Works by Le Hir, Hervé

Results: 35

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 11, p. 1124, doi. 10.1038/nsmb.2420

By:

Saulière, Jérôme;
Murigneux, Valentine;
Wang, Zhen;
Marquenet, Emélie;
Barbosa, Isabelle;
Le Tonquèze, Olivier;
Audic, Yann;
Paillard, Luc;
Crollius, Hugues Roest;
Le Hir, Hervé

Publication type:

Article

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 10, p. 983, doi. 10.1038/nsmb.2380

By:

Barbosa, Isabelle;
Haque, Nazmul;
Fiorini, Francesca;
Barrandon, Charlotte;
Tomasetto, Catherine;
Blanchette, Marco;
Le Hir, Hervé

Publication type:

Article

The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 4, p. 378, doi. 10.1038/nsmb.2242

By:

Murachelli, Andrea Giovanni;
Ebert, Judith;
Basquin, Claire;
Le Hir, Hervé;
Conti, Elena

Publication type:

Article

The exon junction complex differentially marks spliced junctions.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1269, doi. 10.1038/nsmb.1890

By:

Saulière, Jérôme;
Haque, Nazmul;
Harms, Scot;
Barbosa, Isabelle;
Blanchette, Marco;
Le Hir, Hervé

Publication type:

Article

A UPF3-mediated regulatory switch that maintains RNA surveillance.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 7, p. 747, doi. 10.1038/nsmb.1612

By:

Wai-Kin Chan;
Bhalla, Angela D.;
Le Hir, Hervé;
Lam Son Nguyen;
Lulu Huang;
Gécz, Jozef;
Wilkinson, Miles F.

Publication type:

Article

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 1, p. 85, doi. 10.1038/nsmb1330

By:

Chamieh, Hala;
Ballut, Lionel;
Bonneau, Fabien;
Le Hir, Hervé

Publication type:

Article

Nonsense‐mediated mRNA decay involves two distinct Upf1‐bound complexes.

Published in:

EMBO Journal, 2018, v. 37, n. 21, p. N.PAG, doi. 10.15252/embj.201899278

By:

Dehecq, Marine;
Decourty, Laurence;
Namane, Abdelkader;
Proux, Caroline;
Kanaan, Joanne;
Le Hir, Hervé;
Jacquier, Alain;
Saveanu, Cosmin

Publication type:

Article

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 10, p. 861, doi. 10.1038/nsmb990

By:

Ballut, Lionel;
Marchadier, Brice;
Baguet, Aurélie;
Tomasetto, Catherine;
Séraphin, Bertrand;
Le Hir, Hervé

Publication type:

Article

5′-End RET Splicing: Absence of Variants in Normal Tissues and Intron Retention in Pheochromocytomas.

Published in:

Oncology, 2002, v. 63, n. 1, p. 84, doi. 10.1159/000065725

By:

Le Hir, Hervé;
Charlet-Berguerand, Nicolas;
de Franciscis, Vittorio;
Thermes, Claude

Publication type:

Article

Relative Expression of the RET9 and RET51 Isoforms in Human Pheochromocytomas.

Published in:

Oncology, 2000, v. 58, n. 4, p. 311, doi. 10.1159/000012118

By:

Le Hir, Hervé;
Charlet-Berguerand, Nicolas;
Gimenez-Roqueplo, Anne-Paule;
Mannelli, Massimo;
Plouin, Pierre-François;
de Franciscis, Vittorio;
Thermes, Claude

Publication type:

Article

Comprehensive mapping of exon junction complex binding sites reveals universal EJC deposition in Drosophila.

Published in:

BMC Biology, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12915-023-01749-1

By:

Morillo, Lucía;
Paternina, Toni;
Alasseur, Quentin;
Genovesio, Auguste;
Schwartz, Schraga;
Le Hir, Hervé

Publication type:

Article

UPF1-like helicase grip on nucleic acids dictates processivity.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06313-y

By:

Kanaan, Joanne;
Raj, Saurabh;
Decourty, Laurence;
Saveanu, Cosmin;
Croquette, Vincent;
Le Hir, Hervé

Publication type:

Article

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-017-02793-6

By:

Fiorini, Francesca;
Robin, Jean-Philippe;
Kanaan, Joanne;
Borowiak, Malgorzata;
Croquette, Vincent;
Le Hir, Hervé;
Jalinot, Pierre;
Mocquet, Vincent

Publication type:

Article

Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 5, p. 954, doi. 10.1128/MCB.06130-11

By:

Michelle, Laetitia;
Cloutier, Alexandre;
Toutant, Johanne;
Shkreta, Lulzim;
Thibault, Philippe;
Durand, Mathieu;
Garneau, Daniel;
Gendron, Daniel;
Lapointe, Elvy;
Couture, Sonia;
Le Hir, Hervé;
Klinck, Roscoe;
Elela, Sherif Abou;
Prinos, Panagiotis;
Chabot, Benoit

Publication type:

Article

Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21590-w

By:

Kwon, Oh Sung;
Mishra, Rahul;
Safieddine, Adham;
Coleno, Emeline;
Alasseur, Quentin;
Faucourt, Marion;
Barbosa, Isabelle;
Bertrand, Edouard;
Spassky, Nathalie;
Le Hir, Hervé

Publication type:

Article

A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21585-7

By:

Safieddine, Adham;
Coleno, Emeline;
Salloum, Soha;
Imbert, Arthur;
Traboulsi, Abdel-Meneem;
Kwon, Oh Sung;
Lionneton, Frederic;
Georget, Virginie;
Robert, Marie-Cécile;
Gostan, Thierry;
Lecellier, Charles-Henri;
Chouaib, Racha;
Pichon, Xavier;
Le Hir, Hervé;
Zibara, Kazem;
Mueller, Florian;
Walter, Thomas;
Peter, Marion;
Bertrand, Edouard

Publication type:

Article

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

Published in:

EMBO Journal, 2000, v. 19, n. 24, p. 6860, doi. 10.1093/emboj/19.24.6860

By:

Le Hir, Hervé;
Izaurralde, Elisa;
Maquat, Lynne E.;
Moore, Melissa J.

Publication type:

Article

New Species of Human Tyrosine Hydroxylase mRNA Are Produced in Variable Amounts in Adrenal Medulla and Are Overexpressed in Progressive Supranuclear Palsy.

Published in:

Journal of Neurochemistry, 1996, v. 67, n. 1, p. 19, doi. 10.1046/j.1471-4159.1996.67010019.x

By:

Dumas, Sylvie;
Le Hir, Hervé;
Bodeau-Péan, Sylvie;
Hirsch, Etienne;
Thermes, Claude;
Mallet, Jacques

Publication type:

Article

A Novel Rat Tyrosine Hydroxylase mRNA Species Generated by Alternative Splicing.

Published in:

Journal of Neurochemistry, 1996, v. 66, n. 5, p. 1819, doi. 10.1046/j.1471-4159.1996.66051819.x

By:

Lanièce, Philippe;
Le Hir, Hervé;
Bodeau-Péan, Sylvie;
Charon, Yves;
Valentin, Luc;
Thermes, Claude;
Mallet, Jacques;
Dumas, Sylvie

Publication type:

Article

RNA anchoring of Upf1 facilitates recruitment of Dcp2 in the NMD decapping complex.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 5, p. 1, doi. 10.1093/nar/gkaf160

By:

Ruiz-Gutierrez, Nadia;
Dupas, Jeanne;
Auquier, Elvire;
Barbarin-Bocahu, Irène;
Gaudon-Plesse, Claudine;
Saveanu, Cosmin;
Graille, Marc;
Le Hir, Hervé

Publication type:

Article

role for AKT1 in nonsense-mediated mRNA decay.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 19, p. 11022, doi. 10.1093/nar/gkab882

By:

Palma, Martine;
Leroy, Catherine;
Salomé-Desnoulez, Sophie;
Werkmeister, Elisabeth;
Kong, Rebekah;
Mongy, Marc;
Le Hir, Hervé;
Lejeune, Fabrice

Publication type:

Article

NCBP3 positively impacts mRNA biogenesis.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 18, p. 10413, doi. 10.1093/nar/gkaa744

By:

Yuhui Dou;
Barbosa, Isabelle;
Hua Jiang;
Iasillo, Claudia;
Molloy, Kelly R.;
Schulze, Wiebke Manuela;
Cusack, Stephen;
Schmid, Manfred;
Le Hir, Hervé;
LaCava, John;
Jensen, Torben Heick

Publication type:

Article

Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 10, p. 5670, doi. 10.1093/nar/gkaa267

By:

Busetto, Virginia;
Barbosa, Isabelle;
Basquin, Jérôme;
Marquenet, Émelie;
Hocq, Rémi;
Hennion, Magali;
Paternina, Janio Antonio;
Namane, Abdelkader;
Conti, Elena;
Bensaude, Olivier;
Le Hir, Hervé

Publication type:

Article

Monitored eCLIP: high accuracy mapping of RNA-protein interactions.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 21, p. 11553, doi. 10.1093/nar/gky858

By:

Hocq, Rémi;
Paternina, Janio;
Alasseur, Quentin;
Genovesio, Auguste;
Le Hir, Hervé

Publication type:

Article

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 5, p. 2648, doi. 10.1093/nar/gky040

By:

Gowravaram, Manjeera;
Bonneau, Fabien;
Kanaan, Joanne;
Maciej, Vincent D;
Fiorini, Francesca;
Raj, Saurabh;
Croquette, Vincent;
Le Hir, Hervé;
Chakrabarti, Sutapa

Publication type:

Article

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities.

Published in:

Nature Communications, 2015, v. 6, n. 7, p. 7581, doi. 10.1038/ncomms8581

By:

Fiorini, Francesca;
Bagchi, Debjani;
Le Hir, Hervé;
Croquette, Vincent

Publication type:

Article

Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans.

Published in:

PLoS Biology, 2024, v. 22, n. 9, p. 1, doi. 10.1371/journal.pbio.3002821

By:

Barbarin-Bocahu, Irène;
Ulryck, Nathalie;
Rigobert, Amandine;
Ruiz Gutierrez, Nadia;
Decourty, Laurence;
Raji, Mouna;
Garkhal, Bhumika;
Le Hir, Hervé;
Saveanu, Cosmin;
Graille, Marc

Publication type:

Article

The protein Mago provides a link between splicing and mRNA localization.

Published in:

EMBO Reports, 2001, v. 2, n. 12, p. 1119, doi. 10.1093/embo-reports/kve245

By:

Le Hir, Hervé;
Gatfield, David;
Braun, Isabelle C.;
Forler, Daniel;
Izaurralde, Elisa

Publication type:

Article

Transcriptome-wide modulation of splicing by the Exon Junction Complex.

Published in:

Genome Biology, 2014, v. 15, n. 12, p. 192, doi. 10.1186/s13059-014-0551-7

By:

Wang, Zhen;
Murigneux, Valentine;
Le Hir, Hervé

Publication type:

Article

Exon-junction complex association with stalled ribosomes and slow translation-independent disassembly.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48371-5

By:

Bensaude, Olivier;
Barbosa, Isabelle;
Morillo, Lucia;
Dikstein, Rivka;
Le Hir, Hervé

Publication type:

Article

Insights into the design and interpretation of iCLIP experiments.

Published in:

Genome Biology, 2017, v. 18, p. 1, doi. 10.1186/s13059-016-1130-x

By:

Haberman, Nejc;
Huppertz, Ina;
Attig, Jan;
König, Julian;
Zhen Wang;
Hauer, Christian;
Hentze, Matthias W.;
Kulozik, Andreas E.;
Hir, Hervé Le;
Curk, Tomaž;
Sibley, Christopher R.;
Zarnack, Kathi;
Ule, Jernej

Publication type:

Article

A mechanistic study of helicases with magnetic traps.

Published in:

Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 7, p. 1314, doi. 10.1002/pro.3187

By:

Hodeib, Samar;
Raj, Saurabh;
Manosas, Maria;
Zhang, Weiting;
Bagchi, Debjani;
Ducos, Bertrand;
Fiorini, Francesca;
Kanaan, Joanne;
Le Hir, Hervé;
Allemand, Jean‐François;
Bensimon, David;
Croquette, Vincent

Publication type:

Article

ALFA: annotation landscape for aligned reads.

Published in:

BMC Genomics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12864-019-5624-2

By:

Bahin, Mathieu;
Noël, Benoit F.;
Murigneux, Valentine;
Bernard, Charles;
Bastianelli, Leila;
Le Hir, Hervé;
Lebreton, Alice;
Genovesio, Auguste

Publication type:

Article

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 4, p. 2404, doi. 10.1093/nar/gks1320

By:

Fiorini, Francesca;
Boudvillain, Marc;
Le Hir, Hervé

Publication type:

Article

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 4, p. 1289, doi. 10.1093/nar/gkm016

By:

Buchet-Poyau, Karine;
Courchet, Julien;
Hir, Hervé Le;
Séraphin, Bertrand;
Scoazec, Jean-Yves;
Duret, Laurent;
Domon-Dell, Claire;
Freund, Jean-Noël;
Billaud, Marc

Publication type:

Article