Works by Lea, Susan M

Results: 42

Architecture of the major component of the type III secretion system export apparatus.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 99, doi. 10.1038/nsmb.2452

By:

Abrusci, Patrizia;
Vergara-Irigaray, Marta;
Johnson, Steven;
Beeby, Morgan D;
Hendrixson, David R;
Roversi, Pietro;
Friede, Miriam E;
Deane, Janet E;
Jensen, Grant J;
Tang, Christoph M;
Lea, Susan M

Publication type:

Article

Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout.

Published in:

2009

By:

Hodgkinson, Julie L.;
Horsley, Ashley;
Stabat, David;
Simon, Martha;
Johnson, Steven;
da Fonseca, Paula C. A.;
Morris, Edward P.;
Wall, Joseph S.;
Lea, Susan M.;
Blocker, Ariel J.

Publication type:

Correction Notice

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 5, p. 477, doi. 10.1038/nsmb.1599

By:

Hodgkinson, Julie L.;
Horsley, Ashley;
Stabat, David;
Simon, Martha;
Johnson, Steven;
da Fonseca, Paula C. A.;
Morris, Edward P.;
Wall, Joseph S.;
Lea, Susan M.;
Blocker, Ariel J.

Publication type:

Article

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 849, doi. 10.1038/nsmb.1457

By:

Cordle, Jemima;
Johnson, Steven;
Zi Yan Tay, Joyce;
Roversi, Pietro;
Wilkin, Marian B;
De Madrid, Beatriz Hernández;
Shimizu, Hideyuki;
Jensen, Sacha;
Whiteman, Pat;
Jin, Boquan;
Redfield, Christina;
Baron, Martin;
Lea, Susan M;
Handford, Penny A

Publication type:

Article

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02895-4

By:

Harding, Rachel J.;
Deme, Justin C.;
Hevler, Johannes F.;
Tamara, Sem;
Lemak, Alexander;
Cantle, Jeffrey P.;
Szewczyk, Magdalena M.;
Begeja, Nola;
Goss, Siobhan;
Zuo, Xiaobing;
Loppnau, Peter;
Seitova, Alma;
Hutchinson, Ashley;
Fan, Lixin;
Truant, Ray;
Schapira, Matthieu;
Carroll, Jeffrey B.;
Heck, Albert J. R.;
Lea, Susan M.;
Arrowsmith, Cheryl H.

Publication type:

Article

The Characterization of Weak Protein–Protein Interactions: Evidence from DEER for the Trimerization of a von Willebrand Factor A Domain in SolutionJ.E.B. is supported by a studentship from the Engineering and Physical Science Research Council and RJMA by a studentship from the Medical Research Council. C.R.T. would like to thank the Royal Society for a University Research Fellowship. C. Bauer is thanked for technical support. DEER=double electron electron resonance.

Published in:

Angewandte Chemie International Edition, 2006, v. 45, n. 7, p. 1058, doi. 10.1002/anie.200503720

By:

Janet E. Banham;
Christiane R. Timmel;
Rachel J. M. Abbott;
Susan M. Lea;
Gunnar Jeschke

Publication type:

Article

Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding Protein.

Published in:

PLoS Pathogens, 2013, v. 9, n. 8, p. 1, doi. 10.1371/journal.ppat.1003528

By:

Jongerius, Ilse;
Lavender, Hayley;
Tan, Lionel;
Ruivo, Nicola;
Exley, Rachel M.;
Caesar, Joseph J. E.;
Lea, Susan M.;
Johnson, Steven;
Tang, Christoph M.

Publication type:

Article

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules.

Published in:

PLoS Pathogens, 2012, v. 8, n. 10, p. 1, doi. 10.1371/journal.ppat.1002981

By:

Johnson, Steven;
Tan, Lionel;
van der Veen, Stijn;
Caesar, Joseph;
De Jorge, Elena Goicoechea;
Harding, Rachel J.;
Xilian Bai;
Exley, Rachel M.;
Ward, Philip N.;
Ruivo, Nicola;
Trivedi, Kaushali;
Cumber, Elspeth;
Jones, Rhian;
Newham, Luke;
Staunton, David;
Ufret-Vincenty, Rafael;
Borrow, Ray;
Pickering, Matthew C.;
Lea, Susan M.;
Tang, Christoph M.

Publication type:

Article

The CD46-Jagged1 interaction is critical for human TH1 immunity.

Published in:

Nature Immunology, 2012, v. 13, n. 12, p. 1213, doi. 10.1038/ni.2454

By:

Le Friec, Gaëlle;
Sheppard, Devon;
Whiteman, Pat;
Karsten, Christian M;
Shamoun, Salley Al-Tilib;
Laing, Adam;
Bugeon, Laurence;
Dallman, Margaret J;
Melchionna, Teresa;
Chillakuri, Chandramouli;
Smith, Richard A;
Drouet, Christian;
Couzi, Lionel;
Fremeaux-Bacchi, Veronique;
Köhl, Jörg;
Waddington, Simon N;
McDonnell, James M;
Baker, Alastair;
Handford, Penny A;
Lea, Susan M

Publication type:

Article

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5.

Published in:

Nature Immunology, 2008, v. 9, n. 8, p. 945, doi. 10.1038/ni0808-945

By:

Fredslund, Folmer;
Laursen, Nick S;
Roversi, Pietro;
Jenner, Lasse;
Oliveira, Cristiano L P;
Pedersen, Jan S;
Nunn, Miles A;
Lea, Susan M;
Discipio, Richard;
Sottrup-Jensen, Lars;
Andersen, Gregers R

Publication type:

Article

Structure of and influence of a tick complement inhibitor on human complement component 5.

Published in:

Nature Immunology, 2008, v. 9, n. 7, p. 753, doi. 10.1038/ni.1625

By:

Fredslund, Folmer;
Laursen, Nick S;
Roversi, Pietro;
Jenner, Lasse;
Oliveira, Cristiano L P;
Pedersen, Jan S;
Nunn, Miles A;
Lea, Susan M;
Discipio, Richard;
Sottrup-Jensen, Lars;
Andersen, Gregers R

Publication type:

Article

EspM2 is a RhoA guanine nucleotide exchange factor.

Published in:

Cellular Microbiology, 2010, v. 12, n. 5, p. 654, doi. 10.1111/j.1462-5822.2009.01423.x

By:

Arbeloa, Ana;
Garnett, James;
Lillington, James;
Bulgin, Richard R.;
Berger, Cedric N.;
Lea, Susan M.;
Matthews, Steve;
Frankel, Gad

Publication type:

Article

Structure and function of a family of tick-derived complement inhibitors targeting properdin.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27920-2

By:

Braunger, Katharina;
Ahn, Jiyoon;
Jore, Matthijs M.;
Johnson, Steven;
Tang, Terence T. L.;
Pedersen, Dennis V.;
Andersen, Gregers R.;
Lea, Susan M.

Publication type:

Article

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27414-1

By:

Parker, Joanne L.;
Deme, Justin C.;
Kolokouris, Dimitrios;
Kuteyi, Gabriel;
Biggin, Philip C.;
Lea, Susan M.;
Newstead, Simon

Publication type:

Article

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26162-6

By:

Klug, Yoel A.;
Deme, Justin C.;
Corey, Robin A.;
Renne, Mike F.;
Stansfeld, Phillip J.;
Lea, Susan M.;
Carvalho, Pedro

Publication type:

Article

Investigating the structure of the factor B vWF-A domain/CD55 protein–protein complex using DEER spectroscopy: successes and pitfalls.

Published in:

Molecular Physics, 2013, v. 111, n. 18/19, p. 2865, doi. 10.1080/00268976.2013.827754

By:

Lovett, Janet E.;
Abbott, Rachel J.M.;
Roversi, Pietro;
Johnson, Steven;
Caesar, Joseph J.E.;
Doria, Marianna;
Jeschke, Gunnar;
Timmel, Christiane R.;
Lea, Susan M.

Publication type:

Article

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

Published in:

EMBO Journal, 2017, v. 36, n. 15, p. 2204, doi. 10.15252/embj.201796632

By:

Suckling, Richard J;
Korona, Boguslawa;
Whiteman, Pat;
Chillakuri, Chandramouli;
Holt, Laurie;
Handford, Penny A;
Lea, Susan M

Publication type:

Article

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 3, p. 276, doi. 10.1038/nsmb902

By:

Cordes, Frank S;
Roversi, Pietro;
Kraiczy, Peter;
Simon, Markus M;
Brade, Volker;
Jahraus, Oliver;
Wallis, Russell;
Skerka, Christine;
Zipfel, Peter F;
Wallich, Reinhard;
Lea, Susan M

Publication type:

Article

Identification and characterization of the 'missing' terminal enzyme for siroheme biosynthesis in α-proteobacteria.

Published in:

Molecular Microbiology, 2014, v. 92, n. 1, p. 153, doi. 10.1111/mmi.12542

By:

Bali, Shilpa;
Rollauer, Sarah;
Roversi, Pietro;
Raux‐Deery, Evelyne;
Lea, Susan M.;
Warren, Martin J.;
Ferguson, Stuart J.

Publication type:

Article

Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system.

Published in:

Molecular Microbiology, 2008, v. 69, n. 1, p. 267, doi. 10.1111/j.1365-2958.2008.06293.x

By:

Deane, Janet E.;
Graham, Stephen C.;
Mitchell, Edward P.;
Flot, David;
Johnson, Steven;
Lea, Susan M.

Publication type:

Article

Structure and function of a family of tick-derived complement inhibitors targeting properdin.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27920-2

By:

Braunger, Katharina;
Ahn, Jiyoon;
Jore, Matthijs M.;
Johnson, Steven;
Tang, Terence T. L.;
Pedersen, Dennis V.;
Andersen, Gregers R.;
Lea, Susan M.

Publication type:

Article

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli

Published in:

FEBS Letters, 2007, v. 581, n. 21, p. 4091, doi. 10.1016/j.febslet.2007.07.044

By:

Orriss, George L.;
Tarry, Michael J.;
Ize, Bérengère;
Sargent, Frank;
Lea, Susan M.;
Palmer, Tracy;
Berks, Ben C.

Publication type:

Article

The conserved C2 phospholipid‐binding domain in Delta contributes to robust Notch signalling.

Published in:

EMBO Reports, 2021, v. 22, n. 10, p. 1, doi. 10.15252/embr.202152729

By:

Martins, Torcato;
Meng, Yao;
Korona, Boguslawa;
Suckling, Richard;
Johnson, Steven;
Handford, Penny A;
Lea, Susan M;
Bray, Sarah J

Publication type:

Article

The DNA transporter ComEC has metal‐dependent nuclease activity that is important for natural transformation.

Published in:

Molecular Microbiology, 2021, v. 116, n. 2, p. 416, doi. 10.1111/mmi.14720

By:

Silale, Augustinas;
Lea, Susan M.;
Berks, Ben C.

Publication type:

Article

Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

Published in:

Molecular Microbiology, 2016, v. 99, n. 4, p. 749, doi. 10.1111/mmi.13267

By:

McDowell, Melanie A.;
Marcoux, Julien;
McVicker, Gareth;
Johnson, Steven;
Fong, Yu Hang;
Stevens, Rebecca;
Bowman, Lesley A. H.;
Degiacomi, Matteo T.;
Yan, Jun;
Wise, Adam;
Friede, Miriam E.;
Benesch, Justin L. P.;
Deane, Janet E.;
Tang, Christoph M.;
Robinson, Carol V.;
Lea, Susan M.

Publication type:

Article

Timing is everything: the regulation of type III secretion.

Published in:

Cellular & Molecular Life Sciences, 2010, v. 67, n. 7, p. 1065, doi. 10.1007/s00018-009-0230-0

By:

Deane, Janet E.;
Abrusci, Patrizia;
Johnson, Steven;
Lea, Susan M.

Publication type:

Article

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

Published in:

EMBO Journal, 1999, v. 18, n. 3, p. 543, doi. 10.1093/emboj/18.3.543

By:

Fry, Elizabeth E.;
Lea, Susan M.;
Jackson, Terry;
Newman, John W. I.;
Ellard, Fiona M.;
Blakemore, Wendy E.;
Abu-Ghazaleh, Robin;
Samuel, Alan;
King, Andrew M. Q.;
Stuart, David I.

Publication type:

Article

Structure and assembly of the NOT10:11 module of the CCR4-NOT complex.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05122-4

By:

Levdansky, Yevgen;
Raisch, Tobias;
Deme, Justin C.;
Pekovic, Filip;
Elmlund, Hans;
Lea, Susan M.;
Valkov, Eugene

Publication type:

Article

Modularity of Zorya defense systems during phage inhibition.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57397-2

By:

Mariano, Giuseppina;
Deme, Justin C.;
Readshaw, Jennifer J.;
Grobbelaar, Matthew J.;
Keenan, Mackenzie;
El-Masri, Yasmin;
Bamford, Lindsay;
Songra, Suraj;
Blower, Tim R.;
Palmer, Tracy;
Lea, Susan M.

Publication type:

Article

Structural investigation of an RNA device that regulates PD-1 expression in mammalian cells.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 5, p. 1, doi. 10.1093/nar/gkaf156

By:

Stagno, Jason R;
Deme, Justin C;
Dwivedi, Vibha;
Lee, Yun-Tzai;
Lee, Hyun Kyung;
Yu, Ping;
Chen, Szu-Yun;
Fan, Lixin;
Degenhardt, Maximilia F S;
Chari, Raj;
Young, Howard A;
Lea, Susan M;
Wang, Yun-Xing

Publication type:

Article

Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM.

Published in:

Nucleic Acids Research, 2023, v. 51, n. 18, p. 9952, doi. 10.1093/nar/gkad651

By:

Ding, Jienyu;
Deme, Justin C;
Stagno, Jason R;
Yu, Ping;
Lea, Susan M;
Wang, Yun-Xing

Publication type:

Article

SAS-6 oligomerization: the key to the centriole?

Published in:

2011

By:

Cottee, Matthew A;
Raff, Jordan W;
Lea, Susan M;
Roque, Hélio

Publication type:

Opinion

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates.

Published in:

2009

By:

Schneider, Muriel C.;
Prosser, Beverly E.;
Caesar, Joseph J. E.;
Kugelberg, Elisabeth;
Li, Su;
Zhang, Qian;
Quoraishi, Sadik;
Lovett, Janet E.;
Deane, Janet E.;
Sim, Robert B.;
Roversi, Pietro;
Johnson, Steven;
Tang, Christoph M.;
Lea, Susan M.

Publication type:

Letter

The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15071-9

By:

Kuhlen, Lucas;
Johnson, Steven;
Zeitler, Andreas;
Bäurle, Sandra;
Deme, Justin C.;
Caesar, Joseph J. E.;
Debo, Rebecca;
Fisher, Joseph;
Wagner, Samuel;
Lea, Susan M.

Publication type:

Article

A type VII-secreted lipase toxin with reverse domain arrangement.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44221-y

By:

Garrett, Stephen R.;
Mietrach, Nicole;
Deme, Justin;
Bitzer, Alina;
Yang, Yaping;
Ulhuq, Fatima R.;
Kretschmer, Dorothee;
Heilbronner, Simon;
Smith, Terry K.;
Lea, Susan M.;
Palmer, Tracy

Publication type:

Article

Charakterisierung schwacher Protein-Protein-Wechselwirkungen: Detektion der Trimerisierung einer Von-Willebrand-Faktor-A-Domäne in Lösung durch DEERJ.E.B. wurde durch ein Stipendium des Engineering and Physical Science Research Council...

Published in:

Angewandte Chemie, 2006, v. 118, n. 7, p. 1074, doi. 10.1002/ange.200503720

By:

Janet E. Banham;
Christiane R. Timmel;
Rachel J. M. Abbott;
Susan M. Lea;
Gunnar Jeschke

Publication type:

Article

Structure of the TatC core of the twin-arginine protein transport system.

Published in:

Nature, 2012, v. 492, n. 7428, p. 210, doi. 10.1038/nature11683

By:

Rollauer, Sarah E.;
Tarry, Michael J.;
Graham, James E.;
Jääskeläinen, Mari;
Jäger, Franziska;
Johnson, Steven;
Krehenbrink, Martin;
Liu, Sai-Man;
Lukey, Michael J.;
Marcoux, Julien;
McDowell, Melanie A.;
Rodriguez, Fernanda;
Roversi, Pietro;
Stansfeld, Phillip J.;
Robinson, Carol V.;
Sansom, Mark S. P.;
Palmer, Tracy;
Högbom, Martin;
Berks, Ben C.;
Lea, Susan M.

Publication type:

Article

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.07236

By:

Cottee, Matthew A.;
Muschalik, Nadine;
Johnson, Steven;
Leveson, Joanna;
Raff, Jordan W.;
Lea, Susan M.

Publication type:

Article

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.05345

By:

Chappell, Paul;
Lea, Susan M.;
Roversi, Pietro;
Meziane, El Kahina;
Harrison, Michael;
Magiera, Lukasz;
Hermann, Clemens;
Mears, Laura;
Wrobel, Antony G.;
Durant, Charlotte;
Kaufman, Jim;
Nielsen, Lise Lotte;
Buus, Soren;
Ternette, Nicola;
Mwangi, William;
Butter, Colin;
Nair, Venugopal;
Ahyee, Trudy;
Duggleby, Richard;
Madrigal, Alejandro

Publication type:

Article

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein.

Published in:

PLoS ONE, 2021, v. 16, n. 6, p. 1, doi. 10.1371/journal.pone.0252800

By:

Kuhlen, Lucas;
Johnson, Steven;
Cao, Jerry;
Deme, Justin C.;
Lea, Susan M.

Publication type:

Article

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 9, p. 2406, doi. 10.1110/ps.03455604

By:

White, Jennifer;
Lukacik, Petra;
Esser, Dirk;
Steward, Michael;
Giddings, Naomi;
Bright, Jeremy R.;
Fritchley, Sarah J.;
Morgan, B. Paul;
Lea, Susan M.;
Smith, Geoffrey P.;
Smith, Richard A.G.

Publication type:

Article

Functional Analysis of the Interdependence between DNA Uptake Sequence and Its Cognate ComP Receptor during Natural Transformation in Neisseria Species.

Published in:

PLoS Genetics, 2013, v. 9, n. 12, p. 1, doi. 10.1371/journal.pgen.1004014

By:

Berry, Jamie-Lee;
Cehovin, Ana;
McDowell, Melanie A.;
Lea, Susan M.;
Pelicic, Vladimir

Publication type:

Article