Works by Lambert, Jean-Charles

Results: 130

Genome-wide and gene-based association implicates FRMD6 in alzheimer disease.

Published in:

Human Mutation, 2012, v. 33, n. 3, p. 521, doi. 10.1002/humu.22009

By:

Hong, Mun-Gwan;
Reynolds, Chandra A.;
Feldman, Adina L.;
Kallin, Mikael;
Lambert, Jean-Charles;
Amouyel, Philippe;
Ingelsson, Erik;
Pedersen, Nancy L.;
Prince, Jonathan A.

Publication type:

Article

High‐Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.

Published in:

Current Protocols, 2023, v. 3, n. 10, p. 1, doi. 10.1002/cpz1.904

By:

Coulon, Audrey;
Siedlecki‐Wullich, Dolores;
Najdek, Chloé;
Gelle, Carla;
Ayral, Anne‐Marie;
Demiautte, Florie;
Lambert, Erwan;
Vandeputte, Alexandre;
Brodin, Priscille;
Mendes, Tiago;
Lambert, Jean‐Charles;
Kilinc, Devrim;
Dumont, Julie;
Chapuis, Julien

Publication type:

Article

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03287-y

By:

Sarnowski, Chloé;
Ghanbari, Mohsen;
Bis, Joshua C.;
Logue, Mark;
Fornage, Myriam;
Mishra, Aniket;
Ahmad, Shahzad;
Beiser, Alexa S.;
Boerwinkle, Eric;
Bouteloup, Vincent;
Chouraki, Vincent;
Cupples, L Adrienne;
Damotte, Vincent;
DeCarli, Charles S.;
DeStefano, Anita L.;
Djoussé, Luc;
Fohner, Alison E.;
Franz, Carol E.;
Kautz, Tiffany F.;
Lambert, Jean-Charles

Publication type:

Article

MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms.

Published in:

Frontiers in Molecular Neuroscience, 2014, p. 1, doi. 10.3389/fnmol.2014.00067

By:

Delay, Charlotte;
Dorval, Véronique;
Fok, Alice;
Grenier-Boley, Benjamin;
Lambert, Jean-Charles;
Hsiung, G.-Y.;
Hébert, Sébastien S.

Publication type:

Article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Published in:

Nature Genetics, 2013, v. 45, n. 12, p. 1452, doi. 10.1038/ng.2802

By:

Lambert, Jean-Charles;
Ibrahim-Verbaas, Carla A;
Harold, Denise;
Naj, Adam C;
Sims, Rebecca;
Bellenguez, Céline;
Jun, Gyungah;
DeStefano, Anita L;
Bis, Joshua C;
Beecham, Gary W;
Grenier-Boley, Benjamin;
Russo, Giancarlo;
Thornton-Wells, Tricia A;
Jones, Nicola;
Smith, Albert V;
Chouraki, Vincent;
Thomas, Charlene;
Ikram, M Arfan;
Zelenika, Diana;
Vardarajan, Badri N

Publication type:

Article

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.

Published in:

Nature Genetics, 2013, v. 45, n. 5, p. 518, doi. 10.1038/ng.2581

By:

Germain, Marine;
Eyries, Mélanie;
Montani, David;
Poirier, Odette;
Girerd, Barbara;
Dorfmüller, Peter;
Coulet, Florence;
Nadaud, Sophie;
Maugenre, Svetlana;
Guignabert, Christophe;
Carpentier, Wassila;
Vonk-Noordegraaf, Anton;
Lévy, Marilyne;
Chaouat, Ari;
Lambert, Jean-Charles;
Bertrand, Marion;
Dupuy, Anne-Marie;
Letenneur, Luc;
Lathrop, Mark;
Amouyel, Philippe

Publication type:

Article

Common variants at 12q14 and 12q24 are associated with hippocampal volume.

Published in:

Nature Genetics, 2012, v. 44, n. 5, p. 545, doi. 10.1038/ng.2237

By:

Bis, Joshua C;
DeCarli, Charles;
Smith, Albert Vernon;
van der Lijn, Fedde;
Crivello, Fabrice;
Fornage, Myriam;
Debette, Stephanie;
Shulman, Joshua M;
Schmidt, Helena;
Srikanth, Velandai;
Schuur, Maaike;
Yu, Lei;
Choi, Seung-Hoan;
Sigurdsson, Sigurdur;
Verhaaren, Benjamin F J;
DeStefano, Anita L;
Lambert, Jean-Charles;
Jack, Clifford R;
Struchalin, Maksim;
Stankovich, Jim

Publication type:

Article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Published in:

Nature Genetics, 2011, v. 43, n. 5, p. 429, doi. 10.1038/ng.803

By:

Hollingworth, Paul;
Harold, Denise;
Sims, Rebecca;
Gerrish, Amy;
Lambert, Jean-Charles;
Carrasquillo, Minerva M.;
Abraham, Richard;
Hamshere, Marian L.;
Pahwa, Jaspreet Singh;
Moskvina, Valentina;
Dowzell, Kimberley;
Jones, Nicola;
Stretton, Alexandra;
Thomas, Charlene;
Richards, Alex;
Ivanov, Dobril;
Widdowson, Caroline;
Chapman, Jade;
Lovestone, Simon;
Powell, John

Publication type:

Article

Deciphering genetic susceptibility to frontotemporal lobar dementia.

Published in:

Nature Genetics, 2010, v. 42, n. 3, p. 189, doi. 10.1038/ng0310-189

By:

Lambert, Jean-Charles;
Amouyel, Philippe

Publication type:

Article

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

Published in:

Nature Genetics, 2009, v. 41, n. 10, p. 1094, doi. 10.1038/ng.439

By:

Lambert, Jean-Charles;
Heath, Simon;
Even, Gael;
Campion, Dominique;
Sleegers, Kristel;
Hiltunen, Mikko;
Combarros, Onofre;
Zelenika, Diana;
Bullido, Maria J.;
Tavernier, Béatrice;
Letenneur, Luc;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Fiévet, Nathalie;
Barberger-Gateau, Pascale;
Engelborghs, Sebastiaan;
de Deyn, Peter;
Mateo, Ignacio;
Franck, Ana

Publication type:

Article

α-2 macroglobulin gene and Alzheimer disease.

Published in:

Nature Genetics, 1999, v. 22, n. 1, p. 17, doi. 10.1038/8726

By:

Rudrasingham, Varuni;
Wavrant-De Vrièze, Fabienne;
Lambert, Jean-Charles;
Chakraverty, Sumi;
Kehoe, Patrick;
Crook, Richard;
Amouyel, Philippe;
Wu, William;
Rice, Frances;
Pérez-Tur, Jordi;
Frigard, Bernard;
Morris, John C.;
Carty, Stephanie;
Petersen, Ronald;
Cottel, Dominique;
Tunstall, Nigel;
Holmans, Peter;
Lovestone, Simon;
Chartier-Harlin, Marie-Christine

Publication type:

Article

Head-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 1, p. 286, doi. 10.3390/ijms26010286

By:

Puerta, Raquel;
Cano, Amanda;
García-González, Pablo;
García-Gutiérrez, Fernando;
Capdevila, Maria;
de Rojas, Itziar;
Olivé, Clàudia;
Blázquez-Folch, Josep;
Sotolongo-Grau, Oscar;
Miguel, Andrea;
Montrreal, Laura;
Martino-Adami, Pamela;
Khan, Asif;
Orellana, Adelina;
Sung, Yun Ju;
Frikke-Schmidt, Ruth;
Marchant, Natalie;
Lambert, Jean Charles;
Rosende-Roca, Maitée;
Alegret, Montserrat

Publication type:

Article

Association between Parkinson's disease and the HLA-DRB1 locus.

Published in:

Movement Disorders, 2012, v. 27, n. 9, p. 1104, doi. 10.1002/mds.25035

By:

Ahmed, Ismaïl;
Tamouza, Ryad;
Delord, Marc;
Krishnamoorthy, Rajagopal;
Tzourio, Christophe;
Mulot, Claire;
Nacfer, Magali;
Lambert, Jean-Charles;
Beaune, Philippe;
Laurent-Puig, Pierre;
Loriot, Marie-Anne;
Charron, Dominique;
Elbaz, Alexis

Publication type:

Article

A 3’-UTR polymorphism in the oxidized LDL receptor 1 gene increases Aβ<sub>40</sub> load as cerebral amyloid angiopathy in Alzheimer’s disease.

Published in:

Acta Neuropathologica, 2006, v. 111, n. 1, p. 15, doi. 10.1007/s00401-005-1108-3

By:

Jing Shi;
Jinzhou Tian;
Pritchard, Antonia;
Lendon, Corinne;
Lambert, Jean-Charles;
Iwatsubo, Takeshi;
Mann, David M. A.

Publication type:

Article

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-021-01285-5

By:

Lambert, Erwan;
Saha, Orthis;
Soares Landeira, Bruna;
Melo de Farias, Ana Raquel;
Hermant, Xavier;
Carrier, Arnaud;
Pelletier, Alexandre;
Gadaut, Johanna;
Davoine, Lindsay;
Dupont, Cloé;
Amouyel, Philippe;
Bonnefond, Amélie;
Lafont, Frank;
Abdelfettah, Farida;
Verstreken, Patrik;
Chapuis, Julien;
Barois, Nicolas;
Delahaye, Fabien;
Dermaut, Bart;
Lambert, Jean-Charles

Publication type:

Article

Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.

Published in:

Translational Psychiatry, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41398-022-02055-0

By:

Hou, Jiahui;
Hess, Jonathan L.;
Armstrong, Nicola;
Bis, Joshua C.;
Grenier-Boley, Benjamin;
Karlsson, Ida K.;
Leonenko, Ganna;
Numbers, Katya;
O'Brien, Eleanor K.;
Shadrin, Alexey;
Thalamuthu, Anbupalam;
Yang, Qiong;
Andreassen, Ole A.;
Brodaty, Henry;
Gatz, Margaret;
Kochan, Nicole A.;
Lambert, Jean-Charles;
Laws, Simon M.;
Masters, Colin L.;
Mather, Karen A.

Publication type:

Article

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0094661

By:

Escott-Price, Valentina;
Bellenguez, Céline;
Wang, Li-San;
Choi, Seung-Hoan;
Harold, Denise;
Jones, Lesley;
Holmans, Peter;
Gerrish, Amy;
Vedernikov, Alexey;
Richards, Alexander;
DeStefano, Anita L.;
Lambert, Jean-Charles;
Ibrahim-Verbaas, Carla A.;
Naj, Adam C.;
Sims, Rebecca;
Jun, Gyungah;
Bis, Joshua C.;
Beecham, Gary W.;
Grenier-Boley, Benjamin;
Russo, Giancarlo

Publication type:

Article

Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079848

By:

Merle, Bénédicte M. J.;
Maubaret, Cécilia;
Korobelnik, Jean-François;
Delyfer, Marie-Noëlle;
Rougier, Marie-Bénédicte;
Lambert, Jean-Charles;
Amouyel, Philippe;
Malet, Florence;
Le Goff, Mélanie;
Dartigues, Jean-François;
Barberger-Gateau, Pascale;
Delcourt, Cécile

Publication type:

Article

Caution in Interpreting Results from Imputation Analysis When Linkage Disequilibrium Extends over a Large Distance: A Case Study on Venous Thrombosis.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038538

By:

Germain, Marine;
Saut, Noémie;
Oudot-Mellakh, Tiphaine;
Letenneur, Luc;
Dupuy, Anne-Marie;
Bertrand, Marion;
Alessi, Marie-Christine;
Lambert, Jean-Charles;
Zelenika, Diana;
Emmerich, Joseph;
Tiret, Laurence;
Cambien, Francois;
Lathrop, Mark;
Amouyel, Philippe;
Morange, Pierre-Emmanuel;
Trégouët, David-Alexandre

Publication type:

Article

Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels.

Published in:

PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0029480

By:

Féart, Catherine;
Helmer, Catherine;
Fleury, Hervé;
Béjot, Yannick;
Ritchie, Karen;
Amouyel, Philippe;
Schraen-Maschke, Susanna;
Buée, Luc;
Lambert, Jean-Charles;
Letenneur, Luc;
Dartigues, Jean- François

Publication type:

Article

Genetics of Venous Thrombosis: Insights from a New Genome Wide Association Study.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025581

By:

Germain, Marine;
Saut, Noémie;
Greliche, Nicolas;
Dina, Christian;
Lambert, Jean-Charles;
Perret, Claire;
Cohen, William;
Oudot-Mellakh, Tiphaine;
Antoni, Guillemette;
Alessi, Marie-Christine;
Zelenika, Diana;
Cambien, François;
Tiret, Laurence;
Bertrand, Marion;
Dupuy, Anne-Marie;
Letenneur, Luc;
Emmerich, Joseph;
Amouyel, Philippe;
Trégouet, David-Alexandre;
Morange, Pierre-Emmanuel

Publication type:

Article

Association of Plasma Aβ Peptides with Blood Pressure in the Elderly.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018536

By:

Lambert, Jean-Charles;
Dallongeville, Jean;
Ellis, Kathryn A.;
Schraen-Maschke, Susanna;
Lui, James;
Laws, Simon;
Dumont1,2,3, Julie;
Richard, Florence;
Cottel, Dominique;
Berr, Claudine;
Ames, David;
Masters, Colin L.;
Rowe, Christopher C.;
Szoeke, Cassandra;
Tzourio, Christophe;
Dartigues, Jean-François;
Buée, Luc;
Martins, Ralph;
Amouyel, Philippe

Publication type:

Article

Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairment.

Published in:

Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02355-z

By:

Xicota, Laura;
Lagarde, Julien;
Eysert, Fanny;
Grenier-Boley, Benjamin;
Rivals, Isabelle;
Botté, Alexandra;
Forlani, Sylvie;
Landron, Sophie;
Gautier, Clément;
Gabriel, Cecilia;
Bottlaender, Michel;
Lambert, Jean-Charles;
Chami, Mounia;
Sarazin, Marie;
Potier, Marie-Claude

Publication type:

Article

How local reference panels improve imputation in French populations.

Published in:

Scientific Reports, 2024, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49931-3

By:

Herzig, Anthony F.;
Velo‐Suárez, Lourdes;
Campion, Dominique;
Dartigues, Jean-François;
Lambert, Jean-Charles;
Ludwig, Thomas;
Grenier-Boley, Benjamin;
Letort, Sébastien;
Lindenbaum, Pierre;
Meyer, Vincent;
Quenez, Olivier;
Bellenguez, Céline;
Clézio, Camille Charbonnier-Le;
Giemza, Joanna;
Chatel, Stéphanie;
Férec, Claude;
Le Marec, Hervé;
Letenneur, Luc;
Nicolas, Gaël;
Rouault, Karen

Publication type:

Article

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease.

Published in:

Journal of Human Genetics, 2010, v. 55, n. 10, p. 707, doi. 10.1038/jhg.2010.92

By:

Mun-Gwan Hong;
Alexeyenko, Andrey;
Lambert, Jean-Charles;
Amouyel, Philippe;
Prince, Jonathan A.

Publication type:

Article

Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.

Published in:

Clinical Neuropsychologist, 2025, v. 39, n. 1, p. 83, doi. 10.1080/13854046.2024.2344869

By:

Sampatakakis, Stefanos N.;
Mourtzi, Niki;
Charisis, Sokratis;
Mamalaki, Eirini;
Ntanasi, Eva;
Hatzimanolis, Alex;
Ramirez, Alfredo;
Lambert, Jean-Charles;
Yannakoulia, Mary;
Kosmidis, Mary H.;
Dardiotis, Efthimios;
Hadjigeorgiou, Georgios;
Megalou, Maria;
Sakka, Paraskevi;
Scarmeas, Nikolaos

Publication type:

Article

Common polygenic variation enhances risk prediction for Alzheimer's disease.

Published in:

2015

By:

Escott-Price, Valentina;
Sims, Rebecca;
Bannister, Christian;
Harold, Denise;
Vronskaya, Maria;
Majounie, Elisa;
Badarinarayan, Nandini;
Morgan, Kevin;
Passmore, Peter;
Holmes, Clive;
Powell, John;
Brayne, Carol;
Gill, Michael;
Mead, Simon;
Goate, Alison;
Cruchaga, Carlos;
Lambert, Jean-Charles;
van Duijn, Cornelia;
Maier, Wolfgang;
Ramirez, Alfredo

Publication type:

journal article

Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2025, v. 21, n. 3, p. 1, doi. 10.1002/alz.70014

By:

D'Aoust, Tim;
Clocchiatti‐Tuozzo, Santiago;
Rivier, Cyprien A.;
Mishra, Aniket;
Hachiya, Tsuyoshi;
Grenier‐Boley, Benjamin;
Soumaré, Aïcha;
Duperron, Marie‐Gabrielle;
Le Grand, Quentin;
Bouteloup, Vincent;
Proust‐Lima, Cécile;
Samieri, Cécilia;
Neuffer, Jeanne;
Sargurupremraj, Muralidharan;
Chêne, Geneviève;
Helmer, Catherine;
Thibault, Mura;
Amouyel, Philippe;
Lambert, Jean‐Charles;
Kamatani, Yoichiro

Publication type:

Article

Proteogenomic Evaluation of Cerebrospinal Fluid in Alzheimer's Disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S2, p. 1, doi. 10.1002/alz.086066

By:

Puerta, Raquel;
García‐González, Pablo;
de Rojas, Itziar;
Olivé, Clàudia;
García‐Gutiérrez, Fernando;
Sotolongo‐Grau, Oscar;
Smets, Bart;
Emon, Asif;
Sung, Yun Ju;
Frikke‐Schmidt, Ruth;
Marchant, Natalie L;
Lambert, Jean‐Charles;
Valero, Sergi;
Marquié, Marta;
Ramirez, Alfredo;
Cruchaga, Carlos;
Fernández, Victoria;
Cano, Amanda;
Boada, Mercè;
Socorro, Alfredo Cabrera

Publication type:

Article

Presynaptic toxicity of the AD susceptibility gene BIN1.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.088949

By:

Dourlen, Pierre;
Lambert, Erwan;
Freire‐Regatillo, Alejandra;
Gelle, Carla;
Leclerc, Valentin;
Barois, Nicolas;
Hermant, Xavier;
Malfoi, Tommy;
Verstreken, Patrik;
Amouyel, Philippe;
Lafont, Frank;
Kilinc, Devrim;
Lambert, Jean‐Charles

Publication type:

Article

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 3, p. 2282, doi. 10.1002/alz.13550

By:

Le Borgne, Julie;
Amouyel, Philippe;
Andreassen, Ole;
Frikke‐Schmidt, Ruth;
Hiltunen, Mikko;
Ingelsson, Martin;
Ramirez, Alfredo;
Rossi, Giacomina;
Ruiz, Agustin;
Sanchez‐Juan, Pascual;
Sims, Rebecca;
Sleegers, Kristel;
Tsolaki, Magda;
van der Lee, Sven J.;
Williams, Julie;
Lambert, Jean‐Charles;
Bellenguez, Céline

Publication type:

Article

Head‐to‐head comparison of aptamer‐ and antibody‐based proteomic platforms in CSF samples of a real‐world large cohort of a memory clinic.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082299

By:

Puerta, Raquel;
Cano, Amanda;
Smets, Bart;
García‐González, Pablo;
Haidar, Mansour;
Olivé, Clàudia;
Emon, Asif;
de Rojas, Itziar;
Sung, Yun Ju;
Frikke‐Schmidt, Ruth;
Marchant, Natalie L;
Lambert, Jean‐Charles;
Valero, Sergi;
Ramirez, Alfredo;
Cruchaga, Carlos;
Boada, Mercè;
Socorro, Alfredo Cabrera;
Ruiz, Agustin

Publication type:

Article

Screening Alzheimer's genetic risk factors against amyloid‐βeta synaptotoxicity.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076297

By:

Gelle, Carla;
Siedlecki‐Wullich, Dolores;
Coulon, Audrey;
Chapuis, Julien;
Lambert, Jean‐Charles;
Kilinc, Devrim

Publication type:

Article

Analysis of Alzheimer's disease‐related synaptic alterations using microfluidic microglia/neuron co‐cultures.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074852

By:

Siedlecki‐Wullich, Dolores;
Ayral, Anne‐Marie;
Buiche, Valerie;
Lambert, Jean‐Charles;
Kilinc, Devrim

Publication type:

Article

Screening tyrosine kinases for their involvement in synaptotoxicity induced by tau microtubule‐binding region fibrils.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074854

By:

Hodonou, Kelly;
Siedlecki‐Wullich, Dolores;
Vreulx, Anais‐Camille;
Lambert, Jean‐Charles;
Kilinc, Devrim

Publication type:

Article

FERMT2 cleavage impacts APP metabolism in a Src‐dependent manner.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073037

By:

NAJDEK, Chloé;
Demiautte, Florie;
Ayral, Anne‐Marie;
Flaig, Amandine;
Eysert, Fanny;
Lambert, Jean‐Charles;
Chapuis, Julien

Publication type:

Article

APP‐dependent cell adhesion is regulated by GWAS genes.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076644

By:

Chapuis, Julien;
NAJDEK, Chloé;
Coulon, Audrey;
Eysert, Fanny;
Grenier‐Boley, Benjamin;
Bellenguez, Céline;
Demiautte, Florie;
Amouyel, Philippe;
Dumont, Julie;
Kilinc, Devrim;
Lambert, Jean‐Charles

Publication type:

Article

APP‐dependent cell adhesion is regulated by GWAS genes.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076644

By:

Chapuis, Julien;
NAJDEK, Chloé;
Coulon, Audrey;
Eysert, Fanny;
Grenier‐Boley, Benjamin;
Bellenguez, Céline;
Demiautte, Florie;
Amouyel, Philippe;
Dumont, Julie;
Kilinc, Devrim;
Lambert, Jean‐Charles

Publication type:

Article

Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 9, p. 3794, doi. 10.1002/alz.12980

By:

Mourtzi, Niki;
Charisis, Sokratis;
Tsapanou, Angeliki;
Ntanasi, Eva;
Hatzimanolis, Alexandros;
Ramirez, Alfredo;
Heilmann‐Heimbach, Stefanie;
Grenier‐Boley, Benjamin;
Lambert, Jean‐Charles;
Yannakoulia, Mary;
Kosmidis, Mary;
Dardiotis, Efthimios;
Hadjigeorgiou, Georgiios;
Sakka, Paraskevi;
Georgakis, Marios;
Yaakov, Stern;
Scarmeas, Nikolaos

Publication type:

Article

Cell‐autonomous role of the AD susceptibility gene BIN1 in the regulation of hiPSC‐derived neurons network activity.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.062236

By:

Saha, Orthis;
De Farias, Ana‐Raquel Melo;
Pelletier, Alexandre R;
Kilinc, Devrim;
Delahaye, Fabien R;
Queiroz, Claudio M;
Lambert, Jean‐Charles;
Costa, Marcos R

Publication type:

Article

An enrichment of rare variants and the lysosomal pathways are important contributors to early onset Alzheimer disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.055341

By:

Fernandez, Victoria;
Pottier, Cyril P;
Budde, John P.;
Wang, Fengxian;
Norton, Joanne;
Gentsch, Jen;
Morris, John C.;
Goate, Alison M.;
Beecham, Gary W.;
Reitz, Christiane;
Ertekin‐Taner, Nilufer;
Dickson, Dennis W;
Graff‐Radford, Neill R.;
Boeve, Bradley F.;
Petersen, Ronald C.;
Kauwe, John;
Holstege, Henne;
Hulsman, Marc;
Bellenguez, Céline;
Lambert, Jean‐Charles

Publication type:

Article

Role of the late‐onset Alzheimer's disease risk genes bin1 and ptk2b in the hyperexcitability of hiPSC‐derived neurons.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.053632

By:

De Farias, Ana‐Raquel Melo;
Saha, Orthis;
Lambert, Jean‐Charles;
Costa, Marcos Romualdo

Publication type:

Article

High‐content screening of Alzheimer's disease genetic risk factors based on synaptic density analysis.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058660

By:

Coulon, Audrey;
Mendes, Tiago;
Kilinc, Devrim;
Dumont, Julie;
Chapuis, Julien;
Lambert, Jean‐Charles

Publication type:

Article

Development of a fast and versatile method for genome‐wide association studies of longitudinal data: Genetics/endophenotypes.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042441

By:

Kleineidam, Luca;
Andrade, Victor;
Wagner, Michael;
Lambert, Jean‐Charles;
Ruiz, Agustín;
Ramirez, Alfredo

Publication type:

Article

Alzheimer's genetic risk factor FERMT2 (kindlin‐2) controls axonal growth and synaptic plasticity in an APP‐dependent manner: Genetics: Genetics and omics of AD II.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041966

By:

Eysert, Fanny;
CoulonVreulx, AudreyAnais‐Camille;
Flaig, Amandine;
Mendes, Tiago;
Grenier‐Boley, Benjamin;
Demiautte, Florie;
Amouyel, Philippe;
Dumont, Julie;
Kilinc, Devrim;
Lambert, Jean‐Charles;
Chapuis, Julien

Publication type:

Article

Isoform‐dependent neurotoxicity of the Alzheimer disease risk factor BIN1: Molecular and cell biology/endosomal‐lysosomal dysfunction.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039402

By:

Lambert, Erwan;
Abdelfettah, Farida;
Barois, Nicolas;
Vandekerkhove, Dirk;
Hermant, Xavier;
Ayral, Anne‐Marie;
Davoine, Lindsay;
Dupont, Cloe;
Lafont, Frank;
Amouyel, Philippe;
Chapuis, Julien;
Verstreken, Patrik;
Dermaut, Bart;
Lambert, Jean‐Charles;
Dourlen, Pierre

Publication type:

Article

Differential transcript usage unravels transcriptional alterations in Alzheimer's disease human brains: Genetics/omics and systems biology.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.038695

By:

Marques‐Coelho, Diego;
Iohan, Lukas;
Lambert, Jean‐Charles;
Costa, Marcos Romualdo

Publication type:

Article

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0237-8

By:

Sottejeau, Yoann;
Bretteville, Alexis;
Cantrelle, François-Xavier;
Malmanche, Nicolas;
Demiaute, Florie;
Mendes, Tiago;
Delay, Charlotte;
Alves, Harmony Alves Dos;
Flaig, Amandine;
Davies, Peter;
Dourlen, Pierre;
Dermaut, Bart;
Laporte, Jocelyn;
Amouyel, Philippe;
Lippens, Guy;
Chapuis, Julien;
Landrieu, Isabelle;
Lambert, Jean-Charles

Publication type:

Article

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.

Published in:

Scientific Reports, 2017, p. 40764, doi. 10.1038/srep40764

By:

Malmanche, Nicolas;
Dourlen, Pierre;
Gistelinck, Marc;
Demiautte, Florie;
Link, Nichole;
Dupont, Cloé;
Vanden Broeck, Lies;
Werkmeister, Elisabeth;
Amouyel, Philippe;
Bongiovanni, Antonino;
Bauderlique, Hélène;
Moechars, Dieder;
Royou, Anne;
Bellen, Hugo J.;
Lafont, Frank;
Callaerts, Patrick;
Lambert, Jean-Charles;
Dermaut, Bart

Publication type:

Article

The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.

Published in:

Human Molecular Genetics, 2000, v. 9, n. 15, p. 2275, doi. 10.1093/oxfordjournals.hmg.a018918

By:

Lambert, Jean-Charles;
Goumidi, Louisa;
Vrièze, Fabienne Wavrant-De;
Frigard, Bernard;
Harris, Judith M.;
Cummings, Alistair;
Coates, John;
Pasquier, Florence;
Cottel, Dominique;
Gaillac, Marianne;
Clair, David;
Mann, David M.A.;
Hardy, John;
Lendon, Corinne L.;
Amouyel, Philippe;
Chartier-Harlin, Marie-Christine

Publication type:

Article