Works matching AU Lauffenburger, Douglas A.

Results: 179

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium.

Published in:

PLoS Biology, 2012, v. 10, n. 9, p. 1, doi. 10.1371/journal.pbio.1001393

By:

Lau, Ken S.;
Cortez-Retamozo, Virna;
Philips, Sarah R.;
Pittet, Mikael J.;
Lauffenburger, Douglas A.;
Haigis, Kevin M.

Publication type:

Article

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death.

Published in:

PLoS Biology, 2008, v. 6, n. 12, p. e299, doi. 10.1371/journal.pbio.0060299

By:

Albeck, John G.;
Burke, John M.;
Spencer, Sabrina L.;
Lauffenburger, Douglas A.;
Sorger, Peter K.

Publication type:

Article

Marrow-Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness.

Published in:

Biotechnology & Bioengineering, 2011, v. 108, n. 5, p. 1181, doi. 10.1002/bit.23027

By:

Peyton, Shelly R.;
Kalcioglu, Z. Ilke;
Cohen, Joshua C.;
Runkle, Anne P.;
Van Vliet, Krystyn J.;
Lauffenburger, Douglas A.;
Griffith, Linda G.

Publication type:

Article

Quantitative methods for developing Fc mutants with extended half-lives.

Published in:

Biotechnology & Bioengineering, 2005, v. 92, n. 6, p. 748, doi. 10.1002/bit.20624

By:

Kamei, Daniel T.;
Lao, Bert J.;
Ricci, Margaret Speed;
Deshpande, Rohini;
Xu, Han;
Tidor, Bruce;
Lauffenburger, Douglas A.

Publication type:

Article

Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix.

Published in:

Biotechnology & Bioengineering, 2004, v. 88, n. 3, p. 264, doi. 10.1002/bit.20244

By:

Prudhomme, Wendy A.;
Duggar, Keith H.;
Lauffenburger, Douglas A.

Publication type:

Article

Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis.

Published in:

Biotechnology & Bioengineering, 2003, v. 84, n. 5, p. 505, doi. 10.1002/bit.10799

By:

Sowmya Viswanathan;
Tania Benatar;
Maria Mileikovsky;
Douglas A. Lauffenburger;
Andras Nagy

Publication type:

Article

MATHEMATICAL ANALYSIS OF CELL TRANSPORT PHENOMENA: BACTERIAL CHEMOTAXIS IN THE CAPILLARY ASSAY.

Published in:

Chemical Engineering Communications, 1987, v. 58, n. 1-6, p. 339, doi. 10.1080/00986448708911975

By:

STAFFELD, PETER O.;
LAUFFENBURGER, DOUGLAS A.;
QUINN, JOHN A.

Publication type:

Article

ROCK in a Stiff Place.

Published in:

Science Translational Medicine, 2011, v. 3, n. 112, p. 1, doi. 10.1126/scitranslmed.3003389

By:

Lauffenburger, Douglas A.

Publication type:

Article

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.

Published in:

Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-1949-z

By:

Holland, Christian H.;
Tanevski, Jovan;
Perales-Patón, Javier;
Gleixner, Jan;
Kumar, Manu P.;
Mereu, Elisabetta;
Joughin, Brian A.;
Stegle, Oliver;
Lauffenburger, Douglas A.;
Heyn, Holger;
Szalai, Bence;
Saez-Rodriguez, Julio

Publication type:

Article

Integrating cell-level kinetic modeling into the design of engineered protein therapeutics.

Published in:

Nature Biotechnology, 2005, v. 23, n. 2, p. 191, doi. 10.1038/nbt1064

By:

Rao, Balaji M.;
Lauffenburger, Douglas A.;
Wittrup, K. Dane

Publication type:

Article

Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”.

Published in:

Nature Biotechnology, 2002, v. 20, n. 9, p. 908, doi. 10.1038/nbt725

By:

Sarkar, Casim A.;
Lowenhaupt, Ky;
Horan, Thomas;
Boone, Thomas C.;
Tidor, Bruce;
Lauffenburger, Douglas A.

Publication type:

Article

Pharmacometrics and Systems Pharmacology 2030.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 1, p. 76, doi. 10.1002/cpt.1683

By:

Mentré, France;
Friberg, Lena E.;
Duffull, Stephen;
French, Jonathan;
Lauffenburger, Douglas A.;
Li, Lang;
Mager, Donald E.;
Sinha, Vikram;
Sobie, Eric;
Zhao, Ping

Publication type:

Article

Characterization of the expression of the pro-metastatic Mena isoform during breast tumor progression.

Published in:

Clinical & Experimental Metastasis, 2016, v. 33, n. 3, p. 249, doi. 10.1007/s10585-015-9775-5

By:

Oudin, Madeleine;
Hughes, Shannon;
Rohani, Nazanin;
Moufarrej, Mira;
Jones, Joan;
Condeelis, John;
Lauffenburger, Douglas;
Gertler, Frank

Publication type:

Article

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.

Published in:

Biotechnology & Bioengineering, 2017, v. 114, n. 11, p. 2648, doi. 10.1002/bit.26370

By:

Chen, Wen L.K.;
Edington, Collin;
Suter, Emily;
Yu, Jiajie;
Velazquez, Jeremy J.;
Velazquez, Jason G.;
Shockley, Michael;
Large, Emma M.;
Venkataramanan, Raman;
Hughes, David J.;
Stokes, Cynthia L.;
Trumper, David L.;
Carrier, Rebecca L.;
Cirit, Murat;
Griffith, Linda G.;
Lauffenburger, Douglas A.

Publication type:

Article

Common effector processing mediates cell-specific responses to stimuli.

Published in:

2007

By:

Miller-Jensen, Kathryn;
Janes, Kevin A.;
Brugge, Joan S.;
Lauffenburger, Douglas A.

Publication type:

Letter

Mechanotransduction through growth-factor shedding into the extracellular space.

Published in:

Nature, 2004, v. 429, n. 6987, p. 83, doi. 10.1038/nature02543

By:

Tschumperlin, Daniel J.;
Dai, Guohao;
Maly, Ivan V.;
Kikuchi, Tadashi;
Laiho, Lily H.;
McVittie, Anna K.;
Haley, Kathleen J.;
Lilly, Craig M.;
So, Peter T. C.;
Lauffenburger, Douglas A.;
Kamm, Roger D.;
Drazen, Jeffrey M.

Publication type:

Article

IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment.

Published in:

Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.676135

By:

Clark, Amanda M.;
Heusey, Haley L.;
Griffith, Linda G.;
Lauffenburger, Douglas. A.;
Wells, Alan

Publication type:

Article

Artificial neural networks enable genome-scale simulations of intracellular signaling.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30684-y

By:

Nilsson, Avlant;
Peters, Joshua M.;
Meimetis, Nikolaos;
Bryson, Bryan;
Lauffenburger, Douglas A.

Publication type:

Article

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27201-y

By:

Herman, Jonathan D.;
Wang, Chuangqi;
Loos, Carolin;
Yoon, Hyunah;
Rivera, Johanna;
Eugenia Dieterle, M.;
Haslwanter, Denise;
Jangra, Rohit K.;
Bortz III, Robert H.;
Bar, Katharine J.;
Julg, Boris;
Chandran, Kartik;
Lauffenburger, Douglas;
Pirofski, Liise-anne;
Alter, Galit

Publication type:

Article

Landscape of Human Immunodeficiency Virus Neutralization Susceptibilities Across Tissue Reservoirs.

Published in:

Clinical Infectious Diseases, 2022, v. 75, n. 8, p. 1342, doi. 10.1093/cid/ciac164

By:

Wang, Chuangqi;
Schlub, Timothy E;
Yu, Wen Han;
Tan, C Sabrina;
Stefic, Karl;
Gianella, Sara;
Smith, Davey M;
Lauffenburger, Douglas A;
Chaillon, Antoine;
Julg, Boris

Publication type:

Article

Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer.

Published in:

Clinical Infectious Diseases, 2022, v. 75, n. 8, p. 1359, doi. 10.1093/cid/ciac156

By:

Dolatshahi, Sepideh;
Butler, Audrey L;
Siedner, Mark J;
Ngonzi, Joseph;
Edlow, Andrea G;
Adong, Julian;
Jennewein, Madeleine F;
Atyeo, Caroline;
Bassett, Ingrid V;
Roberts, Drucilla J;
Lauffenburger, Douglas A;
Alter, Galit;
Bebell, Lisa M

Publication type:

Article

Model for ER chaperone dynamics and secretory protein interactions.

Published in:

AIChE Journal, 1996, v. 42, n. 5, p. 1443, doi. 10.1002/aic.690420525

By:

Robinson, Anne Skaja;
Lauffenburger, Douglas A.

Publication type:

Article

Physical forces and the mammalian cell. Edited by J. A. Frangos, Academic Press, 1993, 400 pp.

Published in:

AIChE Journal, 1994, v. 40, n. 4, p. 738, doi. 10.1002/aic.690400417

By:

Lauffenburger, Douglas A.

Publication type:

Article

Measurement of individual cell migration parameters for human tissue cells.

Published in:

AIChE Journal, 1992, v. 38, n. 7, p. 1092, doi. 10.1002/aic.690380712

By:

DiMilla, Paul A.;
Quinn, John A.;
Albelda, Steven M.;
Lauffenburger, Douglas A.

Publication type:

Article

Cell transport in the millipore filter assay.

Published in:

AIChE Journal, 1989, v. 35, n. 3, p. 459, doi. 10.1002/aic.690350314

By:

Buettner, Helen M.;
Lauffenburger, Douglas A.;
Zigmond, Sally H.

Publication type:

Article

Deconstructing (and reconstructing) cell migration.

Published in:

Microscopy Research & Technique, 1998, v. 43, n. 5, p. 358, doi. 10.1002/(SICI)1097-0029(19981201)43:5<358::AID-JEMT2>3.0.CO;2-D

By:

Maheshwari, Gargi;
Lauffenburger, Douglas A.

Publication type:

Article

Modeling of signalresponse cascades using decision tree analysis.

Published in:

Bioinformatics, 2005, v. 21, n. 9, p. 2027, doi. 10.1093/bioinformatics/bti278

By:

Sampsa Hautaniemi;
Sourabh Kharait;
Akihiro Iwabu;
Alan Wells;
Douglas A. Lauffenburger

Publication type:

Article

Bayesian analysis of signaling networks governing embryonic stem cell fate decisions.

Published in:

Bioinformatics, 2005, v. 21, n. 6, p. 741, doi. 10.1093/bioinformatics/bti056

By:

Peter J. Woolf;
Wendy Prudhomme;
Laurence Daheron;
George Q. Daley;
Douglas A. Lauffenburger

Publication type:

Article

Collecting and organizing systematic sets of protein data.

Published in:

Nature Reviews Molecular Cell Biology, 2006, v. 7, n. 11, p. 803, doi. 10.1038/nrm2042

By:

Albeck, John G.;
MacBeath, Gavin;
White, Forest M.;
Sorger, Peter K.;
Lauffenburger, Douglas A.;
Gaudet, Suzanne

Publication type:

Article

Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production.

Published in:

2016

By:

Ip, Blanche;
Cilfone, Nicholas A.;
Belkina, Anna C.;
DeFuria, Jason;
Jagannathan‐Bogdan, Madhumita;
Zhu, Min;
Kuchibhatla, Ramya;
McDonnell, Marie E.;
Xiao, Qiang;
Kepler, Thomas B.;
Apovian, Caroline M.;
Lauffenburger, Douglas A.;
Nikolajczyk, Barbara S.

Publication type:

journal article

Selective transfer of maternal antibodies in preterm and fullterm children.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-18973-4

By:

Dolatshahi, Sepideh;
Butler, Audrey L.;
Pou, Christian;
Henckel, Ewa;
Bernhardsson, Anna Karin;
Gustafsson, Anna;
Bohlin, Kajsa;
Shin, Sally A.;
Lauffenburger, Douglas A.;
Brodin, Petter;
Alter, Galit

Publication type:

Article

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

Published in:

PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0170975

By:

Nicholas, Dequina;
Proctor, Elizabeth A.;
Raval, Forum M.;
Ip, Blanche C.;
Habib, Chloe;
Ritou, Eleni;
Grammatopoulos, Tom N.;
Steenkamp, Devin;
Dooms, Hans;
Apovian, Caroline M.;
Lauffenburger, Douglas A.;
Nikolajczyk, Barbara S.

Publication type:

Article

Analysis of Mammalian Cell Growth Factor Receptor Dynamics<sup>a</sup>.

Published in:

Annals of the New York Academy of Sciences, 1987, v. 506, n. 1, p. 147, doi. 10.1111/j.1749-6632.1987.tb23816.x

By:

LAUFFENBURGER, DOUGLAS A.;
LINDERMAN, JENNIFER;
BERKOWITZ, LYLE

Publication type:

Article

Bacterial Chemotaxis.

Published in:

Annals of the New York Academy of Sciences, 1987, v. 506, n. 1, p. 281, doi. 10.1111/j.1749-6632.1987.tb23827.x

By:

LAUFFENBURGER, DOUGLAS A.;
RIVERO, MERCEDES;
KELLY, FRANCIS;
FORD, ROSEANNE;
DiRIENZO, JOSEPH

Publication type:

Article

Model for the Dynamics of Colicin Plasmids in Continuous Culture<sup>a</sup>.

Published in:

Annals of the New York Academy of Sciences, 1986, v. 469, n. 1, p. 97, doi. 10.1111/j.1749-6632.1986.tb26488.x

By:

LAUFFENBURGER, DOUGLAS A.

Publication type:

Article

Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters.

Published in:

Biotechnology & Applied Biochemistry, 2005, v. 042, n. 2, p. 119

By:

Sowmya Viswanathan;
Ryan E. Davey;
Donavan Cheng;
Riyad C. Raghu;
Douglas A. Lauffenburger;
Peter W. Zandstra

Publication type:

Article

Differences in HPV-specific antibody Fc-effector functions following Gardasil® and Cervarix® vaccination.

Published in:

NPJ Vaccines, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41541-023-00628-8

By:

Roy, Vicky;
Jung, Wonyeong;
Linde, Caitlyn;
Coates, Emily;
Ledgerwood, Julie;
Costner, Pamela;
Yamshchikov, Galina;
Streeck, Hendrik;
Juelg, Boris;
Lauffenburger, Douglas A.;
Alter, Galit

Publication type:

Article

Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design.

Published in:

NPJ Vaccines, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41541-023-00613-1

By:

Loos, Carolin;
Coccia, Margherita;
Didierlaurent, Arnaud M.;
Essaghir, Ahmed;
Fallon, Jonathan K.;
Lauffenburger, Douglas;
Luedemann, Corinne;
Michell, Ashlin;
van der Most, Robbert;
Zhu, Alex Lee;
Alter, Galit;
Burny, Wivine

Publication type:

Article

Autocrine epidermal growth factor signaling stimulates directionally persistent mammary...

Published in:

Journal of Cell Biology, 2001, v. 155, n. 7, p. 1123, doi. 10.1083/jcb.200109060

By:

Maheshwari, Gargi;
Wiley, H. Steven;
Lauffenburger, Douglas A.

Publication type:

Article

Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis.

Published in:

Arthritis & Rheumatology, 2018, v. 70, n. 4, p. 566, doi. 10.1002/art.40399

By:

Fleury, Michelle;
Belkina, Anna C.;
Proctor, Elizabeth A.;
Zammitti, Christopher;
Simms, Robert W.;
Lauffenburger, Douglas A.;
Snyder‐Cappione, Jennifer E.;
Lafyatis, Robert;
Dooms, Hans

Publication type:

Article

New biological solutions to the many problems of our time.

Published in:

Automatisierungstechnik, 2024, v. 72, n. 7, p. 585, doi. 10.1515/auto-2024-0069

By:

Lauffenburger, Douglas A.;
Koeppl, Heinz

Publication type:

Article

All-human microphysical model of metastasis therapy.

Published in:

Stem Cell Research & Therapy, 2013, v. 4, p. 1, doi. 10.1186/scrt372

By:

Wheeler, Sarah E.;
Borenstein, Jeffrey T.;
Clark, Amanda M.;
Ebrahimkhani, Mohammad R.;
Fox, Ira J.;
Griffith, Linda;
Inman, Walker;
Lauffenburger, Douglas;
Nguyen, Transon;
Pillai, Venkateswaran C.;
Prantil-Baun, Rachelle;
Stolz, Donna B.;
Taylor, Donald;
Ulrich, Theresa;
Venkataramanan, Raman;
Wells, Alan;
Young, Carissa

Publication type:

Article

Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation.

Published in:

Science Translational Medicine, 2014, v. 6, n. 222, p. 1, doi. 10.1126/scitranslmed.3007988

By:

Beste, Michael T.;
Pfäffle-Doyle, Nicole;
Prentice, Emily A.;
Morris, Stephanie N.;
Lauffenburger, Douglas A.;
Isaacson, Keith B.;
Griffith, Linda G.

Publication type:

Article

Interleukin‐2 mutants with enhanced α‐receptor subunit binding affinity.

Published in:

Protein Engineering, 2003, v. 16, n. 12, p. 1081, doi. 10.1093/protein/gzg111

By:

Balaji M. Rao;
Andrew T. Girvin;
Thomas Ciardelli;
Douglas A. Lauffenburger;
K.Dane Wittrup

Publication type:

Article

A microphysiological system model of therapy for liver micrometastases.

Published in:

Experimental Biology & Medicine, 2014, v. 239, n. 9, p. 1170, doi. 10.1177/1535370214532596

By:

Clark, Amanda M;
Wheeler, Sarah E;
Taylor, Donald P;
Pillai, Venkateswaran C;
Young, Carissa L;
Prantil-Baun, Rachelle;
Nguyen, Transon;
Stolz, Donna B;
Borenstein, Jeffrey T;
Lauffenburger, Douglas A;
Venkataramanan, Raman;
Griffith, Linda G;
Wells, Alan

Publication type:

Article

pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.

Published in:

Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 5, p. 1030, doi. 10.1110/ps.0230103

By:

Ricci, Margaret Speed;
Sarkar, Casim A.;
Fallon, Eric M.;
Lauffenburger, Douglas A.;
Brems, David N.

Publication type:

Article

Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data.

Published in:

PLoS Computational Biology, 2007, v. 3, n. 1, p. 35, doi. 10.1371/journal.pcbi.0030004

By:

Kumar, Neil;
Wolf-Yadlin, Alejandro;
White, Forest M.;
Lauffenburger, Douglas A.

Publication type:

Article

pH Sensitivity of epidermal growth factor receptor complexes.

Published in:

Journal of Cellular Biochemistry, 1993, v. 51, n. 3, p. 312, doi. 10.1002/jcb.240510310

By:

Nunez, Marissa;
Mayo, Kevin H.;
Starbuck, Cindy;
Lauffenburger, Douglas

Publication type:

Article

Receptor-mediated targeting of gene delivery vectors: Insights from molecular mechanisms for improved vehicle design.

Published in:

Biotechnology & Bioengineering, 2000, v. 70, n. 6, p. 593, doi. 10.1002/1097-0290(20001220)70:6<593::AID-BIT1>3.0.CO;2-N

By:

Varga, Csanad M.;
Wickham, Thomas J.;
Lauffenburger, Douglas A.

Publication type:

Article

Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions.

Published in:

Biotechnology & Bioengineering, 2000, v. 70, n. 2, p. 225, doi. 10.1002/1097-0290(20001020)70:2<225::AID-BIT12>3.0.CO;2-S

By:

Haugh, Jason M.;
Wells, Alan;
Lauffenburger, Douglas A.

Publication type:

Article