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Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice.
Published in:
2014
By:
- Yu, Da-Hai;
- Waterland, Robert A;
- Zhang, Pumin;
- Schady, Deborah;
- Chen, Miao-Hsueh;
- Guan, Yongtao;
- Gadkari, Manasi;
- Shen, Lanlan
Publication type:
journal article
Targeted p16<sup>Ink4a</sup> epimutation causes tumorigenesis and reduces survival in mice.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 9, p. 3708, doi. 10.1172/JCI76507
By:
- Da-Hai Yu;
- Waterland, Robert A.;
- Pumin Zhang;
- Schady, Deborah;
- Miao-Hsueh Chen;
- Yongtao Guan;
- Gadkari, Manasi;
- Lanlan Shen
Publication type:
Article
Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing.
Published in:
Nucleic Acids Research, 2014, v. 42, n. 6, p. e43, doi. 10.1093/nar/gkt1325
By:
- Kunde-Ramamoorthy, Govindarajan;
- Coarfa, Cristian;
- Laritsky, Eleonora;
- Kessler, Noah J.;
- Harris, R. Alan;
- Xu, Mingchu;
- Chen, Rui;
- Shen, Lanlan;
- Milosavljevic, Aleksandar;
- Waterland, Robert A.
Publication type:
Article
Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.
Published in:
Nucleic Acids Research, 2012, v. 40, n. 15, p. 7257, doi. 10.1093/nar/gks429
By:
- Zhang, Yan;
- Shu, Jingmin;
- Si, Jiali;
- Shen, Lanlan;
- Estecio, Marcos R.H.;
- Issa, Jean-Pierre J.
Publication type:
Article
The concurrence of DNA methylation and demethylation is associated with transcription regulation.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25521-7
By:
- Shi, Jiejun;
- Xu, Jianfeng;
- Chen, Yiling Elaine;
- Li, Jason Sheng;
- Cui, Ya;
- Shen, Lanlan;
- Li, Jingyi Jessica;
- Li, Wei
Publication type:
Article
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Published in:
Nature Genetics, 2008, v. 40, n. 6, p. 741, doi. 10.1038/ng.159
By:
- Kondo, Yutaka;
- Shen, Lanlan;
- Cheng, Alfred S;
- Ahmed, Saira;
- Boumber, Yanis;
- Charo, Chantale;
- Yamochi, Tadanori;
- Urano, Takeshi;
- Furukawa, Koichi;
- Kwabi-Addo, Bernard;
- Gold, David L.;
- Sekido, Yoshitaka;
- Huang, Tim Hui-Ming;
- Issa, Jean-Pierre J.
Publication type:
Article
Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.
Published in:
Hepatology Research, 2007, v. 37, n. 11, p. 974, doi. 10.1111/j.1872-034X.2007.00141.x
By:
- Kondo, Yutaka;
- Shen, Lanlan;
- Suzuki, Seiji;
- Kurokawa, Tsuyoshi;
- Masuko, Kazuo;
- Tanaka, Yasuhito;
- Kato, Hideaki;
- Mizuno, Yoshiki;
- Yokoe, Masamichi;
- Sugauchi, Fuminaka;
- Hirashima, Noboru;
- Orito, Etsuro;
- Osada, Hirotaka;
- Ueda, Ryuzo;
- Yi Guo;
- Xinli Chen;
- Issa, Jean-Pierre J.;
- Sekido, Yoshitaka
Publication type:
Article
Surface etching mechanism of carbon-doped GeSbTe phase change material in fluorocarbon plasma.
Published in:
Applied Physics A: Materials Science & Processing, 2016, v. 122, n. 9, p. 1, doi. 10.1007/s00339-016-0381-4
By:
- Shen, Lanlan;
- Song, Sannian;
- Song, Zhitang;
- Li, Le;
- Guo, Tianqi;
- Cheng, Yan;
- Lv, Shilong;
- Wu, Liangcai;
- Liu, Bo;
- Feng, Songlin
Publication type:
Article
DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis.
Published in:
PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027889
By:
- Konishi, Kazuo;
- Watanabe, Yoshiyuki;
- Shen, Lanlan;
- Yi Guo;
- Castoro, Ryan J.;
- Kondo, Kimie;
- Woonbok Chung;
- Ahmed, Saira;
- Jelinek, Jaroslav;
- Boumber, Yanis A.;
- Estecio, Marcos R.;
- Maegawa, Shinji;
- Kondo, Yutaka;
- Itoh, Fumio;
- Imawari, Michio;
- Hamilton, Stanley R.;
- Issa, Jean-Pierre J.
Publication type:
Article
Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer.
Published in:
PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023320
By:
- Watanabe, Yoshiyuki;
- Castoro, Ryan J.;
- Kim, Hyun Soo;
- North, Brittany;
- Oikawa, Ritsuko;
- Hiraishi, Tetsuya;
- Ahmed, Saira S.;
- Woonbok Chung;
- Mee-Yon Cho;
- Toyota, Minoru;
- Itoh, Fumio;
- Estecio, Marcos R. H.;
- Lanlan Shen;
- Jelinek, Jaroslav;
- Issa, Jean-Pierre J.
Publication type:
Article
Identification of Novel Tumor Markers in Prostate, Colon and Breast Cancer by Unbiased Methylation Profiling.
Published in:
PLoS ONE, 2008, v. 3, n. 4, p. 1, doi. 10.1371/journal.pone.0002079
By:
- Woonbok Chung;
- Kwabi-Addo, Bernard;
- Ittmann, Michael;
- Jelinek, Jaroslav;
- Shen, Lanlan;
- Yinhua Yu;
- Issa, Jean-Pierre J.
Publication type:
Article
Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells.
Published in:
PLoS ONE, 2008, v. 3, n. 4, p. 1, doi. 10.1371/journal.pone.0002037
By:
- Kondo, Yutaka;
- Shen, Lanlan;
- Ahmed, Saira;
- Boumber, Yanis;
- Sekido, Yoshitaka;
- Haddad, Bassem R.;
- Issa, Jean-Pierre J.
Publication type:
Article
Synergistic Effects of Thermal Pretreatment, Ultrasound and High-Pressure Processing on the Recovery of Bioactive Compounds from Echinacea Juice.
Published in:
Current Topics in Nutraceutical Research, 2020, v. 18, n. 2, p. 144, doi. 10.37290/ctnr2641-452X.18:144-151
By:
- Qingping Fan;
- Ailing Hui;
- Wencheng Zhang;
- Chuanxiang Fu;
- Lanlan Shen;
- Sai Wang;
- Wei Zhang;
- Biao Du;
- Huawei Zhang
Publication type:
Article
MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer.
Published in:
JNCI: Journal of the National Cancer Institute, 2005, v. 97, n. 18, p. 1330, doi. 10.1093/jnci/dji275
By:
- Shen, Lanlan;
- Kondo, Yutaka;
- Rosner, Gary L.;
- Lianchun Xiao;
- Hernandez, Natalie Supunpong;
- Vilaythong, Jill;
- Houlihan, P. Scott;
- Krouse, Robert S.;
- Prasad, Anil R.;
- Einspahr, Janine G.;
- Buckmeier, Julie;
- Alberts, David S.;
- Hamilton, Stanley R.;
- Issa, Jean-Pierre J.
Publication type:
Article
DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma.
Published in:
JNCI: Journal of the National Cancer Institute, 2002, v. 94, n. 10, p. 755, doi. 10.1093/jnci/94.10.755
By:
- Lanlan Shen;
- Ahuja, Nita;
- Habib, Nagy A.;
- Toyota, Minoru;
- Rashid, Asif
Publication type:
Article
Selectivity Mechanism of Hsp90 Isoform Inhibition Through Computational Investigation.
Published in:
Journal of Computational Biophysics & Chemistry, 2023, v. 22, n. 2, p. 189, doi. 10.1142/S2737416523500114
By:
- Xu, Hanqing;
- Wang, Hanxun;
- Hu, Baichun;
- Gao, Yinli;
- Shen, Lanlan;
- Wang, Jian
Publication type:
Article
Decitabine improves patient outcomes in myelodysplastic syndromesSee related editorial on pages 1650‐2 and accompanying article on pages 1744‐50, this issue.: Results of a phase III randomized study.
Published in:
Cancer (0008543X), 2006, v. 106, n. 8, p. 1794
By:
- Hagop Kantarjian;
- Jean‐Pierre J. Issa;
- Craig S. Rosenfeld;
- John M. Bennett;
- Maher Albitar;
- John DiPersio;
- Virginia Klimek;
- James Slack;
- Carlos de Castro;
- Farhad Ravandi;
- Richard Helmer;
- Lanlan Shen;
- Stephen D. Nimer;
- Richard Leavitt;
- Azra Raza;
- Hussain Saba
Publication type:
Article
Properties of Ti-Sb-Te doped with SbSe alloy for application in nonvolatile phase change memory.
Published in:
Journal of Materials Science: Materials in Electronics, 2017, v. 28, n. 1, p. 923, doi. 10.1007/s10854-016-5608-9
By:
- Shen, Lanlan;
- Song, Sannian;
- Song, Zhitang;
- Li, Le;
- Guo, Tianqi;
- Cheng, Yan;
- Wu, Liangcai;
- Liu, Bo;
- Feng, Songlin
Publication type:
Article
IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.
Published in:
Carcinogenesis, 2010, v. 31, n. 3, p. 342, doi. 10.1093/carcin/bgp179
By:
- Suzuki, Hiromu;
- Igarashi, Shinichi;
- Nojima, Masanori;
- Maruyama, Reo;
- Yamamoto, Eiichiro;
- Kai, Masahiro;
- Akashi, Hirofumi;
- Watanabe, Yoshiyuki;
- Yamamoto, Hiroyuki;
- Sasaki, Yasushi;
- Itoh, Fumio;
- Imai, Kohzoh;
- Sugai, Tamotsu;
- Shen, Lanlan;
- Issa, Jean-Pierre J.;
- Shinomura, Yasuhisa;
- Tokino, Takashi;
- Toyota, Minoru
Publication type:
Article
Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas.
Published in:
Carcinogenesis, 2008, v. 29, n. 10, p. 1901, doi. 10.1093/carcin/bgn170
By:
- Wentao Gao;
- Yutaka Kondo;
- Lanlan Shen;
- Yasuhiro Shimizu;
- Tsuyoshi Sano;
- Kenji Yamao;
- Atsushi Natsume;
- Yasuhiro Goto;
- Motokazu Ito;
- Hideki Murakami;
- Hirotaka Osada;
- Jiexin Zhang;
- Jean-Pierre J. Issa;
- Yoshitaka Sekido
Publication type:
Article
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Published in:
FASEB Journal, 2008, v. 22, n. 6, p. 1981, doi. 10.1096/fj.07-098301
By:
- Xiangsheng Zuo;
- Lanlan Shen;
- Jean-Pierre Issa;
- Ofir Moy;
- Morris, Jeffrey S.;
- Lippman, Scott M.;
- Shureiqi, Imad
Publication type:
Article
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles.
Published in:
PLoS Pathogens, 2011, v. 7, n. 2, p. 1, doi. 10.1371/journal.pgen.1001252
By:
- Waterland, Robert A.;
- Kellermayer, Richard;
- Laritsky, Eleonora;
- Rayco-Solon, Pura;
- Harris, R. Alan;
- Travisano, Michael;
- Wenjuan Zhang;
- Torskaya, Maria S.;
- Jiexin Zhang;
- Lanlan Shen;
- Manary, Mark J.;
- Prentice, Andrew M.
Publication type:
Article
Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 6, p. 1579, doi. 10.1093/hmg/ddt548
By:
- Li, Ge;
- Zhang, Wenjuan;
- Baker, Maria S.;
- Laritsky, Eleonora;
- Mattan-Hung, Natalia;
- Yu, Dahai;
- Kunde-Ramamoorthy, Govindarajan;
- Simerly, Richard B.;
- Chen, Rui;
- Shen, Lanlan;
- Waterland, Robert A.
Publication type:
Article
Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.
Published in:
International Journal of Cancer, 2010, v. 127, n. 9, p. 2095, doi. 10.1002/ijc.25225
By:
- An, Byonggu;
- Kondo, Yutaka;
- Okamoto, Yasuyuki;
- Shinjo, Keiko;
- Kanemitsu, Yukihide;
- Komori, Koji;
- Hirai, Takashi;
- Sawaki, Akira;
- Tajika, Masahiro;
- Nakamura, Tsuneya;
- Yamao, Kenji;
- Yatabe, Yasushi;
- Fujii, Makiko;
- Murakami, Hideki;
- Osada, Hirotaka;
- Tani, Tohru;
- Matsuo, Keitaro;
- Shen, Lanlan;
- Issa, Jean-Pierre J.;
- Sekido, Yoshitaka
Publication type:
Article
Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation.
Published in:
2019
By:
- Iqbal, Najeeha T.;
- Syed, Sana;
- Sadiq, Kamran;
- Khan, Marium N.;
- Iqbal, Junaid;
- Ma, Jennie Z.;
- Umrani, Fayaz;
- Ahmed, Sheraz;
- Maier, Elizabeth A.;
- Denson, Lee A.;
- Haberman, Yael;
- McNeal, Monica M.;
- Setchell, Kenneth D. R.;
- Zhao, Xueheng;
- Qureshi, Shahida;
- Shen, Lanlan;
- Moskaluk, Christopher A.;
- Liu, Ta-Chiang;
- Yilmaz, Omer;
- Brown, Donald E.
Publication type:
journal article
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02689-y
By:
- Yang, Li;
- Chen, Xiaomin;
- Lee, Christy;
- Shi, Jiejun;
- Lawrence, Emily B.;
- Zhang, Lanjing;
- Li, Yumei;
- Gao, Nan;
- Jung, Sung Yun;
- Creighton, Chad J.;
- Li, Jingyi Jessica;
- Cui, Ya;
- Arimura, Sumimasa;
- Lei, Yunping;
- Li, Wei;
- Shen, Lanlan
Publication type:
Article
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02689-y
By:
- Yang, Li;
- Chen, Xiaomin;
- Lee, Christy;
- Shi, Jiejun;
- Lawrence, Emily B.;
- Zhang, Lanjing;
- Li, Yumei;
- Gao, Nan;
- Jung, Sung Yun;
- Creighton, Chad J.;
- Li, Jingyi Jessica;
- Cui, Ya;
- Arimura, Sumimasa;
- Lei, Yunping;
- Li, Wei;
- Shen, Lanlan
Publication type:
Article
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02689-y
By:
- Yang, Li;
- Chen, Xiaomin;
- Lee, Christy;
- Shi, Jiejun;
- Lawrence, Emily B.;
- Zhang, Lanjing;
- Li, Yumei;
- Gao, Nan;
- Jung, Sung Yun;
- Creighton, Chad J.;
- Li, Jingyi Jessica;
- Cui, Ya;
- Arimura, Sumimasa;
- Lei, Yunping;
- Li, Wei;
- Shen, Lanlan
Publication type:
Article
Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2023, v. 42, n. 1, p. 1, doi. 10.1186/s13046-023-02689-y
By:
- Yang, Li;
- Chen, Xiaomin;
- Lee, Christy;
- Shi, Jiejun;
- Lawrence, Emily B.;
- Zhang, Lanjing;
- Li, Yumei;
- Gao, Nan;
- Jung, Sung Yun;
- Creighton, Chad J.;
- Li, Jingyi Jessica;
- Cui, Ya;
- Arimura, Sumimasa;
- Lei, Yunping;
- Li, Wei;
- Shen, Lanlan
Publication type:
Article
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles.
Published in:
PLoS Genetics, 2010, v. 6, n. 12, p. 1, doi. 10.1371/journal.pgen.1001252
By:
- Waterland, Robert A.;
- Kellermayer, Richard;
- Laritsky, Eleonora;
- Rayco-Solon, Pura;
- Harris, R. Alan;
- Travisano, Michael;
- Wenjuan Zhang;
- Torskaya, Maria S.;
- Jiexin Zhang;
- Lanlan Shen;
- Manary, Mark J.;
- Prentice, Andrew M.
Publication type:
Article
An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection.
Published in:
PLoS Genetics, 2008, v. 4, n. 8, p. 1, doi. 10.1371/journal.pgen.1000162
By:
- Boumber, Yanis A.;
- Kondo, Yutaka;
- Xuqi Chen;
- Lanlan Shen;
- Yi Guo;
- Tellez, Carmen;
- Estécio, Marcos R. H.;
- Ahmed, Saira;
- Issa, Jean-Pierre J.
Publication type:
Article
Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters.
Published in:
PLoS Genetics, 2007, v. 3, n. 10, p. e181, doi. 10.1371/journal.pgen.0030181
By:
- Shen, Lanlan;
- Kondo, Yutaka;
- Yi Guo;
- Jiexin Zhang;
- Li Zhang;
- Ahmed, Saira;
- Jingmin Shu;
- Xinli Chen;
- Waterland, Robert A.;
- Issa, Jean-Pierre J.
Publication type:
Article
Epigenetic maturation in colonic mucosa continues beyond infancy in mice.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 11, p. 2168, doi. 10.1093/hmg/ddq095
By:
- Kellermayer, Richard;
- Balasa, Alfred;
- Zhang, Wenjuan;
- Lee, Stefi;
- Mirza, Sherin;
- Chakravarty, Abrita;
- Szigeti, Reka;
- Laritsky, Eleonora;
- Tatevian, Nina;
- Smith, C. Wayne;
- Shen, Lanlan;
- Waterland, Robert A.
Publication type:
Article
Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development.
Published in:
Human Molecular Genetics, 2009, v. 18, n. 16, p. 3026, doi. 10.1093/hmg/ddp241
By:
- Waterland, Robert A.;
- Kellermayer, Richard;
- Rached, Marie-Therese;
- Tatevian, Nina;
- Gomes, Marcus V.;
- Zhang, Jiexin;
- Zhang, Li;
- Chakravarty, Abrita;
- Zhu, Wei;
- Laritsky, Eleonora;
- Zhang, Wenjuan;
- Wang, Xiaodan;
- Shen, Lanlan
Publication type:
Article
The DNA methylome of pediatric brain tumors appears shaped by structural variation and predicts survival.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-51276-y
By:
- Chen, Fengju;
- Zhang, Yiqun;
- Shen, Lanlan;
- Creighton, Chad J.
Publication type:
Article
Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice.
Published in:
Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12691
By:
- Parikh, Neha;
- Shuck, Ryan L.;
- Gagea, Mihai;
- Shen, Lanlan;
- Donehower, Lawrence A.
Publication type:
Article
Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.
Published in:
PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197408
By:
- Schraw, Jeremy M.;
- Yiu, Teresa T.;
- Lupo, Philip J.;
- Tsavachidis, Spiridon;
- Rau, Rachel;
- Bondy, Melissa L.;
- Rabin, Karen R.;
- Shen, Lanlan;
- Scheurer, Michael E.
Publication type:
Article

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