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Using Mendelian Randomisation to search for modifiable risk factors influencing the development of clonal haematopoiesis.
Published in:
2024
By:
- Hislop, Jessica M.;
- Went, Molly;
- Mills, Charlie;
- Sud, Amit;
- Law, Philip J.;
- Houlston, Richard S.
Publication type:
Letter
Exploiting gene dependency to inform drug development for multiple myeloma.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-16940-7
By:
- Went, Molly;
- Hoang, Phuc H.;
- Law, Philip J.;
- Kaiser, Martin F.;
- Houlston, Richard S.
Publication type:
Article
Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
Published in:
Scientific Reports, 2017, p. 41071, doi. 10.1038/srep41071
By:
- Law, Philip J.;
- Sud, Amit;
- Mitchell, Jonathan S.;
- Henrion, Marc;
- Orlando, Giulia;
- Lenive, Oleg;
- Broderick, Peter;
- Speedy, Helen E.;
- Johnson, David C.;
- Kaiser, Martin;
- Weinhold, Niels;
- Cooke, Rosie;
- Sunter, Nicola J.;
- Jackson, Graham H.;
- Summerfield, Geoffrey;
- Harris, Robert J.;
- Pettitt, Andrew R.;
- Allsup, David J.;
- Carmichael, Jonathan;
- Bailey, James R.
Publication type:
Article
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41819-0
By:
- Thomas, Minta;
- Su, Yu-Ru;
- Rosenthal, Elisabeth A.;
- Sakoda, Lori C.;
- Schmit, Stephanie L.;
- Timofeeva, Maria N.;
- Chen, Zhishan;
- Fernandez-Rozadilla, Ceres;
- Law, Philip J.;
- Murphy, Neil;
- Carreras-Torres, Robert;
- Diez-Obrero, Virginia;
- van Duijnhoven, Franzel J. B.;
- Jiang, Shangqing;
- Shin, Aesun;
- Wolk, Alicja;
- Phipps, Amanda I.;
- Burnett-Hartman, Andrea;
- Gsur, Andrea;
- Chan, Andrew T.
Publication type:
Article
Impact of atopy on risk of glioma: a Mendelian randomisation study.
Published in:
2018
By:
- Disney-Hogg, Linden;
- Cornish, Alex J.;
- Sud, Amit;
- Law, Philip J.;
- Kinnersley, Ben;
- Jacobs, Daniel I.;
- Ostrom, Quinn T.;
- Labreche, Karim;
- Eckel-Passow, Jeanette E.;
- Armstrong, Georgina N.;
- Claus, Elizabeth B.;
- Il’yasova, Dora;
- Schildkraut, Joellen;
- Barnholtz-Sloan, Jill S.;
- Olson, Sara H.;
- Bernstein, Jonine L.;
- Lai, Rose K.;
- Schoemaker, Minouk J.;
- Simon, Matthias;
- Hoffmann, Per
Publication type:
journal article
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13069-6
By:
- Vijayakrishnan, Jayaram;
- Qian, Maoxiang;
- Studd, James B.;
- Yang, Wenjian;
- Kinnersley, Ben;
- Law, Philip J.;
- Broderick, Peter;
- Raetz, Elizabeth A.;
- Allan, James;
- Pui, Ching-Hon;
- Vora, Ajay;
- Evans, William E.;
- Moorman, Anthony;
- Yeoh, Allen;
- Yang, Wentao;
- Li, Chunliang;
- Bartram, Claus R.;
- Mullighan, Charles G.;
- Zimmerman, Martin;
- Hunger, Stephen P.
Publication type:
Article
Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11582-2
By:
- Speedy, Helen E.;
- Orlando, Giulia;
- Law, Philip J.;
- Catovsky, Daniel;
- Houlston, Richard S.;
- Beekman, Renée;
- Martín-García, David;
- Beà, Sílvia;
- Clot, Guillem;
- Martín-Subero, José I.;
- Campo, Elias;
- Puente, Xose S.;
- López-Otín, Carlos;
- Chapaprieta, Vicente;
- Gutiérrez-Abril, Jesús;
- Puiggròs, Montserrat;
- Torrents, David;
- Allan, James M.
Publication type:
Article
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09775-w
By:
- Law, Philip J.;
- Timofeeva, Maria;
- Fernandez-Rozadilla, Ceres;
- Broderick, Peter;
- Studd, James;
- Fernandez-Tajes, Juan;
- Farrington, Susan;
- Svinti, Victoria;
- Palles, Claire;
- Orlando, Giulia;
- Sud, Amit;
- Holroyd, Amy;
- Penegar, Steven;
- Theodoratou, Evropi;
- Vaughan-Shaw, Peter;
- Campbell, Harry;
- Zgaga, Lina;
- Hayward, Caroline;
- Campbell, Archie;
- Harris, Sarah
Publication type:
Article
Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08106-9
By:
- Vijayakrishnan, Jayaram;
- Studd, James;
- Broderick, Peter;
- Kinnersley, Ben;
- Holroyd, Amy;
- Law, Philip J.;
- Kumar, Rajiv;
- Allan, James M.;
- Harrison, Christine J.;
- Moorman, Anthony V.;
- Vora, Ajay;
- Roman, Eve;
- Rachakonda, Sivaramakrishna;
- Kinsey, Sally E.;
- Sheridan, Eamonn;
- Thompson, Pamela D.;
- Irving, Julie A.;
- Koehler, Rolf;
- Hoffmann, Per;
- Nöthen, Markus M.
Publication type:
Article
Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08107-8
By:
- Went, Molly;
- Sud, Amit;
- Försti, Asta;
- Halvarsson, Britt-Marie;
- Weinhold, Niels;
- Kimber, Scott;
- van Duin, Mark;
- Thorleifsson, Gudmar;
- Holroyd, Amy;
- Johnson, David C.;
- Ni Li;
- Orlando, Giulia;
- Law, Philip J.;
- Ali, Mina;
- Bowang Chen;
- Mitchell, Jonathan S.;
- Gudbjartsson, Daniel F.;
- Kuiper, Rowan;
- Stephens, Owen W.;
- Bertsch, Uta
Publication type:
Article
Author Correction: Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08105-w
By:
- Sud, Amit;
- Thomsen, Hauke;
- Law, Philip J.;
- Försti, Asta;
- da Silva Filho, Miguel Inacio;
- Holroyd, Amy;
- Broderick, Peter;
- Orlando, Giulia;
- Lenive, Oleg;
- Wright, Lauren;
- Cooke, Rosie;
- Easton, Douglas;
- Pharoah, Paul;
- Dunning, Alison;
- Peto, Julian;
- Canzian, Federico;
- Eeles, Rosalind;
- Kote-Jarai, Zsofia;
- Muir, Kenneth;
- Pashayan, Nora
Publication type:
Article
MADIBA: A web server toolkit for biological interpretation of Plasmodium and plant gene clusters.
Published in:
BMC Genomics, 2008, v. 9, p. 1, doi. 10.1186/1471-2164-9-105
By:
- Law, Philip J.;
- Claudel-Renard, Clotilde;
- Joubert, Fourie;
- Louw, Abraham I.;
- Berger, Dave K.
Publication type:
Article
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis.
Published in:
Neuro-Oncology, 2020, v. 22, n. 2, p. 207, doi. 10.1093/neuonc/noz209
By:
- Saunders, Charlie N;
- Cornish, Alex J;
- Kinnersley, Ben;
- Law, Philip J;
- Claus, Elizabeth B;
- Il'yasova, Dora;
- Schildkraut, Joellen;
- Barnholtz-Sloan, Jill S;
- Olson, Sara H;
- Bernstein, Jonine L;
- Lai, Rose K;
- Chanock, Stephen;
- Rajaraman, Preetha;
- Johansen, Christoffer;
- Jenkins, Robert B;
- Melin, Beatrice S;
- Wrensch, Margaret R;
- Sanson, Marc;
- Bondy, Melissa L;
- Houlston, Richard S
Publication type:
Article
A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study.
Published in:
Neuro-Oncology, 2019, v. 21, n. 8, p. 1039, doi. 10.1093/neuonc/noz088
By:
- Labreche, Karim;
- Daniau, Mailys;
- Sud, Amit;
- Law, Philip J;
- Royer-Perron, Louis;
- Holroyd, Amy;
- Broderick, Peter;
- Went, Molly;
- Benazra, Marion;
- Ahle, Guido;
- Soubeyran, Pierre;
- Taillandier, Luc;
- Chinot, Olivier L;
- Casasnovas, Olivier;
- Bay, Jacques-Olivier;
- Jardin, Fabrice;
- Oberic, Lucie;
- Fabbro, Michel;
- Damaj, Gandhi;
- Brion, Annie
Publication type:
Article
Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis.
Published in:
International Journal of Cancer, 2022, v. 151, n. 1, p. 83, doi. 10.1002/ijc.33945
By:
- Zhou, Xuan;
- Wang, Lijuan;
- Xiao, Jiarui;
- Sun, Jing;
- Yu, Lili;
- Zhang, Han;
- Meng, Xiangrui;
- Yuan, Shuai;
- Timofeeva, Maria;
- Law, Philip J.;
- Houlston, Richard S.;
- Ding, Kefeng;
- Dunlop, Malcolm G.;
- Theodoratou, Evropi;
- Li, Xue
Publication type:
Article
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Published in:
Nature Communications, 2017, v. 8, n. 2, p. 14175, doi. 10.1038/ncomms14175
By:
- Law, Philip J.;
- Berndt, Sonja I.;
- Speedy, Helen E.;
- Camp, Nicola J.;
- Sava, Georgina P.;
- Skibola, Christine F.;
- Holroyd, Amy;
- Joseph, Vijai;
- Sunter, Nicola J.;
- Nieters, Alexandra;
- Bea, Silvia;
- Monnereau, Alain;
- Martin-Garcia, David;
- Goldin, Lynn R.;
- Clot, Guillem;
- Teras, Lauren R.;
- Quintela, Inés;
- Birmann, Brenda M.;
- Jayne, Sandrine;
- Cozen, Wendy
Publication type:
Article
Influence of obesity-related risk factors in the aetiology of glioma.
Published in:
2018
By:
- Disney-Hogg, Linden;
- Sud, Amit;
- Law, Philip J.;
- Cornish, Alex J.;
- Kinnersley, Ben;
- Ostrom, Quinn T.;
- Labreche, Karim;
- Eckel-Passow, Jeanette E.;
- Armstrong, Georgina N.;
- Claus, Elizabeth B.;
- Il’yasova, Dora;
- Schildkraut, Joellen;
- Barnholtz-Sloan, Jill S.;
- Olson, Sara H.;
- Bernstein, Jonine L.;
- Lai, Rose K.;
- Swerdlow, Anthony J.;
- Simon, Matthias;
- Hoffmann, Per;
- Nöthen, Markus M.
Publication type:
journal article
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.
Published in:
2016
By:
- Jarvis, David;
- Mitchell, Jonathan S;
- Law, Philip J;
- Palin, Kimmo;
- Tuupanen, Sari;
- Gylfe, Alexandra;
- Hänninen, Ulrika A;
- Cajuso, Tatiana;
- Tanskanen, Tomas;
- Kondelin, Johanna;
- Kaasinen, Eevi;
- Sarin, Antti-Pekka;
- Kaprio, Jaakko;
- Eriksson, Johan G;
- Rissanen, Harri;
- Knekt, Paul;
- Pukkala, Eero;
- Jousilahti, Pekka;
- Salomaa, Veikko;
- Ripatti, Samuli
Publication type:
journal article
Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 11, p. 2349, doi. 10.1093/hmg/ddw087
By:
- Orlando, Giulia;
- Law, Philip J.;
- Palin, Kimmo;
- Tuupanen, Sari;
- Gylfe, Alexandra;
- Hänninen, Ulrika;
- Cajuso, Tatiana;
- Tanskanen, Tomas;
- Kondelin, Johanna;
- Kaasinen, Eevi;
- Sarin, Antti-Pekka;
- Kaprio, Jaakko;
- Eriksson, Johan G.;
- Rissanen, Harri;
- Knekt, Paul;
- Pukkala, Eero;
- Jousilahti, Pekka;
- Salomaa, Veikko;
- Ripatti, Samuli;
- Palotie, Aarno
Publication type:
Article
Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
Published in:
International Journal of Cancer, 2018, v. 142, n. 3, p. 540, doi. 10.1002/ijc.31076
By:
- Tanskanen, Tomas;
- van den Berg, Linda;
- Välimäki, Niko;
- Aavikko, Mervi;
- Ness‐Jensen, Eivind;
- Hveem, Kristian;
- Wettergren, Yvonne;
- Bexe Lindskog, Elinor;
- Tõnisson, Neeme;
- Metspalu, Andres;
- Silander, Kaisa;
- Orlando, Giulia;
- Law, Philip J.;
- Tuupanen, Sari;
- Gylfe, Alexandra E.;
- Hänninen, Ulrika A.;
- Cajuso, Tatiana;
- Kondelin, Johanna;
- Sarin, Antti‐Pekka;
- Pukkala, Eero
Publication type:
Article
Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.
Published in:
International Journal of Cancer, 2017, v. 140, n. 12, p. 2701, doi. 10.1002/ijc.30709
By:
- Rodriguez‐Broadbent, Henry;
- Law, Philip J.;
- Sud, Amit;
- Palin, Kimmo;
- Tuupanen, Sari;
- Gylfe, Alexandra;
- Hänninen, Ulrika A.;
- Cajuso, Tatiana;
- Tanskanen, Tomas;
- Kondelin, Johanna;
- Kaasinen, Eevi;
- Sarin, Antti‐Pekka;
- Ripatti, Samuli;
- Eriksson, Johan G.;
- Rissanen, Harri;
- Knekt, Paul;
- Pukkala, Eero;
- Jousilahti, Pekka;
- Salomaa, Veikko;
- Palotie, Aarno
Publication type:
Article
Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk.
Published in:
British Journal of Cancer, 2023, v. 129, n. 8, p. 1306, doi. 10.1038/s41416-023-02397-6
By:
- Zhou, Xuan;
- Xiao, Qian;
- Jiang, Fangyuan;
- Sun, Jing;
- Wang, Lijuan;
- Yu, Lili;
- Zhou, Yajing;
- Zhao, Jianhui;
- Zhang, Han;
- Yuan, Shuai;
- Timofeeva, Maria;
- Spiliopoulou, Athina;
- Mesa-Eguiagaray, Ines;
- Farrington, Susan M.;
- Law, Philip J.;
- Houlston, Richard S.;
- Ding, Kefeng;
- Dunlop, Malcolm G.;
- Theodoratou, Evropi;
- Li, Xue
Publication type:
Article
Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank.
Published in:
2022
By:
- Zhang, Xiaomeng;
- Li, Xue;
- He, Yazhou;
- Law, Philip J;
- Farrington, Susan M;
- Campbell, Harry;
- Tomlinson, Ian P M;
- Houlston, Richard S;
- Dunlop, Malcolm G;
- Timofeeva, Maria;
- Theodoratou, Evropi
Publication type:
journal article
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.
Published in:
2021
By:
- Zhang, Xiaomeng;
- Theodoratou, Evropi;
- Li, Xue;
- Farrington, Susan M.;
- Law, Philip J.;
- Broderick, Peter;
- Walker, Marion;
- Klimentidis, Yann C.;
- Rees, Jessica M. B.;
- Houlston, Richard S.;
- Tomlinson, Ian P. M.;
- Burgess, Stephen;
- Campbell, Harry;
- Dunlop, Malcolm G.;
- Timofeeva, Maria
Publication type:
journal article
Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.
Published in:
2021
By:
- Culliford, Richard;
- Cornish, Alex J.;
- Law, Philip J.;
- Farrington, Susan M.;
- Palin, Kimmo;
- Jenkins, Mark A.;
- Casey, Graham;
- Hoffmeister, Michael;
- Brenner, Hermann;
- Chang-Claude, Jenny;
- Kirac, Iva;
- Maughan, Tim;
- Brezina, Stefanie;
- Gsur, Andrea;
- Cheadle, Jeremy P.;
- Aaltonen, Lauri A.;
- Dunlop, Malcom G.;
- Houlston, Richard S.
Publication type:
journal article
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.
Published in:
2021
By:
- Saunders, Charlie N.;
- Cornish, Alex J.;
- Kinnersley, Ben;
- Law, Philip J.;
- Houlston, Richard S.;
- Collaborators;
- Claus, Elizabeth B.;
- Il'yasova, Dora;
- Schildkraut, Joellen;
- Barnholtz-Sloan, Jill S.;
- Olson, Sara H.;
- Bernstein, Jonine L.;
- Lai, Rose K.;
- Chanock, Stephen;
- Rajaraman, Preetha;
- Johansen, Christoffer;
- Jenkins, Robert B.;
- Melin, Beatrice S.;
- Wrensch, Margaret R.;
- Sanson, Marc
Publication type:
journal article
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04989-w
By:
- Went, Molly;
- Sud, Amit;
- Försti, Asta;
- Halvarsson, Britt-Marie;
- Weinhold, Niels;
- Kimber, Scott;
- van Duin, Mark;
- Thorleifsson, Gudmar;
- Holroyd, Amy;
- Johnson, David C.;
- Li, Ni;
- Orlando, Giulia;
- Law, Philip J.;
- Ali, Mina;
- Chen, Bowang;
- Mitchell, Jonathan S.;
- Gudbjartsson, Daniel F.;
- Kuiper, Rowan;
- Stephens, Owen W.;
- Bertsch, Uta
Publication type:
Article
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03178-z
By:
- Vijayakrishnan, Jayaram;
- Studd, James;
- Broderick, Peter;
- Kinnersley, Ben;
- Holroyd, Amy;
- Law, Philip J.;
- Kumar, Rajiv;
- Allan, James M.;
- Harrison, Christine J.;
- Moorman, Anthony V.;
- Vora, Ajay;
- Roman, Eve;
- Rachakonda, Sivaramakrishna;
- Kinsey, Sally E.;
- Sheridan, Eamonn;
- Thompson, Pamela D.;
- Irving, Julie A.;
- Koehler, Rolf;
- Hoffmann, Per;
- Nöthen, Markus M.
Publication type:
Article
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.
Published in:
Nature Communications, 2017, v. 8, n. 12, p. 1, doi. 10.1038/s41467-017-00320-1
By:
- Sud, Amit;
- Thomsen, Hauke;
- Law, Philip J.;
- Försti, Asta;
- da Silva Filho, Miguel Inacio;
- Holroyd, Amy;
- Broderick, Peter;
- Orlando, Giulia;
- Lenive, Oleg;
- Wright, Lauren;
- Cooke, Rosie;
- Easton, Douglas;
- Pharoah, Paul;
- Dunning, Alison;
- Peto, Julian;
- Canzian, Federico;
- Eeles, Rosalind;
- Kote-Jarai, ZSofia;
- Muir, Kenneth;
- Pashayan, Nora
Publication type:
Article
Mendelian randomization provides support for obesity as a risk factor for meningioma.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-36186-6
By:
- Takahashi, Hannah;
- Cornish, Alex J.;
- Sud, Amit;
- Law, Philip J.;
- Disney-Hogg, Linden;
- Calvocoressi, Lisa;
- Lu, Lingeng;
- Hansen, Helen M.;
- Smirnov, Ivan;
- Walsh, Kyle M.;
- Schramm, Johannes;
- Hoffmann, Per;
- Nöthen, Markus M.;
- Jöckel, Karl-Heinz;
- Schildkraut, Joellen M.;
- Simon, Matthias;
- Bondy, Melissa;
- Wrensch, Margaret;
- Wiemels, Joseph L.;
- Claus, Elizabeth B.
Publication type:
Article
Relationship between genetically determined telomere length and glioma risk.
Published in:
Neuro-Oncology, 2022, v. 24, n. 2, p. 171, doi. 10.1093/neuonc/noab208
By:
- Saunders, Charlie N;
- Kinnersley, Ben;
- Culliford, Richard;
- Cornish, Alex J;
- Law, Philip J;
- Houlston, Richard S
Publication type:
Article
Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer.
Published in:
JNCI: Journal of the National Cancer Institute, 2024, v. 116, n. 8, p. 1303, doi. 10.1093/jnci/djae089
By:
- Sun, Jing;
- Zhao, Jianhui;
- Zhou, Siyun;
- Li, Xinxuan;
- Li, Tengfei;
- Wang, Lijuan;
- Yuan, Shuai;
- Chen, Dong;
- Law, Philip J;
- Larsson, Susanna C;
- Farrington, Susan M;
- Houlston, Richard S;
- Dunlop, Malcolm G;
- Theodoratou, Evropi;
- Li, Xue
Publication type:
Article

Found: 32