Works by Lam, Fred C.

Results: 31

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis.

Published in:

Science Translational Medicine, 2025, v. 17, n. 805, p. 1, doi. 10.1126/scitranslmed.adu2459

By:

Chafe, Shawn C.;
Zhai, Kui;
Aghaei, Nikoo;
Miletic, Petar;
Huang, Zhi;
Brown, Kevin R.;
Mobilio, Daniel;
Young, Daniel;
Suk, Yujin;
Grewal, Shan;
McKenna, Dillon;
Alizada, Zahra;
Kieliszek, Agata M.;
Lam, Fred C.;
Escudero, Laura;
Huang, Qian;
Huebner, Ariana;
Lu, Jack;
Ang, Patrick;
Anand, Alisha

Publication type:

Article

Integrated management of metastatic spinal tumors: current status and future directions.

Published in:

Medical Oncology, 2025, v. 42, n. 6, p. 1, doi. 10.1007/s12032-025-02764-8

By:

Kim, Min J.;
Marianayagam, Neelan J.;
Chandra, Ankush;
Ranalli, Carlotta;
Schonfeld, Ethan;
Avila-Madrigal, Juan P.;
Flusche, Ann Marie E.;
Schoeffler, Katherine;
Alomari, Safwan;
Rao, Namratha B.;
Yoo, Kelly;
Lam, Fred C.;
Park, David J.;
Fanous, Andrew A.;
Chang, Steven D.;
Lim, Michael;
Veeravagu, Anand

Publication type:

Article

Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?

Published in:

Brain Sciences (2076-3425), 2025, v. 15, n. 6, p. 649, doi. 10.3390/brainsci15060649

By:

Lam, Fred C.;
Byun, John;
Guru, Santosh;
AbuReesh, Deyaldeen;
Hori, Yusuke S.;
Rahimy, Elham;
Pollom, Erqi Liu;
Soltys, Scott;
Park, David J.;
Chang, Steven D.

Publication type:

Article

Use of Carbon Fiber Implants to Improve the Safety and Efficacy of Radiation Therapy for Spine Tumor Patients.

Published in:

2025

By:

Lam, Fred C.;
Guru, Santosh;
AbuReesh, Deyaldeen;
Hori, Yusuke S.;
Chuang, Cynthia;
Liu, Lianli;
Wang, Lei;
Gu, Xuejun;
Szalkowski, Gregory A.;
Wang, Ziyi;
Wohlers, Christopher;
Tayag, Armine;
Emrich, Sara C.;
Ustrzynski, Louisa;
Zygourakis, Corinna C.;
Desai, Atman;
Hayden Gephart, Melanie;
Byun, John;
Pollom, Erqi Liu;
Rahimy, Elham

Publication type:

Literature Review

"Beyond the Knife"—Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology.

Published in:

Brain Sciences (2076-3425), 2024, v. 14, n. 12, p. 1253, doi. 10.3390/brainsci14121253

By:

Guru, Santosh;
Lam, Fred C.;
Akhavan-Sigari, Amirhossein;
Hori, Yusuke S.;
AbuReesh, Deyaaldeen;
Tayag, Armine;
Emrich, Sara C.;
Ustrzynski, Louisa;
Park, David J.;
Chang, Steven D.

Publication type:

Article

Spondylolisthesis of C2 in an Eight-Week-Old Infant: Long Term Followup.

Published in:

Canadian Journal of Neurological Sciences, 2007, v. 34, n. 3, p. 372, doi. 10.1017/S0317167100006867

By:

Lam, Fred C.;
Mehta, Vivek;
Fox, Richard

Publication type:

Article

Treatment of Secondary Tonsillar Herniation by Lumboperitoneal Shunt Revision.

Published in:

Canadian Journal of Neurological Sciences, 2007, v. 34, n. 2, p. 237, doi. 10.1017/S0317167100006119

By:

Lam, Fred C.;
Wheatley, Matthew B.;
Mehta, Vivek

Publication type:

Article

Stereotactic radiosurgery for brain metastases from malignant melanoma.

Published in:

Surgical Neurology International, 2015, v. 6, n. Suppl 12, p. 1, doi. 10.4103/2152-7806.163315

By:

Christ, Sebastian M.;
Mahadevan, Anand;
Floyd, Scott R.;
Lam, Fred C.;
Chen, Clark C.;
Wong, Eric T.;
Kasper, Ekkehard M.

Publication type:

Article

A comprehensive literature review and meta‐analysis of the prevalence of pan‐cancer BRCA mutations, homologous recombination repair gene mutations, and homologous recombination deficiencies.

Published in:

Environmental & Molecular Mutagenesis, 2022, v. 63, n. 6, p. 308, doi. 10.1002/em.22505

By:

Shao, Changxia;
Wan, Jun;
Lam, Fred C.;
Tang, Huilin;
Marley, Andrew R.;
Song, Yiqing;
Miller, Chelsey;
Brown, Madeline;
Han, Jiali;
Adeboyeje, Gboyega

Publication type:

Article

Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series.

Published in:

2020

By:

Liu, Jianmin;
Rojas, Rafael;
Lam, Fred C.;
Mirza, Farhan A.;
Mahadevan, Anand;
Kasper, Ekkehard M.

Publication type:

journal article

Intramedullary Metastases to Conus Medullaris: A Review of the Literature with a Case Illustration.

Published in:

Brain Sciences (2076-3425), 2024, v. 14, n. 8, p. 761, doi. 10.3390/brainsci14080761

By:

Kaya, Serdar;
Lam, Fred C.;
Stevenson, Mary Ann;
Motiei-Langroudi, Rouzbeh;
Kasper, Ekkehard M.

Publication type:

Article

Surgical Morbidity in Relation to the Surgical Approach for Olfactory Groove Meningiomas—A Pooled Analysis of 1016 Patients and Proposal of a New Reporting System.

Published in:

Brain Sciences (2076-3425), 2023, v. 13, n. 6, p. 896, doi. 10.3390/brainsci13060896

By:

Kasper, Ekkehard M.;
Mirza, Farhan A.;
Kaya, Serdar;
Walker, Robert;
Starnoni, Daniele;
Daniel, Roy T.;
Nair, Ramesh;
Lam, Fred C.

Publication type:

Article

Current Treatment Approaches and Global Consensus Guidelines for Brain Metastases in Melanoma.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.885472

By:

Tan, Xiang-Lin;
Le, Amy;
Lam, Fred C.;
Scherrer, Emilie;
Kerr, Robert G.;
Lau, Anthony C.;
Han, Jiali;
Jiang, Ruixuan;
Diede, Scott J.;
Shui, Irene M.

Publication type:

Article

Primary Extradural Tumors of the Spine - Case Review with Evidence-guided Management.

Published in:

Surgical Neurology International, 2014, v. 5, p. S373, doi. 10.4103/2152-7806.139673

By:

Lam, Fred C.;
Arle, Jeffrey E.;
Glazer, Paul A.;
Kasper, Ekkehard M.

Publication type:

Article

Fibrin sealant augmentation with autologous pericranium for duraplasty after suboccipital decompression in Chiari 1 patients: A case series.

Published in:

2013

By:

Lam, Fred C.;
Penumaka, Anirudh;
Chen, Clark C.;
Fischer, Edwin G.;
Kasper, Ekkehard M.

Publication type:

Case Study

"Time is brain" the Gifford factor - or: Why do some civilian gunshot wounds to the head do unexpectedly well? A case series with outcomes analysis and a management guide.

Published in:

Surgical Neurology International, 2012, v. 3, n. 1, p. 524, doi. 10.4103/2152-7806.100187

By:

Lin, David J.;
Lam, Fred C.;
Siracuse, Jeffrey J.;
Thomas, Ajith;
Kasper, Ekkehard M.

Publication type:

Article

"Hitting all the right markers to save a life" Solitary fibrous tumors of the central nervous system: Case series and review of the literature.

Published in:

2012

By:

Kasper, Ekkehard;
Boruchow, Scott;
Lam, Fred C.;
Zinn, Pascal O.;
Anderson, Matthew;
Mahadevan, Anand

Publication type:

Case Study

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04315-4

By:

Lam, Fred C.;
Morton, Stephen W.;
Wyckoff, Jeffrey;
Tu-Lan Vu Han;
Mun Kyung Hwang;
Maffa, Amanda;
Balkanska-Sinclair, Elena;
Yaffe, Michael B.;
Floyd, Scott R.;
Hammond, Paula T.

Publication type:

Article

Cervical spine instability following cervical laminectomies for Chiari II malformation: a retrospective cohort study.

Published in:

Child's Nervous System, 2009, v. 25, n. 1, p. 71, doi. 10.1007/s00381-008-0694-5

By:

Lam, Fred C.;
Irwin, Beverly J.;
Poskitt, Kenneth J.;
Steinbok, Paul

Publication type:

Article

Isolated unilateral hypoglossal nerve palsy due to an atlanto-occipital juxta-articular cyst: illustrative case.

Published in:

Journal of Neurosurgery Case Lessons, 2025, v. 9, n. 12, p. 1, doi. 10.3171/CASE24776

By:

Nasta, Shagun R.;
Persad, Amit R.;
Hori, Yusuke S.;
Lam, Fred C.;
Abu-Reesh, Deyaaldeen;
Tayag, Armine;
Ustrzynski, Louisa;
Emrich, Sara C.;
Dillon, William P.;
El-Sayed, Ivan H.;
Chang, Steven D.;
Park, David J.

Publication type:

Article

Coexisting sellar Rathke cleft cyst and planum sphenoidale meningioma: illustrative case.

Published in:

Journal of Neurosurgery Case Lessons, 2025, v. 9, n. 3, p. 1, doi. 10.3171/CASE24551

By:

Akhavan-Sigari, Amirhossein;
Park, David J.;
Harary, Paul M.;
Chivakula, Maya;
Theodros, Debebe;
Bharani, Krishna L.;
Hori, Yusuke S.;
Persad, Amit R. L.;
Lam, Fred C.

Publication type:

Article

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17958-z

By:

Kong, Yi Wen;
Dreaden, Erik C.;
Morandell, Sandra;
Zhou, Wen;
Dhara, Sanjeev S.;
Sriram, Ganapathy;
Lam, Fred C.;
Patterson, Jesse C.;
Quadir, Mohiuddin;
Dinh, Anh;
Shopsowitz, Kevin E.;
Varmeh, Shohreh;
Yilmaz, Ömer H.;
Lippard, Stephen J.;
Reinhardt, H. Christian;
Hemann, Michael T.;
Hammond, Paula T.;
Yaffe, Michael B.

Publication type:

Article

BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.

Published in:

Nature Communications, 2020, v. 11, p. 1, doi. 10.1038/s41467-020-17503-y

By:

Lam, Fred C.;
Yi Wen Kong;
Qiuying Huang;
Tu-Lan Vu Han;
Maffa, Amanda D.;
Kasper, Ekkehard M.;
Yaffe, Michael B.

Publication type:

Article

Nicotine Increases Impulsivity and Decreases Willingness to Exert Cognitive Effort despite Improving Attention in “Slacker” Rats: Insights into Cholinergic Regulation of Cost/Benefit Decision Making.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111580

By:

Hosking, Jay G.;
Lam, Fred C. W.;
Winstanley, Catharine A.

Publication type:

Article

Primary epidural lymphocyte-depleted Hodgkin's lymphoma of the thoracic spine - presentation of a rare disease variant.

Published in:

BMC Neurology, 2012, v. 12, n. 1, p. 64, doi. 10.1186/1471-2377-12-64

By:

Kasper, Ekkehard M.;
Lam, Fred C.;
Luedi, Markus M.;
Zinn, Pascal O.;
Pihan, German A.

Publication type:

Article

Moment method for the estimation of mass transfer coefficients for physiological pharmacokinetic models.

Published in:

Biopharmaceutics & Drug Disposition, 1991, v. 12, n. 2, p. 127, doi. 10.1002/bdd.2510120206

By:

Gallo, James M.;
Lam, Fred C.;
Perrier, Donald G.

Publication type:

Article

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Published in:

Nature, 2013, v. 498, n. 7453, p. 246, doi. 10.1038/nature12147

By:

Floyd, Scott R.;
Pacold, Michael E.;
Huang, Qiuying;
Clarke, Scott M.;
Lam, Fred C.;
Cannell, Ian G.;
Bryson, Bryan D.;
Rameseder, Jonathan;
Lee, Michael J.;
Blake, Emily J.;
Fydrych, Anna;
Ho, Richard;
Greenberger, Benjamin A.;
Chen, Grace C.;
Maffa, Amanda;
Del Rosario, Amanda M.;
Root, David E.;
Carpenter, Anne E.;
Hahn, William C.;
Sabatini, David M.

Publication type:

Article

Addressing disparities in delivery of cancer care for patients with melanoma brain metastases—Not just a simple case of rurality.

Published in:

Neuro-Oncology Advances, 2023, v. 5, n. 1, p. 1, doi. 10.1093/noajnl/vdad113

By:

Riggs, Joseph;
Ahn, Hyejeong;
Longmoore, Hailee;
Jardim, Pedro;
Kim, Min J;
Kasper, Ekkehard M;
Han, Jiali;
Lam, Fred C

Publication type:

Article

Inducing DNA damage through R-loops to kill cancer cells.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 1, p. 1, doi. 10.1080/23723556.2020.1848233

By:

Lam, Fred C.;
Kong, Yi Wen;
Yaffe, Michael B.

Publication type:

Article

THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL SYNERGISTIC COMBINATIONS WITH ENHANCED SAFETY PROFILES FOR THE TREATMENT OF MEDULLOBLASTOMA AND GLIOBLASTOMA.

Published in:

Neuro-Oncology, 2019, v. 21, p. ii118, doi. 10.1093/neuonc/noz036.227

By:

Lam, Fred C;
Vu-Han, Tu-Lan;
Kooj, Bert Van de;
Kong, Yi Wen;
Bandopadhayay, Pratiti;
Beroukhim, Rameen;
Sarkaria, Jann;
Hammond, Paula;
Yaffe, Michael

Publication type:

Article

A Review of the Neurosurgical Management of Brain Metastases During Pregnancy.

Published in:

Canadian Journal of Neurological Sciences, 2021, v. 48, n. 5, p. 698, doi. 10.1017/cjn.2020.254

By:

Proskynitopoulos, Phileas J.;
Lam, Fred C.;
Sharma, Sunjay;
Young, Brett C.;
Laviv, Yosef;
Kasper, Ekkehard M.

Publication type:

Article