Works by Langosch, Dieter

Results: 34

Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins.

Published in:

Bioinformatics, 2013, v. 29, n. 13, p. 1623, doi. 10.1093/bioinformatics/btt247

By:

Kirrbach, Jan;
Krugliak, Miriam;
Ried, Christian L.;
Pagel, Philipp;
Arkin, Isaiah T.;
Langosch, Dieter

Publication type:

Article

Gas-phase behavior of noncovalent transmembrane segment complexes.

Published in:

Rapid Communications in Mass Spectrometry: RCM, 2008, v. 22, n. 24, p. 4089, doi. 10.1002/rcm.3843

By:

Weigang, Linda M. M.;
Langosch, Dieter;
Letzel, Thomas

Publication type:

Article

Solid-phase synthesis and purification of a set of uniformly <sup>13</sup>C, <sup>15</sup>N labelled de novo designed membrane fusogenic peptides.

Published in:

Journal of Peptide Science, 2007, v. 13, n. 2, p. 75, doi. 10.1002/psc.786

By:

Agrawal, Prashant R.;
Hofmann, Mathias W.;
Meeuwenoord, Nico J.;
Filippov, Dmitri V.;
Stalz, Holger;
Hulsbergen, Frans;
Langosch, Dieter;
Overkleeft, Hermen S.;
De Groot, Huub

Publication type:

Article

In Vitro Selection of Self-Interacting Transmembrane Segments--Membrane Proteins Approached from a Different Perspective.

Published in:

IUBMB Life, 2002, v. 54, n. 3, p. 109, doi. 10.1080/15216540214538

By:

Langosch, Dieter;
Lindner, Eric;
Gurezka, Rolf

Publication type:

Article

A ToxR-based dominant-negative system to investigate heterotypic transmembrane domain interactions.

Published in:

Proteins, 2006, v. 65, n. 4, p. 803, doi. 10.1002/prot.21226

By:

Lindner, Eric;
Langosch, Dieter

Publication type:

Article

Understanding the energetics of helical peptide orientation in membranes.

Published in:

Proteins, 2005, v. 58, n. 4, p. 913, doi. 10.1002/prot.20383

By:

Sengupta, Durba;
Meinhold, Lars;
Langosch, Dieter;
Ullmann, G. Matthias;
Smith, Jeremy C.

Publication type:

Article

Interaction of Transmembrane Helices by a Knobs-lnto-Holes Packing Characteristic of Soluble Coiled Coils

Published in:

Proteins, 1998, v. 31, n. 2, p. 150

By:

Langosch, Dieter;
Heringa, Jaap

Publication type:

Article

Aβ42-lowering compounds interfere with APP transmembrane sequence dimerization

Published in:

2010

By:

Richter, Luise;
Munter, Lisa-Marie;
Ness, Julia;
Hildebrand, Peter W.;
Joshi, Mangesh;
Unterreitmeier, Stephanie;
Bulic, Bruno;
Beyermann, Michael;
Gust, Ronald;
Reif, Bernd;
Weggen, Sascha;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

Structural dynamics of the transmembrane domain of the amyloid precursor protein (APP) determined by deuterium/hydrogen exchange

Published in:

2009

By:

Pester, Oxana;
Stelzer, Walter;
Poschner, Bernard C.;
Münter, Lisa-Maria;
Multhaup, Gerd;
Langosch, Dieter

Publication type:

Abstract

Nsaids modulate app dimerization

Published in:

2009

By:

Richter, Luise;
Munter, Lisa Marie;
Fehse, Susanne;
Unterreitmeier, Stephanie;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

Reassessment of APP Familial Alzheimer's Disease (FAD) mutations

Published in:

2009

By:

Munter, Lisa M.;
Botev, Anne;
Richter, Luise;
Weise, Chris;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

O1-03-04: Deleterious effects of familial Alzheimer's disease (FAD) mutations in APP are mediated through the GxxxG interaction motif

Published in:

2008

By:

Munter, Lisa M.;
Harmeier, Anja;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

O1-02-05: Dimerization of the APP transmembrane sequence is critical for Aβ42 generation

Published in:

2006

By:

Munter, Lisa M.;
Voigt, Philipp;
Lindner, Eric;
Schaefer, Michael;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

O1-02-05: Dimerization of the APP transmembrane sequence is critical for Aβ42 generation

Published in:

2006

By:

Munter, Lisa M.;
Voigt, Philipp;
Lindner, Eric;
Schaefer, Michael;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Abstract

Solid State NMR Investigation of the Interaction between Biomimetic Lipid Bilayers and de novo Designed Fusogenic Peptides.

Published in:

ChemBioChem, 2007, v. 8, n. 5, p. 493, doi. 10.1002/cbic.200600518

By:

Agrawal, Prashant;
Kiihne, Suzanne;
Hollander, Johan;
Hulsbergen, Frans;
Hofmann, Mathias;
Langosch, Dieter;
de Groot, Huub

Publication type:

Article

Author Correction: Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions.

Published in:

2020

By:

Schanzenbach, Christoph;
Schmidt, Fabian C.;
Breckner, Patrick;
Teese, Mark G.;
Langosch, Dieter

Publication type:

Correction Notice

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity.

Published in:

EMBO Molecular Medicine, 2022, v. 14, n. 10, p. 1, doi. 10.15252/emmm.202216084

By:

Güner, Gökhan;
Aßfalg, Marlene;
Zhao, Kai;
Dreyer, Tobias;
Lahiri, Shibojyoti;
Lo, Yun;
Slivinschi, Bianca Ionela;
Imhof, Axel;
Jocher, Georg;
Strohm, Laura;
Behrends, Christian;
Langosch, Dieter;
Bronger, Holger;
Nimsky, Christopher;
Bartsch, Jörg W;
Riddell, Stanley R;
Steiner, Harald;
Lichtenthaler, Stefan F

Publication type:

Article

Is lipid flippase activity of SNARE transmembrane domains required for membrane fusion?

Published in:

FEBS Letters, 2011, v. 585, n. 7, p. 1021, doi. 10.1016/j.febslet.2011.02.033

By:

Langer, Marcella;
Langosch, Dieter

Publication type:

Article

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase.

Published in:

Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04470-5

By:

Werner, Nadine T.;
Högel, Philipp;
Güner, Gökhan;
Stelzer, Walter;
Wozny, Manfred;
Aßfalg, Marlene;
Lichtenthaler, Stefan F.;
Steiner, Harald;
Langosch, Dieter

Publication type:

Article

Cleavage efficiency of the intramembrane protease γ‐secretase is reduced by the palmitoylation of a substrate's transmembrane domain.

Published in:

FASEB Journal, 2024, v. 38, n. 2, p. 1, doi. 10.1096/fj.202302152R

By:

Aßfalg, Marlene;
Güner, Gökhan;
Müller, Stephan A.;
Breimann, Stephan;
Langosch, Dieter;
Muhle‐Goll, Claudia;
Frishman, Dmitrij;
Steiner, Harald;
Lichtenthaler, Stefan F.

Publication type:

Article

Strategies for Prokaryotic Expression of Eukaryotic Membrane Proteins.

Published in:

Traffic, 2001, v. 2, n. 2, p. 99, doi. 10.1034/j.1600-0854.2001.020204.x

By:

Laage, Rico;
Langosch, Dieter

Publication type:

Article

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41766-1

By:

Götz, Alexander;
Högel, Philipp;
Silber, Mara;
Chaitoglou, Iro;
Luy, Burkhard;
Muhle-Goll, Claudia;
Scharnagl, Christina;
Langosch, Dieter

Publication type:

Article

Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 18, p. 14396, doi. 10.3390/ijms241814396

By:

Pauli, Theresa M.;
Julius, Ayse;
Costa, Francesco;
Eschrig, Sabine;
Moosmüller, Judith;
Fischer, Lea;
Schanzenbach, Christoph;
Schmidt, Fabian C.;
Ortner, Martin;
Langosch, Dieter

Publication type:

Article

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-24772-8

By:

Papadopoulou, Alkmini A.;
Stelzer, Walter;
Silber, Mara;
Schlosser, Christine;
Spitz, Charlotte;
Haug-Kröper, Martina;
Straub, Tobias;
Müller, Stephan A.;
Lichtenthaler, Stefan F.;
Muhle-Goll, Claudia;
Langosch, Dieter;
Fluhrer, Regina

Publication type:

Article

Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix.

Published in:

Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 7, p. 1097, doi. 10.1002/pro.2094

By:

Stelzer, Walter;
Langosch, Dieter

Publication type:

Article

Stabilization of conformationally dynamic helices by covalently attached acyl chains.

Published in:

Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 8, p. 1801, doi. 10.1002/pro.155

By:

Poschner, Bernhard C.;
Langosch, Dieter

Publication type:

Article

Interaction and conformational dynamics of membrane‐spanning protein helices.

Published in:

Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 7, p. 1343, doi. 10.1002/pro.154

By:

Langosch, Dieter;
Arkin, Isaiah T.

Publication type:

Article

The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics.

Published in:

ChemBioChem, 2013, v. 14, n. 15, p. 1943, doi. 10.1002/cbic.201300322

By:

Pester, Oxana;
Götz, Alexander;
Multhaup, Gerd;
Scharnagl, Christina;
Langosch, Dieter

Publication type:

Article

The interface of a membrane-spanning leucine zipper mapped by asparagine-scanning mutagenesis.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 2, p. 555, doi. 10.1110/ps.03357404

By:

Ruan, Weiming;
Lindner, Eric;
Langosch, Dieter

Publication type:

Article

The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues.

Published in:

1998

By:

Brosig, Bettina;
Langosch, Dieter

Publication type:

Other

Conserved conformational dynamics of membrane fusion protein transmembrane domains and flanking regions indicated by sequence statistics.

Published in:

Proteins, 2011, v. 79, n. 8, p. 2418, doi. 10.1002/prot.23063

By:

Neumann, Sindy;
Langosch, Dieter

Publication type:

Article

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

Published in:

EMBO Journal, 2014, v. 33, n. 21, p. 2492, doi. 10.15252/embj.201488208

By:

Chen, Chia‐yi;
Malchus, Nicole S;
Hehn, Beate;
Stelzer, Walter;
Avci, Dönem;
Langosch, Dieter;
Lemberg, Marius K

Publication type:

Article

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42.

Published in:

EMBO Journal, 2007, v. 26, n. 6, p. 1702, doi. 10.1038/sj.emboj.7601616

By:

Munter, Lisa-Marie;
Voigt, Philipp;
Harmeier, Anja;
Kaden, Daniela;
Gottschalk, Kay E.;
Weise, Christoph;
Pipkorn, Rüdiger;
Schaefer, Michael;
Langosch, Dieter;
Multhaup, Gerd

Publication type:

Article

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Published in:

Biological Chemistry, 2017, v. 398, n. 4, p. 441, doi. 10.1515/hsz-2016-0269

By:

Langosch, Dieter;
Steiner, Harald

Publication type:

Article