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Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport.
Published in:
2012
By:
- Braun D;
- Kim TD;
- le Coutre P;
- Köhrle J;
- Hershman JM;
- Schweizer U;
- Braun, Doreen;
- Kim, Theo D;
- le Coutre, Philipp;
- Köhrle, Josef;
- Hershman, Jerome M;
- Schweizer, Ulrich
Publication type:
journal article
Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571.
Published in:
2000
By:
- Gambacorti-Passerini, Carlo;
- Barni, Rossella;
- Gambacorti-Passerini, C;
- Barni, R;
- le Coutre, P;
- Zucchetti, M;
- Cabrita, G;
- Cleris, L;
- Rossi, F;
- Gianazza, E;
- Brueggen, J;
- Cozens, R;
- Pioltelli, P;
- Pogliani, E;
- Corneo, G;
- Formelli, F;
- D'Incalci, M
Publication type:
journal article
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor.
Published in:
1999
By:
- le Coutre, Philipp;
- Mologni, Luca;
- Cleris, Loredana;
- Marchesi, Edoardo;
- Buchdunger, Elisabeth;
- Giardini, Roberto;
- Formelli, Franca;
- Gambacorti-Passerini, Carlo;
- le Coutre, P;
- Mologni, L;
- Cleris, L;
- Marchesi, E;
- Buchdunger, E;
- Giardini, R;
- Formelli, F;
- Gambacorti-Passerini, C
Publication type:
journal article
Guest commentaries. Nilotinib: a viewpoint by Philipp le Coutre.
Published in:
2008
By:
- le Coutre P
Publication type:
Journal Article
Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias.
Published in:
Bone Marrow Transplantation, 2005, v. 36, n. 8, p. 683, doi. 10.1038/sj.bmt.1705123
By:
- Massenkeil, G.;
- Nagy, M.;
- Neuburger, S.;
- Tamm, I.;
- Lutz, C.;
- le Coutre, P.;
- Rosen, O.;
- Wernecke, K.-D.;
- Dörken, B.;
- Arnold, R.
Publication type:
Article
Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique.
Published in:
Annals of Hematology, 2003, v. 82, n. 10, p. 660, doi. 10.1007/s00277-003-0690-5
By:
- Kreuzer, K.-A.;
- le Coutre, P.;
- Landt, O.;
- Na, I.-K.;
- Schwarz, M.;
- Schultheis, K.;
- Hochhaus, A.;
- Dörken, B.
Publication type:
Article
Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique.
Published in:
Annals of Hematology, 2003, v. 82, n. 5, p. 284, doi. 10.1007/s00277-003-0644-y
By:
- Kreuzer, K.-A.;
- le Coutre, P.;
- Landt, O.;
- Na, I.-K.;
- Schwarz, M.;
- Schultheis, K.;
- Hochhaus, A.;
- Dörken, B.
Publication type:
Article
Phase II study of nilotinib in patients with relapsed or refractory Philadelphia chromosome--positive acute lymphoblastic leukemia.
Published in:
2013
By:
- Ottmann, O G;
- Larson, R A;
- Kantarjian, H M;
- le Coutre, P D;
- Baccarani, M;
- Hochhaus, A;
- Kim, D W;
- Fan, X;
- Novick, S;
- Giles, F J
Publication type:
clinical trial
Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib.
Published in:
Leukemia (08876924), 2013, v. 27, n. 6, p. 1316, doi. 10.1038/leu.2013.70
By:
- Kim, T D;
- Rea, D;
- Schwarz, M;
- Grille, P;
- Nicolini, F E;
- Rosti, G;
- Levato, L;
- Giles, F J;
- Dombret, H;
- Mirault, T;
- Labussière, H;
- Lindhorst, R;
- Haverkamp, W;
- Buschmann, I;
- Dörken, B;
- le Coutre, P D
Publication type:
Article
Phase II study of nilotinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia.
Published in:
Leukemia (08876924), 2013, v. 27, n. 6, p. 1411, doi. 10.1038/leu.2012.324
By:
- Ottmann, O G;
- Larson, R A;
- Kantarjian, H M;
- le Coutre, P D;
- Baccarani, M;
- Hochhaus, A;
- Kim, D W;
- Fan, X;
- Novick, S;
- Giles, F J
Publication type:
Article
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis.
Published in:
Leukemia (08876924), 2013, v. 27, n. 6, p. 1310, doi. 10.1038/leu.2013.69
By:
- Giles, F J;
- Mauro, M J;
- Hong, F;
- Ortmann, C-E;
- McNeill, C;
- Woodman, R C;
- Hochhaus, A;
- le Coutre, P D;
- Saglio, G
Publication type:
Article
Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance.
Published in:
Leukemia (08876924), 2013, v. 27, n. 4, p. 907, doi. 10.1038/leu.2012.305
By:
- Jabbour, E;
- le Coutre, P D;
- Cortes, J;
- Giles, F;
- Bhalla, K N;
- Pinilla-Ibarz, J;
- Larson, R A;
- Gattermann, N;
- Ottmann, O G;
- Hochhaus, A;
- Hughes, T P;
- Saglio, G;
- Radich, J P;
- Kim, D-W;
- Martinelli, G;
- Reynolds, J;
- Woodman, R C;
- Baccarani, M;
- Kantarjian, H M
Publication type:
Article
Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.
Published in:
Leukemia (08876924), 2013, v. 27, n. 1, p. 107, doi. 10.1038/leu.2012.181
By:
- Giles, F J;
- le Coutre, P D;
- Pinilla-Ibarz, J;
- Larson, R A;
- Gattermann, N;
- Ottmann, O G;
- Hochhaus, A;
- Radich, J P;
- Saglio, G;
- Hughes, T P;
- Martinelli, G;
- Kim, D-W;
- Novick, S;
- Gillis, K;
- Fan, X;
- Cortes, J;
- Baccarani, M;
- Kantarjian, H M
Publication type:
Article
MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.
Published in:
Leukemia (08876924), 2013, v. 27, n. 1, p. 113, doi. 10.1038/leu.2012.186
By:
- Giles, F J;
- Swords, R T;
- Nagler, A;
- Hochhaus, A;
- Ottmann, O G;
- Rizzieri, D A;
- Talpaz, M;
- Clark, J;
- Watson, P;
- Xiao, A;
- Zhao, B;
- Bergstrom, D;
- Le Coutre, P D;
- Freedman, S J;
- Cortes, J E
Publication type:
Article
Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase.
Published in:
Leukemia (08876924), 2012, v. 26, n. 5, p. 959, doi. 10.1038/leu.2011.355
By:
- Giles, F J;
- Kantarjian, H M;
- le Coutre, P D;
- Baccarani, M;
- Mahon, F-X;
- Blakesley, R E;
- Gallagher, N J;
- Gillis, K;
- Goldberg, S L;
- Larson, R A;
- Hochhaus, A;
- Ottmann, O G
Publication type:
Article
Nilotinib in patients with Ph+ chronic myeloid leukemia in accelerated phase following imatinib resistance or intolerance: 24-month follow-up results.
Published in:
Leukemia (08876924), 2012, v. 26, n. 6, p. 1189, doi. 10.1038/leu.2011.323
By:
- le Coutre, P D;
- Giles, F J;
- Hochhaus, A;
- Apperley, J F;
- Ossenkoppele, G J;
- Blakesley, R;
- Shou, Y;
- Gallagher, N J;
- Baccarani, M;
- Cortes, J;
- Kantarjian, H M
Publication type:
Article
NIH-defined graft-versus-host disease after reduced intensity or myeloablative conditioning in patients with acute myeloid leukemia.
Published in:
2012
By:
- Terwey, T H;
- Vega-Ruiz, A;
- Hemmati, P G;
- Martus, P;
- Dietz, E;
- le Coutre, P;
- Massenkeil, G;
- Dörken, B;
- Arnold, R
Publication type:
Letter
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia.
Published in:
2009
By:
- Shimoni, A;
- Leiba, M;
- Schleuning, M;
- Martineau, G;
- Renaud, M;
- Koren-Michowitz, M;
- Ribakovski, E;
- le Coutre, P;
- Arnold, R;
- Guilhot, F;
- Nagler, A
Publication type:
Letter
Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon a/ara-C.
Published in:
Leukemia (08876924), 2003, v. 17, n. 12, p. 2392, doi. 10.1038/sj.leu.2403157
By:
- Müller, M.C.;
- Gattermann, N.;
- Lahaye, T.;
- Deininger, M.W.N.;
- Berndt, A.;
- Fruehauf, S.;
- Neubauer, A.;
- Fischer, T.;
- Hossfeld, D.K.;
- Schneller, F.;
- Krause, S.W.;
- Nerl, C.;
- Sayer, H.G.;
- Ottmann, O.G.;
- Waller, C.;
- Aulitzky, W.;
- le Coutre, P.;
- Freund, M.;
- Merx, K.
Publication type:
Article
Autologous peripheral blood stem cell transplantation of stem cells harvested in imatinib-induced complete cytogenetic remission: an example of in vivo purging in CML.
Published in:
2003
By:
- le Coutre, P.;
- Kreuzer, K.A.;
- Massenkeil, G.;
- Baskaynak, G.;
- Zschieschang, P.;
- Genvresse, I.;
- Lupberger, J.;
- Mapara, M.;
- Dörken, B.;
- Arnold, R.
Publication type:
Letter
CURRENT THERAPY OF SECONDARY CNS INVOLVEMENT IN MALIGNANT LYMPHOMA: DATA FROM A MULTICENTER PROSPECTIVE INTERNATIONAL REGISTRY.
Published in:
Hematological Oncology, 2017, v. 35, p. 196, doi. 10.1002/hon.2438_58
By:
- Korfel, A.;
- Schroers, R.;
- Schlegel, U.;
- Schmitz, N.;
- Hofer, S.;
- Bairey, O.;
- Schmidt ‐ Hieber, M.;
- Le Coutre, P.;
- Janz, M.;
- Reimer, P.;
- Martus, P.
Publication type:
Article
Expanding Nilotinib Access in Clinical Trials (ENACT): an open-label, multicenter study of oral nilotinib in adult patients with imatinib-resistant or imatinib-intolerant Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase.
Published in:
2012
By:
- Nicolini FE;
- Turkina A;
- Shen ZX;
- Gallagher N;
- Jootar S;
- Powell BL;
- De Souza C;
- Zheng M;
- Szczudlo T;
- le Coutre P;
- Nicolini, Franck E;
- Turkina, Anna;
- Shen, Zhi-Xiang;
- Gallagher, Neil;
- Jootar, Saengsuree;
- Powell, Bayard L;
- De Souza, Carmino;
- Zheng, Ming;
- Szczudlo, Tomasz;
- le Coutre, Philipp
Publication type:
journal article
Activity and tolerability of nilotinib: a retrospective multicenter analysis of chronic myeloid leukemia patients who are imatinib resistant or intolerant.
Published in:
2010
By:
- Koren-Michowitz M;
- le Coutre P;
- Duyster J;
- Scheid C;
- Panayiotidis P;
- Prejzner W;
- Rowe JM;
- Schwarz M;
- Goldschmidt N;
- Nagler A;
- Koren-Michowitz, Maya;
- le Coutre, Philipp;
- Duyster, Justus;
- Scheid, Christof;
- Panayiotidis, Panayiotis;
- Prejzner, Witold;
- Rowe, Jacob M;
- Schwarz, Michaela;
- Goldschmidt, Neta;
- Nagler, Arnon
Publication type:
journal article
Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation.
Published in:
Transplant Infectious Disease, 2008, v. 10, n. 4, p. 290, doi. 10.1111/j.1399-3062.2007.00296.x
By:
- Neuburger, S.;
- Massenkeil, G.;
- Seibold, M.;
- Lutz, C.;
- Tamm, I.;
- le Coutre, P.;
- Graf, B.;
- Doerken, B.;
- Arnold, R.
Publication type:
Article
Reduced-Intensity Conditioning Using Fludarabine and Antithymocyte Globulin Alone Allows Stable Engraftment in a Patient with Dyskeratosis Congenita.
Published in:
Acta Haematologica, 2010, v. 124, n. 4, p. 200, doi. 10.1159/000318721
By:
- Vuong, L. G.;
- Hemmati, P. G.;
- Neuburger, S.;
- Terwey, T. H.;
- Vulliamy, T.;
- Dokal, I.;
- le Coutre, P.;
- Dörken, B.;
- Arnold, R.
Publication type:
Article
Severe peripheral arterial disease during nilotinib therapy.
Published in:
2011
By:
- Le Coutre P;
- Rea D;
- Abruzzese E;
- Dombret H;
- Trawinska MM;
- Herndlhofer S;
- Dörken B;
- Valent P;
- Le Coutre, Philipp;
- Rea, Delphine;
- Abruzzese, Elisabetta;
- Dombret, Hervé;
- Trawinska, Malgorzata M;
- Herndlhofer, Susanne;
- Dörken, Bernd;
- Valent, Peter
Publication type:
Letter

Found: 26