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Conformation- and activation-based BRET sensors differentially report on GPCR–G protein coupling.
- Published in:
- Science Signaling, 2024, v. 17, n. 841, p. 1, doi. 10.1126/scisignal.adi4747
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- Publication type:
- Article
Robust and Seamless Integration of Thiol‐Ene‐Epoxy Thermosets with Thermoplastics and Glass as Hybrid Microfluidic Devices Suitable for Drug Studies.
- Published in:
- Advanced Materials Interfaces, 2024, v. 11, n. 14, p. 1, doi. 10.1002/admi.202300972
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- Publication type:
- Article
Consequences of Amyloid‐β Deficiency for the Liver.
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- Advanced Science, 2024, v. 11, n. 18, p. 1, doi. 10.1002/advs.202307734
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- Publication type:
- Article
Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety Assessments.
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- Advanced Healthcare Materials, 2024, v. 13, n. 11, p. 1, doi. 10.1002/adhm.202303561
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- Publication type:
- Article
Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences.
- Published in:
- Human Genomics, 2024, v. 18, n. 1, p. 1, doi. 10.1186/s40246-024-00610-y
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- Publication type:
- Article
Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety Assessments.
- Published in:
- Advanced Healthcare Materials, 2024, v. 13, n. 11, p. 1, doi. 10.1002/adhm.202303561
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- Publication type:
- Article
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
- Published in:
- Molecular Systems Biology, 2024, v. 20, n. 4, p. 374, doi. 10.1038/s44320-024-00024-x
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- Publication type:
- Article
Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models.
- Published in:
- Biotechnology Journal, 2024, v. 19, n. 3, p. 1, doi. 10.1002/biot.202300684
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- Publication type:
- Article
The choice of ultra‐low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function.
- Published in:
- Biotechnology Journal, 2024, v. 19, n. 2, p. 1, doi. 10.1002/biot.202300587
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- Publication type:
- Article
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45122-4
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- Publication type:
- Article
The choice of ultra‐low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function.
- Published in:
- Biotechnology Journal, 2024, v. 19, n. 2, p. 1, doi. 10.1002/biot.202300587
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- Publication type:
- Article
Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis.
- Published in:
- Diabetologia, 2024, v. 67, n. 1, p. 137, doi. 10.1007/s00125-023-06020-4
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- Publication type:
- Article
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection.
- Published in:
- EMBO Journal, 2023, v. 42, n. 23, p. 1, doi. 10.15252/embj.2023114086
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- Publication type:
- Article
Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling.
- Published in:
- 2023
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- Publication type:
- Editorial
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41893-4
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- Publication type:
- Article
Structural variation of the coding and non-coding human pharmacogenome.
- Published in:
- NPJ Genomic Medicine, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41525-023-00371-y
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- Publication type:
- Article
Two different isoforms of osteopontin modulate myelination and axonal integrity.
- Published in:
- FASEB Bioadvances, 2023, v. 5, n. 8, p. 336, doi. 10.1096/fba.2023-00030
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- Publication type:
- Article
Incorporating New Approach Methodologies into Regulatory Nonclinical Pharmaceutical Safety Assessment.
- Published in:
- Altex, 2023, v. 40, n. 3, p. 519, doi. 10.14573/altex.2212081
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- Publication type:
- Article
Rewiring of catecholamine‐induced calcium signalling is an early event in non‐alcoholic fatty liver disease.
- Published in:
- Journal of Physiology, 2023, v. 601, n. 8, p. 1317, doi. 10.1113/JP284526
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- Publication type:
- Article
Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences.
- Published in:
- Human Genomics, 2023, v. 17, n. 1, p. 1, doi. 10.1186/s40246-023-00461-z
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- Publication type:
- Article
Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia.
- Published in:
- Advanced Science, 2022, v. 9, n. 34, p. 1, doi. 10.1002/advs.202203368
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- Publication type:
- Article
A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing.
- Published in:
- Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 6, p. 452, doi. 10.1111/bcpt.13779
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- Publication type:
- Article
PharmVar GeneFocus: CYP3A5.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 6, p. 1159, doi. 10.1002/cpt.2563
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- Publication type:
- Article
CFTR reduces the proliferation of lung adenocarcinoma and is a strong predictor of survival in both smokers and non-smokers.
- Published in:
- Journal of Cancer Research & Clinical Oncology, 2022, v. 148, n. 12, p. 3293, doi. 10.1007/s00432-022-04106-x
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- Publication type:
- Article
ORGANOTYPIC AND MICROPHYSIOLOGICAL HUMAN TISSUE MODELS FOR TRANSLATIONAL TOXICOLOGY AND PHARMACOLOGY.
- Published in:
- 2022
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- Publication type:
- Abstract
TACRINE-SQUARAMIDE DERIVATIVES AS POTENT CHOLINESTERASE INHIBITORS.
- Published in:
- 2022
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- Publication type:
- Abstract
CYP2C19 and CYP2D6 Genotypes and Metabolizer Status Distribution in a Bulgarian Psychiatric Cohort.
- Published in:
- Journal of Personalized Medicine, 2022, v. 12, n. 7, p. 1187, doi. 10.3390/jpm12071187
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- Publication type:
- Article
Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health.
- Published in:
- Human Genetics, 2022, v. 141, n. 6, p. 1113, doi. 10.1007/s00439-021-02385-x
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- Publication type:
- Article
Genetic Variant ABCC1 rs45511401 Is Associated with Increased Response to Statins in Patients with Familial Hypercholesterolemia.
- Published in:
- Pharmaceutics, 2022, v. 14, n. 5, p. 944, doi. 10.3390/pharmaceutics14050944
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- Publication type:
- Article
Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds.
- Published in:
- AAPS Journal, 2022, v. 24, n. 2, p. 1, doi. 10.1208/s12248-022-00689-y
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- Publication type:
- Article
An overlooked subset of Cx3cr1<sup>wt/wt</sup> microglia in the Cx3cr1<sup>CreER-Eyfp/wt</sup> mouse has a repopulation advantage over Cx3cr1<sup>CreER-Eyfp/wt</sup> microglia following microglial depletion.
- Published in:
- 2022
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- Publication type:
- journal article
3D human liver spheroids for translational pharmacology and toxicology.
- Published in:
- Basic & Clinical Pharmacology & Toxicology, 2022, v. 130, p. 5, doi. 10.1111/bcpt.13587
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- Publication type:
- Article
Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 3, p. 626, doi. 10.1002/cpt.2289
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- Publication type:
- Article
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.
- Published in:
- Advanced Science, 2021, v. 8, n. 16, p. 1, doi. 10.1002/advs.202100106
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- Publication type:
- Article
Editorial: Population Pharmacogenomics (PGx): From Variant Identification to Clinical Implementation.
- Published in:
- 2021
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- Publication type:
- Editorial
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.
- Published in:
- Advanced Science, 2021, v. 8, n. 16, p. 1, doi. 10.1002/advs.202100106
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- Publication type:
- Article
PharmVar GeneFocus: CYP2B6.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 1, p. 82, doi. 10.1002/cpt.2166
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- Publication type:
- Article
The prevalence, genetic complexity and population-specific founder effects of human autosomal recessive disorders.
- Published in:
- NPJ Genomic Medicine, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41525-021-00203-x
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- Publication type:
- Article
Magnesium enhances cardiomyocyte proliferation and suppresses cardiac fibrosis induced by chronic ACTH exposure in rats.
- Published in:
- Magnesium Research, 2021, v. 34, n. 2, p. 74, doi. 10.1684/mrh.2021.0484
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- Publication type:
- Article
Insulin-dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific glucose sensor with nanoliter input volume.
- Published in:
- FASEB Journal, 2021, v. 35, n. 3, p. 1, doi. 10.1096/fj.202001989RR
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- Publication type:
- Article
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection.
- Published in:
- EMBO Molecular Medicine, 2021, v. 13, n. 1, p. 1, doi. 10.15252/emmm.202013426
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- Publication type:
- Article
Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 160, doi. 10.1002/cpt.1944
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- Publication type:
- Article
Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.
- Published in:
- 2020
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- Publication type:
- journal article
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes.
- Published in:
- Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 844, doi. 10.1002/cpt.1860
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- Publication type:
- Article
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients.
- Published in:
- EMBO Molecular Medicine, 2020, v. 12, n. 8, p. 1, doi. 10.15252/emmm.202012697
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- Publication type:
- Article
A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration.
- Published in:
- Advanced Science, 2020, v. 7, n. 15, p. 1, doi. 10.1002/advs.202000248
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- Publication type:
- Article
Documentation of clinically relevant genomic biomarker allele frequencies in the next‐generation FINDbase worldwide database.
- Published in:
- Human Mutation, 2020, v. 41, n. 6, p. 1112, doi. 10.1002/humu.24018
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- Publication type:
- Article
Ethnogeographic and inter-individual variability of human ABC transporters.
- Published in:
- Human Genetics, 2020, v. 139, n. 5, p. 623, doi. 10.1007/s00439-020-02150-6
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- Publication type:
- Article
Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients.
- Published in:
- International Journal of Cancer, 2020, v. 146, n. 9, p. 2475, doi. 10.1002/ijc.32898
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- Publication type:
- Article
Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation.
- Published in:
- NPJ Genomic Medicine, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41525-020-0119-2
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- Publication type:
- Article