Works by Lau, Kwok-Fai

Results: 29

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene.

Published in:

2019

By:

Leńska‐Mieciek, Marta;
Charzewska, Agnieszka;
Królicki, Leszek;
Hoffman‐Zacharska, Dorota;
Chen, Zhefan Stephen;
Lau, Kwok‐Fai;
Chan, Ho Yin Edwin;
Gambin, Tomasz;
Fiszer, Urszula;
Leńska-Mieciek, Marta;
Hoffman-Zacharska, Dorota;
Lau, Kwok-Fai

Publication type:

Case Study

Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers.

Published in:

Oncologist, 2018, v. 23, n. 11, p. 1273, doi. 10.1634/theoncologist.2018-0012

By:

Tsang, Julia Y.S.;
Lee, Michelle A.;
Ni, Yun‐Bi;
Chan, Siu‐Ki;
Cheung, Sai‐Yin;
Chan, Wai‐Wa;
Lau, Kwok‐Fai;
Tse, Gary M.K.

Publication type:

Article

Insulin stimulates atypical protein kinase C‐mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6‐Rac1 signaling.

Published in:

FASEB Journal, 2022, v. 36, n. 11, p. 1, doi. 10.1096/fj.202200757R

By:

Chau, Dennis Dik‐Long;
Li, Wen;
Chan, Wai Wa Ray;
Sun, Jacquelyne Ka‐Li;
Zhai, Yuqi;
Chow, Hei‐Man;
Lau, Kwok‐Fai

Publication type:

Article

ARF6‐Rac1 signaling‐mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

Published in:

FASEB Journal, 2020, v. 34, n. 12, p. 16397, doi. 10.1096/fj.202001703R

By:

Chan, Wai Wa Ray;
Li, Wen;
Chang, Raymond Chuen Chung;
Lau, Kwok‐Fai

Publication type:

Article

Fe65: Roles Beyond Amyloid Precursor Protein Processing.

Published in:

Cellular & Molecular Biology Letters, 2015, v. 20, n. 1, p. 66, doi. 10.1515/cmble-2015-0002

By:

Chow, Wan Ning Vanessa;
Cheung, Hei Nga Maggie;
Li, Wen;
Lau, Kwok-Fai

Publication type:

Article

Myriapod genomes reveal ancestral horizontal gene transfer and hormonal gene loss in millipedes.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30690-0

By:

So, Wai Lok;
Nong, Wenyan;
Xie, Yichun;
Baril, Tobias;
Ma, Hai-yao;
Qu, Zhe;
Haimovitz, Jasmine;
Swale, Thomas;
Gaitan-Espitia, Juan Diego;
Lau, Kwok Fai;
Tobe, Stephen S.;
Bendena, William G.;
Kai, Zhen-peng;
Hayward, Alexander;
Hui, Jerome H. L.

Publication type:

Article

Genomic Organization and Promoter Cloning of the Human X11α Gene APBA1.

Published in:

DNA & Cell Biology, 2012, v. 31, n. 5, p. 651, doi. 10.1089/dna.2011.1447

By:

Chai, Ka-Ho;
McLoughlin, Declan M.;
Chan, Ting Fung;
Chan, Ho Yin Edwin;
Lau, Kwok-Fai

Publication type:

Article

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

Published in:

Human Molecular Genetics, 2007, v. 16, n. 22, p. 2720, doi. 10.1093/hmg/ddm226

By:

De Vos, Kurt J.;
Chapman, Anna L.;
Tennant, Maria E.;
Manser, Catherine;
Tudor, Elizabeth L.;
Lau, Kwok-Fai;
Brownlees, Janet;
Ackerley, Steven;
Shaw, Pamela J.;
McLoughlin, Declan M.;
Shaw, Christopher E.;
Leigh, P. Nigel;
Miller, Christopher C.J.;
Grierson, Andrew J.

Publication type:

Article

p35/cdk5 binds and phosphorylates β-catenin and regulates β-catenin/presenilin-1 interaction.

Published in:

European Journal of Neuroscience, 2001, v. 13, n. 2, p. 241, doi. 10.1111/j.1460-9568.2001.01376.x

By:

Kesavapany, Sashi;
Lau, Kwok‐Fai;
McLoughlin, Declan M.;
Brownlees, Janet;
Ackerley, Steven;
Leigh, P. Nigel;
Shaw, Christopher E.;
Miller, Christopher C. J.

Publication type:

Article

Micro-RNA Clusters Integrate Evolutionary Constraints on Expression and Target Affinities: The miR-6/5/4/286/3/309 Cluster in Drosophila.

Published in:

Molecular Biology & Evolution, 2020, v. 37, n. 10, p. 2955, doi. 10.1093/molbev/msaa146

By:

Zhe, Qu;
Yiu, Wing Chung;
Yip, Ho Yin;
Nong, Wenyan;
Yu, Clare W C;
Lee, Ivy H T;
Wong, Annette Y P;
Wong, Nicola W Y;
Cheung, Fiona K M;
Chan, Ting Fung;
Lau, Kwok Fai;
Zhong, Silin;
Chu, Ka Hou;
Tobe, Stephen S;
Ferrier, David E K;
Bendena, William G;
Hui, Jerome H L

Publication type:

Article

Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers.

Published in:

Breast Cancer Research & Treatment, 2013, v. 142, n. 2, p. 311, doi. 10.1007/s10549-013-2756-y

By:

Tsang, Julia Y. S.;
Kwok, Ying Kin;
Chan, Kit Wing;
Ni, Yun-Bi;
Chow, Wan Ning Vanessa;
Lau, Kwok Fai;
Shao, Mu-Min;
Chan, Siu Ki;
Tan, Puay-Hoon;
Tse, Gary M.

Publication type:

Article

DNA Microarray Expression Analysis of Baicalin-Induced Differentiation of C17.2 Neural Stem Cells.

Published in:

ChemBioChem, 2012, v. 13, n. 9, p. 1286, doi. 10.1002/cbic.201200145

By:

Li, Ming;
Choi, Sze-Ting;
Tsang, Kam-Sze;
Shaw, Pang-Chui;
Lau, Kwok-Fai

Publication type:

Article

Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin.

Published in:

ChemBioChem, 2011, v. 12, n. 3, p. 449, doi. 10.1002/cbic.201000570

By:

Li, Ming;
Tsang, Kam-Sze;
Choi, Sze-Ting;
Li, Karen;
Shaw, Pang-Chui;
Lau, Kwok-Fai

Publication type:

Article

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.

Published in:

Journal of Cellular Biochemistry, 2010, v. 109, n. 4, p. 782, doi. 10.1002/jcb.22457

By:

Yu, Hoi-Tin;
Chan, William Wai-Lun;
Chai, Ka-Ho;
Lee, Chris Wing-Cheung;
Chang, Raymond Chuen-Chung;
Yu, Man-Shan;
McLoughlin, Declan M.;
Miller, Christopher C.J.;
Lau, Kwok-Fai

Publication type:

Article

Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65.

Published in:

Biology (2079-7737), 2025, v. 14, n. 1, p. 97, doi. 10.3390/biology14010097

By:

Chan, Wai Wa Ray;
Chow, Jessica;
Chau, Dennis Dik-Long;
Zhai, Yuqi;
Lau, Kwok-Fai

Publication type:

Article

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Published in:

Nature Communications, 2014, v. 5, n. 6, p. 3996, doi. 10.1038/ncomms4996

By:

Stoica, Radu;
De Vos, Kurt J.;
Paillusson, Sébastien;
Mueller, Sarah;
Sancho, Rosa M.;
Lau, Kwok-Fai;
Vizcay-Barrena, Gema;
Lin, Wen-Lang;
Xu, Ya-Fei;
Lewis, Jada;
Dickson, Dennis W.;
Petrucelli, Leonard;
Mitchell, Jacqueline C.;
Shaw, Christopher E.;
Miller, Christopher C. J.

Publication type:

Article

Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.

Published in:

2010

By:

Mitchell JC;
Perkinton MS;
Yates DM;
Lau KF;
Rogelj B;
Miller CC;
McLoughlin DM;
Mitchell, Jacqueline C;
Perkinton, Michael S;
Yates, Darran M;
Lau, Kwok-Fai;
Rogelj, Boris;
Miller, Christopher C J;
McLoughlin, Declan M

Publication type:

journal article

Expression of the Neuronal Adaptor Protein X11α Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease.

Published in:

Journal of Alzheimer's Disease, 2010, v. 20, n. 1, p. 31, doi. 10.3233/JAD-2010-1341

By:

Mitchell, Jacqueline C.;
Perkinton, Michael S.;
Yates, Darran M.;
Lau, Kwok-Fai;
Rogelj, Boris;
Miller, Christopher C. J.;
McLoughlin, Declan M.

Publication type:

Article

RAC1 -Amplified and RAC1 -A159V Hotspot-Mutated Head and Neck Cancer Sensitive to the Rac Inhibitor EHop-016 In Vivo: A Proof-of-Concept Study.

Published in:

Cancers, 2025, v. 17, n. 3, p. 361, doi. 10.3390/cancers17030361

By:

Chan, Helen Hoi Yin;
Ngan, Hoi-Lam;
Ng, Yuen-Keng;
Law, Chun-Ho;
Poon, Peony Hiu Yan;
Chan, Ray Wai Wa;
Lau, Kwok-Fai;
Piao, Wenying;
Li, Hui;
Wang, Lan;
Chan, Jason Ying Kuen;
Su, Yu-Xiong;
Yeung, Thomas Chun Kit;
Wong, Eileen;
Li, Angela Wing Tung;
Verhoeft, Krista Roberta;
Liu, Yuchen;
He, Yukai;
Tsui, Stephen Kwok-Wing;
Mills, Gordon B.

Publication type:

Article

Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.

Published in:

Signal Transduction & Targeted Therapy, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41392-023-01657-4

By:

Iyaswamy, Ashok;
Thakur, Abhimanyu;
Guan, Xin-Jie;
Krishnamoorthi, Senthilkumar;
Fung, Tsz Yan;
Lu, Kejia;
Gaurav, Isha;
Yang, Zhijun;
Su, Cheng-Fu;
Lau, Kwok-Fai;
Zhang, Kui;
Ng, Roy Chun-Laam;
Lian, Qizhou;
Cheung, King-Ho;
Ye, Keqiang;
Chen, Huanhuan Joyce;
Li, Min

Publication type:

Article

Role of amyloid precursor protein interacting protein fe65 in neurite outgrowth.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P505, doi. 10.1016/j.jalz.2015.06.596

By:

Lau, Kwok-Fai;
Cheung, Hei Nga;
Edwin Chan, Ho Yin

Publication type:

Article

Identification of engulfment adaptor protein 1 as a novel Alzheimer's disease amyloid precursor protein interacting protein

Published in:

2012

By:

Hao, Candy;
Chan, Ho Yin;
Christopher, Miller;
Lau, Kwok-Fai

Publication type:

Abstract

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.

Published in:

EMBO Reports, 2018, v. 19, n. 9, p. 1, doi. 10.15252/embr.201745409

By:

Chen, Zhefan Stephen;
Li, Li;
Peng, Shaohong;
Chen, Francis M.;
Zhang, Qian;
An, Ying;
Lin, Xiao;
Li, Wen;
Koon, Alex Chun;
Chan, Ting‐Fung;
Lau, Kwok‐Fai;
Ngo, Jacky Chi Ki;
Wong, Wing Tak;
Kwan, Kin Ming;
Chan, Ho Yin Edwin

Publication type:

Article

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.

Published in:

Scientific Reports, 2017, p. 43650, doi. 10.1038/srep43650

By:

Cheung, Derek Hang-Cheong;
Ho, Sai-Tim;
Lau, Kwok-Fai;
Jin, Rui;
Wang, Ya-Nan;
Kung, Hsiang-Fu;
Huang, Jun-Jian;
Shaw, Pang-Chui

Publication type:

Article

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 6, p. 1299, doi. 10.1093/hmg/ddr559

By:

De Vos, Kurt J.;
Mórotz, Gábor M.;
Stoica, Radu;
Tudor, Elizabeth L.;
Lau, Kwok-Fai;
Ackerley, Steven;
Warley, Alice;
Shaw, Christopher E.;
Miller, Christopher C.J.

Publication type:

Article

Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 19, p. 3787, doi. 10.1093/hmg/ddr297

By:

Tsoi, Ho;
Lau, Chi Kong;
Lau, Kwok Fai;
Chan, Ho Yin Edwin

Publication type:

Article

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

Published in:

Human Molecular Genetics, 2011, v. 20, n. 9, p. 1738, doi. 10.1093/hmg/ddr049

By:

Chan, Wing Man;
Tsoi, Ho;
Wu, Chi Chung;
Wong, Chi Hang;
Cheng, Tat Cheung;
Li, Hoi Yeung;
Lau, Kwok Fai;
Shaw, Pang Chui;
Perrimon, Norbert;
Chan, Ho Yin Edwin

Publication type:

Article

X11β rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 23, p. 4492, doi. 10.1093/hmg/ddp408

By:

Mitchell, Jacqueline C.;
Ariff, Belall B.;
Yates, Darran M.;
Lau, Kwok-Fai;
Perkinton, Michael S.;
Rogelj, Boris;
Stephenson, John D.;
Miller, Christopher C.J.;
McLoughlin, Declan M.

Publication type:

Article

The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing.

Published in:

Cellular & Molecular Life Sciences, 2024, v. 81, n. 1, p. 1, doi. 10.1007/s00018-024-05351-8

By:

Chau, Dennis Dik-Long;
Yu, Zhicheng;
Chan, Wai Wa Ray;
Yuqi, Zhai;
Chang, Raymond Chuen Chung;
Ngo, Jacky Chi Ki;
Chan, Ho Yin Edwin;
Lau, Kwok-Fai

Publication type:

Article