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Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability.
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- PEDS: Protein Engineering, Design & Selection, 2019, v. 32, n. 6, p. 277, doi. 10.1093/protein/gzz046
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- Article
Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics.
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- Molecules, 2015, v. 20, n. 9, p. 16435, doi. 10.3390/molecules200916435
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- Article
The allosteric modulation of complement C5 by knob domain peptides.
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- eLife, 2021, p. 1, doi. 10.7554/eLife.63586
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- Article
Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.
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- PLoS Biology, 2020, v. 18, n. 9, p. 1, doi. 10.1371/journal.pbio.3000821
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- Article
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20825-6
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- Article
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
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- Scientific Reports, 2017, p. 37716, doi. 10.1038/srep37716
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- Article
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.
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- Scientific Reports, 2017, p. 41306, doi. 10.1038/srep41306
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- Article
Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases.
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- Antibodies (2073-4468), 2015, v. 4, n. 3, p. 170, doi. 10.3390/antib4030170
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- Article
Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins.
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- Antibodies (2073-4468), 2014, v. 3, n. 4, p. 289, doi. 10.3390/antib3040289
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- Article
Modular design of bi- and multi-specific knob domain fusions.
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- Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1384467
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- Article
Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery.
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- Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1216967
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- Article
Serum albumin binding knob domains engineered within a V<sub>H</sub> framework III bispecific antibody format and as chimeric peptides.
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- Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1170357
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- Article
Antibody-enabled small-molecule drug discovery.
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- Nature Reviews Drug Discovery, 2012, v. 11, n. 7, p. 519, doi. 10.1038/nrd3756
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- Article
Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F.
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- Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.01894
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- Article
Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
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- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.714055
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- Article