Works by Lashuel, Hilal A.
Results: 101
Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization.
- Published in:
- Angewandte Chemie, 2024, v. 136, n. 3, p. 1, doi. 10.1002/ange.202314587
- By:
- Publication type:
- Article
Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 10, p. 4088, doi. 10.1002/ange.201913001
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- Publication type:
- Article
Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding.
- Published in:
- Angewandte Chemie, 2019, v. 131, n. 6, p. 1630, doi. 10.1002/ange.201805238
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- Publication type:
- Article
A glimpse of a possible amyloidogenic intermediate of transthyretin.
- Published in:
- Nature Structural Biology, 2000, v. 7, n. 9, p. 754
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- Publication type:
- Article
Lead (Pb) exposure and its effect on APP proteolysis and Aβ aggregation.
- Published in:
- FASEB Journal, 2005, v. 19, n. 14, p. 2083, doi. 10.1096/fj.05-4375fje
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- Publication type:
- Article
Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in alpha-synuclein transgenic mice.
- Published in:
- BMC Neuroscience, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2202-14-135
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- Publication type:
- Article
Cover Picture: Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach (ChemPhysChem 15/2013).
- Published in:
- ChemPhysChem, 2013, v. 14, n. 15, p. 3421, doi. 10.1002/cphc.201390071
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- Publication type:
- Article
Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach.
- Published in:
- ChemPhysChem, 2013, v. 14, n. 15, p. 3476, doi. 10.1002/cphc.201300633
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- Publication type:
- Article
Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases.
- Published in:
- ChemBioChem, 2021, v. 22, n. 1, p. 217, doi. 10.1002/cbic.202000508
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- Publication type:
- Article
Arab world needs its science diaspora.
- Published in:
- 2011
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- Publication type:
- Letter
Islam: governments need to reform education and build a scientific culture.
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- 2006
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- Publication type:
- Letter
A century-old debate on protein aggregation and neurodegeneration enters the clinic.
- Published in:
- Nature, 2006, v. 443, n. 7113, p. 774, doi. 10.1038/nature05290
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- Publication type:
- Article
Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons.
- Published in:
- Neuroscience Bulletin, 2012, v. 28, n. 3, p. 233, doi. 10.1007/s12264-012-1239-1
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- Publication type:
- Article
Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.
- Published in:
- Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00889
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- Publication type:
- Article
Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson's Disease with Semisynthetic Ubiquitinated α-Synuclein.
- Published in:
- Angewandte Chemie International Edition, 2011, v. 50, n. 2, p. 405, doi. 10.1002/anie.201005546
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- Publication type:
- Article
Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems.
- Published in:
- Angewandte Chemie International Edition, 2010, v. 49, n. 33, p. 5628, doi. 10.1002/anie.200906670
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- Publication type:
- Article
Highly Efficient and Chemoselective Peptide Ubiquitylation.
- Published in:
- Angewandte Chemie International Edition, 2009, v. 48, n. 43, p. 8090, doi. 10.1002/anie.200902936
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- Publication type:
- Article
Disruption of Amyloid-Derived Peptide Assemblies through the Controlled Induction of a β-Sheet to α-Helix Transformation: Application of the Switch Concept.
- Published in:
- Angewandte Chemie International Edition, 2007, v. 46, n. 15, p. 2681, doi. 10.1002/anie.200603681
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- Publication type:
- Article
A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.
- Published in:
- ChemBioChem, 2016, v. 17, n. 24, p. 2353, doi. 10.1002/cbic.201600474
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- Publication type:
- Article
Chemical Synthesis and Expression of the HIV-1 Rev Protein.
- Published in:
- ChemBioChem, 2011, v. 12, n. 7, p. 1097, doi. 10.1002/cbic.201100033
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- Publication type:
- Article
Amyloids Go Genomic: Insights Regarding the Sequence Determinants of Prion Formation from Genome-Wide Studies.
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- ChemBioChem, 2009, v. 10, n. 12, p. 1951, doi. 10.1002/cbic.200900373
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- Publication type:
- Article
Switch-Peptides: Design and Characterization of Controllable Super-Amyloid-Forming Host-Guest Peptides as Tools for Identifying Anti-Amyloid Agents.
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- ChemBioChem, 2008, v. 9, n. 13, p. 2104, doi. 10.1002/cbic.200800245
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- Publication type:
- Article
Branched KLVFF Tetramers Strongly Potentiate Inhibition of β-Amyloid Aggregation.
- Published in:
- ChemBioChem, 2007, v. 8, n. 15, p. 1857, doi. 10.1002/cbic.200700338
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- Publication type:
- Article
Pronounced a-Synuclein Pathology in a Seeding- Based Mouse Model Is Not Sufficient to Induce Mitochondrial Respiration Deficits in the Striatum and Amygdala.
- Published in:
- eNeuro, 2020, v. 7, n. 4, p. 1, doi. 10.1523/ENEURO.0110-20.2020
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- Publication type:
- Article
Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.
- Published in:
- Toxicology Research, 2016, v. 5, n. 2, p. 407, doi. 10.1039/c5tx00303b
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- Publication type:
- Article
Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 5, p. 906, doi. 10.3390/cells11050906
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- Publication type:
- Article
Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26684-z
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- Publication type:
- Article
Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model.
- Published in:
- Molecular Neurodegeneration, 2010, v. 5, p. 47, doi. 10.1186/1750-1326-5-47
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- Publication type:
- Article
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
- Published in:
- Quarterly Reviews of Biophysics, 2006, v. 39, n. 2, p. 167, doi. 10.1017/S0033583506004422
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- Publication type:
- Article
The many faces of α-synuclein: from structure and toxicity to therapeutic target.
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- 2013
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- Publication type:
- research
The many faces of ?-synuclein: from structure and toxicity to therapeutic target.
- Published in:
- Nature Reviews Neuroscience, 2013, v. 14, n. 1, p. 38, doi. 10.1038/nrn3406
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- Publication type:
- Article
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity.
- Published in:
- NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00388-7
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- Publication type:
- Article
Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies.
- Published in:
- NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00357-0
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- Publication type:
- Article
Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery.
- Published in:
- NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00310-1
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- Publication type:
- Article
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
- Published in:
- NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00203-9
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- Publication type:
- Article
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01575-4
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- Publication type:
- Article
Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson’s Disease.
- Published in:
- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140880
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- Publication type:
- Article
The Role of post-translational modification (phosphorylation) in modulating alpha-synuclein, structure, aggregation and toxicity
- Published in:
- 2009
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- Publication type:
- Abstract
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
- Published in:
- Journal of Neurochemistry, 2013, v. 125, n. 4, p. 491, doi. 10.1111/jnc.12226
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- Publication type:
- Article
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
- Published in:
- Journal of Neurochemistry, 2013, v. 124, n. 5, p. 1, doi. 10.1111/jnc.12226
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- Publication type:
- Article
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97334-z
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- Publication type:
- Article
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04594-x
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- Publication type:
- Article
Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization.
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 3, p. 1, doi. 10.1002/anie.202314587
- By:
- Publication type:
- Article
Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 10, p. 4059, doi. 10.1002/anie.201913001
- By:
- Publication type:
- Article
Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding.
- Published in:
- Angewandte Chemie International Edition, 2019, v. 58, n. 6, p. 1616, doi. 10.1002/anie.201805238
- By:
- Publication type:
- Article
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset.
- Published in:
- Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00439-2
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- Publication type:
- Article
Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington's disease.
- Published in:
- Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01172-z
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- Publication type:
- Article
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39314-7
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- Publication type:
- Article
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
- Published in:
- EMBO Journal, 2020, v. 39, n. 17, p. 1, doi. 10.15252/embj.2020104671
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- Publication type:
- Article
Membrane scission driven by the PROPPIN Atg18.
- Published in:
- EMBO Journal, 2017, v. 36, n. 22, p. 3274, doi. 10.15252/embj.201796859
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- Publication type:
- Article