Works by Lazarov, Orly

Results: 33

Of Mice and Men: Neurogenesis, Cognition and Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2013, v. 5, p. 1, doi. 10.3389/fnagi.2013.00043

By:

Lazarov, Orly;
Marr, Robert

Publication type:

Article

Alzheimer's disease and neurogenesis: Familial(r) signaling, new roles

Published in:

2011

By:

Lazarov, Orly;
Gadadhar, Archana;
Marr, Robert

Publication type:

Abstract

Rescue of impaired neurogenesis and attenuation of neuropathology in FAD-linked transgenic mice by environmental factors

Published in:

2010

By:

Jennifer Hu, Yuan-Shih;
Xu, Peng;
Pigino, Gustavo;
Brady, Scott T.;
Larson, John;
Lazarov, Orly

Publication type:

Abstract

P3-382: The role Of presenilin-1 in adult neurogenesis: Implications for Alzheimer's disease

Published in:

2008

By:

Gadadhar, Archana;
Marr, Robert;
Lazarov, Orly

Publication type:

Abstract

P3-381: Familial Alzheimer's disease pathology differentially affects discrete neurogenic niches in the adult brain

Published in:

2008

By:

Demars, Michael P.;
Lazarov, Orly

Publication type:

Abstract

AM-11: Enriched environments

Published in:

2007

By:

Lazarov, Orly

Publication type:

Abstract

Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking FMRP.

Published in:

Hippocampus, 2012, v. 22, n. 6, p. 1220, doi. 10.1002/hipo.20989

By:

Lazarov, Orly;
Demars, Michael P.;
Da Tommy Zhao, Kai;
Ali, Haroon M.;
Grauzas, Vanessa;
Kney, Adam;
Larson, John

Publication type:

Article

Deficits in hippocampal neurogenesis in obesity-dependent and -independent type-2 diabetes mellitus mouse models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73401-9

By:

Bonds, Jacqueline A.;
Shetti, Aashutosh;
Stephen, Terilyn K. L.;
Bonini, Marcelo G.;
Minshall, Richard D.;
Lazarov, Orly

Publication type:

Article

Expression of a Familial Alzheimer's Disease-Linked Presenilin-1 Variant Enhances Perforant Pathway Lesion-Induced Neuronal Loss in the Entorhinal Cortex.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 2, p. 429, doi. 10.1523/JNEUROSCI.3961-05.2006

By:

Lazarov, Orly;
Peterson, Letia D.;
Peterson, Daniel A.;
Sisodia, Sangram S.

Publication type:

Article

Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 44, p. 10220, doi. 10.1523/JNEUROSCI.2773-05.2005

By:

Perez, Sylvia E.;
Lazarov, Orly;
Koprich, James B.;
Er-Yun Chen;
Rodriguez-Menendez, Virginia;
Lipton, Jack W.;
Sisodia, Sangram S.;
Mufson, Elliott J.

Publication type:

Article

Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 9, p. 2386, doi. 10.1523/JNEUROSCI.3089-04.2005

By:

Lazarov, Orly;
Morfini, Gerardo A.;
Lee, Edward B.;
Farah, Mohamed H.;
Szodorai, Anita;
DeBoer, Scott R.;
Koliatsos, Vassilis E.;
Kins, Stefan;
Lee, Virginia M.-Y.;
Wong, Philip C.;
Price, Donald L.;
Brady, Scott T.;
Sisodia, Sangram S.

Publication type:

Article

Presenilin-1-Dependent Transcriptome Changes.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 6, p. 1571, doi. 10.1523/JNEUROSCI.4145-04.2005

By:

Mirnics, Károly;
Korade, Zeljka;
Schor, Nina F.;
Arion, Dominique;
Unger, Travis;
Macioce, Melissa;
Douglass, Katherine C.;
Lazarov, Orly;
Terrano, David;
Sabatini, Michael;
Sisodia, Sangram S.

Publication type:

Article

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1ΔE9 mice.

Published in:

FASEB Journal, 2010, v. 24, n. 6, p. 1667, doi. 10.1096/fj.09-136945

By:

Yuan-Shih Hu;
Peng Xu;
Pigino, Gustavo;
Brady, Scott T.;
Larson, John;
Lazarov, Orly

Publication type:

Article

Longitudinal excitation-inhibition balance altered by sex and APOE-ε4.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07876-5

By:

Burns, Andrew P.;
Fortel, Igor;
Zhan, Liang;
Lazarov, Orly;
Mackin, R. Scott;
Demos, Alexander P.;
Bendlin, Barbara;
Leow, Alex

Publication type:

Article

β-amyloid cytotoxicity is prevented by natural achillolide A.

Published in:

Journal of Natural Medicines, 2018, v. 72, n. 3, p. 626, doi. 10.1007/s11418-018-1191-0

By:

Elmann, Anat;
Telerman, Alona;
Ofir, Rivka;
Kashman, Yoel;
Lazarov, Orly

Publication type:

Article

Peripheral nerve-stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve.

Published in:

Glia (0894-1491), 1998, v. 24, n. 3, p. 329, doi. 10.1002/(SICI)1098-1136(199811)24:3<329::AID-GLIA7>3.0.CO;2-X

By:

Lazarov-Spiegler, Orly;
Solomon, Arieh S.;
Schwartz, Michal

Publication type:

Article

Differential effects of central and peripheral nerves on macrophages and microglia.

Published in:

Glia (0894-1491), 1998, v. 23, n. 3, p. 181, doi. 10.1002/(SICI)1098-1136(199807)23:3<181::AID-GLIA1>3.0.CO;2-8

By:

Zeev-Brann, Adi Ben;
Lazarov-Spiegler, Orly;
Brenner, Talma;
Schwartz, Michal

Publication type:

Article

Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions.

Published in:

2017

By:

Lamotte, Guillaume;
Shah, Raj C.;
Lazarov, Orly;
Corcos, Daniel M.

Publication type:

journal article

Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer’s Disease Pathology Precursors.

Published in:

Journal of Neuroscience, 2019, v. 39, n. 43, p. 8576, doi. 10.1523/JNEUROSCI.0730-19.2019

By:

Bonds, Jacqueline A.;
Shetti, Aashutosh;
Bheri, Abdullah;
Zhenlong Chen;
Disouky, Ahmed;
Tai, Leon;
Mao Mao;
Head, Brian P.;
Bonini, Marcelo G.;
Haus, Jacob M.;
Minshall, Richard D.;
Lazarov, Orly

Publication type:

Article

Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2023, v. 14, p. 01, doi. 10.3389/fnagi.2022.1085989

By:

Morrissey, Zachery D.;
Jin Gao;
Liang Zhan;
Weiguo Li;
Fortel, Igor;
Takaomi Saido;
Takashi Saito;
Bakker, Arnold;
Mackin, Scott;
Ajilore, Olusola;
Lazarov, Orly;
Leow, Alex D.

Publication type:

Article

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131266

By:

Bonds, Jacqueline A.;
Kuttner-Hirshler, Yafit;
Bartolotti, Nancy;
Tobin, Matthew K.;
Pizzi, Michael;
Marr, Robert;
Lazarov, Orly

Publication type:

Article

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064460

By:

Hu, Yuan-Shih;
Long, Nancy;
Pigino, Gustavo;
Brady, Scott T.;
Lazarov, Orly

Publication type:

Article

Presenilin-1 Regulates Neural Progenitor Cell Differentiation in the Adult Brain.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 7, p. 2615, doi. 10.1523/JNEUROSCI.4767-10.2011

By:

Gadadhar, Archana;
Marr, Robert;
Lazarov, Orly

Publication type:

Article

Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 26, p. 7011, doi. 10.1523/JNEUROSCI.4272-06.2007

By:

Lazarov, Orly;
Morfini, Gerardo A.;
Pigino, Gustavo;
Gadadhar, Archana;
Xiangjun Chen;
Robinson, John;
Hanson Ho;
Brady, Scott T.;
Sisodia, Sangram S.

Publication type:

Article

Mapping lipids associated with Aβ plaques in a mouse model of Alzheimer's disease via multiscale mass spectrometry imaging.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S8, p. 1, doi. 10.1002/alz.095788

By:

Trinklein, Timothy;
Rubakhin, Stanislav S.;
Asadian, Marisa;
Sabitha, K.R.;
Lazarov, Orly;
Lam, Fan;
Sweedler, Jonathan V

Publication type:

Article

In vivo proton MR spectroscopy of the metabolic effects of familial Alzheimer's-linked mutant variants

Published in:

2012

By:

Venkatasubramanian, Palamadai;
Kuttner, Yafit;
Aksenov, Daniil;
Apolinario, Joan;
Wyrwicz, Alice;
Lazarov, Orly

Publication type:

Abstract

Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease.

Published in:

Frontiers in Dementia, 2025, p. 1, doi. 10.3389/frdem.2025.1546433

By:

Morrissey, Zachery D.;
Kumar, Pavan;
Phan, Trongha X.;
Maienschein-Cline, Mark;
Leow, Alex;
Lazarov, Orly

Publication type:

Article

Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis.

Published in:

2020

By:

Tobin, Matthew K.;
Stephen, Terilyn K. L.;
Lopez, Kyra L.;
Pergande, Melissa R.;
Bartholomew, Amelia M.;
Cologna, Stephanie M.;
Lazarov, Orly

Publication type:

journal article

All in the family: how the APPs regulate neurogenesis.

Published in:

Frontiers in Neuroscience, 2012, v. 6, p. 1, doi. 10.3389/fnins.2012.00081

By:

Lazarov, Orly;
Demars, Michael P.

Publication type:

Article

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition.

Published in:

Molecular Neurodegeneration, 2017, v. 12, p. 1, doi. 10.1186/s13024-017-0207-7

By:

Hollands, Carolyn;
Tobin, Matthew Kyle;
Hsu, Michael;
Musaraca, Kianna;
Mishra, Rachana;
Lazarov, Orly;
Tzong-Shiue Yu;
Kernie, Steven G.

Publication type:

Article

Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 3014, doi. 10.1093/brain/awad028

By:

Shetti, Aashutosh U;
Ramakrishnan, Abhirami;
Romanova, Liudmila;
Li, Wenping;
Vo, Khanh;
Volety, Ipsita;
Ratnayake, Ishara;
Stephen, Terilyn;
Minshall, Richard D;
Cologna, Stephanie M;
Lazarov, Orly

Publication type:

Article

Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 10, p. 1573, doi. 10.1038/jcbfm.2014.130

By:

Tobin, Matthew K;
Bonds, Jacqueline A;
Minshall, Richard D;
Pelligrino, Dale A;
Testai, Fernando D;
Lazarov, Orly

Publication type:

Article

Brain-immune interactions: implication for cognitive impairments in Alzheimer's disease and autoimmune disorders.

Published in:

Journal of Leukocyte Biology, 2024, v. 116, n. 6, p. 1269, doi. 10.1093/jleuko/qiae134

By:

Kadam, Rashmi;
Gupta, Muskan;
Lazarov, Orly;
Prabhakar, Bellur S

Publication type:

Article