Works by Lambris, John D.

Results: 99

Clinical C3 Inhibition With AMY‐101 Reveals Novel Insights Into IL‐8‐Driven Inflammation in COVID‐19.

Published in:

Immunology, 2025, v. 175, n. 3, p. 288, doi. 10.1111/imm.13930

By:

Antoniadou, Christina;
Natsi, Anastasia‐Maria;
Mastellos, Dimitrios C.;
Papadimitriou, Evangelos;
Gavriilidis, Efstratios;
Tsironidou, Victoria;
Papadopoulos, Vasileios;
Eftalitsidis, Evgenios;
Κoffa, Μaria;
Huber‐Lang, Markus;
Risitano, Antonio M.;
Yancopoulou, Despina;
Germanidis, Georgios;
Ritis, Konstantinos;
Lambris, John D.;
Skendros, Panagiotis

Publication type:

Article

Complement: a key system for immune surveillance and homeostasis.

Published in:

Nature Immunology, 2010, v. 11, n. 9, p. 785, doi. 10.1038/ni.1923

By:

Ricklin, Daniel;
Hajishengallis, George;
Kun Yang;
Lambris, John D.

Publication type:

Article

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.

Published in:

Nature Immunology, 2009, v. 10, n. 7, p. 721, doi. 10.1038/ni.1756

By:

Rooijakkers, Suzan H. M.;
Jin Wu;
Ruyken, Maartje;
van Domselaar, Robert;
Planken, Karel L.;
Tzekou, Apostolia;
Ricklin, Daniel;
Lambris, John D.;
Janssen, Bert J. C.;
van Strijp, Jos A. G.;
Gros, Piet

Publication type:

Article

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators.

Published in:

Nature Immunology, 2009, v. 10, n. 7, p. 728, doi. 10.1038/ni.1755

By:

Jin Wu;
You-Qiang Wu;
Ricklin, Daniel;
Janssen, Bert J. C.;
Lambris, John D.;
Gros, Piet

Publication type:

Article

Modulation of the antitumor immune response by complement.

Published in:

Nature Immunology, 2008, v. 9, n. 11, p. 1225, doi. 10.1038/ni.1655

By:

Markiewski, Maciej M;
DeAngelis, Robert A;
Benencia, Fabian;
Ricklin-Lichtsteiner, Salome K;
Koutoulaki, Anna;
Gerard, Craig;
Coukos, George;
Lambris, John D

Publication type:

Article

A structural basis for complement inhibition by Staphylococcus aureus.

Published in:

Nature Immunology, 2007, v. 8, n. 4, p. 430, doi. 10.1038/ni1450

By:

Hammel, Michal;
Sfyroera, Georgia;
Ricklin, Daniel;
Magotti, Paola;
Lambris, John D;
Geisbrecht, Brian V

Publication type:

Article

Complement modulation reverses pathology in Y402H‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function.

Published in:

Stem Cells Translational Medicine, 2020, v. 9, n. 12, p. 1585, doi. 10.1002/sctm.20-0211

By:

Cerniauskas, Edvinas;
Kurzawa‐Akanbi, Marzena;
Xie, Long;
Hallam, Dean;
Moya‐Molina, Marina;
White, Kathryn;
Steel, David;
Doherty, Mary;
Whitfield, Phil;
Al‐Aama, Jumana;
Armstrong, Lyle;
Kavanagh, David;
Lambris, John D.;
Korolchuk, Viktor I.;
Harris, Claire;
Lako, Majlinda

Publication type:

Article

In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 01, doi. 10.3389/fimmu.2023.1101387

By:

Gerogianni, Alexandra;
Bal, Melissa;
Mohlin, Camilla;
Woodruff, Trent M.;
Lambris, John D.;
Mollnes, Tom E.;
Sjöström, Dick J.;
Nilsson, Per H.

Publication type:

Article

Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin.

Published in:

Journal of Molecular Recognition, 2009, v. 22, n. 6, p. 495, doi. 10.1002/jmr.972

By:

Magotti, Paola;
Ricklin, Daniel;
Qu, Hongchang;
Wu, You-Qiang;
Kaznessis, Yiannis N.;
Lambris, John D.

Publication type:

Article

C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing.

Published in:

Journal of Orthopaedic Research, 2012, v. 30, n. 4, p. 581, doi. 10.1002/jor.21561

By:

Recknagel, Stefan;
Bindl, Ronny;
Kurz, Julian;
Wehner, Tim;
Schoengraf, Philipp;
Ehrnthaller, Christian;
Qu, Hongchang;
Gebhard, Florian;
Huber-Lang, Markus;
Lambris, John D.;
Claes, Lutz;
Ignatius, Anita

Publication type:

Article

Acute Lung Injury and Fibrosis in a Baboon Model of Escherichia coli Sepsis.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2014, v. 50, n. 2, p. 439, doi. 10.1165/rcmb.2013-0219OC

By:

Keshari, Ravi S.;
Silasi-Mansat, Robert;
Hua Zhu;
Popescu, Narcis I.;
Peer, Glenn;
Chaaban, Hala;
Lambris, John D.;
Polf, Holly;
Lupu, Cristina;
Kinasewitz, Gary;
Lupu, Florea

Publication type:

Article

Complement evasion by human pathogens.

Published in:

Nature Reviews Microbiology, 2008, v. 6, n. 2, p. 132, doi. 10.1038/nrmicro1824

By:

Lambris, John D.;
Ricklin, Daniel;
Geisbrecht, Brian V.

Publication type:

Article

Partial hepatectomy induced liver proteome changes in mice.

Published in:

Proteomics, 2005, v. 5, n. 1, p. 318, doi. 10.1002/pmic.200400913

By:

Christoph W. Strey;
Mike S. Winters;
Maciej M. Markiewski;
John D. Lambris

Publication type:

Article

Complement‐targeted therapeutics: An emerging field enabled by academic drug discovery.

Published in:

American Journal of Hematology, 2023, v. 98, p. S82, doi. 10.1002/ajh.26875

By:

Lamers, Christina;
Ricklin, Daniel;
Lambris, John D.

Publication type:

Article

Structure of C3b reveals conformational changes that underlie complement activity.

Published in:

Nature, 2006, v. 444, n. 7116, p. 213, doi. 10.1038/nature05172

By:

Janssen, Bert J. C.;
Christodoulidou, Agni;
McCarthy, Andrew;
Lambris, John D.;
Gros, Piet

Publication type:

Article

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells.

Published in:

Cells (2073-4409), 2023, v. 12, n. 6, p. 887, doi. 10.3390/cells12060887

By:

Kuhn, Amelie;
Riegger, Jana;
Teixeira, Graciosa Q.;
Huber-Lang, Markus;
Lambris, John D.;
Neidlinger-Wilke, Cornelia;
Brenner, Rolf E.

Publication type:

Article

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25745-7

By:

Schmitz, Robin;
Fitch, Zachary W.;
Schroder, Paul M.;
Choi, Ashley Y.;
Manook, Miriam;
Yoon, Janghoon;
Song, Mingqing;
Yi, John S.;
Khandelwal, Sanjay;
Arepally, Gowthami M.;
Farris, Alton B.;
Reis, Edimara S.;
Lambris, John D.;
Kwun, Jean;
Knechtle, Stuart J.

Publication type:

Article

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24021-y

By:

Doni, Andrea;
Parente, Raffaella;
Laface, Ilaria;
Magrini, Elena;
Cunha, Cristina;
Colombo, Federico Simone;
Lacerda, João F.;
Campos, António;
Mapelli, Sarah N.;
Petroni, Francesca;
Porte, Rémi;
Schorn, Tilo;
Inforzato, Antonio;
Mercier, Toine;
Lagrou, Katrien;
Maertens, Johan;
Lambris, John D.;
Bottazzi, Barbara;
Garlanda, Cecilia;
Botto, Marina

Publication type:

Article

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

Published in:

Stem Cells, 2014, v. 32, n. 9, p. 2430, doi. 10.1002/stem.1729

By:

Moll, Guido;
Alm, Jessica J.;
Davies, Lindsay C.;
von Bahr, Lena;
Heldring, Nina;
Stenbeck-Funke, Lillemor;
Hamad, Osama A.;
Hinsch, Robin;
Ignatowicz, Lech;
Locke, Matthew;
Lönnies, Helena;
Lambris, John D.;
Teramura, Yuji;
Nilsson-Ekdahl, Kristina;
Nilsson, Bo;
Blanc, Katarina

Publication type:

Article

Conformational interconversion in compstatin probed with molecular dynamics simulations.

Published in:

Proteins, 2003, v. 53, n. 1, p. 130, doi. 10.1002/prot.10491

By:

Buddhadeb Mallik;
John D. Lambris;
Dimitrios Morikis

Publication type:

Article

Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis.

Published in:

2022

By:

Gonçales, Relber A.;
Novais Bastos, Helder;
Duarte-Oliveira, Cláudio;
Antunes, Daniela;
Sokhatska, Oksana;
Jacob, Maria;
Rolo, Rui;
Campos, Cláudia F.;
Sasaki, Sergio D.;
Donato, Alessia;
Mapelli, Sarah N.;
Costa, Sandra;
Souto Moura, Conceição;
Delgado, Luís;
Morais, António;
Torrado, Egídio;
van de Veerdonk, Frank L.;
Weichhart, Thomas;
Lambris, John D.;
Silvestre, Ricardo

Publication type:

journal article

Is complement the culprit behind COVID-19 vaccine-related adverse reactions?

Published in:

2021

By:

Mastellos, Dimitrios C.;
Skendros, Panagiotis;
Lambris, John D.

Publication type:

journal article

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.

Published in:

2020

By:

Skendros, Panagiotis;
Mitsios, Alexandros;
Chrysanthopoulou, Akrivi;
Mastellos, Dimitrios C.;
Metallidis, Simeon;
Rafailidis, Petros;
Ntinopoulou, Maria;
Sertaridou, Eleni;
Tsironidou, Victoria;
Tsigalou, Christina;
Tektonidou, Maria;
Konstantinidis, Theocharis;
Papagoras, Charalampos;
Mitroulis, Ioannis;
Germanidis, Georgios;
Lambris, John D.;
Ritis, Konstantinos;
Tektonidou, Maria G

Publication type:

journal article

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.

Published in:

2006

By:

Köhl, Jörg;
Baelder, Ralf;
Lewkowich, Ian P.;
Pandey, Manoj K.;
Hawlisch, Heiko;
Lihua Wang;
Best, Jennifer;
Herman, Nancy S.;
Sproles, Alyssa A.;
Zwirner, Jörg;
Whitsett, Jeffrey A.;
Gerard, Craig;
Sfyroera, Georgia;
Lambris, John D.;
Wills-Karp, Marsha;
Köhl, Jörg;
Wang, Lihua;
Zwirner, Jörg

Publication type:

journal article

Complement-Dependent Mechanisms and Interventions in Periodontal Disease.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00406

By:

Hajishengallis, George;
Kajikawa, Tetsuhiro;
Hajishengallis, Evlambia;
Maekawa, Tomoki;
Reis, Edimara S.;
Mastellos, Dimitrios C.;
Yancopoulou, Despina;
Hasturk, Hatice;
Lambris, John D.

Publication type:

Article

Factor h c-Terminal Domains are critical for regulation of Platelet/granulocyte aggregate Formation.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01586

By:

Blatt, Adam Z.;
Saggu, Gurpanna;
Cortes, Claudio;
Herbert, Andrew P.;
Kavanagh, David;
Ricklin, Daniel;
Lambris, John D.;
Ferreira, Viviana P.

Publication type:

Article

Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape.

Published in:

Expert Review of Hematology, 2014, v. 7, n. 5, p. 583, doi. 10.1586/17474086.2014.953926

By:

Mastellos, Dimitrios C;
Ricklin, Daniel;
Yancopoulou, Despina;
Risitano, Antonio;
Lambris, John D

Publication type:

Article

Complement inhibition decreases early fibrogenic events in the lung of septic baboons.

Published in:

Journal of Cellular & Molecular Medicine, 2015, v. 19, n. 11, p. 2549, doi. 10.1111/jcmm.12667

By:

Silasi‐Mansat, Robert;
Zhu, Hua;
Georgescu, Constantin;
Popescu, Narcis;
Keshari, Ravi S.;
Peer, Glenn;
Lupu, Cristina;
Taylor, Fletcher B.;
Pereira, Heloise Anne;
Kinasewitz, Gary;
Lambris, John D.;
Lupu, Florea

Publication type:

Article

Complexity of complement activation in sepsis.

Published in:

Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 6a, p. 2245, doi. 10.1111/j.1582-4934.2008.00504.x

By:

Markiewski, Maciej M.;
DeAngelis, Robert A.;
Lambris, John D.

Publication type:

Article

Microbial manipulation of receptor crosstalk in innate immunity.

Published in:

2011

By:

Hajishengallis, George;
Lambris, John D.

Publication type:

journal article

Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood.

Published in:

Xenotransplantation, 2017, v. 24, n. 1, p. n/a, doi. 10.1111/xen.12262

By:

Abicht, Jan‐Michael;
Kourtzelis, Ioannis;
Reichart, Bruno;
Koutsogiannaki, Sophia;
Primikyri, Alexandra;
Lambris, John D.;
Chavakis, Triantafyllos;
Holdt, Lesca;
Kind, Alexander;
Guethoff, Sonja;
Mayr, Tanja

Publication type:

Article

Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy.

Published in:

OncoImmunology, 2017, v. 6, n. 9, p. N.PAG, doi. 10.1080/2162402X.2017.1326442

By:

Facciabene, Andrea;
De Sanctis, Francesco;
Pierini, Stefano;
Reis, Edimara S.;
Balint, Klara;
Facciponte, John;
Rueter, Jens;
Kagabu, Masahiro;
Magotti, Paola;
Lanitis, Evripidis;
DeAngelis, Robert A.;
Buckanovich, Ronald J.;
Song, Wenchao C.;
Lambris, John D.;
Coukos, George

Publication type:

Article

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33003-7

By:

Lamers, Christina;
Xue, Xiaoguang;
Smieško, Martin;
van Son, Henri;
Wagner, Bea;
Berger, Nadja;
Sfyroera, Georgia;
Gros, Piet;
Lambris, John D.;
Ricklin, Daniel

Publication type:

Article

Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury.

Published in:

Science Translational Medicine, 2015, v. 7, n. 297, p. 1, doi. 10.1126/scitranslmed.aab1482

By:

Sweigard, J. Harry;
Hidetaka Matsumoto;
Smith, Kaylee E.;
Kim, Leo A.;
Paschalis, Eleftherios I.;
Yoko Okonuki;
Castillejos, Alexandra;
Keiko Kataoka;
Eiichi Hasegawa;
Ryoji Yanai;
Husain, Deeba;
Lambris, John D.;
Vavvas, Demetrios;
Miller, Joan W.;
Connor, Kip M.

Publication type:

Article

Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood.

Published in:

Innate Immunity, 2014, v. 20, n. 1, p. 68, doi. 10.1177/1753425913482993

By:

Egge, Kjetil H;
Thorgersen, Ebbe B;
Lindstad, Julie K;
Pharo, Anne;
Lambris, John D;
Barratt-Due, Andreas;
Mollnes, Tom E

Publication type:

Article

Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity.

Published in:

Innate Immunity, 2010, v. 16, n. 4, p. 254, doi. 10.1177/1753425909340420

By:

Thorgersen, Ebbe Billmann;
Ludviksen, Judith K.;
Lambris, John D.;
Sfyroera, Georgia;
Nielsen, Erik Waage;
Mollnes, Tom Eirik

Publication type:

Article

Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.

Published in:

Protein Science: A Publication of the Protein Society, 2008, v. 17, n. 11, p. 1894, doi. 10.1110/ps.036624.108

By:

Haspel, Nurit;
Ricklin, Daniel;
Geisbrecht, Brian V.;
Kavraki, Lydia E.;
Lambris, John D.

Publication type:

Article

Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility.

Published in:

Journal of Biomedical Materials Research, Part A, 2011, v. 97A, n. 1, p. 74, doi. 10.1002/jbm.a.33030

By:

Engberg, Anna E.;
Rosengren-Holmberg, Jenny P.;
Chen, Hui;
Nilsson, Bo;
Lambris, John D.;
Nicholls, Ian A.;
Ekdahl, Kristina N.

Publication type:

Article

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Published in:

EMBO Journal, 2016, v. 35, n. 10, p. 1133, doi. 10.15252/embj.201593673

By:

Forneris, Federico;
Wu, Jin;
Xue, Xiaoguang;
Ricklin, Daniel;
Lin, Zhuoer;
Sfyroera, Georgia;
Tzekou, Apostolia;
Volokhina, Elena;
Granneman, Joke CM;
Hauhart, Richard;
Bertram, Paula;
Liszewski, M Kathryn;
Atkinson, John P;
Lambris, John D;
Gros, Piet

Publication type:

Article

A protective role for the fifth complement component (c5) in allergic airway disease.

Published in:

2006

By:

Drouin SM;
Sinha M;
Sfyroera G;
Lambris JD;
Wetsel RA;
Drouin, Scott M;
Sinha, Meenal;
Sfyroera, Georgia;
Lambris, John D;
Wetsel, Rick A

Publication type:

journal article

A Protective Role for the Fifth Complement Component (C5) in Allergic Airway Disease.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2006, v. 173, n. 8, p. 852, doi. 10.1164/rccm.200503-334OC

By:

Drouin, Scott M.;
Sinha, Meenal;
Sfyroera, Georgia;
Lambris, John D.;
Wetsel, Rick A.

Publication type:

Article

Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.

Published in:

2004

By:

Park, Jung-Won;
Taube, Christian;
Joetham, Anthony;
Takeda, Katsuyuki;
Kodama, Taku;
Dakhama, Azzeddine;
McConville, Glen;
Allen, Corrie B.;
Sfyroera, Georgia;
Shultz, Lenny D.;
Lambris, John D.;
Giclas, Patricia C.;
Michael Holers, V.;
Gelfand, Erwin W.;
Holers, V Michael

Publication type:

journal article

CMAP: Complement Map Database.

Published in:

Bioinformatics, 2013, v. 29, n. 14, p. 1832, doi. 10.1093/bioinformatics/btt269

By:

Yang, Kun;
Dinasarapu, Ashok R.;
Reis, Edimara S.;
DeAngelis, Robert A.;
Ricklin, Daniel;
Subramaniam, Shankar;
Lambris, John D.

Publication type:

Article

Structure and biology of complement protein C3, a connecting link between innate and acquired immunity.

Published in:

Immunological Reviews, 2001, v. 180, n. 1, p. 35, doi. 10.1034/j.1600-065x.2001.1800103.x

By:

Sahu, Arvind;
Lambris, John D.

Publication type:

Article

Evolution and diversity of the complement system of poikilothermic vertebrates.

Published in:

Immunological Reviews, 1998, v. 166, n. 1, p. 39, doi. 10.1111/j.1600-065X.1998.tb01251.x

By:

Sunyer, J. Oriol;
Lambris, John D.

Publication type:

Article

Solution structure of Compstatin, a potent complement inhibitor

Published in:

Protein Science: A Publication of the Protein Society, 1998, v. 7, n. 3, p. 619

By:

Morikis, Dimitrios;
Assa-Munt, Nuria;
Sahu, Arvind;
Lambris, John D.

Publication type:

Article

In Vivo Significance of ITK-SLP-76 Interaction in Cytokine Production.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 14, p. 17, doi. 10.1128/MCB.01657-09

By:

Grasis, Juris A.;
Guimond, David M.;
Cam, Nicholas R.;
Herman, Krystal;
Magotti, Paola;
Lambris, John D.;
Tsoukas, Constantine D.

Publication type:

Article

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.

Published in:

Journal of Cellular Biochemistry, 2011, v. 112, n. 9, p. 2594, doi. 10.1002/jcb.23186

By:

Ignatius, Anita;
Schoengraf, Philipp;
Kreja, Ludwika;
Liedert, Astrid;
Recknagel, Stefan;
Kandert, Sebastian;
Brenner, Rolf E.;
Schneider, Marion;
Lambris, John D.;
Huber-Lang, Markus

Publication type:

Article

A 'rule of 3' to revive Greek science, research and innovation.

Published in:

Nature Immunology, 2015, v. 16, n. 12, p. 1206, doi. 10.1038/ni.3322

By:

Kollias, George;
Lambris, John D

Publication type:

Article

Aegean reflections on innate immunity.

Published in:

Nature Immunology, 2013, v. 14, n. 10, p. 1025, doi. 10.1038/ni.2690

By:

Hajishengallis, George;
Mantovani, Alberto;
Moretta, Alessandro;
Lambris, John D

Publication type:

Article