Works by LeSage, Mark

Results: 33

IND‐enabling studies of vaccines to treat heroin and oxycodone use disorders.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02440

By:

Raleigh, Michael;
King, Samantha;
Saykao, Amy;
Robinson, Christine;
Baruffaldi, Federico;
Gradinati, Valeria;
Winston, Scott;
LeSage, Mark;
Pentel, Paul;
Pravetoni, Marco

Publication type:

Article

Comparison of the Relative Abuse Liability of Electronic Cigarette Aerosol Extracts and Nicotine Alone in Adolescent Rats: A Behavioral Economic Analysis.

Published in:

International Journal of Environmental Research & Public Health, 2020, v. 17, n. 3, p. 860, doi. 10.3390/ijerph17030860

By:

Harris, Andrew C.;
Smethells, John R.;
Palumbo, Mary;
Goniewicz, Maciej;
LeSage, Mark G.

Publication type:

Article

The relative reinforcing efficacy of nicotine in an adolescent rat model of attention-deficit hyperactivity disorder.

Published in:

Frontiers in Psychiatry, 2023, p. 1, doi. 10.3389/fpsyt.2023.1154773

By:

Smethells, John R.;
Burroughs, Danielle;
Saykao, Amy;
LeSage, Mark G.

Publication type:

Article

Consortium on Methods Evaluating Tobacco: Research Tools to Inform US Food and Drug Administration Regulation of Snus.

Published in:

2018

By:

Berman, Micah L;
Bickel, Warren K;
Harris, Andrew C;
LeSage, Mark G;
O'Connor, Richard J;
Stepanov, Irina;
Shields, Peter G;
Hatsukami, Dorothy K

Publication type:

journal article

The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.

Published in:

BMC Biotechnology, 2018, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12896-018-0457-7

By:

Pentel, Paul R.;
Raleigh, Michael D.;
LeSage, Mark G.;
Thisted, Thomas;
Horrigan, Stephen;
Biesova, Zuzana;
Kalnik, Matthew W.

Publication type:

Article

Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review.

Published in:

Psychopharmacology, 1998, v. 139, n. 3, p. 169, doi. 10.1007/s002130050702

By:

Stafford, David;
LeSage, Mark G.;
Glowa, J. R.

Publication type:

Article

A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models.

Published in:

NPJ Vaccines, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41541-023-00697-9

By:

Crouse, Bethany;
Miller, Shannon M.;
Muelken, Peter;
Hicks, Linda;
Vigliaturo, Jennifer R.;
Marker, Cheryl L.;
Guedes, Alonso G. P.;
Pentel, Paul R.;
Evans, Jay T.;
LeSage, Mark G.;
Pravetoni, Marco

Publication type:

Article

Magnitude and predictors of elasticity of demand for morphine are similar in male and female rats.

Published in:

Frontiers in Behavioral Neuroscience, 2024, p. 1, doi. 10.3389/fnbeh.2024.1443364

By:

Harris, Andrew C.;
Muelken, Peter;
Liu, Shirelle X.;
Smethells, John R.;
LeSage, Mark G.;
Gewirtz, Jonathan C.

Publication type:

Article

Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats.

Published in:

Psychopharmacology, 2020, v. 237, n. 8, p. 2279, doi. 10.1007/s00213-020-05532-w

By:

Swain, Yayi;
Muelken, Peter;
Skansberg, Annika;
Lanzdorf, Danielle;
Haave, Zachary;
LeSage, Mark G.;
Gewirtz, Jonathan C.;
Harris, Andrew C.

Publication type:

Article

Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats.

Published in:

Journal of Orthopaedic Research, 2006, v. 24, n. 7, p. 1472, doi. 10.1002/jor.20187

By:

Skott, Martin;
Andreassen, Troels T.;
Ulrich-Vinther, Michael;
Chen, X.;
Keyler, Dan E.;
LeSage, Mark G.;
Pentel, Paul R.;
Bechtold, Joan E.;
Soballe, Kjeld

Publication type:

Article

A Bayesian hierarchical model for demand curve analysis.

Published in:

2018

By:

Yen-Yi Ho;
Tien Nhu Vo;
Haitao Chu;
Le Sage, Mark G.;
Xianghua Luo;
Le, Chap T.;
Ho, Yen-Yi;
Nhu Vo, Tien;
Chu, Haitao;
LeSage, Mark G;
Luo, Xianghua

Publication type:

journal article

Effects of a heroin vaccine on heroin self‐administration and its pharmacokinetic correlates (658.5).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.658.5

By:

Raleigh, Michael;
Pentel, Paul;
LeSage, Mark

Publication type:

Article

Translational research in medication development for nicotine dependence.

Published in:

2007

By:

Lerman, Caryn;
LeSage, Mark G.;
Perkins, Kenneth A.;
O'Malley, Stephanie S.;
Siegel, Steven J.;
Benowitz, Neal L.;
Corrigall, William A.

Publication type:

journal article

EFFECTS OF ANORECTIC DRUGS ON FOOD INTAKE UNDER PROGRESSIVE-RATIO AND FREE-ACCESS CONDITIONS IN RATS.

Published in:

Journal of the Experimental Analysis of Behavior, 2004, v. 82, n. 3, p. 275, doi. 10.1901/jeab.2004.82-275

By:

LeSage, Mark G.;
Stafford, David;
Glowa, John R.

Publication type:

Article

Effects of D-amphetamine on response acquisition with immediate and delayed reinforcement.

Published in:

Journal of the Experimental Analysis of Behavior, 1996, v. 66, n. 3, p. 349, doi. 10.1901/jeab.1996.66-349

By:

LeSage, Mark G.;
Byrne, Tom

Publication type:

Article

Correction: The Anti-(+)-Methamphetamine Monoclonal Antibody mAb7F9 Attenuates Acute (+)-Methamphetamine Effects on Intracranial Self-Stimulation in Rats.

Published in:

PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0138959

By:

Harris, Andrew C.;
LeSage, Mark G.;
Shelley, David;
Perry, Jennifer L.;
Pentel, Paul R.;
Owens, S. Michael

Publication type:

Article

The Anti-(+)-Methamphetamine Monoclonal Antibody mAb7F9 Attenuates Acute (+)-Methamphetamine Effects on Intracranial Self-Stimulation in Rats.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0118787

By:

Harris, Andrew C.;
LeSage, Mark G.;
Shelley, David;
Perry, Jennifer L.;
Pentel, Paul R.;
Owens, S. Michael

Publication type:

Article

Pharmacokinetic Correlates of the Effects of a Heroin Vaccine on Heroin Self-Administration in Rats.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115696

By:

Raleigh, Michael D.;
Pentel, Paul R.;
LeSage, Mark G.

Publication type:

Article

Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101807

By:

Pravetoni, Marco;
Pentel, Paul R.;
Potter, David N.;
Chartoff, Elena H.;
Tally, Laura;
LeSage, Mark G.

Publication type:

Article

Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats.

Published in:

Frontiers in Neuroscience, 2022, p. 1, doi. 10.3389/fnins.2022.868088

By:

Harris, Andrew C.;
Muelken, Peter;
Alcheva, Aleksandra;
Stepanov, Irina;
LeSage, Mark G.

Publication type:

Article

Attenuating nicotine's effects with high affinity human anti-nicotine monoclonal antibodies.

Published in:

PLoS ONE, 2021, v. 16, n. 7, p. 1, doi. 10.1371/journal.pone.0254247

By:

Raleigh, Michael D.;
Beltraminelli, Nicola;
Fallot, Stephanie;
LeSage, Mark G.;
Saykao, Amy;
Pentel, Paul R.;
Fuller, Steve;
Thisted, Thomas;
Biesova, Zuzanna;
Horrigan, Stephen;
Sampey, Darryl;
Zhou, Bin;
Kalnik, Matthew W.

Publication type:

Article

Impact of Tobacco Regulation on Animal Research: New Perspectives and Opportunities.

Published in:

Nicotine & Tobacco Research, 2012, v. 14, n. 11, p. 1319, doi. 10.1093/ntr/nts162

By:

Donny, Eric C.;
Taylor, Tracy G.;
LeSage, Mark G.;
Levin, Melissa;
Buffalari, Deanne M.;
Joel, Danielle;
Sved, Alan F.

Publication type:

Article

Developing the science base for reducing tobacco harm.

Published in:

2007

By:

Hatsukami, Dorothy K.;
Joseph, Anne M.;
LeSage, Mark;
Jensen, Joni;
Murphy, Sharon E.;
Pentel, Paul R.;
Kotlyar, Michael;
Borgida, Eugene;
Chap Le;
Hecht, Stephen S.;
Le, Chap

Publication type:

journal article

Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats.

Published in:

Psychopharmacology, 2012, v. 220, n. 3, p. 565, doi. 10.1007/s00213-011-2514-y

By:

Harris, Andrew;
Stepanov, Irina;
Pentel, Paul;
LeSage, Mark

Publication type:

Article

A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats.

Published in:

Psychopharmacology, 2011, v. 217, n. 2, p. 153, doi. 10.1007/s00213-011-2273-9

By:

Harris, Andrew;
Pentel, Paul;
Burroughs, Danielle;
Staley, Mylissa;
LeSage, Mark

Publication type:

Article

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.

Published in:

Psychopharmacology, 2010, v. 209, n. 2, p. 203, doi. 10.1007/s00213-010-1792-0

By:

LeSage, Mark G.;
Perry, Jennifer L.;
Kotz, Catherine M.;
Shelley, David;
Corrigall, William A.

Publication type:

Article

Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose.

Published in:

Psychopharmacology, 2009, v. 205, n. 4, p. 599, doi. 10.1007/s00213-009-1567-7

By:

Harris, Andrew C.;
Pentel, Paul R.;
LeSage, Mark G.

Publication type:

Article

Toward a nonhuman model of contingency management: effects of reinforcing abstinence from nicotine self-administration in rats with an alternative nondrug reinforcer.

Published in:

Psychopharmacology, 2009, v. 203, n. 1, p. 13, doi. 10.1007/s00213-008-1362-x

By:

LeSage, Mark

Publication type:

Article

Prevalence, magnitude, and correlates of an extinction burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions.

Published in:

Psychopharmacology, 2007, v. 194, n. 3, p. 395, doi. 10.1007/s00213-007-0848-2

By:

Harris, Andrew C.;
Pentel, Paul R.;
LeSage, Mark G.

Publication type:

Article

Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats.

Published in:

Psychopharmacology, 2007, v. 194, n. 3, p. 413, doi. 10.1007/s00213-007-0830-z

By:

LeSage, Mark G.;
Keyler, Daniel E.;
Burroughs, Danielle;
Pentel, Paul R.

Publication type:

Article

Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats.

Published in:

Psychopharmacology, 2006, v. 184, n. 3/4, p. 409, doi. 10.1007/s00213-005-0027-2

By:

LeSage, Mark G.;
Keyler, Daniel E.;
Hieda, Yoko;
Collins, Greg;
Burroughs, Danielle;
Chap Le;
Pentel, Paul R.

Publication type:

Article

Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations.

Published in:

Psychopharmacology, 2003, v. 170, n. 3, p. 278, doi. 10.1007/s00213-003-1539-2

By:

LeSage, Mark G.;
Keyler, Daniel E.;
Collins, Greg;
Pentel, Paul R.

Publication type:

Article

Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery.

Published in:

Psychopharmacology, 2000, v. 153, n. 1, p. 148, doi. 10.1007/s002130000430

By:

LeSage, Mark G.;
Stafford, David;
Glowa, John R.

Publication type:

Article