Works by Lambris, John D.

Results: 95

Complement: a key system for immune surveillance and homeostasis.
Published in:
Nature Immunology, 2010, v. 11, n. 9, p. 785, doi. 10.1038/ni.1923
By:
- Ricklin, Daniel;
- Hajishengallis, George;
- Kun Yang;
- Lambris, John D.
Publication type:
Article
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Published in:
Nature Immunology, 2009, v. 10, n. 7, p. 721, doi. 10.1038/ni.1756
By:
- Rooijakkers, Suzan H. M.;
- Jin Wu;
- Ruyken, Maartje;
- van Domselaar, Robert;
- Planken, Karel L.;
- Tzekou, Apostolia;
- Ricklin, Daniel;
- Lambris, John D.;
- Janssen, Bert J. C.;
- van Strijp, Jos A. G.;
- Gros, Piet
Publication type:
Article
Structure of complement fragment C3b–factor H and implications for host protection by complement regulators.
Published in:
Nature Immunology, 2009, v. 10, n. 7, p. 728, doi. 10.1038/ni.1755
By:
- Jin Wu;
- You-Qiang Wu;
- Ricklin, Daniel;
- Janssen, Bert J. C.;
- Lambris, John D.;
- Gros, Piet
Publication type:
Article
Modulation of the antitumor immune response by complement.
Published in:
Nature Immunology, 2008, v. 9, n. 11, p. 1225, doi. 10.1038/ni.1655
By:
- Markiewski, Maciej M;
- DeAngelis, Robert A;
- Benencia, Fabian;
- Ricklin-Lichtsteiner, Salome K;
- Koutoulaki, Anna;
- Gerard, Craig;
- Coukos, George;
- Lambris, John D
Publication type:
Article
A structural basis for complement inhibition by Staphylococcus aureus.
Published in:
Nature Immunology, 2007, v. 8, n. 4, p. 430, doi. 10.1038/ni1450
By:
- Hammel, Michal;
- Sfyroera, Georgia;
- Ricklin, Daniel;
- Magotti, Paola;
- Lambris, John D;
- Geisbrecht, Brian V
Publication type:
Article
Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood.
Published in:
Xenotransplantation, 2017, v. 24, n. 1, p. n/a, doi. 10.1111/xen.12262
By:
- Abicht, Jan‐Michael;
- Kourtzelis, Ioannis;
- Reichart, Bruno;
- Koutsogiannaki, Sophia;
- Primikyri, Alexandra;
- Lambris, John D.;
- Chavakis, Triantafyllos;
- Holdt, Lesca;
- Kind, Alexander;
- Guethoff, Sonja;
- Mayr, Tanja
Publication type:
Article
Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation.
Published in:
Xenotransplantation, 2008, v. 15, n. 4, p. 225, doi. 10.1111/j.1399-3089.2008.00482.x
By:
- Goto, Masafumi;
- Tjernberg, Jenny;
- Dufrane, Denis;
- Elgue, Graciela;
- Brandhorst, Daniel;
- Ekdahl, Kristina Nilsson;
- Brandhorst, Heidi;
- Wennberg, Lars;
- Kurokawa, Yoshimochi;
- Satomi, Susumu;
- Lambris, John D.;
- Gianello, Pierre;
- Korsgren, Olle;
- Nilsson, Bo
Publication type:
Article
Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.
Published in:
Xenotransplantation, 1999, v. 6, n. 1, p. 52, doi. 10.1034/j.1399-3089.1999.00007.x
By:
- Fiane, Arnt E.;
- Mollnes, Tom E.;
- Videm, VIBEKE;
- Hovig, TORSTEIN;
- Høgåsen, Kolbjørn;
- Mellbye, Ove J.;
- Spruce, LYNN;
- Moore, William T.;
- Sahu, ARVIND;
- Lambris, John D.
Publication type:
Article
Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin.
Published in:
Journal of Molecular Recognition, 2009, v. 22, n. 6, p. 495, doi. 10.1002/jmr.972
By:
- Magotti, Paola;
- Ricklin, Daniel;
- Qu, Hongchang;
- Wu, You-Qiang;
- Kaznessis, Yiannis N.;
- Lambris, John D.
Publication type:
Article
Complement-targeted therapeutics.
Published in:
Nature Biotechnology, 2007, v. 25, n. 11, p. 1265, doi. 10.1038/nbt1342
By:
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Complexity of complement activation in sepsis.
Published in:
Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 6a, p. 2245, doi. 10.1111/j.1582-4934.2008.00504.x
By:
- Markiewski, Maciej M.;
- DeAngelis, Robert A.;
- Lambris, John D.
Publication type:
Article
Protection of innate immunity by C5aR antagonist in septic mice.
Published in:
FASEB Journal, 2002, v. 16, n. 12, p. 1567, doi. 10.1096/fj.02-0209com
By:
- Huber‐Lang, Markus S.;
- Riedeman, Niels C.;
- Sarma, J. Vidya;
- Younkin, Ellen M.;
- McGuire, Stephanie R.;
- Laudes, Ines J.;
- Lu, Kristina T.;
- Guo, Ren‐Feng;
- Neff, Thomas A.;
- Padgaonkar, Vaishalee A.;
- Lambris, John D.;
- Spruce, L.;
- Mastellos, D.;
- Zetoune, Firas S.;
- Ward, Peter A.
Publication type:
Article
Structure of C3b reveals conformational changes that underlie complement activity.
Published in:
Nature, 2006, v. 444, n. 7116, p. 213, doi. 10.1038/nature05172
By:
- Janssen, Bert J. C.;
- Christodoulidou, Agni;
- McCarthy, Andrew;
- Lambris, John D.;
- Gros, Piet
Publication type:
Article
Microbial manipulation of receptor crosstalk in innate immunity.
Published in:
2011
By:
- Hajishengallis, George;
- Lambris, John D.
Publication type:
journal article
Factor h c-Terminal Domains are critical for regulation of Platelet/granulocyte aggregate Formation.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01586
By:
- Blatt, Adam Z.;
- Saggu, Gurpanna;
- Cortes, Claudio;
- Herbert, Andrew P.;
- Kavanagh, David;
- Ricklin, Daniel;
- Lambris, John D.;
- Ferreira, Viviana P.
Publication type:
Article
The Complement System Is Critical in Maintaining Retinal Integrity during Aging.
Published in:
Frontiers in Aging Neuroscience, 2018, p. 1, doi. 10.3389/fnagi.2018.00015
By:
- Mukai, Ryo;
- Okunuki, Yoko;
- Husain, Deeba;
- Kim, Clifford B.;
- Lambris, John D.;
- Connor, Kip M.
Publication type:
Article
Acute Lung Injury and Fibrosis in a Baboon Model of Escherichia coli Sepsis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2014, v. 50, n. 2, p. 439, doi. 10.1165/rcmb.2013-0219OC
By:
- Keshari, Ravi S.;
- Silasi-Mansat, Robert;
- Hua Zhu;
- Popescu, Narcis I.;
- Peer, Glenn;
- Chaaban, Hala;
- Lambris, John D.;
- Polf, Holly;
- Lupu, Cristina;
- Kinasewitz, Gary;
- Lupu, Florea
Publication type:
Article
Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis.
Published in:
2022
By:
- Gonçales, Relber A.;
- Novais Bastos, Helder;
- Duarte-Oliveira, Cláudio;
- Antunes, Daniela;
- Sokhatska, Oksana;
- Jacob, Maria;
- Rolo, Rui;
- Campos, Cláudia F.;
- Sasaki, Sergio D.;
- Donato, Alessia;
- Mapelli, Sarah N.;
- Costa, Sandra;
- Souto Moura, Conceição;
- Delgado, Luís;
- Morais, António;
- Torrado, Egídio;
- van de Veerdonk, Frank L.;
- Weichhart, Thomas;
- Lambris, John D.;
- Silvestre, Ricardo
Publication type:
journal article
Complement evasion by human pathogens.
Published in:
Nature Reviews Microbiology, 2008, v. 6, n. 2, p. 132, doi. 10.1038/nrmicro1824
By:
- Lambris, John D.;
- Ricklin, Daniel;
- Geisbrecht, Brian V.
Publication type:
Article
Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells.
Published in:
Cells (2073-4409), 2023, v. 12, n. 6, p. 887, doi. 10.3390/cells12060887
By:
- Kuhn, Amelie;
- Riegger, Jana;
- Teixeira, Graciosa Q.;
- Huber-Lang, Markus;
- Lambris, John D.;
- Neidlinger-Wilke, Cornelia;
- Brenner, Rolf E.
Publication type:
Article
Bothrops jararaca Snake Venom Inflammation Induced in Human Whole Blood: Role of the Complement System.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.885223
By:
- Thyago Bispo Leonel;
- Megale Gabrili, Joel José;
- Cristina Squaiella-Baptistão, Carla;
- Woodruff, Trent M.;
- Lambris, John D.;
- Tambourgi, Denise V.
Publication type:
Article
Diet-induced hepatocellular carcinoma in genetically predisposed mice.
Published in:
Human Molecular Genetics, 2009, v. 18, n. 16, p. 2975, doi. 10.1093/hmg/ddp236
By:
- Hill-Baskin, Annie E.;
- Markiewski, Maciej M.;
- Buchner, David A.;
- Shao, Haifeng;
- DeSantis, David;
- Hsiao, Gene;
- Subramaniam, Shankar;
- Berger, Nathan A.;
- Croniger, Colleen;
- Lambris, John D.;
- Nadeau, Joseph H.
Publication type:
Article
Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33003-7
By:
- Lamers, Christina;
- Xue, Xiaoguang;
- Smieško, Martin;
- van Son, Henri;
- Wagner, Bea;
- Berger, Nadja;
- Sfyroera, Georgia;
- Gros, Piet;
- Lambris, John D.;
- Ricklin, Daniel
Publication type:
Article
C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25745-7
By:
- Schmitz, Robin;
- Fitch, Zachary W.;
- Schroder, Paul M.;
- Choi, Ashley Y.;
- Manook, Miriam;
- Yoon, Janghoon;
- Song, Mingqing;
- Yi, John S.;
- Khandelwal, Sanjay;
- Arepally, Gowthami M.;
- Farris, Alton B.;
- Reis, Edimara S.;
- Lambris, John D.;
- Kwun, Jean;
- Knechtle, Stuart J.
Publication type:
Article
Complement inhibition decreases early fibrogenic events in the lung of septic baboons.
Published in:
Journal of Cellular & Molecular Medicine, 2015, v. 19, n. 11, p. 2549, doi. 10.1111/jcmm.12667
By:
- Silasi‐Mansat, Robert;
- Zhu, Hua;
- Georgescu, Constantin;
- Popescu, Narcis;
- Keshari, Ravi S.;
- Peer, Glenn;
- Lupu, Cristina;
- Taylor, Fletcher B.;
- Pereira, Heloise Anne;
- Kinasewitz, Gary;
- Lambris, John D.;
- Lupu, Florea
Publication type:
Article
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.
Published in:
2016
By:
- Gustavsen, Alice;
- Nymo, Stig;
- Landsem, Anne;
- Christiansen, Dorte;
- Ryan, Liv;
- Husebye, Harald;
- Lau, Corinna;
- Pischke, Søren E.;
- Lambris, John D.;
- Espevik, Terje;
- Mollnes, Tom E.
Publication type:
journal article
Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.
Published in:
EMBO Journal, 2016, v. 35, n. 10, p. 1133, doi. 10.15252/embj.201593673
By:
- Forneris, Federico;
- Wu, Jin;
- Xue, Xiaoguang;
- Ricklin, Daniel;
- Lin, Zhuoer;
- Sfyroera, Georgia;
- Tzekou, Apostolia;
- Volokhina, Elena;
- Granneman, Joke CM;
- Hauhart, Richard;
- Bertram, Paula;
- Liszewski, M Kathryn;
- Atkinson, John P;
- Lambris, John D;
- Gros, Piet
Publication type:
Article
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
Published in:
Nature Communications, 2013, v. 4, n. 8, p. 2312, doi. 10.1038/ncomms3312
By:
- Haynes, Tracy;
- Luz-Madrigal, Agustin;
- Reis, Edimara S.;
- Echeverri Ruiz, Nancy P.;
- Grajales-Esquivel, Erika;
- Tzekou, Apostolia;
- Tsonis, Panagiotis A.;
- Lambris, John D.;
- Del Rio-Tsonis, Katia
Publication type:
Article
Blood protein-polymer adsorption: Implications for understanding complement-mediated hemoincompatibility.
Published in:
Journal of Biomedical Materials Research, Part A, 2011, v. 97A, n. 1, p. 74, doi. 10.1002/jbm.a.33030
By:
- Engberg, Anna E.;
- Rosengren-Holmberg, Jenny P.;
- Chen, Hui;
- Nilsson, Bo;
- Lambris, John D.;
- Nicholls, Ian A.;
- Ekdahl, Kristina N.
Publication type:
Article
Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β.
Published in:
Journal of Cellular Biochemistry, 2011, v. 112, n. 9, p. 2594, doi. 10.1002/jcb.23186
By:
- Ignatius, Anita;
- Schoengraf, Philipp;
- Kreja, Ludwika;
- Liedert, Astrid;
- Recknagel, Stefan;
- Kandert, Sebastian;
- Brenner, Rolf E.;
- Schneider, Marion;
- Lambris, John D.;
- Huber-Lang, Markus
Publication type:
Article
Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury.
Published in:
Science Translational Medicine, 2015, v. 7, n. 297, p. 1, doi. 10.1126/scitranslmed.aab1482
By:
- Sweigard, J. Harry;
- Hidetaka Matsumoto;
- Smith, Kaylee E.;
- Kim, Leo A.;
- Paschalis, Eleftherios I.;
- Yoko Okonuki;
- Castillejos, Alexandra;
- Keiko Kataoka;
- Eiichi Hasegawa;
- Ryoji Yanai;
- Husain, Deeba;
- Lambris, John D.;
- Vavvas, Demetrios;
- Miller, Joan W.;
- Connor, Kip M.
Publication type:
Article
Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk.
Published in:
Science Signaling, 2010, v. 3, n. 109, p. 1, doi. 10.1126/scisignal.2000697
By:
- Wang, Min;
- Krauss, Jennifer L.;
- Domon, Hisanori;
- Hosur, Kavita B.;
- Liang, Shuang;
- Magotti, Paola;
- Triantafilou, Martha;
- Triantafilou, Kathy;
- Lambris, John D.;
- Hajishengallis, George
Publication type:
Article
Development of a New Pharmacophore Model That Discriminates Active Compstatin Analogs.
Published in:
Chemical Biology & Drug Design, 2008, v. 72, n. 4, p. 249, doi. 10.1111/j.1747-0285.2008.00709.x
By:
- Ting-Lan Chiu;
- Mulakala, Chandrika;
- Lambris, John D.;
- Kaznessis, Yiannis N.
Publication type:
Article
The alternative complement pathway regulates pathological angiogenesis in the retina.
Published in:
FASEB Journal, 2014, v. 28, n. 7, p. 3171, doi. 10.1096/fj.14-251041
By:
- Sweigard, J. Harry;
- Ryoji Yanai;
- Gaissert, Philipp;
- Saint-Geniez, Magali;
- Kataoka, Keiko;
- Thanos, Aristomenis;
- Stahl, Gregory L.;
- Lambris, John D.;
- Connor, Kip M.
Publication type:
Article
Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation.
Published in:
FASEB Journal, 2013, v. 27, n. 7, p. 2768, doi. 10.1096/fj.12-225888
By:
- Kourtzelis, Ioannis;
- Rafail, Stavros;
- DeAngelis, Robert A.;
- Foukas, Periklis G.;
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
A protective role for the fifth complement component (c5) in allergic airway disease.
Published in:
2006
By:
- Drouin SM;
- Sinha M;
- Sfyroera G;
- Lambris JD;
- Wetsel RA;
- Drouin, Scott M;
- Sinha, Meenal;
- Sfyroera, Georgia;
- Lambris, John D;
- Wetsel, Rick A
Publication type:
journal article
A Protective Role for the Fifth Complement Component (C5) in Allergic Airway Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2006, v. 173, n. 8, p. 852, doi. 10.1164/rccm.200503-334OC
By:
- Drouin, Scott M.;
- Sinha, Meenal;
- Sfyroera, Georgia;
- Lambris, John D.;
- Wetsel, Rick A.
Publication type:
Article
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
Published in:
2004
By:
- Park, Jung-Won;
- Taube, Christian;
- Joetham, Anthony;
- Takeda, Katsuyuki;
- Kodama, Taku;
- Dakhama, Azzeddine;
- McConville, Glen;
- Allen, Corrie B.;
- Sfyroera, Georgia;
- Shultz, Lenny D.;
- Lambris, John D.;
- Giclas, Patricia C.;
- Michael Holers, V.;
- Gelfand, Erwin W.;
- Holers, V Michael
Publication type:
journal article
C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2009, v. 29, n. 1, p. 98, doi. 10.1038/jcbfm.2008.95
By:
- Rynkowski, Michal A.;
- Kim, Grace H.;
- Garrett, Matthew C.;
- Zacharia, Brad E.;
- Otten, Marc L.;
- Sosunov, Sergei A.;
- Komotar, Ricardo J.;
- Hassid, Benjamin G.;
- Ducruet, Andrew F.;
- Lambris, John D.;
- Connolly, E. Sander
Publication type:
Article
Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques.
Published in:
Molecular Therapy, 2015, v. 23, n. 6, p. 1066, doi. 10.1038/mt.2015.49
By:
- Evgin, Laura;
- Acuna, Sergio A;
- Tanese de Souza, Christiano;
- Marguerie, Monique;
- Lemay, Chantal G;
- Ilkow, Carolina S;
- Findlay, C Scott;
- Falls, Theresa;
- Parato, Kelley A;
- Hanwell, David;
- Goldstein, Alyssa;
- Lopez, Roberto;
- Lafrance, Sandra;
- Breitbach, Caroline J;
- Kirn, David;
- Atkins, Harold;
- Auer, Rebecca C;
- Thurman, Joshua M;
- Stahl, Gregory L;
- Lambris, John D
Publication type:
Article
More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 233, doi. 10.1111/imr.12467
By:
- Hajishengallis, George;
- Lambris, John D.
Publication type:
Article
Protection of host cells by complement regulators.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 152, doi. 10.1111/imr.12475
By:
- Schmidt, Christoph Q.;
- Lambris, John D.;
- Ricklin, Daniel
Publication type:
Article
Preformed mediators of defense-Gatekeepers enter the spotlight.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 5, doi. 10.1111/imr.12497
By:
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article
Complement component C3 - The 'Swiss Army Knife' of innate immunity and host defense.
Published in:
Immunological Reviews, 2016, v. 274, n. 1, p. 33, doi. 10.1111/imr.12500
By:
- Ricklin, Daniel;
- Reis, Edimara S.;
- Mastellos, Dimitrios C.;
- Gros, Piet;
- Lambris, John D.
Publication type:
Article
Structure and biology of complement protein C3, a connecting link between innate and acquired immunity.
Published in:
Immunological Reviews, 2001, v. 180, n. 1, p. 35, doi. 10.1034/j.1600-065x.2001.1800103.x
By:
- Sahu, Arvind;
- Lambris, John D.
Publication type:
Article
Evolution and diversity of the complement system of poikilothermic vertebrates.
Published in:
Immunological Reviews, 1998, v. 166, n. 1, p. 39, doi. 10.1111/j.1600-065X.1998.tb01251.x
By:
- Sunyer, J. Oriol;
- Lambris, John D.
Publication type:
Article
The Challenges and Promise of Complement Therapeutics for Ocular Diseases.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01007
By:
- Park, Dong Ho;
- Connor, Kip M.;
- Lambris, John D.
Publication type:
Article
Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.
Published in:
2019
By:
- Karasu, Ebru;
- Nilsson, Bo;
- Köhl, Jörg;
- Lambris, John D.;
- Huber-Lang, Markus
Publication type:
Correction Notice
Complement-Dependent Mechanisms and Interventions in Periodontal Disease.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00406
By:
- Hajishengallis, George;
- Kajikawa, Tetsuhiro;
- Hajishengallis, Evlambia;
- Maekawa, Tomoki;
- Reis, Edimara S.;
- Mastellos, Dimitrios C.;
- Yancopoulou, Despina;
- Hasturk, Hatice;
- Lambris, John D.
Publication type:
Article
Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin.
Published in:
ChemMedChem, 2014, v. 9, n. 10, p. 2223, doi. 10.1002/cmdc.201402212
By:
- Huang, Yijun;
- Reis, Edimara S.;
- Knerr, Patrick J.;
- van der Donk, Wilfred A.;
- Ricklin, Daniel;
- Lambris, John D.
Publication type:
Article