Works by Lauffenburger, Douglas A.

Results: 179

Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1601420

By:

Datta, Anisha;
Bahlmann, Laura C.;
Gong, Diana N.;
Tevonian, Erin N.;
Lorens, James B.;
Lauffenburger, Douglas A.

Publication type:

Article

Flexible informatics for linking experimental data to mathematical models via DataRail.

Published in:

Bioinformatics, 2008, v. 24, n. 6, p. 840, doi. 10.1093/bioinformatics/btn018

By:

Julio Saez-Rodriguez;
Arthur Goldsipe;
Jeremy Muhlich;
Leonidas G. Alexopoulos;
Bjorn Millard;
Douglas A. Lauffenburger;
Peter K. Sorger

Publication type:

Article

Towards an interpretable deep learning model of cancer.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00822-y

By:

Nilsson, Avlant;
Meimetis, Nikolaos;
Lauffenburger, Douglas A.

Publication type:

Article

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.

Published in:

Science Immunology, 2018, v. 3, n. 26, p. 1, doi. 10.1126/sciimmunol.aat7796

By:

Lofano, Giuseppe;
Gorman, Matthew J.;
Yousif, Ashraf S.;
Wen-Han Yu;
Fox, Julie M.;
Dugast, Anne-Sophie;
Ackerman, Margaret E.;
Suscovich, Todd J.;
Weiner, Joshua;
Barouch, Dan;
Streeck, Hendrik;
Little, Susan;
Smith, Davey;
Richman, Douglas;
Lauffenburger, Douglas;
Walker, Bruce D.;
Diamond, Michael S.;
Alter, Galit

Publication type:

Article

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.

Published in:

Fluids & Barriers of the CNS, 2017, v. 14, p. 1, doi. 10.1186/s12987-017-0070-5

By:

Conrad, Catharina;
Dorzweiler, Kristina;
Miller, Miles A.;
Lauffenburger, Douglas A.;
Strik, Herwig;
Bartsch, Jörg W.

Publication type:

Article

Translatable pathways classification (TransPath-C) for inferring processes germane to human biology from animal studies data: example application in neurobiology.

Published in:

Integrative Biology, 2021, v. 13, n. 10, p. 237, doi. 10.1093/intbio/zyab016

By:

Carroll, Molly J;
Garcia-Reyero, Natàlia;
Perkins, Edward J;
Lauffenburger, Douglas A

Publication type:

Article

Cell surface integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.

Published in:

Integrative Biology, 2021, v. 13, n. 6, p. 153, doi. 10.1093/intbio/zyab009

By:

Starchenko, Alina;
Graves-Deal, Ramona;
Brubaker, Douglas;
Li, Cunxi;
Yang, Yuping;
Singh, Bhuminder;
Coffey, Robert J;
Lauffenburger, Douglas A

Publication type:

Article

Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Published in:

Integrative Biology, 2019, v. 11, n. 7, p. 301, doi. 10.1093/intbio/zyz025

By:

Strasser, Samantha Dale;
Ghazi, Phaedra C;
Starchenko, Alina;
Boukhali, Myriam;
Edwards, Amanda;
Suarez-Lopez, Lucia;
Lyons, Jesse;
Changelian, Paul S;
Monahan, Joseph B;
Jacobsen, Jon;
Brubaker, Douglas K;
Joughin, Brian A;
Yaffe, Michael B;
Haas, Wilhelm;
Lauffenburger, Douglas A;
Haigis, Kevin M

Publication type:

Article

A new publisher for our new biology.

Published in:

Integrative Biology, 2019, v. 11, n. 1, p. 3, doi. 10.1093/intbio/zyy001

By:

Lauffenburger, Douglas A

Publication type:

Article

An engineering design approach to systems biology.

Published in:

Integrative Biology, 2017, v. 9, n. 7, p. 574, doi. 10.1039/c7ib00014f

By:

Janes, Kevin A.;
Chandran, Preethi L.;
Ford, Roseanne M.;
Lazzara, Matthew J.;
Papin, Jason A.;
Peirce, Shayn M.;
Saucerman, Jeffrey J.;
Lauffenburger, Douglas A.

Publication type:

Article

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function.

Published in:

Integrative Biology, 2017, v. 9, n. 4, p. 271, doi. 10.1039/c6ib00245e

By:

Cook, Christi D.;
Hill, Abby S.;
Guo, Margaret;
Stockdale, Linda;
Papps, Julia P.;
Isaacson, Keith B.;
Lauffenburger, Douglas A.;
Griffith, Linda G.

Publication type:

Article

Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia.

Published in:

Integrative Biology, 2016, v. 8, n. 7, p. 761, doi. 10.1039/c6ib00040a

By:

Wilson, Jennifer L.;
Dalin, Simona;
Gosline, Sara;
Hemann, Michael;
Fraenkel, Ernest;
Lauffenburger, Douglas A.

Publication type:

Article

Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.

Published in:

Integrative Biology, 2016, v. 8, n. 1, p. 73, doi. 10.1039/c5ib00283d

By:

Gordonov, Simon;
Hwang, Mun Kyung;
Wells, Alan;
Gertler, Frank B.;
Lauffenburger, Douglas A.;
Bathe, Mark

Publication type:

Article

Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury.

Published in:

Integrative Biology, 2015, v. 7, n. 8, p. 904, doi. 10.1039/c4ib00294f

By:

Melas, Ioannis N.;
Sakellaropoulos, Theodore;
Iorio, Francesco;
Alexopoulos, Leonidas G.;
Loh, Wei-Yin;
Lauffenburger, Douglas A.;
Saez-Rodriguez, Julio;
Bai, Jane P. F.

Publication type:

Article

High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.

Published in:

Integrative Biology, 2015, v. 7, n. 5, p. 513, doi. 10.1039/c5ib00019j

By:

Wu, Lidan;
Claas, Allison M.;
Sarkar, Aniruddh;
Lauffenburger, Douglas A.;
Han, Jongyoon

Publication type:

Article

Evolution of a Biological Journal.

Published in:

Integrative Biology, 2014, v. 6, n. 1, p. 8, doi. 10.1039/c3ib90043f

By:

Lauffenburger, Douglas A.

Publication type:

Article

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

Published in:

Integrative Biology, 2013, v. 5, n. 11, p. 1355, doi. 10.1039/c3ib40062j

By:

Lau, Ken S.;
Schrier, Sarah B.;
Gierut, Jessica;
Lyons, Jesse;
Lauffenburger, Douglas A.;
Haigis, Kevin M.

Publication type:

Article

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Published in:

Integrative Biology, 2013, v. 5, n. 7, p. 940, doi. 10.1039/c3ib40013a

By:

Miraldi, Emily R.;
Sharfi, Hadar;
Friedline, Randall H.;
Johnson, Hannah;
Zhang, Tejia;
Lau, Ken S.;
Ko, Hwi Jin;
Curran, Timothy G.;
Haigis, Kevin M.;
Yaffe, Michael B.;
Bonneau, Richard;
Lauffenburger, Douglas A.;
Kahn, Barbara B.;
Kim, Jason K.;
Neel, Benjamin G.;
Saghatelian, Alan;
White, Forest M.

Publication type:

Article

Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines.

Published in:

Integrative Biology, 2013, v. 5, n. 3, p. 510, doi. 10.1039/c2ib20090b

By:

Rimchala, Tharathorn;
Kamm, Roger D.;
Lauffenburger, Douglas A.

Publication type:

Article

Our new look at biology.

Published in:

Integrative Biology, 2013, v. 5, n. 1, p. 15, doi. 10.1039/c2ib90056d

By:

Lauffenburger, Douglas A.

Publication type:

Article

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.

Published in:

Integrative Biology, 2012, v. 4, n. 10, p. 1237, doi. 10.1039/c2ib20091k

By:

Noonan, Ericka M.;
Shah, Dharini;
Yaffe, Michael B.;
Lauffenburger, Douglas A.;
Samson, Leona D.

Publication type:

Article

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.

Published in:

Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-1949-z

By:

Holland, Christian H.;
Tanevski, Jovan;
Perales-Patón, Javier;
Gleixner, Jan;
Kumar, Manu P.;
Mereu, Elisabetta;
Joughin, Brian A.;
Stegle, Oliver;
Lauffenburger, Douglas A.;
Heyn, Holger;
Szalai, Bence;
Saez-Rodriguez, Julio

Publication type:

Article

Modeling of signalresponse cascades using decision tree analysis.

Published in:

Bioinformatics, 2005, v. 21, n. 9, p. 2027, doi. 10.1093/bioinformatics/bti278

By:

Sampsa Hautaniemi;
Sourabh Kharait;
Akihiro Iwabu;
Alan Wells;
Douglas A. Lauffenburger

Publication type:

Article

Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.

Published in:

Bioinformatics, 2005, v. 21, n. 6, p. 741, doi. 10.1093/bioinformatics/bti056

By:

Peter J. Woolf;
Wendy Prudhomme;
Laurence Daheron;
George Q. Daley;
Douglas A. Lauffenburger

Publication type:

Article

Mena binds α5 integrin directly and modulates α5β1 function.

Published in:

Journal of Cell Biology, 2012, v. 198, n. 4, p. 657, doi. 10.1083/jcb.201202079

By:

Gupton, Stephanie L.;
Riquelme, Daisy;
Hughes-Alford, Shannon K.;
Tadros, Jenny;
Rudina, Shireen S.;
Hynes, Richard O.;
Lauffenburger, Douglas;
Gertler, Frank B.

Publication type:

Article

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis.

Published in:

Arthritis & Rheumatology, 2018, v. 70, n. 4, p. 566, doi. 10.1002/art.40399

By:

Fleury, Michelle;
Belkina, Anna C.;
Proctor, Elizabeth A.;
Zammitti, Christopher;
Simms, Robert W.;
Lauffenburger, Douglas A.;
Snyder‐Cappione, Jennifer E.;
Lafyatis, Robert;
Dooms, Hans

Publication type:

Article

Differential Levels of Soluble Inflammatory Markers by Human Immunodeficiency Virus Controller Status and Demographics.

Published in:

Open Forum Infectious Diseases, 2015, v. 2, n. 1, p. 1, doi. 10.1093/ofid/ofu117

By:

Li, Jonathan Z.;
Arnold, Kelly B.;
Lo, Janet;
Dugast, Anne-Sophie;
Plants, Jill;
Ribaudo, Heather J.;
Cesa, Kevin;
Heisey, Andrea;
Kuritzkes, Daniel R.;
Lauffenburger, Douglas A.;
Alter, Galit;
Landay, Alan;
Grinspoon, Steven;
Pereyra, Florencia

Publication type:

Article

Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09319-1

By:

Dalin, Simona;
Grauman-Boss, Beatrice;
Lauffenburger, Douglas A.;
Hemann, Michael T.

Publication type:

Article

Artificial neural networks enable genome-scale simulations of intracellular signaling.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30684-y

By:

Nilsson, Avlant;
Peters, Joshua M.;
Meimetis, Nikolaos;
Bryson, Bryan;
Lauffenburger, Douglas A.

Publication type:

Article

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27201-y

By:

Herman, Jonathan D.;
Wang, Chuangqi;
Loos, Carolin;
Yoon, Hyunah;
Rivera, Johanna;
Eugenia Dieterle, M.;
Haslwanter, Denise;
Jangra, Rohit K.;
Bortz III, Robert H.;
Bar, Katharine J.;
Julg, Boris;
Chandran, Kartik;
Lauffenburger, Douglas;
Pirofski, Liise-anne;
Alter, Galit

Publication type:

Article

Growth Factor-Induced Cell Motility in Tumor Invasion.

Published in:

Acta Oncologica, 2002, v. 41, n. 2, p. 124, doi. 10.1080/028418602753669481

By:

Wells, Alan;
Kassis, Jareer;
Solava, James;
Turner, Timothy;
Lauffenburger, Douglas A.

Publication type:

Article

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.

Published in:

Science Signaling, 2018, v. 11, n. 520, p. 1, doi. 10.1126/scisignal.aal1601

By:

Jones, Douglas S.;
Jenney, Anne P.;
Joughin, Brian A.;
Sorger, Peter K.;
Lauffenburger, Douglas A.

Publication type:

Article

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis.

Published in:

Science Signaling, 2018, v. 11, n. 519, p. 1, doi. 10.1126/scisignal.aan3580

By:

Lyons, Jesse;
Brubaker, Douglas K.;
Ghazi, Phaedra C.;
Baldwin, Katherine R.;
Edwards, Amanda;
Boukhali, Myriam;
Strasser, Samantha Dale;
Suarez-Lopez, Lucia;
Lin, Yi-Jang;
Yajnik, Vijay;
Kissil, Joseph L.;
Haas, Wilhelm;
Lauffenburger, Douglas A.;
Haigis, Kevin M.

Publication type:

Article

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.

Published in:

Science Signaling, 2016, v. 9, n. 431, p. 1, doi. 10.1126/scisignal.aad3373

By:

Chitforoushzadeh, Zeinab;
Zi Ye;
Sheng, Ziran;
LaRue, Silvia;
Fry, Rebecca C.;
Lauffenburger, Douglas A.;
Janes, Kevin A.

Publication type:

Article

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Published in:

Science Signaling, 2015, v. 8, n. 407, p. 1, doi. 10.1126/scisignal.aac7235

By:

Gierut, Jessica J.;
Wood, Levi B.;
Lau, Ken S.;
Yi-Jang Lin;
Genetti, Casie;
Samatar, Ahmed A.;
Lauffenburger, Douglas A.;
Haigis, Kevin M.

Publication type:

Article

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals.

Published in:

Science Signaling, 2015, v. 8, n. 399, p. 1, doi. 10.1126/scisignal.aab0808

By:

Arnold, Kelly B.;
Szeto, Gregory L.;
Alter, Galit;
Irvine, Darrell J.;
Lauffenburger, Douglas A.

Publication type:

Article

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.

Published in:

Science Signaling, 2015, v. 8, n. 378, p. 1, doi. 10.1126/scisignal.aaa1977

By:

Travers, Timothy;
Camacho, Carlos J.;
Hanshuang Shao;
Wells, Alan;
Joughin, Brian A.;
Lauffenburger, Douglas A.

Publication type:

Article

Prioritisation and Network Analysis of Crohn's Disease Susceptibility Genes.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0108624

By:

Muraro, Daniele;
Lauffenburger, Douglas A.;
Simmons, Alison

Publication type:

Article

PKCδ Localization at the Membrane Increases Matrix Traction Force Dependent on PLCγ1/EGFR Signaling.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077434

By:

Jamison, Joshua;
Lauffenburger, Douglas;
Wang, James C.-H.;
Wells, Alan

Publication type:

Article

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050085

By:

Mitsos, Alexander;
Melas, Ioannis N.;
Morris, Melody K.;
Saez-Rodriguez, Julio;
Lauffenburger, Douglas A.;
Alexopoulos, Leonidas G.

Publication type:

Article

BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041343

By:

Lau, Ken S.;
Zhang, Tinghu;
Kendall, Krystle R.;
Lauffenburger, Douglas;
Gray, Nathanael S.;
Haigis, Kevin M.

Publication type:

Article

Acidic Extracellular pH Promotes Activation of Integrin αvβ3.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0015746

By:

Paradise, Ranjani K.;
Lauffenburger, Douglas A.;
Van Vliet, Krystyn J.

Publication type:

Article

Model for ER chaperone dynamics and secretory protein interactions.

Published in:

AIChE Journal, 1996, v. 42, n. 5, p. 1443, doi. 10.1002/aic.690420525

By:

Robinson, Anne Skaja;
Lauffenburger, Douglas A.

Publication type:

Article

Physical forces and the mammalian cell. Edited by J. A. Frangos, Academic Press, 1993, 400 pp.

Published in:

AIChE Journal, 1994, v. 40, n. 4, p. 738, doi. 10.1002/aic.690400417

By:

Lauffenburger, Douglas A.

Publication type:

Article

Measurement of individual cell migration parameters for human tissue cells.

Published in:

AIChE Journal, 1992, v. 38, n. 7, p. 1092, doi. 10.1002/aic.690380712

By:

DiMilla, Paul A.;
Quinn, John A.;
Albelda, Steven M.;
Lauffenburger, Douglas A.

Publication type:

Article

Cell transport in the millipore filter assay.

Published in:

AIChE Journal, 1989, v. 35, n. 3, p. 459, doi. 10.1002/aic.690350314

By:

Buettner, Helen M.;
Lauffenburger, Douglas A.;
Zigmond, Sally H.

Publication type:

Article

A computer‐controlled system for simulating heat stroke in vitro.

Published in:

FASEB Journal, 2013, v. 27, p. 1201.8, doi. 10.1096/fasebj.27.1_supplement.1201.8

By:

Clarke, David C;
Zhou, Dennis;
Inman, Walker;
Barker, Caroline J;
Leon, Lisa R;
Lauffenburger, Douglas A

Publication type:

Article

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.

Published in:

Molecular Systems Biology, 2012, v. 8, n. 1, p. 568, doi. 10.1038/msb.2012.1

By:

Tentner, Andrea R;
Lee, Michael J;
Ostheimer, Gerry J;
Samson, Leona D;
Lauffenburger, Douglas A;
Yaffe, Michael B

Publication type:

Article

Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.

Published in:

Molecular Systems Biology, 2011, v. 7, n. 1, p. 1, doi. 10.1038/msb.2011.85

By:

Aldridge, Bree B;
Gaudet, Suzanne;
Lauffenburger, Douglas A;
Sorger, Peter K

Publication type:

Article

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.

Published in:

Molecular Systems Biology, 2009, v. 5, n. 1, p. 239, doi. 10.1038/msb.2008.74

By:

Chen, William W;
Schoeberl, Birgit;
Jasper, Paul J;
Niepel, Mario;
Nielsen, Ulrik B;
Lauffenburger, Douglas A;
Sorger, Peter K

Publication type:

Article