Works by Lazar, Mitchell A.

Results: 82

Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49632-z

By:

Paneru, Bam D.;
Chini, Julia;
McCright, Sam J.;
DeMarco, Nicole;
Miller, Jessica;
Joannas, Leonel D.;
Henao-Mejia, Jorge;
Titchenell, Paul M.;
Merrick, David M.;
Lim, Hee-Woong;
Lazar, Mitchell A.;
Hill, David A.

Publication type:

Article

An Open-Label Trial of the PPAR γ Ligand Rosiglitazone for Active Ulcerative Colitis.

Published in:

American Journal of Gastroenterology (Springer Nature), 2001, v. 96, n. 12, p. 3323, doi. 10.1111/j.1572-0241.2001.05333.x

By:

Lewis, James D.;
Lichtenstein, Gary R.;
Stein, Robert B.;
Deren, Julius J.;
Judge, Thomas A.;
Fogt, Franz;
Furth, Emma E.;
Demissie, E. J.;
Hurd, Linda B.;
Su, Chinyu G.;
Keilbaugh, Sue A.;
Lazar, Mitchell A.;
Wu, Gary D.

Publication type:

Article

The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.

Published in:

Endocrinology, 2023, v. 164, n. 6, p. 1, doi. 10.1210/endocr/bqad069

By:

Adlanmerini, Marine;
Lazar, Mitchell A

Publication type:

Article

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.

Published in:

2008

By:

Alenghat, Theresa;
Meyers, Katherine;
Mullican, Shannon E.;
Leitner, Kirstin;
Adeniji-Adele, Adetoun;
Avila, Jacqueline;
Bućan, Maja;
Ahima, Rexford S.;
Kaestner, Klaus H.;
Lazar, Mitchell A.

Publication type:

Letter

Up, down, and all around the epigenomic regulation of metabolism.

Published in:

2012

By:

Lazar, Mitchell A.

Publication type:

Abstract

Central Resistin Induces Hepatic Insulin Resistance via Neuropeptide Y.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 47, p. 12924, doi. 10.1523/JNEUROSCI.2443-07.2007

By:

Singhal, Neel S.;
Lazar, Mitchell A.;
Ahima, Rexford S.

Publication type:

Article

Interconnections between circadian clocks and metabolism.

Published in:

2021

By:

Guan, Dongyin;
Lazar, Mitchell A.

Publication type:

journal article

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice.

Published in:

2021

By:

Adlanmerini, Marine;
Nguyen, Hoang C. B.;
Krusen, Brianna M.;
Teng, Clare W.;
Geisler, Caroline E.;
Peed, Lindsey C.;
Carpenter, Bryce J.;
Hayes, Matthew R.;
Lazar, Mitchell A.;
Nguyen, Hoang Cb

Publication type:

journal article

Reversing the curse on PPARγ.

Published in:

2018

By:

Lazar, Mitchell A.

Publication type:

journal article

Maturing of the nuclear receptor family.

Published in:

2017

By:

Lazar, Mitchell A.

Publication type:

journal article

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 7, p. 2428, doi. 10.1172/JCI60580

By:

Sinha, Rohit Anthony;
You, Seo-Hee;
Zhou, Jin;
Siddique, Mobin M.;
Bay, Boon-Huat;
Zhu, Xuguang;
Privalsky, Martin L.;
Cheng, Sheue-Yann;
Stevens, Robert D.;
Summers, Scott A.;
Newgard, Christopher B.;
Lazar, Mitchell A.;
Yen, Paul M.

Publication type:

Article

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

Published in:

2009

By:

Qatanani, Mohammed;
Szwergold, Nava A.;
Greaves, David A.;
Ahima, Rexford S.;
Lazar, Mitchell A.;
Szwergold, Nava R;
Greaves, David R

Publication type:

journal article

Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.

Published in:

2006

By:

McVay, Laila D.;
Keilbaugh, Sue A.;
Wong, Tracie M. H.;
Kierstein, Sonja;
Shin, Marcus E.;
Lehrke, Michael;
Lefterova, Martina I.;
Shifflett, D. Edward;
Barnes, Sean L.;
Cominelli, Fabio;
Cohn, Steven M.;
Hecht, Gail;
Lazar, Mitchell A.;
Haczku, Angela;
Wu, Gary D.

Publication type:

journal article

PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1.

Published in:

2005

By:

Chui, Patricia C.;
Guan, Hong-Ping;
Lehrke, Michael;
Lazar, Mitchell A.

Publication type:

journal article

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Published in:

2004

By:

Wilson-Fritch, Leanne;
Nicoloro, Sarah;
Chouinard, My;
Lazar, Mitchell A.;
Chui, Patricia C.;
Leszyk, John;
Straubhaar, Juerg;
Czech, Michael P.;
Corvera, Silvia

Publication type:

journal article

The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.

Published in:

EMBO Reports, 2005, v. 6, n. 5, p. 445, doi. 10.1038/sj.embor.7400391

By:

Hartman, Helen B;
Yu, Jiujiu;
Alenghat, Theresa;
Ishizuka, Takahiro;
Lazar, Mitchell A

Publication type:

Article

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.

Published in:

Journal of Cell Biology, 2003, v. 160, n. 7, p. 1017, doi. 10.1083/jcb.200209065

By:

Kao, Gary D.;
McKenna, W. Gillies;
Guenther, Matthew G.;
Muschel, Ruth J.;
Lazar, Mitchell A.;
Yen, Tim J.

Publication type:

Article

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 2, p. 764, doi. 10.1523/JNEUROSCI.5052-10.2011

By:

McQuown, Susan C.;
Barrett, Ruth M.;
Matheos, Dina P.;
Post, Rebecca J.;
Rogge, George A.;
Alenghat, Theresa;
Mullican, Shannon E.;
Jones, Steven;
Rusche, James R.;
Lazar, Mitchell A.;
Wood, Marcelo A.

Publication type:

Article

Resistin Levels in Human Immunodeficiency VirusInfected Patients with Lipoatrophy Decrease in Response to Rosiglitazone.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2005, v. 90, n. 6, p. 3423, doi. 10.1210/jc.2005-0287

By:

Kamin, Daniel;
Hadigan, Colleen;
Lehrke, Michael;
Mazza, Sasha;
Lazar, Mitchell A.;
Grinspoon, Steven

Publication type:

Article

Thermal Denaturation of Native Striatal Tyrosine Hydroxylase: Increased Thermolability of the Phosphorylated Form of the Enzyme.

Published in:

Journal of Neurochemistry, 1981, v. 36, n. 2, p. 677, doi. 10.1111/j.1471-4159.1981.tb01641.x

By:

Lazar, Mitchell A.;
Truscott, Roger J. W.;
Raese, Joachim D.;
Barchas, Jack D.

Publication type:

Article

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40927-1

By:

Lee, Jiyeon;
Dimitry, Julie M.;
Song, Jong Hee;
Son, Minsoo;
Sheehan, Patrick W.;
King, Melvin W.;
Travis Tabor, G.;
Goo, Young Ah;
Lazar, Mitchell A.;
Petrucelli, Leonard;
Musiek, Erik S.

Publication type:

Article

Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.

Published in:

EMBO Molecular Medicine, 2014, v. 6, n. 9, p. 1124, doi. 10.15252/emmm.201404170

By:

Hoeksema, Marten A;
Gijbels, Marion JJ;
Van den Bossche, Jan;
Velden, Saskia;
Sijm, Ayestha;
Neele, Annette E;
Seijkens, Tom;
Stöger, J Lauran;
Meiler, Svenja;
Boshuizen, Marieke CS;
Dallinga‐Thie, Geesje M;
Levels, Johannes HM;
Boon, Louis;
Mullican, Shannon E;
Spann, Nathanael J;
Cleutjens, Jack P;
Glass, Chris K;
Lazar, Mitchell A;
Vries, Carlie JM;
Biessen, Erik AL

Publication type:

Article

Inflamed about obesity.

Published in:

Nature Medicine, 2004, v. 10, n. 2, p. 126, doi. 10.1038/nm0204-126

By:

Lehrke, Michael;
Lazar, Mitchell A.

Publication type:

Article

Reply to A futile cycle" induced by thiazolidinediones in human adipose tissue?".

Published in:

Nature Medicine, 2003, v. 9, n. 7, p. 812, doi. 10.1038/nm0703-812

By:

Guan, Hong-Ping;
Lazar, Mitchell A

Publication type:

Article

A futile metabolic cycle activated in adipocytes by antidiabetic agents.

Published in:

Nature Medicine, 2002, v. 8, n. 10, p. 1122, doi. 10.1038/nm780

By:

Guan, Hong-Ping;
Li, Yong;
Jensen, Mette Valentin;
Newgard, Christopher B.;
Steppan, Claire M.;
Lazar, Mitchell A.

Publication type:

Article

Progress in cardiovascular biology: PPAR for the course.

Published in:

Nature Medicine, 2001, v. 7, n. 1, p. 23, doi. 10.1038/83301

By:

Lazar, Mitchell A.

Publication type:

Article

Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues.

Published in:

BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-758

By:

Schupp, Michael;
Fang Chen;
Briggs, Erika R.;
Rao, Shilpa;
Pelzmann, Helmut J.;
Pessentheiner, Ariane R.;
Bogner-Strauss, Juliane G.;
Lazar, Mitchell A.;
Baldwin, Don;
Prokesch, Andreas

Publication type:

Article

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver.

Published in:

BMC Genomics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2164-14-337

By:

Everett, Logan J.;
Le Lay, John;
Lukovac, Sabina;
Bernstein, Diana;
Steger, David J.;
Lazar, Mitchell A.;
Kaestner, Klaus H.

Publication type:

Article

Macrophage-Derived Human Resistin Is Induced in Multiple Helminth Infections and Promotes Inflammatory Monocytes and Increased Parasite Burden.

Published in:

PLoS Pathogens, 2015, v. 11, n. 1, p. 1, doi. 10.1371/journal.ppat.1004579

By:

Jang, Jessica C.;
Chen, Gang;
Wang, Spencer H.;
Barnes, Mark A.;
Chung, Josiah I.;
Camberis, Mali;
Le Gros, Graham;
Cooper, Philip J.;
Steel, Cathy;
Nutman, Thomas B.;
Lazar, Mitchell A.;
Nair, Meera G.

Publication type:

Article

Pruning of the Adipocyte Peroxisome Proliferator-Activated Receptor γ Cistrome by Hematopoietic Master Regulator PU.1.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 16, p. 3354, doi. 10.1128/MCB.00599-13

By:

DiSpirito, Joanna R.;
Bin Fang;
Fenfen Wang;
Lazar, Mitchell A.

Publication type:

Article

Pruning of the Adipocyte Peroxisome Proliferator-Activated Receptor γ Cistrome by Hematopoietic Master Regulator PU.1.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 15, p. 3354, doi. 10.1128/MCB.00599-13

By:

DiSpirito, Joanna R.;
Bin Fang;
Fenfen Wang;
Lazar, Mitchell A.

Publication type:

Article

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor λ Function in Adipocytes and Macrophages.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 9, p. 2078, doi. 10.1128/MCB.01651-09

By:

Lefterova, Martina I.;
Steger, David J.;
Zhuo, David;
Qatanani, Mohammed;
Mullican, Shannon E.;
Tuteja, Geetu;
Manduchi, Elisabetta;
Grant, Gregory R.;
Lazar, Mitchell A.

Publication type:

Article

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 8, p. 27, doi. 10.1128/MCB.02076-07

By:

Steger, David J.;
Lefterova, Martina I.;
Lei Ying;
Stonestrom, Aaron J.;
Schupp, Michael;
Zhuo, David;
Vakoc, Adam L.;
Ja-Eun Kim;
Junjie Chen;
Lazar, Mitchell A.;
Blobel, Gerd A.;
Vakoc, Christopher R.

Publication type:

Article

Bifunctional Role of Rev-erb α in Adipocyte Differentiation.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 7, p. 9, doi. 10.1128/MCB.01608-07

By:

Jing Wang;
Lazar, Mitchell A.

Publication type:

Article

Resistin: molecular history and prognosis.

Published in:

Journal of Molecular Medicine, 2003, v. 81, n. 4, p. 218, doi. 10.1007/s00109-003-0428-9

By:

Banerjee, Ronadip R.;
Lazar, Mitchell A.

Publication type:

Article

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.

Published in:

Nature, 1998, v. 391, n. 6669, p. 815, doi. 10.1038/35901

By:

Grignani, Francesco;
De Matteis, Silvia;
Nervi, Clara;
Tomassoni, Lucia;
Gelmetti, Vania;
Cioce, Mario;
Fanelli, Mirco;
Ruthardt, Marthin;
Ferrara, Fabiana F.;
Zamir, Iris;
Seiser, Christian;
Grignani, Fausto;
Lazar, Mitchell A.;
Minucci, Saverio;
Pelicci, Pier Giuseppe

Publication type:

Article

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00772-5

By:

Armour, Sean M.;
Remsberg, Jarrett R.;
Damle, Manashree;
Sidoli, Simone;
Ho, Wesley Y.;
Zhenghui Li;
Garcia, Benjamin A.;
Lazar, Mitchell A.

Publication type:

Article

The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease.

Published in:

Nutrients, 2022, v. 14, n. 15, p. 3136, doi. 10.3390/nu14153136

By:

Woodie, Lauren N.;
Oral, Kaan T.;
Krusen, Brianna M.;
Lazar, Mitchell A.

Publication type:

Article

Tyrosine Hydroxylase from Bovine Striatum: Catalytic Properties of the Phosphorylated and Nonphosphorylated Forms of the Purified Enzyme.

Published in:

Journal of Neurochemistry, 1982, v. 39, n. 2, p. 409, doi. 10.1111/j.1471-4159.1982.tb03962.x

By:

Lazar, Mitchell A.;
Lockfeld, Alexandre J.;
Truscott, Roger J. W.;
Barchas, Jack D.

Publication type:

Article

Nuclear receptor Rev-erbα: a heme receptor that coordinates circadian rhythm and metabolism.

Published in:

Nuclear Receptor Signaling, 2010, v. 8, p. 1, doi. 10.1621/nrs.08001

By:

Lei Yin;
Nan Wu;
Lazar, Mitchell A.

Publication type:

Article

An Inflammatory Cascade Leading to Hyperresistinemia in Humans.

Published in:

PLoS Medicine, 2004, v. 1, n. 2, p. 161, doi. 10.1371/journal.pmed.0010045

By:

Lehrke, Michael;
Reilly, Muredach P.;
Millington, Segan C.;
Iqbal, Nayyar;
Rader, Daniel J.;
Lazar, Mitchell A.

Publication type:

Article

Cardiomyocyte-specific disruption of the circadian BMAL1–REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05537-z

By:

Latimer, Mary N.;
Williams, Lamario J.;
Shanmugan, Gobinath;
Carpenter, Bryce J.;
Lazar, Mitchell A.;
Dierickx, Pieterjan;
Young, Martin E.

Publication type:

Article

HIV Protease Inhibitor-Specific Alterations in Human Adipocyte Differentiation and Metabolism<sup>*</sup>.

Published in:

Obesity (19307381), 2006, v. 14, n. 6, p. 994, doi. 10.1038/oby.2006.114

By:

Kim, Roy J.;
Wilson, Camella G.;
Wabitsch, Martin;
Lazar, Mitchell A.;
Steppan, Claire M.

Publication type:

Article

Phosphorylated MED1 links transcription recycling and cancer growth.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 8, p. 4450, doi. 10.1093/nar/gkac246

By:

Chen, Zhong;
Ye, Zhenqing;
Soccio, Raymond E;
Nakadai, Tomoyoshi;
Hankey, William;
Zhao, Yue;
Huang, Furong;
Yuan, Fuwen;
Wang, Hongyan;
Cui, Zhifen;
Sunkel, Benjamin;
Wu, Dayong;
Dzeng, Richard K;
Thomas-Ahner, Jennifer M;
Huang, Tim H M;
Clinton, Steven K;
Huang, Jiaoti;
Lazar, Mitchell A;
Jin, Victor X;
Roeder, Robert G

Publication type:

Article

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.

Published in:

Nature Medicine, 2012, v. 18, n. 6, p. 934, doi. 10.1038/nm.2744

By:

Sun, Zheng;
Miller, Russell A;
Patel, Rajesh T;
Chen, Jie;
Dhir, Ravindra;
Wang, Hong;
Zhang, Dongyan;
Graham, Mark J;
Unterman, Terry G;
Shulman, Gerald I;
Sztalryd, Carole;
Bennett, Michael J;
Ahima, Rexford S;
Birnbaum, Morris J;
Lazar, Mitchell A

Publication type:

Article

Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation.

Published in:

Nature Medicine, 2008, v. 14, n. 2, p. 188, doi. 10.1038/nm1706

By:

Hosooka, Tetsuya;
Noguchi, Tetsuya;
Kotani, Ko;
Nakamura, Takehiro;
Sakaue, Hiroshi;
Inoue, Hiroshi;
Ogawa, Wataru;
Tobimatsu, Kazutoshi;
Takazawa, Kazuo;
Sakai, Mashito;
Matsuki, Yasushi;
Hiramatsu, Ryuji;
Yasuda, Tomoharu;
Lazar, Mitchell A;
Yamanashi, Yuji;
Kasuga, Masato

Publication type:

Article

The humoral side of insulin resistance.

Published in:

Nature Medicine, 2006, v. 12, n. 1, p. 43, doi. 10.1038/nm0106-43

By:

Lazar, Mitchell A.

Publication type:

Article

Double SET point: G9a makes its mark in adipogenesis.

Published in:

EMBO Journal, 2013, v. 32, n. 1, p. 4, doi. 10.1038/emboj.2012.320

By:

Cristancho, Ana G;
Lazar, Mitchell A

Publication type:

Article

Adipogenic hotspots: where the action is.

Published in:

EMBO Journal, 2011, v. 30, n. 8, p. 1418, doi. 10.1038/emboj.2011.80

By:

Steger, David J;
Lazar, Mitchell A

Publication type:

Article

The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor.

Published in:

EMBO Journal, 2006, v. 25, n. 17, p. 3966, doi. 10.1038/sj.emboj.7601280

By:

Alenghat, Theresa;
Yu, Jiujiu;
Lazar, Mitchell A.

Publication type:

Article