Works by Lake, Richard A

Results: 64

Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen.

Published in:

OncoImmunology, 2015, v. 4, n. 7, p. N.PAG, doi. 10.1080/2162402X.2015.1011492

By:

Creaney, Jenette;
Ma, Shaokang;
Sneddon, Sophie A;
Tourigny, Michelle R;
Dick, Ian M;
Leon, Justine S;
Khong, Andrea;
Fisher, Scott A;
Lake, Richard A;
Lesterhuis, W Joost;
Nowak, Anna K;
Leary, Shay;
Watson, Mark W;
Robinson, Bruce W

Publication type:

Article

Restoration of defective cross-presentation in tumors by gemcitabine.

Published in:

OncoImmunology, 2015, v. 4, n. 5, p. 0, doi. 10.1080/2162402X.2015.1005501

By:

McDonnell, Alison M;
Lesterhuis, W Joost;
Khong, Andrea;
Nowak, Anna K;
Lake, Richard A;
Currie, Andrew J;
Robinson, Bruce WS

Publication type:

Article

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy.

Published in:

Frontiers in Immunology, 2020, p. 1, doi. 10.3389/fimmu.2020.00223

By:

Zemek, Rachael M.;
Chin, Wee Loong;
Nowak, Anna K.;
Millward, Michael J.;
Lake, Richard A.;
Lesterhuis, W. Joost

Publication type:

Article

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.

Published in:

BMC Research Notes, 2018, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13104-018-3953-x

By:

Chee, Jonathan;
Watson, Mark W.;
Chopra, Abha;
Nguyen, Bella;
Cook, Alistair M.;
Creaney, Jenette;
Lesterhuis, Willem J.;
Robinson, Bruce W.;
Lee, Y. C. Gary;
Nowak, Anna K.;
Lake, Richard A.;
McDonnell, Alison M.

Publication type:

Article

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

Published in:

Nature Genetics, 2011, v. 43, n. 7, p. 668, doi. 10.1038/ng.855

By:

Bott, Matthew;
Brevet, Marie;
Taylor, Barry S.;
Shimizu, Shigeki;
Ito, Tatsuo;
Lu Wang;
Creaney, Jenette;
Lake, Richard A.;
Zakowski, Maureen F.;
Reva, Boris;
Sander, Chris;
Delsite, Robert;
Powell, Simon;
Qin Zhou;
Shen, Ronglai;
Olshen, Adam;
Rusch, Valerie;
Ladanyi, Marc

Publication type:

Article

The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.

Published in:

BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-969

By:

Khong, Andrea;
Cleaver, Amanda L.;
Alatas, Muhammad Fahmi;
Wylie, Ben C.;
Connor, Theresa;
Fisher, Scott A.;
Broomfield, Steve;
Lesterhuis, Willem J.;
Currie, Andrew J.;
Lake, Richard A.;
Robinson, Bruce W.

Publication type:

Article

The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.

Published in:

2014

By:

Khong, Andrea;
Cleaver, Amanda L;
Fahmi Alatas, Muhammad;
Wylie, Ben C;
Connor, Theresa;
Fisher, Scott A;
Broomfield, Steve;
Lesterhuis, Willem J;
Currie, Andrew J;
Lake, Richard A;
Robinson, Bruce W

Publication type:

journal article

Correction to: Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used.

Published in:

2021

By:

Fear, Vanessa S.;
Forbes, Catherine A.;
Neeve, Samuel A.;
Fisher, Scott A.;
Chee, Jonathan;
Waithman, Jason;
Ma, Shao Kang;
Lake, Richard;
Nowak, Anna K.;
Creaney, Jenette;
Brown, Matthew D.;
Saunders, Christobel;
Robinson, Bruce W. S.

Publication type:

Correction Notice

Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used.

Published in:

Cancer Immunology, Immunotherapy, 2021, v. 70, n. 11, p. 3249, doi. 10.1007/s00262-021-02934-3

By:

Fear, Vanessa S.;
Forbes, Catherine A.;
Neeve, Samuel A.;
Fisher, Scott A.;
Chee, Jonathan;
Waithman, Jason;
Ma, Shao Kang;
Lake, Richard;
Nowak, Anna K.;
Creaney, Jenette;
Brown, Matthew D.;
Saunders, Christobel;
Robinson, Bruce W. S.

Publication type:

Article

Peripheral CD8 T cell proliferation is prognostic for patients with advanced thoracic malignancies.

Published in:

Cancer Immunology, Immunotherapy, 2013, v. 62, n. 3, p. 529, doi. 10.1007/s00262-012-1360-z

By:

McCoy, Melanie;
Nowak, Anna;
Most, Robbert;
Dick, Ian;
Lake, Richard

Publication type:

Article

Tumor eradication after cyclophosphamide depends on concurrent depletion of regulatory T cells: a role for cycling TNFR2-expressing effector-suppressor T cells in limiting effective chemotherapy.

Published in:

Cancer Immunology, Immunotherapy, 2009, v. 58, n. 8, p. 1219, doi. 10.1007/s00262-008-0628-9

By:

Most, Robbert G.;
Currie, Andrew J.;
Mahendran, Sathish;
Prosser, Amy;
Darabi, Anna;
Robinson, Bruce W. S.;
Nowak, Anna K.;
Lake, Richard A.

Publication type:

Article

Long-term exposure of mesothelial cells to SV40 and asbestos leads to malignant transformation and chemotherapy resistance.

Published in:

Carcinogenesis, 2014, v. 35, n. 2, p. 407, doi. 10.1093/carcin/bgt322

By:

Cleaver, Amanda L.;
Bhamidipaty, Kasia;
Wylie, Ben;
Connor, Theresa;
Robinson, Cleo;
Robinson, Bruce W.;
Mutsaers, Steven E.;
Lake, Richard A.

Publication type:

Article

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32567-8

By:

Zemek, Rachael M.;
Chin, Wee Loong;
Fear, Vanessa S.;
Wylie, Ben;
Casey, Thomas H.;
Forbes, Cath;
Tilsed, Caitlin M.;
Boon, Louis;
Guo, Belinda B.;
Bosco, Anthony;
Forrest, Alistair R. R.;
Millward, Michael J.;
Nowak, Anna K.;
Lake, Richard A.;
Lassmann, Timo;
Joost Lesterhuis, W.

Publication type:

Article

Chemotherapy Enhances Cross-Presentation of Nuclear Tumor Antigens.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0107894

By:

Anyaegbu, Chidozie C.;
Lake, Richard A.;
Heel, Kathy;
Robinson, Bruce W.;
Fisher, Scott A.

Publication type:

Article

Statins Do Not Alter the Incidence of Mesothelioma in Asbestos Exposed Mice or Humans.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103025

By:

Robinson, Cleo;
Alfonso, Helman;
Woo, Samantha;
Walsh, Amy;
Olsen, Nola;
Musk, Arthur W.;
Robinson, Bruce W. S.;
Nowak, Anna K.;
Lake, Richard A.

Publication type:

Article

Synergistic Effect of CTLA-4 Blockade and Cancer Chemotherapy in the Induction of Anti-Tumor Immunity.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061895

By:

Lesterhuis, W. Joost;
Salmons, Joanne;
Nowak, Anna K.;
Rozali, Esdy N.;
Khong, Andrea;
Dick, Ian M.;
Harken, Julie A.;
Robinson, Bruce W.;
Lake, Richard A.

Publication type:

Article

Cyclophosphamide Chemotherapy Sensitizes Tumor Cells to TRAIL-Dependent CD8 T Cell-Mediated Immune Attack Resulting in Suppression of Tumor Growth.

Published in:

PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0006982

By:

van der Most, Robbert G.;
Currie, Andrew J.;
Cleaver, Amanda L.;
Salmons, Joanne;
Nowak, Anna K.;
Mahendran, Sathish;
Larma, Irma;
Prosser, Amy;
Robinson, Bruce W. S.;
Smyth, Mark J.;
Scalzo, Anthony A.;
Degli-Esposti, Mariapia A.;
Lake, Richard A.

Publication type:

Article

Oral antidiabetic agents.

Published in:

Nursing Standard, 2005, v. 19, n. 36, p. 105

By:

Jordan, Sue;
Lake, Richard

Publication type:

Article

Insulin.

Published in:

Nursing Standard, 2005, v. 19, n. 32, p. 96

By:

Jordan, Sue;
Lake, Richard

Publication type:

Article

Prescription drugs: uses and effects: Anticoagulants.

Published in:

Nursing Standard, 2005, v. 19, n. 19, p. 113

By:

Lake, Richard;
Jordan, Sue

Publication type:

Article

Consistent gene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma.

Published in:

2015

By:

Robinson, Cleo;
Dick, Ian M.;
Wise, Michael J.;
Holloway, Andrew;
Diyagama, Dileepa;
Robinson, Bruce W. S.;
Creaney, Jenette;
Lake, Richard A.

Publication type:

journal article

The Domain Structure and Functional Relationships in the Bacterial Superantigen, SEB.

Published in:

Biological Chemistry, 1995, v. 376, n. 5, p. 303

By:

Hayball, John D.;
O'Hehir, Robyn E.;
Lamb, Jonathan R.;
Lake, Richard A.

Publication type:

Article

Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy.

Published in:

Scientific Data, 2024, v. 11, n. 1, p. 1, doi. 10.1038/s41597-024-03294-0

By:

Chin, Wee Loong;
Zemek, Rachael M.;
Tilsed, Caitlin M.;
Forrest, Alistair R. R.;
Fear, Vanessa S.;
Forbes, Catherine;
Boon, Louis;
Bosco, Anthony;
Guo, Belinda B.;
Millward, Michael J.;
Nowak, Anna K.;
Lake, Richard A.;
Lesterhuis, W. Joost;
Lassmann, Timo

Publication type:

Article

Tumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy.

Published in:

European Journal of Immunology, 2015, v. 45, n. 1, p. 49, doi. 10.1002/eji.201444722

By:

McDonnell, Alison M.;
Lesterhuis, Willem Joost;
Khong, Andrea;
Nowak, Anna K.;
Lake, Richard A.;
Currie, Andrew J.;
Robinson, Bruce W. S.

Publication type:

Article

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment.

Published in:

Science Translational Medicine, 2019, v. 11, n. 501, p. 1, doi. 10.1126/scitranslmed.aav7816

By:

Zemek, Rachael M.;
De Jong, Emma;
Chin, Wee Loong;
Schuster, Iona S.;
Fear, Vanessa S.;
Casey, Thomas H.;
Forbes, Cath;
Dart, Sarah J.;
Leslie, Connull;
Zaitouny, Ayham;
Small, Michael;
Boon, Louis;
Forrest, Alistair R. R.;
Muiri, Daithi O.;
Degli-Esposti, Mariapia A.;
Millward, Michael J.;
Nowak, Anna K.;
Lassmann, Timo;
Bosco, Anthony;
Lake, Richard A.

Publication type:

Article

Voluntary exercise in mesothelioma: effects on tumour growth and treatment response in a murine model.

Published in:

BMC Research Notes, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13104-020-05284-y

By:

Fisher, Scott A.;
Peddle-McIntyre, Carolyn J.;
Burton, Kimberley;
Newton, Robert U.;
Marcq, Elly;
Lake, Richard A.;
Nowak, Anna K.

Publication type:

Article

Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.

Published in:

2001

By:

McLaren, Blair R.;
Whitaker, Darrel;
Robinson, Bruce W.;
Lake, Richard A.;
McLaren, B R;
Whitaker, D;
Robinson, B W;
Lake, R A

Publication type:

journal article

The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop.

Published in:

Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2024.1373003

By:

Fisher, Scott A.;
Patrick, Kimberley;
Hoang, Tracy;
Marcq, Elly;
Behrouzfar, Kiarash;
Young, Sylvia;
Miller, Timothy J.;
Robinson, Bruce W. S.;
Bueno, Raphael;
Nowak, Anna K.;
Lesterhuis, W. Joost;
Morahan, Grant;
Lake, Richard A.

Publication type:

Article

Transient Treg depletion enhances therapeutic anti-cancer vaccination.

Published in:

Immunity, Inflammation & Disease, 2017, v. 5, n. 1, p. 16, doi. 10.1002/iid3.136

By:

Fisher, Scott A.;
Aston, Wayne J.;
Chee, Jonathan;
Khong, Andrea;
Cleaver, Amanda L.;
Solin, Jessica N.;
Ma, Shaokang;
Lesterhuis, W. Joost;
Dick, Ian;
Holt, Robert A.;
Creaney, Jenette;
Boon, Louis;
Robinson, Bruce;
Lake, Richard A.

Publication type:

Article

Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.

Published in:

Scientific Reports, 2015, p. 12298, doi. 10.1038/srep12298

By:

Lesterhuis, W. Joost;
Rinaldi, Catherine;
Rozali, Esdy N.;
Dick, Ian M.;
Khong, Andrea;
Robinson, Bruce W.;
Lake, Richard A.;
Jones, Anya;
Bosco, Anthony;
Boon, Louis;
Nowak, Anna K.

Publication type:

Article

A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers.

Published in:

2021

By:

Cook, Alistair M.;
McDonnell, Alison;
Millward, Michael J;
Creaney, Jenette;
Hasani, Arman;
McMullen, Michelle;
Meniawy, Tarek;
Robinson, Bruce W.S.;
Lake, Richard a;
Nowak, Anna K.

Publication type:

Report

Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.

Published in:

Journal of Translational Medicine, 2014, v. 12, n. 1, p. 1, doi. 10.1186/s12967-014-0245-7

By:

Fisher, Scott A.;
Cleaver, Amanda;
Lakhiani, Devina D.;
Khong, Andrea;
Connor, Theresa;
Wylie, Ben;
Lesterhuis, W. Joost;
Robinson, Bruce W. S.;
Lake, Richard A.

Publication type:

Article

Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.

Published in:

2014

By:

Fisher, Scott A;
Cleaver, Amanda;
Lakhiani, Devina D;
Khong, Andrea;
Connor, Theresa;
Wylie, Ben;
Lesterhuis, W Joost;
Robinson, Bruce Ws;
Lake, Richard A;
Robinson, Bruce W S

Publication type:

journal article

Programmed Death Ligand 2 in Cancer-Induced Immune Suppression.

Published in:

Clinical & Developmental Immunology, 2012, p. 1, doi. 10.1155/2012/656340

By:

Rozali, Esdy N.;
Hato, Stanleyson V.;
Robinson, BruceW.;
Lake, Richard A.;
Joost Lesterhuis, W.

Publication type:

Article

Private specificities can dominate the humoral response to self-antigens in patients with cryptogenic fibrosing alveolitis.

Published in:

Respiratory Research, 2001, v. 2, p. 119, doi. 10.1186/rr46

By:

Robinson, Cleo;
Callow, Marinella;
Stevenson, Sandra;
Robinson, Bruce W. S.;
Lake, Richard A.

Publication type:

Article

Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: Persistent transgene expression despite antibody generation.

Published in:

Cancer Gene Therapy, 2000, v. 7, n. 5, p. 663, doi. 10.1038/sj.cgt.7700133

By:

Mukherjee, Sutapa;
Haenel, Thomas;
Himbeck, Robyn;
Scott, Bernadette;
Ramshaw, Ian;
Lake, Richard A;
Harnett, Gerry;
Phillips, Peter;
Morey, Sue;
Smith, David;
Davidson, J Andrew;
Musk, Arthur W;
Robinson, Bruce

Publication type:

Article

Research Article CD4<sup>+</sup> T cells cross-compete for MHC class II-restricted peptide antigen complexes on the surface of antigen presenting cells.

Published in:

Immunology & Cell Biology, 2004, v. 82, n. 2, p. 103, doi. 10.1046/j.0818-9641.2004.01233.x

By:

Hayball, John D.;
Robinson, Bruce W. S.;
Lake, Richard A.

Publication type:

Article

Altered superantigenic ligands demonstrate the quantitative nature of T-cell activation.

Published in:

Immunology & Cell Biology, 2000, v. 78, n. 6, p. 623, doi. 10.1046/j.1440-1711.2000.00971.x

By:

Hayball, JD;
Hayball, John D;
Lake, Richard A

Publication type:

Article

Partial T cell activation with an altered superantigenic ligand.

Published in:

Immunology & Cell Biology, 2000, v. 78, n. 1, p. 13, doi. 10.1046/j.1440-1711.2000.00880.x

By:

Hayball, John D;
Lake, Richard A;
Hayball, Jd

Publication type:

Article

Cross-presentation of tumour antigens: Evaluation of threshold, duration, distribution and regulation.

Published in:

Immunology & Cell Biology, 1999, v. 77, n. 6, p. 552, doi. 10.1046/j.1440-1711.1999.00876.x

By:

Robinson, Bruce Ws;
Lake, Richard A;
Nelson, Delia J;
Scott, Bernadette A;
Marzo, Amanda L

Publication type:

Article

MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.

Published in:

Immunology & Cell Biology, 1999, v. 77, n. 1, p. 99, doi. 10.1046/j.1440-1711.1999.00794.x

By:

Lake, Richard A;
Robinson, Bruce Ws;
Hayball, John D;
Lake

Publication type:

Article

A function for CD2 on murine B cells?

Published in:

Immunology & Cell Biology, 1997, v. 75, n. 4, p. 333, doi. 10.1038/icb.1997.51

By:

Keogh, Michael-Christopher;
Elliot, James;
Norton, Trisha;
Lake, Richard A.

Publication type:

Article

Tandem peptide epitopes facilitate CD4-dependent activation of T cell clones.

Published in:

Immunology & Cell Biology, 1997, v. 75, n. 2, p. 148, doi. 10.1038/icb.1997.20

By:

Hayball, John D.;
Fidler, Sarah J.;
Palliser, Deborah;
Ann Dm Rees;
Lamb, Jonathan R.;
Lake, Richard A.

Publication type:

Article

Tumor Infiltrating Effector Memory Antigen-Specific CD8<sup>+</sup> T Cells Predict Response to Immune Checkpoint Therapy.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.584423

By:

Principe, Nicola;
Kidman, Joel;
Goh, Siting;
Tilsed, Caitlin M.;
Fisher, Scott A.;
Fear, Vanessa S.;
Forbes, Catherine A.;
Zemek, Rachael M.;
Chopra, Abha;
Watson, Mark;
Dick, Ian M.;
Boon, Louis;
Holt, Robert A.;
Lake, Richard A.;
Nowak, Anna K.;
Lesterhuis, Willem Joost;
McDonnell, Alison M.;
Chee, Jonathan

Publication type:

Article

Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.

Published in:

PLoS ONE, 2023, v. 18, n. 5, p. 1, doi. 10.1371/journal.pone.0274364

By:

Orozco Morales, M. Lizeth;
Rinaldi, Catherine A.;
de Jong, Emma;
Lansley, Sally M.;
Lee, Y. C. Gary;
Zemek, Rachael M.;
Bosco, Anthony;
Lake, Richard A.;
Lesterhuis, W. Joost

Publication type:

Article

Immunological Events Underlying the Induction of T Cell Non-Responsiveness.

Published in:

International Archives of Allergy & Immunology, 1994, v. 104, n. 3, p. 211, doi. 10.1159/000236667

By:

Larché, Mark;
Hoyne, Gerard;
Lake, Richard;
Lamb, Jonathan R.

Publication type:

Article

Serologic Responses in Patients with Malignant Mesothelioma.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2000, v. 22, n. 5, p. 550, doi. 10.1165/ajrcmb.22.5.3930

By:

Robinson, Cleo;
Callow, Marinella;
Stevenson, Sandra;
Scott, Bernadette;
Robinson, Bruce W. S.;
Lake, Richard A.

Publication type:

Article

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice.

Published in:

2017

By:

Aston, Wayne J.;
Hope, Danika E.;
Nowak, Anna K.;
Robinson, Bruce W.;
Lake, Richard A.;
Lesterhuis, W. Joost

Publication type:

journal article

Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters.

Published in:

2017

By:

McDonnell, Alison M.;
Cook, Alistair;
Robinson, Bruce W. S.;
Lake, Richard A.;
Nowak, Anna K.

Publication type:

journal article

Comparing Static Mixer Performances at Pilot and Full Scale for Ozonation, Inactivation of Bacillus subtilis, and Bromate Formation in Water Treatment.

Published in:

Ozone: Science & Engineering, 2004, v. 26, n. 2, p. 207, doi. 10.1080/01919510490439609

By:

Mysore, Chandra;
Leparc, Jérôme;
Lake, Richard;
Agutter, Paula;
Prévost, Michèle

Publication type:

Article