Works matching AU Lazarev, Vladimir F.

Results: 18

"Proteinjury": a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma.

Published in:

Frontiers in Cell & Developmental Biology, 2025, p. 1, doi. 10.3389/fcell.2025.1593122

By:

Lazarev, Vladimir F.;
Alhasan, Bashar A.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity.

Published in:

Aging & Disease, 2021, v. 12, n. 5, p. 1223, doi. 10.14336/AD.2020.1230

By:

Lazarev, Vladimir F.;
Tsolaki, Magda;
Mikhaylova, Elena R.;
Benken, Konstantin A.;
Shevtsov, Maxim A.;
Nikotina, Alina D.;
Lechpammer, Mirna;
Mitkevich, Vladimir A.;
Makarov, Alexander A.;
Moskalev, Alexey A.;
Kozin, Sergey A.;
Margulis, Boris A.;
Guzhova, Irina V.;
Nudler, Evgeny

Publication type:

Article

Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models.

Published in:

Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0160-y

By:

Lazarev, Vladimir F.;
Sverchinsky, Dmitry V.;
Mikhaylova, Elena R.;
Semenyuk, Pavel I.;
Komarova, Elena Y.;
Niskanen, Sergey A.;
Nikotina, Alina D.;
Burakov, Anton V.;
Kartsev, Viktor G.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation.

Published in:

Cancer Immunology, Immunotherapy, 2024, v. 73, n. 2, p. 1, doi. 10.1007/s00262-023-03612-2

By:

Nikotina, Alina D.;
Vladimirova, Snezhana A.;
Kokoreva, Nadezhda E.;
Nevdakha, Valeria A.;
Lazarev, Vladimir F.;
Kuznetcova, Liubov S.;
Komarova, Elena Y.;
Suezov, Roman V.;
Efremov, Sergei;
Leonova, Elizaveta;
Kartsev, Viktor G.;
Aksenov, Nikolay D.;
Margulis, Boris A.;
Guzhova, Irina V.

Publication type:

Article

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 20, p. 3953, doi. 10.1093/hmg/ddr314

By:

Guzhova, Irina V.;
Lazarev, Vladimir F.;
Kaznacheeva, Anastasia V.;
Ippolitova, Maria V.;
Muronetz, Vladimir I.;
Kinev, Alexander V.;
Margulis, Boris A.

Publication type:

Article

Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease.

Published in:

Molecules, 2022, v. 27, n. 24, p. 8950, doi. 10.3390/molecules27248950

By:

Lazarev, Vladimir F.;
Dutysheva, Elizaveta A.;
Mikhaylova, Elena R.;
Trestsova, Maria A.;
Utepova, Irina A.;
Chupakhin, Oleg N.;
Margulis, Boris A.;
Guzhova, Irina V.

Publication type:

Article

Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates.

Published in:

Frontiers in Neuroscience, 2017, p. 1, doi. 10.3389/fnins.2017.00277

By:

Lazarev, Vladimir F.;
Mikhaylova, Elena R.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs.

Published in:

FEBS Letters, 2017, v. 591, n. 24, p. 4074, doi. 10.1002/1873-3468.12913

By:

Sverchinsky, Dmitry V.;
Lazarev, Vladimir F.;
Semenyuk, Pavel I.;
Mitkevich, Vladimir A.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay.

Published in:

FEBS Letters, 2015, v. 589, n. 5, p. 581, doi. 10.1016/j.febslet.2015.01.018

By:

Lazarev, Vladimir F.;
Benken, Konstantin A.;
Semenyuk, Pavel I.;
Sarantseva, Svetlana V.;
Bolshakova, Olga I.;
Mikhaylova, Elena R.;
Muronetz, Vladimir I.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors.

Published in:

FEBS Letters, 2013, v. 587, n. 13, p. 1997, doi. 10.1016/j.febslet.2013.05.022

By:

Margulis, Boris A.;
Vigont, Vladimir;
Lazarev, Vladimir F.;
Kaznacheyeva, Elena V.;
Guzhova, Irina V.

Publication type:

Article

Glyceraldehyde 3-phosphate dehydrogenase augments the intercellular transmission and toxicity of polyglutamine aggregates in a cell model of Huntington disease.

Published in:

Journal of Neurochemistry, 2016, v. 136, n. 5, p. 1052, doi. 10.1111/jnc.13463

By:

Mikhaylova, Elena R.;
Lazarev, Vladimir F.;
Nikotina, Alina D.;
Margulis, Boris A.;
Guzhova, Irina V.

Publication type:

Article

Protein Interactome of Amyloid-β as a Therapeutic Target.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 312, doi. 10.3390/ph16020312

By:

Lazarev, Vladimir F.;
Dutysheva, Elizaveta A.;
Kanunikov, Igor E.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1520, doi. 10.3390/ijms22041520

By:

Mikeladze, Marina A.;
Dutysheva, Elizaveta A.;
Kartsev, Victor G.;
Margulis, Boris A.;
Guzhova, Irina V.;
Lazarev, Vladimir F.;
Nikolaidis, Nikolas

Publication type:

Article

Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 9, p. 2519, doi. 10.3390/ijms19092519

By:

Sverchinsky, Dmitry V.;
Nikotina, Alina D.;
Komarova, Elena Y.;
Mikhaylova, Elena R.;
Aksenov, Nikolay D.;
Lazarev, Vladimir F.;
Mitkevich, Vladimir A.;
Suezov, Roman;
Druzhilovskiy, Dmitry S.;
Poroikov, Vladimir V.;
Margulis, Boris A.;
Guzhova, Irina V.

Publication type:

Article

Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study.

Published in:

Pharmaceutics, 2023, v. 15, n. 1, p. 7, doi. 10.3390/pharmaceutics15010007

By:

Dutysheva, Elizaveta A.;
Mikhaylova, Elena R.;
Trestsova, Maria A.;
Andreev, Alexander I.;
Apushkin, Danila Yu.;
Utepova, Irina A.;
Serebrennikova, Polina O.;
Akhremenko, Eugenia A.;
Aksenov, Nikolay D.;
Bon', Elizaveta I.;
Zimatkin, Sergey M.;
Chupakhin, Oleg N.;
Margulis, Boris A.;
Guzhova, Irina V.;
Lazarev, Vladimir F.

Publication type:

Article

Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target.

Published in:

Pharmaceutics, 2020, v. 12, n. 5, p. 416, doi. 10.3390/pharmaceutics12050416

By:

Lazarev, Vladimir F.;
Guzhova, Irina V.;
Margulis, Boris A.

Publication type:

Article

Pyrrolylquinoxaline-2-One Derivative as a Potent Therapeutic Factor for Brain Trauma Rehabilitation.

Published in:

Pharmaceutics, 2020, v. 12, n. 5, p. 414, doi. 10.3390/pharmaceutics12050414

By:

Dutysheva, Elizaveta A.;
Mikeladze, Marina A.;
Trestsova, Maria A.;
Aksenov, Nikolay D.;
Utepova, Irina A.;
Mikhaylova, Elena R.;
Suezov, Roman V.;
Charushin, Valery N.;
Chupakhin, Oleg N.;
Guzhova, Irina V.;
Margulis, Boris A.;
Lazarev, Vladimir F.

Publication type:

Article

Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02857-0

By:

Sverchinsky, Dmitry V.;
Alhasan, Bashar A.;
Mikeladze, Marina A.;
Lazarev, Vladimir F.;
Kuznetcova, Liubov S.;
Morshneva, Alisa V.;
Nikotina, Alina D.;
Ziewanah, Amr;
Koludarova, Lidia V.;
Starkova, Tatiana Y.;
Margulis, Boris A.;
Guzhova, Irina V.

Publication type:

Article