OpenURL Connection Search

Select item for more details and to access through your institution.

How can drug discovery for psychiatric disorders be improved?
Published in:
2007
By:
- Agid, Yves;
- Buzsáki, György;
- Diamond, David M.;
- Frackowiak, Richard;
- Giedd, Jay;
- Girault, Jean-Antoine;
- Grace, Anthony;
- Lambert, Jeremy J.;
- Manji, Husseini;
- Mayberg, Helen;
- Popoli, Maurizio;
- Prochiantz, Alain;
- Richter-Levin, Gal;
- Somogyi, Peter;
- Spedding, Michael;
- Svenningsson, Per;
- Weinberger, Daniel;
- Buzsáki, György
Publication type:
review
Sedation and Anesthesia Mediated by Distinct GABA[subA] Receptor Isoforms.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 24, p. 8608, doi. 10.1523/JNEUROSCI.23-24-08608.2003
By:
- Reynolds, David S.;
- Rosahl, Thomas W.;
- Cirone, Jennifer;
- O'Meara, Gillian F.;
- Haythornthwaite, Alison;
- Newman, Richard J.;
- Myers, Janice;
- Sur, Cyrille;
- Howell, Owain;
- Rutter, A. Richard;
- Atack, John;
- Macaulay, Alison J.;
- Hadingham, Karen L.;
- Hutson, Peter H.;
- Belelli, Delia;
- Lambert, Jeremy J.;
- Dawson, Gerard R.;
- McKernan, Ruth;
- Whiting, Paul J.
Publication type:
Article
Neurosteroids: endogenous regulators of the GABAA receptor.
Published in:
Nature Reviews Neuroscience, 2005, v. 6, n. 7, p. 565, doi. 10.1038/nrn1703
By:
- Belelli, Delia;
- Lambert, Jeremy J.
Publication type:
Article
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.
Published in:
Journal of Physiology, 2008, v. 586, n. 4, p. 965, doi. 10.1113/jphysiol.2007.145375
By:
- Peden, Dianne R.;
- Petitjean, Caroline M.;
- Herd, Murray B.;
- Durakoglugil, Murat S.;
- Rosahl, Thomas W.;
- Wafford, Keith;
- Homanics, Gregg E.;
- Belelli, Delia;
- Fritschy, Jean-Marc;
- Lambert, Jeremy J.
Publication type:
Article
The expression of GABAAβ subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
Published in:
Journal of Physiology, 2008, v. 586, n. 4, p. 989, doi. 10.1113/jphysiol.2007.146746
By:
- Herd, Murray B.;
- Haythornthwaite, Alison R.;
- Rosahl, Thomas W.;
- Wafford, Keith A.;
- Homanics, Gregg E.;
- Lambert, Jeremy J.;
- Belelli, Delia
Publication type:
Article
The 4′lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.
Published in:
Journal of Physiology, 2000, v. 522, n. 2, p. 187, doi. 10.1111/j.1469-7793.2000.00187.x
By:
- Gunthorpe, Martin J.;
- Peters, John A.;
- Gill, Catherine H.;
- Lambert, Jeremy J.;
- Lummis, Sarah C. R.
Publication type:
Article
Complementary regulation of anaesthetic activation of human (α6β3γ2L) and Drosophila (RDL) GABA receptors by a single amino acid residue.
Published in:
Journal of Physiology, 1999, v. 515, n. 1, p. 3, doi. 10.1111/j.1469-7793.1999.003ad.x
By:
- Pistis, Marco;
- Belelli, Delia;
- McGurk, Karen;
- Peters, John A.;
- Lambert, Jeremy J.
Publication type:
Article
The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor.
Published in:
British Journal of Pharmacology, 1998, v. 124, n. 1, p. 13, doi. 10.1038/sj.bjp.0701787
By:
- McGurk, Karen A;
- Pistis, Marco;
- Belelli, Delia;
- Hope, Anthony G;
- Lambert, Jeremy J
Publication type:
Article
The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.
Published in:
British Journal of Pharmacology, 1997, v. 122, n. 8, p. 1707, doi. 10.1038/sj.bjp.0701563
By:
- Pistis, Marco;
- Belelli, Delia;
- Peters, John A.;
- Lambert, Jeremy J.
Publication type:
Article
Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor.
Published in:
British Journal of Pharmacology, 1997, v. 120, n. 5, p. 749, doi. 10.1038/sj.bjp.0700927
By:
- Hill-Venning, Claire;
- Belelli, Delia;
- Peters, John A;
- Lambert, Jeremy J
Publication type:
Article
Neurosteroid Modulation of Synaptic and Extrasynaptic GABA A Receptors of the Mouse Nucleus Accumbens.
Published in:
Biomolecules (2218-273X), 2024, v. 14, n. 4, p. 460, doi. 10.3390/biom14040460
By:
- Mitchell, Scott J.;
- Phillips, Grant D.;
- Tench, Becks;
- Li, Yunkai;
- Belelli, Delia;
- Martin, Stephen J.;
- Swinny, Jerome D.;
- Kelly, Louise;
- Atack, John R.;
- Paradowski, Michael;
- Lambert, Jeremy J.
Publication type:
Article
Relating neurosteroid modulation of inhibitory neurotransmission to behaviour.
Published in:
Journal of Neuroendocrinology, 2022, v. 34, n. 2, p. 1, doi. 10.1111/jne.13045
By:
- Belelli, Delia;
- Phillips, Grant D.;
- Atack, John R.;
- Lambert, Jeremy J.
Publication type:
Article
Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 50, p. 11513, doi. 10.1523/JNEUROSCI.2679-05.2005
By:
- Belelli, Delia;
- Peden, Dianne R.;
- Rosahl, Thomas W.;
- Wafford, Keith A.;
- Lambert, Jeremy J.
Publication type:
Article
Antidepressants and Antipsychotic Drugs Colocalize with 5-HT3 Receptors in Raft-Like Domains.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 44, p. 10198, doi. 10.1523/JNEUROSCI.2460-05.2005
By:
- Eisensamer, Brigitte;
- Uhr, Manfred;
- Meyr, Sabrina;
- Gimpl, Gerald;
- Deiml, Tobias;
- Rammes, Gerhard;
- Lambert, Jeremy J.;
- Zieglgänsberger, Walter;
- Holsboer, Florian;
- Rupprecht, Rainer
Publication type:
Article
Extrasynaptic Glycine Receptors of Rodent Dorsal Raphe Serotonergic Neurons: A Sensitive Target for Ethanol.
Published in:
Neuropsychopharmacology, 2014, v. 39, n. 5, p. 1232, doi. 10.1038/npp.2013.326
By:
- Maguire, Edward P;
- Mitchell, Elizabeth A;
- Greig, Scott J;
- Corteen, Nicole;
- Balfour, David J K;
- Swinny, Jerome D;
- Lambert, Jeremy J;
- Belelli, Delia
Publication type:
Article
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Published in:
Neuropathology & Applied Neurobiology, 2021, v. 47, n. 4, p. 488, doi. 10.1111/nan.12674
By:
- Kelly, Louise;
- Seifi, Mohsen;
- Ma, Ruolin;
- Mitchell, Scott J.;
- Rudolph, Uwe;
- Viola, Kirsten L.;
- Klein, William L.;
- Lambert, Jeremy J.;
- Swinny, Jerome D.
Publication type:
Article
A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ‐aminobutyric acidergic anticonvulsant.
Published in:
Epilepsia (Series 4), 2020, v. 61, n. 10, p. 2106, doi. 10.1111/epi.16644
By:
- Jones, Alistair;
- Barker‐Haliski, Melissa;
- Ilie, Andrei S.;
- Herd, Murray B.;
- Baxendale, Sarah;
- Holdsworth, Celia J.;
- Ashton, John‐Paul;
- Placzek, Marysia;
- Jayasekera, Bodiabaduge A. P.;
- Cowie, Christopher J. A.;
- Lambert, Jeremy J.;
- Trevelyan, Andrew J.;
- White, H. Steve;
- Marson, Anthony G.;
- Cunliffe, Vincent T.;
- Sills, Graeme J.;
- Morgan, Alan
Publication type:
Article
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.
Published in:
Nature, 2003, v. 424, n. 6946, p. 321, doi. 10.1038/nature01788
By:
- Kelley, Stephen P.;
- Dunlop, James I.;
- Kirkness, Ewen F.;
- Lambert, Jeremy J.;
- Peters, John A.
Publication type:
Article
Control of Inhibition by the Direct Action of Cannabinoids on GABAA Receptors.
Published in:
Cerebral Cortex, 2015, v. 25, n. 9, p. 2440, doi. 10.1093/cercor/bhu045
By:
- Golovko, Tatiana;
- Min, Rogier;
- Lozovaya, Natalia;
- Falconer, Caroline;
- Yatsenko, Natalia;
- Tsintsadze, Timur;
- Tsintsadze, Vera;
- Ledent, Catherine;
- Harvey, Robert J.;
- Belelli, Delia;
- Lambert, Jeremy J.;
- Rozov, Andrei;
- Burnashev, Nail
Publication type:
Article
Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.
Published in:
Journal of Physiology, 2015, v. 593, n. 1, p. 267, doi. 10.1113/jphysiol.2014.280263
By:
- Brown, Adam R.;
- Herd, Murray B.;
- Belelli, Delia;
- Lambert, Jeremy J.
Publication type:
Article
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Published in:
Journal of Physiology, 2011, v. 589, n. 20, p. 4959, doi. 10.1113/jphysiol.2011.216028
By:
- Panzanelli, Patrizia;
- Gunn, Benjamin G.;
- Schlatter, Monika C.;
- Benke, Dietmar;
- Tyagarajan, Shiva K.;
- Scheiffele, Peter;
- Belelli, Delia;
- Lambert, Jeremy J.;
- Rudolph, Uwe;
- Fritschy, Jean-Marc
Publication type:
Article
Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors.
Published in:
Journal of Physiology, 2010, v. 588, n. 4, p. 587, doi. 10.1113/jphysiol.2009.183137
By:
- Peters, John A.;
- Cooper, Michelle A.;
- Carland, Jane E.;
- Livesey, Matthew R.;
- Hales, Tim G.;
- Lambert, Jeremy J.
Publication type:
Article
5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.
Published in:
2013
By:
- Newman, Amy S;
- Batis, Nikolaos;
- Grafton, Gillian;
- Caputo, Francesca;
- Brady, Catherine A;
- Lambert, Jeremy J;
- Peters, John A;
- Gordon, John;
- Brain, Keith L;
- Powell, Andrew D;
- Barnes, Nicholas M
Publication type:
journal article
5- Chloroindole: a potent allosteric modulator of the 5- HT3 receptor.
Published in:
British Journal of Pharmacology, 2013, v. 169, n. 6, p. 1228, doi. 10.1111/bph.12213
By:
- Newman, Amy S;
- Batis, Nikolaos;
- Grafton, Gillian;
- Caputo, Francesca;
- Brady, Catherine A;
- Lambert, Jeremy J;
- Peters, John A;
- Gordon, John;
- Brain, Keith L;
- Powell, Andrew D;
- Barnes, Nicholas M
Publication type:
Article
The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition.
Published in:
European Journal of Neuroscience, 2014, v. 40, n. 3, p. 2487, doi. 10.1111/ejn.12601
By:
- Herd, Murray B.;
- Lambert, Jeremy J.;
- Belelli, Delia
Publication type:
Article
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for δ-GABAA receptors.
Published in:
European Journal of Neuroscience, 2009, v. 29, n. 6, p. 1177, doi. 10.1111/j.1460-9568.2009.06680.x
By:
- Herd, Murray B.;
- Foister, Nicola;
- Chandra, Dev;
- Peden, Dianne R.;
- Homanics, Gregg E.;
- Brown, Verity J.;
- Balfour, David J.K.;
- Lambert, Jeremy J.;
- Belelli, Delia
Publication type:
Article
GABAB receptors in Schwann cells influence proliferation and myelin protein expression.
Published in:
European Journal of Neuroscience, 2004, v. 19, n. 10, p. 2641, doi. 10.1111/j.0953-816X.2004.03368.x
By:
- Magnaghi, Valerio;
- Ballabio, Marinella;
- Cavarretta, Ilaria T. R.;
- Froestl, Wolfgang;
- Lambert, Jeremy J.;
- Zucchi, Ileana;
- Melcangi, Roberto C.
Publication type:
Article
Bi-directional modulation of fast inhibitory synaptic transmission by leptin.
Published in:
Journal of Neurochemistry, 2009, v. 108, n. 1, p. 190, doi. 10.1111/j.1471-4159.2008.05751.x
By:
- Solovyova, Natasha;
- Moult, Peter R.;
- Milojkovic, Bogdan;
- Lambert, Jeremy J.;
- Harvey, Jenni
Publication type:
Article
Synthesis, Conformation and Biological Evaluation of the Enantiomers of 3-Fluoro-γ-Aminobutyric Acid (( R)- and ( S)-3F-GABA): An Analogue of the Neurotransmitter GABA.
Published in:
ChemBioChem, 2007, v. 8, n. 18, p. 2265, doi. 10.1002/cbic.200700371
By:
- Deniau, Gildas;
- Slawin, Alexandra M. Z.;
- Lebl, Tomas;
- Chorki, Fatima;
- Issberner, Jon P.;
- van Mourik, Tanja;
- Heygate, Judith M.;
- Lambert, Jeremy J.;
- Etherington, Lori-An;
- Sillar, Keith T.;
- O'Hagan, David
Publication type:
Article
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
Published in:
Nature, 1999, v. 397, n. 6717, p. 359, doi. 10.1038/16941
By:
- Davies, Paul A.;
- Pistis, Marco;
- Hanna, Michael C.;
- Peters, John A.;
- Lambert, Jeremy J.;
- Hales, Tim G.;
- Kirkness, Ewen F.
Publication type:
Article
Molecular and Functional Diversity of GABA-A Receptors in the Enteric Nervous System of the Mouse Colon.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 31, p. 10361, doi. 10.1523/JNEUROSCI.0441-14.2014
By:
- Seifi, Mohsen;
- Brown, James F.;
- Mills, Jeremy;
- Bhandari, Pradeep;
- Belelli, Delia;
- Lambert, Jeremy J.;
- Rudolph, Uwe;
- Swinny, Jerome D.
Publication type:
Article
Tonic Inhibition of Accumbal Spiny Neurons by Extrasynaptic α4βδ GABAA Receptors Modulates the Actions of Psychostimulants.
Published in:
Journal of Neuroscience, 2014, v. 34, n. 3, p. 823, doi. 10.1523/JNEUROSCI.3232-13.2014
By:
- Maguire, Edward P.;
- Macpherson, Tom;
- Swinny, Jerome D.;
- Dixon, Claire I.;
- Herd, Murray B.;
- Belelli, Delia;
- Stephens, David N.;
- King, Sarah L.;
- Lambert, Jeremy J.
Publication type:
Article
Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 50, p. 19534, doi. 10.1523/JNEUROSCI.1337-13.2013
By:
- Gunn, Benjamin G.;
- Cunningham, Linda;
- Cooper, Michelle A.;
- Corteen, Nicole L.;
- Seifi, Mohsen;
- Swinny, Jerome D.;
- Lambert, Jeremy J.;
- Belelli, Delia
Publication type:
Article
Extrasynaptic GABAA Receptors Couple Presynaptic Activity to Postsynaptic Inhibition in the Somatosensory Thalamus.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 37, p. 14850, doi. 10.1523/JNEUROSCI.1174-13.2013
By:
- Herd, Murray B.;
- Brown, Adam R.;
- Lambert, Jeremy J.;
- Belelli, Delia
Publication type:
Article
GABA-Independent GABAA Receptor Openings Maintain Tonic Currents.
Published in:
Journal of Neuroscience, 2013, v. 33, n. 9, p. 3905, doi. 10.1523/JNEUROSCI.4193-12.2013
By:
- Wlodarczyk, Agnieszka I.;
- Sylantyev, Sergiy;
- Herd, Murray B.;
- Kersante, Flavie;
- Lambert, Jeremy J.;
- Rusakov, Dmitri A.;
- Linthorst, Astrid C. E.;
- Semyanov, Alexey;
- Belelli, Delia;
- Pavlov, Ivan;
- Walker, Matthew C.
Publication type:
Article

Found: 35

How can drug discovery for psychiatric disorders be improved?

Sedation and Anesthesia Mediated by Distinct GABA[subA] Receptor Isoforms.

Neurosteroids: endogenous regulators of the GABA<sub>A</sub> receptor.

Developmental maturation of synaptic and extrasynaptic GABA<sub>A</sub> receptors in mouse thalamic ventrobasal neurones.

The expression of GABA<sub>A</sub>β subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.

The 4′lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT<sub>3A</sub> receptors.

Complementary regulation of anaesthetic activation of human (α<sub>6</sub>β<sub>3</sub>γ<sub>2L</sub>) and Drosophila (RDL) GABA receptors by a single amino acid residue.

The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor.

The interaction of general anaesthetics with recombinant GABA<sub>A</sub> and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.

Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor.

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA A Receptors of the Mouse Nucleus Accumbens.

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour.

Extrasynaptic GABA<sub>A</sub> Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics.

Antidepressants and Antipsychotic Drugs Colocalize with 5-HT<sub>3</sub> Receptors in Raft-Like Domains.

Extrasynaptic Glycine Receptors of Rodent Dorsal Raphe Serotonergic Neurons: A Sensitive Target for Ethanol.

Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.

A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ‐aminobutyric acidergic anticonvulsant.

A cytoplasmic region determines single-channel conductance in 5-HT<sub>3</sub> receptors.

Control of Inhibition by the Direct Action of Cannabinoids on GABA<sub>A</sub> Receptors.

Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

Distinct mechanisms regulate GABA<sub>A</sub> receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors.

5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

5- Chloroindole: a potent allosteric modulator of the 5- HT<sub>3</sub> receptor.

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA<sub>A</sub> receptor-mediated inhibition.

Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for δ-GABA<sub>A</sub> receptors.

GABA<sub>B</sub> receptors in Schwann cells influence proliferation and myelin protein expression.

Bi-directional modulation of fast inhibitory synaptic transmission by leptin.

Synthesis, Conformation and Biological Evaluation of the Enantiomers of 3-Fluoro-γ-Aminobutyric Acid (( R)- and ( S)-3F-GABA): An Analogue of the Neurotransmitter GABA.

The 5-HT3B subunit is a major determinant of serotonin-receptor function.

Molecular and Functional Diversity of GABA-A Receptors in the Enteric Nervous System of the Mouse Colon.

Tonic Inhibition of Accumbal Spiny Neurons by Extrasynaptic α4βδ GABA<sub>A</sub> Receptors Modulates the Actions of Psychostimulants.

Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response.

Extrasynaptic GABA<sub>A</sub> Receptors Couple Presynaptic Activity to Postsynaptic Inhibition in the Somatosensory Thalamus.

GABA-Independent GABA<sub>A</sub> Receptor Openings Maintain Tonic Currents.