Works by Lavecchia, Antonio

Results: 41

Synthesis and in vitro cytotoxicity of benzoxazole‐based PPARα/γ antagonists in colorectal cancer cell lines.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 9, p. 1, doi. 10.1002/ardp.202400086

By:

Moreno‐Rodríguez, Nazaret;
Laghezza, Antonio;
Cerchia, Carmen;
Sokolova, Darina V.;
Spirina, Tatiana S.;
De Filippis, Barbara;
Romanelli, Virgilio;
Recio, Rocío;
Fernández, Inmaculada;
Loiodice, Fulvio;
Pokrovsky, Vadim S.;
Ammazzalorso, Alessandra;
Lavecchia, Antonio

Publication type:

Article

N-Formyl Peptide Receptors Induce Radical Oxygen Production in Fibroblasts Derived From Systemic Sclerosis by Interacting With a Cleaved Form of Urokinase Receptor.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00574

By:

Napolitano, Filomena;
Rossi, Francesca Wanda;
Pesapane, Ada;
Varricchio, Silvia;
Ilardi, Gennaro;
Mascolo, Massimo;
Staibano, Stefania;
Lavecchia, Antonio;
Ragno, Pia;
Selleri, Carmine;
Marone, Gianni;
Matucci-Cerinic, Marco;
de Paulis, Amato;
Montuori, Nunzia

Publication type:

Article

CDC25 Inhibition in Acute Myeloid Leukemia-AStudy of Patient Heterogeneity and the Effects of Different Inhibitors.

Published in:

Molecules, 2017, v. 22, n. 3, p. 446, doi. 10.3390/molecules22030446

By:

Brenner, Annette K.;
Reikvam, Håkon;
Rye, Kristin Paulsen;
Hagen, Karen Marie;
Lavecchia, Antonio;
Bruserud, Øystein

Publication type:

Article

Therapeutic Targeting the Cell Division Cycle 25 (CDC25) Phosphatases in Human Acute Myeloid Leukemia — The Possibility to Target Several Kinases through Inhibition of the Various CDC25 Isoforms.

Published in:

Molecules, 2014, v. 19, n. 11, p. 18414, doi. 10.3390/molecules191118414

By:

Brenner, Annette K.;
Reikvam, Håkon;
Lavecchia, Antonio;
Bruserud, Øystein

Publication type:

Article

Inhibition of 37/67kDa Laminin-1 Receptor Restores APP Maturation and Reduces Amyloid-β in Human Skin Fibroblasts from Familial Alzheimer's Disease.

Published in:

Journal of Personalized Medicine, 2020, v. 10, n. 4, p. 232, doi. 10.3390/jpm10040232

By:

Bhattacharya, Antaripa;
Izzo, Antonella;
Mollo, Nunzia;
Napolitano, Filomena;
Limone, Adriana;
Margheri, Francesca;
Mocali, Alessandra;
Minopoli, Giuseppina;
Lo Bianco, Alessandra;
Di Maggio, Federica;
D'Argenio, Valeria;
Montuori, Nunzia;
Lavecchia, Antonio;
Sarnataro, Daniela

Publication type:

Article

Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction.

Published in:

2012

By:

Di Giovanni, Carmen;
Grottesi, Alessandro;
Lavecchia, Antonio

Publication type:

Letter

Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay.

Published in:

ChemMedChem, 2021, v. 16, n. 8, p. 1325, doi. 10.1002/cmdc.202000874

By:

Rabuffetti, Marco;
Rinaldi, Francesca;
Lo Bianco, Alessandra;
Speranza, Giovanna;
Ubiali, Daniela;
Moraes, Marcela Cristina;
Rodrigues Pereira da Silva, Luiz Claudio;
Massolini, Gabriella;
Calleri, Enrica;
Lavecchia, Antonio

Publication type:

Article

A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects.

Published in:

ChemMedChem, 2021, v. 16, n. 3, p. 484, doi. 10.1002/cmdc.202000564

By:

Yasmin, Sabina;
Cerchia, Carmen;
Badavath, Vishnu Nayak;
Laghezza, Antonio;
Dal Piaz, Fabrizio;
Mondal, Susanta K.;
Atlı, Özlem;
Baysal, Merve;
Vadivelan, Sankaran;
Shankar, S.;
Siddique, Mohd Usman Mohd;
Pattnaik, Ashok Kumar;
Singh, Ravi Pratap;
Loiodice, Fulvio;
Jayaprakash, Venkatesan;
Lavecchia, Antonio

Publication type:

Article

Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine‐2,5‐dione Hybrids as Potential Antitumor Agents.

Published in:

ChemMedChem, 2020, v. 15, n. 19, p. 1813, doi. 10.1002/cmdc.202000458

By:

Tilekar, Kalpana;
Upadhyay, Neha;
Meyer‐Almes, Franz‐Josef;
Loiodice, Fulvio;
Anisimova, Natalia Y.;
Spirina, Tatiana S.;
Sokolova, Darina V.;
Smirnova, Galina B.;
Choe, Jun‐yong;
Pokrovsky, Vadim S.;
Lavecchia, Antonio;
S Ramaa, C

Publication type:

Article

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes.

Published in:

ChemMedChem, 2019, v. 14, n. 8, p. 842, doi. 10.1002/cmdc.201900028

By:

Ettari, Roberta;
Cerchia, Carmen;
Maiorana, Santina;
Guccione, Manuela;
Novellino, Ettore;
Bitto, Alessandra;
Grasso, Silvana;
Lavecchia, Antonio;
Zappalà, Maria

Publication type:

Article

Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 825, doi. 10.3390/antiox12040825

By:

Rullo, Rosario;
Cerchia, Carmen;
Nasso, Rosarita;
Romanelli, Virgilio;
Vendittis, Emmanuele De;
Masullo, Mariorosario;
Lavecchia, Antonio

Publication type:

Article

In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans.

Published in:

Antioxidants, 2022, v. 11, n. 4, p. N.PAG, doi. 10.3390/antiox11040785

By:

Cerchia, Carmen;
Roscetto, Emanuela;
Nasso, Rosarita;
Catania, Maria Rosaria;
De Vendittis, Emmanuele;
Lavecchia, Antonio;
Masullo, Mariorosario;
Rullo, Rosario

Publication type:

Article

Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs).

Published in:

ChemMedChem, 2016, v. 11, n. 11, p. 1172, doi. 10.1002/cmdc.201500439

By:

Perrone, Maria Grazia;
Vitale, Paola;
Panella, Andrea;
Ferorelli, Savina;
Contino, Marialessandra;
Lavecchia, Antonio;
Scilimati, Antonio

Publication type:

Article

On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles.

Published in:

ChemMedChem, 2015, v. 10, n. 3, p. 555, doi. 10.1002/cmdc.201402462

By:

Laghezza, Antonio;
Montanari, Roberta;
Lavecchia, Antonio;
Piemontese, Luca;
Pochetti, Giorgio;
Iacobazzi, Vito;
Infantino, Vittoria;
Capelli, Davide;
De Bellis, Michela;
Liantonio, Antonella;
Pierno, Sabata;
Tortorella, Paolo;
Conte Camerino, Diana;
Loiodice, Fulvio

Publication type:

Article

Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents.

Published in:

ChemMedChem, 2014, v. 9, n. 8, p. 1801, doi. 10.1002/cmdc.201402075

By:

Scarbaci, Kety;
Troiano, Valeria;
Ettari, Roberta;
Pinto, Andrea;
Micale, Nicola;
Di Giovanni, Carmen;
Cerchia, Carmen;
Schirmeister, Tanja;
Novellino, Ettore;
Lavecchia, Antonio;
Zappalà, Maria;
Grasso, Silvana

Publication type:

Article

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition.

Published in:

ChemMedChem, 2012, v. 7, n. 4, p. 629, doi. 10.1002/cmdc.201100530

By:

Perrone, Maria Grazia;
Vitale, Paola;
Malerba, Paola;
Altomare, Angela;
Rizzi, Rosanna;
Lavecchia, Antonio;
Di Giovanni, Carmen;
Novellino, Ettore;
Scilimati, Antonio

Publication type:

Article

Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARα and PPARγ Agonist Activity.

Published in:

ChemMedChem, 2007, v. 2, n. 5, p. 641, doi. 10.1002/cmdc.200600307

By:

Fracchiolla, Giuseppe;
Laghezza, Antonio;
Piemontese, Luca;
Carbonara, Giuseppe;
Lavecchia, Antonio;
Tortorella, Paolo;
Crestani, Maurizio;
Novellino, Ettore;
Loiodice, Fulvio

Publication type:

Article

Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2).

Published in:

ChemMedChem, 2006, v. 1, n. 12, p. 1379, doi. 10.1002/cmdc.200600122

By:

Lavecchia, Antonio;
Costi, Roberta;
Artico, Marino;
Miele, Gaetano;
Novellino, Ettore;
Bergamini, Alberto;
Crespan, Emmanuele;
Maga, Giovanni;
Di Santo, Roberto

Publication type:

Article

Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 1).

Published in:

ChemMedChem, 2006, v. 1, n. 12, p. 1367, doi. 10.1002/cmdc.200600119

By:

Di Santo, Roberto;
Costi, Roberta;
Artico, Marino;
Miele, Gaetano;
Lavecchia, Antonio;
Novellino, Ettore;
Bergamini, Alberto;
Cancio, Reynel;
Maga, Giovanni

Publication type:

Article

Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism.

Published in:

ChemMedChem, 2006, v. 1, n. 5, p. 540, doi. 10.1002/cmdc.200500092

By:

Lavecchia, Antonio;
Cosconati, Sandro;
Limongelli, Vittorio;
Novellino, Ettore

Publication type:

Article

Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.

Published in:

ChemMedChem, 2006, v. 1, n. 1, p. 82, doi. 10.1002/cmdc.200500020

By:

Di Santo, Roberto;
Costi, Roberta;
Artico, Marino;
Ragno, Rino;
Lavecchia, Antonio;
Novellino, Ettore;
Gavuzzo, Enrico;
La Torre, Francesco;
Cirilli, Roberto;
Cancio, Reynel;
Maga, Giovanni

Publication type:

Article

Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41765-2

By:

Sabatino, Lina;
Ziccardi, Pamela;
Cerchia, Carmen;
Muccillo, Livio;
Piemontese, Luca;
Loiodice, Fulvio;
Colantuoni, Vittorio;
Lupo, Angelo;
Lavecchia, Antonio

Publication type:

Article

A<sub>1</sub> adenosine receptor antagonists, 3-aryl[1,2,4]triazino[4,3- a]benzimidazol-4-(10 H)-ones (ATBIs) and N-alkyl and N-acyl-(7-substituted-2-phenylimidazo[1,2- a][1,3,5]triazin-4-yl)amines (ITAs): Different recognition of bovine and human binding sites

Published in:

Drug Development Research, 2004, v. 63, n. 1, p. 1, doi. 10.1002/ddr.10366

By:

Da Settimo, Federico;
Primofiore, Giampaolo;
Taliani, Sabrina;
La Motta, Concettina;
Novellino, Ettore;
Greco, Giovanni;
Lavecchia, Antonio;
Cosimelli, Barbara;
Iadanza, Manuela;
Klotz, Karl-Norbert;
Tuscano, Daniela;
Trincavelli, Maria Letizia;
Martini, Claudia

Publication type:

Article

Editorial: Recent trends in anti-cancer drug discovery by in silico methods.

Published in:

Frontiers in Drug Discovery, 2024, p. 1, doi. 10.3389/fddsv.2024.1420267

By:

Cerchia, Carmen;
Basurto, Jose Correa;
Lupo, Angelo;
Lavecchia, Antonio

Publication type:

Article

Deep generative models in the quest for anticancer drugs: ways forward.

Published in:

Frontiers in Drug Discovery, 2024, p. 1, doi. 10.3389/fddsv.2024.1362956

By:

Romanelli, Virgilio;
Cerchia, Carmen;
Lavecchia, Antonio

Publication type:

Article

The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 6, p. 3156, doi. 10.3390/ijms25063156

By:

Napolitano, Filomena;
Rossi, Francesca Wanda;
de Paulis, Amato;
Lavecchia, Antonio;
Montuori, Nunzia

Publication type:

Article

Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11390, doi. 10.3390/ijms231911390

By:

Bellone, Maria Laura;
Fiengo, Lorenzo;
Cerchia, Carmen;
Cotugno, Roberta;
Bader, Ammar;
Lavecchia, Antonio;
De Tommasi, Nunziatina;
Piaz, Fabrizio Dal

Publication type:

Article

Antagonizing S1P 3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8861, doi. 10.3390/ijms22168861

By:

Corvino, Angela;
Cerqua, Ida;
Lo Bianco, Alessandra;
Caliendo, Giuseppe;
Fiorino, Ferdinando;
Frecentese, Francesco;
Magli, Elisa;
Morelli, Elena;
Perissutti, Elisa;
Santagada, Vincenzo;
Cirino, Giuseppe;
Granato, Elisabetta;
Roviezzo, Fiorentina;
Puliti, Elisa;
Bernacchioni, Caterina;
Lavecchia, Antonio;
Donati, Chiara;
Severino, Beatrice

Publication type:

Article

APP Maturation and Intracellular Localization Are Controlled by a Specific Inhibitor of 37/67 kDa Laminin-1 Receptor in Neuronal Cells.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 5, p. 1738, doi. 10.3390/ijms21051738

By:

Bhattacharya, Antaripa;
Limone, Adriana;
Napolitano, Filomena;
Cerchia, Carmen;
Parisi, Silvia;
Minopoli, Giuseppina;
Montuori, Nunzia;
Lavecchia, Antonio;
Sarnataro, Daniela

Publication type:

Article

Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016).

Published in:

Expert Opinion on Investigational Drugs, 2016, v. 25, n. 10, p. 1215, doi. 10.1080/13543784.2016.1234603

By:

Di Giovanni, Carmen;
Novellino, Ettore;
Chilin, Adriana;
Lavecchia, Antonio;
Marzaro, Giovanni

Publication type:

Article

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability.

Published in:

Scientific Reports, 2017, p. 41273, doi. 10.1038/srep41273

By:

Vasaturo, Michele;
Fiengo, Lorenzo;
De Tommasi, Nunziatina;
Sabatino, Lina;
Ziccardi, Pamela;
Colantuoni, Vittorio;
Bruno, Maurizio;
Cerchia, Carmen;
Novellino, Ettore;
Lupo, Angelo;
Lavecchia, Antonio;
Piaz, Fabrizio Dal

Publication type:

Article

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode.

Published in:

Scientific Reports, 2016, p. 34792, doi. 10.1038/srep34792

By:

Capelli, Davide;
Cerchia, Carmen;
Montanari, Roberta;
Loiodice, Fulvio;
Tortorella, Paolo;
Laghezza, Antonio;
Cervoni, Laura;
Pochetti, Giorgio;
Lavecchia, Antonio

Publication type:

Article

The 37/67kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67kDa LR cell surface localization and interaction with the cellular prion protein.

Published in:

Scientific Reports, 2016, p. 24457, doi. 10.1038/srep24457

By:

Sarnataro, Daniela;
Pepe, Anna;
Altamura, Gennaro;
De Simone, Imma;
Pesapane, Ada;
Nitsch, Lucio;
Montuori, Nunzia;
Lavecchia, Antonio;
Zurzolo, Chiara

Publication type:

Article

A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1488722

By:

Ammazzalorso, Alessandra;
Tacconelli, Stefania;
Contursi, Annalisa;
Hofling, Ulrika;
Cerchia, Carmen;
Di Berardino, Sara;
De Michele, Alessandra;
Amoroso, Rosa;
Lavecchia, Antonio;
Patrignani, Paola

Publication type:

Article

Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1866, doi. 10.1080/14756366.2020.1819257

By:

Aliotta, Federica;
Nasso, Rosarita;
Rullo, Rosario;
Arcucci, Alessandro;
Avagliano, Angelica;
Simonetti, Martina;
Sanità, Gennaro;
Masullo, Mariorosario;
Lavecchia, Antonio;
Ruocco, Maria Rosaria;
Vendittis, Emmanuele De

Publication type:

Article

Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells.

Published in:

Cells (2073-4409), 2022, v. 11, n. 3, p. 466, doi. 10.3390/cells11030466

By:

Limone, Adriana;
Veneruso, Iolanda;
Izzo, Antonella;
Renna, Maurizio;
Bonavita, Raffaella;
Piscitelli, Silvia;
Calì, Gaetano;
De Nicola, Sergio;
Riccio, Patrizia;
D'Argenio, Valeria;
Lavecchia, Antonio;
Sarnataro, Daniela

Publication type:

Article

Amorfrutins are efficient modulators of peroxisome proliferator-activated receptor gamma (PPARγ) with potent antidiabetic and anticancer properties: a patent evaluation of WO2014177593 A1.

Published in:

Expert Opinion on Therapeutic Patents, 2015, v. 25, n. 11, p. 1341, doi. 10.1517/13543776.2015.1076393

By:

Lavecchia, Antonio;
Di Giovanni, Carmen

Publication type:

Article

HDAC4 Inhibitors with Cyclic Linker and Non‐hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation.

Published in:

ChemistrySelect, 2021, v. 6, n. 26, p. 6748, doi. 10.1002/slct.202102061

By:

Tilekar, Kalpana;
Hess, Jessica D.;
Upadhyay, Neha;
Schweipert, Markus;
Flath, Felix;
Gutierrez, Denisse A.;
Loiodice, Fulvio;
Lavecchia, Antonio;
Meyer‐Almes, Franz‐Josef;
Aguilera, Renato J.;
Ramaa, C. S.

Publication type:

Article

Cladosporols and PPARγ: Same Gun, Same Bullet, More Targets.

Published in:

Biomolecules (2218-273X), 2024, v. 14, n. 8, p. 998, doi. 10.3390/biom14080998

By:

Rapuano, Roberta;
Mercuri, Antonella;
Dallavalle, Sabrina;
Moricca, Salvatore;
Lavecchia, Antonio;
Lupo, Angelo

Publication type:

Article

In Silico Drug Design and Discovery: Big Data for Small Molecule Design.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 1, p. 44, doi. 10.3390/biom13010044

By:

Cerchia, Carmen;
Lavecchia, Antonio

Publication type:

Article

Synthesis and Structural Analysis of Cyclic Oligomers Consisting of Furanoid and Pyranoid ε-Sugar Amino Acids.

Published in:

European Journal of Organic Chemistry, 2003, v. 2003, n. 12, p. 2303, doi. 10.1002/ejoc.200300031

By:

Renate M. van Well;
Luciana Marinelli;
Kees Erkelens;
Gijsbert A. van der Marel;
Antonio Lavecchia;
Herman S. Overkleeft;
Jacques H. van Boom;
Horst Kessler;
Mark Overhand

Publication type:

Article