp, Eric;
Brander, Christian;
Allard, Sabine;
Thielemans, Kris;
Martinez-Picado, Javier;
Plana, Montserrat;
García, Felipe;
Gruters, Rob A.

Publication type:

Article

Comparison of Safety and Vector-Specific Immune Responses in Healthy and HIV-Infected Populations Vaccinated with MVA-B.

Published in:

Vaccines, 2019, v. 7, n. 4, p. 178, doi. 10.3390/vaccines7040178

By:

Couto, Elvira;
Diaz-Brito, Vicenç;
Mothe, Beatriz;
Guardo, Alberto C.;
Fernandez, Irene;
Ugarte, Ainoa;
Etcheverry, Flor;
Gómez, Carmen E.;
Esteban, Mariano;
Pich, Judit;
Arnaiz, Joan Albert;
López Bernaldo de Quirós, Juan Carlos;
Brander, Christian;
Plana, Montserrat;
García, Felipe;
Leal, Lorna

Publication type:

Article

Prevention and Treatment of SARS-CoV2 Infection in People Living with HIV: The Need for Specific Data.

Published in:

Infectious Diseases & Therapy, 2022, v. 11, n. 1, p. 1, doi. 10.1007/s40121-021-00547-y

By:

Díaz, Natalia A.;
de Miguel, Rosa;
Agüero, Fernando;
Sued, Omar;
Arribas, José R.;
Ambrosioni, Juan;
the Hospital Clinic COVID-19 in HIV Investigators;
Blanco, José L.;
de la Mora, Lorena;
García-Alcaide, Felipe;
González-Cordón, Ana;
Inciarte, Alexis;
Laguno, Montserrat;
Leal, Lorna;
Martínez-Chamorro, Esteban;
Martínez-Rebollar, María;
Miró, José M.;
Rojas, Jhon F.;
Torres, Berta;
Mallolas, Josep

Publication type:

Article

Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2.

Published in:

NPJ Vaccines, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41541-023-00736-5

By:

Leal, Lorna;
Pich, Judit;
Ferrer, Laura;
Nava, Jocelyn;
Martí-Lluch, Ruth;
Esteban, Ignasi;
Pradenas, Edwards;
Raïch-Regué, Dàlia;
Prenafeta, Antoni;
Escobar, Karla;
Pastor, Carmen;
Ribas-Aulinas, Marc;
Trinitè, Benjamin;
Muñoz-Basagoiti, Jordana;
Domenech, Gemma;
Clotet, Bonaventura;
Corominas, Júlia;
Corpes-Comes, Aida;
Garriga, Carme;
Barreiro, Antonio

Publication type:

Article

Differential miRNA plasma profiles associated with the spontaneous loss of HIV‐1 control: miR‐199a‐3p and its potential role as a biomarker for quick screening of elite controllers.

Published in:

Clinical & Translational Medicine, 2021, v. 11, n. 7, p. 1, doi. 10.1002/ctm2.474

By:

Masip, Jenifer;
Gasca‐Capote, Carmen;
Jimenez‐Leon, María Reyes;
Peraire, Joaquim;
Perez‐Gomez, Alberto;
Alba, Verónica;
Malo, Ana‐Irene;
Leal, Lorna;
Martín, Carmen Rodríguez;
Rallón, Norma;
Viladés, Consuelo;
Olona, Montserrat;
Vidal, Francesc;
Ruiz‐Mateos, Ezequiel;
Rull, Anna

Publication type:

Article

Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial.

Published in:

Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.767370

By:

Leal, Lorna;
Couto, Elvira;
Sánchez-Palomino, Sonsoles;
Climent, Núria;
Fernández, Irene;
Miralles, Laia;
Romero, Yolanda;
González, Tania;
Maleno, Maria José;
Paño, Blanca;
Pich, Judit;
Nicolau, Carlos;
Gatell, José Maria;
Plana, Montserrat;
García, Felipe;
Fernández, Irene;
Hurtado, Carmen;
Climent, Núria;
González, Tania;
Maleno, Maria José

Publication type:

Article

Correction to: iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy.

Published in:

2019

By:

de Jong, Wesley;
Aerts, Joeri;
Allard, Sabine;
Brander, Christian;
Buyze, Jozefien;
Florence, Eric;
van Gorp, Eric;
Vanham, Guido;
Leal, Lorna;
Mothe, Beatriz;
Thielemans, Kris;
Plana, Montse;
Garcia, Félipe;
Gruters, Rob;
iHIVARNA consortium

Publication type:

journal article