Works by Laffey, John G.

Results: 141

Predicting the development of acute respiratory distress syndrome: searching for the “Troponin of ARDS”.

Published in:

2013

By:

G Laffey, John;
Talmor, Daniel;
Laffey, John G

Publication type:

Editorial

The impact of the inflammatory pulmonary microenvironment on the behavior and function of mesenchymal stromal cells.

Published in:

Expert Review of Respiratory Medicine, 2025, v. 19, n. 6, p. 551, doi. 10.1080/17476348.2025.2491715

By:

Warren, Abigail JM;
Liu, Lanzhi;
O'Toole, Daniel P.;
Laffey, John G.;
Masterson, Claire H

Publication type:

Article

Early versus Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2025, v. 211, n. 6, p. 975, doi. 10.1164/rccm.202406-1162OC

By:

Reep, Carmen A. T.;
Wils, Evert-Jan;
Fleuren, Lucas M.;
Breskin, Alexander;
Bellani, Giacomo;
Laffey, John G.;
Brochard, Laurent J.;
Pham, Tài;
Heunks, Leo

Publication type:

Article

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 6, p. 847, doi. 10.3390/jcm8060847

By:

Jerkic, Mirjana;
Masterson, Claire;
Ormesher, Lindsay;
Gagnon, Stéphane;
Goyal, Sakshi;
Rabani, Razieh;
Otulakowski, Gail;
Zhang, Haibo;
Kavanagh, Brian P.;
Laffey, John G.

Publication type:

Article

Use of a novel "Split" ventilation system in bench and porcine modeling of acute respiratory distress syndrome.

Published in:

Physiological Reports, 2022, v. 10, n. 17, p. 1, doi. 10.14814/phy2.15452

By:

Geoghegan, Pierce;
Clarke, Jennifer;
Hogan, Grace;
Keogh, Aoife;
Marsh, Hannah;
Donnelly, Karen;
McEvoy, Natalie;
Doolan, Aoife;
Madden, Stephen F.;
Martin‐Loeches, Ignacio;
Power, Michael;
Laffey, John G.;
Curley, Gerard F.

Publication type:

Article

Correction: Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study.

Published in:

2025

By:

Laffey, Caoimhe M.;
Sheerin, Rionach;
Khazaei, Omid;
McNicholas, Bairbre A.;
Pham, Tài;
Heunks, Leo;
Bellani, Giacomo;
Brochard, Laurent;
Tomescu, Dana;
Simpkin, Andrew J.;
Laffey, John G.

Publication type:

Correction Notice

Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study.

Published in:

Annals of Intensive Care, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s13613-025-01435-1

By:

Laffey, Caoimhe M.;
Sheerin, Rionach;
Khazaei, Omid;
McNicholas, Bairbre A.;
Pham, Tài;
Heunks, Leo;
Bellani, Giacomo;
Brochard, Laurent;
Tomescu, Dana;
Simpkin, Andrew J.;
Laffey, John G.

Publication type:

Article

Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia.

Published in:

Critical Care, 2013, v. 17, n. 2, p. 1, doi. 10.1186/cc12696

By:

Devaney, James;
Curley, Gerard F.;
Hayes, Mairead;
Masterson, Claire;
Ansari, Bilal;
O'Brien, Timothy;
O'Toole, Daniel;
Laffey, John G.

Publication type:

Article

Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia.

Published in:

2013

By:

Devaney, James;
Curley, Gerard F;
Hayes, Mairead;
Masterson, Claire;
Ansari, Bilal;
O'Brien, Timothy;
O'Toole, Daniel;
Laffey, John G

Publication type:

journal article

Clinical review: Stem cell therapies for acute lung injury/acute respiratory distress syndrome - hope or hype?

Published in:

2012

By:

Hayes, Mairead;
Curley, Gerard;
Ansari, Bilal;
Laffey, John G.

Publication type:

journal article

Clinical review: Special populations--critical illness and pregnancy.

Published in:

2011

By:

Neligan, Patrick J;
Laffey, John G

Publication type:

journal article

Clinical review: Special populations - critical illness and pregnancy.

Published in:

Critical Care, 2011, v. 15, n. 4, p. 1, doi. 10.1186/cc10256

By:

Neligan, Patrick J.;
Laffey, John G.

Publication type:

Article

Noninvasive mechanical ventilation in early acute respiratory distress syndrome.

Published in:

Polish Archives of Internal Medicine, 2017, v. 127, n. 9, p. 614, doi. 10.20452/pamw.4088

By:

Grassi, Alice;
Foti, Giuseppe;
Laffey, John G.;
Bellani, Giacomo

Publication type:

Article

A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial.

Published in:

2021

By:

McEvoy, Natalie L.;
Clarke, Jennifer L.;
Mc Elvaney, Oliver J.;
Mc Elvaney, Oisin F.;
Boland, Fiona;
Hyland, Deirdre;
Geoghegan, Pierce;
Donnelly, Karen;
Friel, Oisin;
Cullen, Ailbhe;
Collins, Ann M.;
Fraughen, Daniel;
Martin-Loeches, Ignacio;
Hennessy, Martina;
Laffey, John G.;
Mc Elvaney, Noel G.;
Curley, Gerard F.

Publication type:

Letter

Epidemiology, ventilation management and outcomes of COVID–19 ARDS patients versus patients with ARDS due to pneumonia in the Pre–COVID era.

Published in:

Respiratory Research, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12931-024-02910-2

By:

van der Ven, Fleur–Stefanie L. I. M.;
Blok, Siebe G.;
Azevedo, Luciano C.;
Bellani, Giacomo;
Botta, Michela;
Estenssoro, Elisa;
Fan, Eddy;
Ferreira, Juliana Carvalho;
Laffey, John G.;
Martin–Loeches, Ignacio;
Motos, Ana;
Pham, Tai;
Peñuelas, Oscar;
Pesenti, Antonio;
Pisani, Luigi;
Neto, Ary Serpa;
Schultz, Marcus J.;
Torres, Antoni;
Tsonas, Anissa M.;
Paulus, Frederique

Publication type:

Article

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries.

Published in:

Reproductive Biology & Endocrinology, 2009, v. 7, p. 1, doi. 10.1186/1477-7827-7-34

By:

Maharaj, Chrisen H.;
O'Toole, Daniel;
Lynch, Tadhg;
Carney, John;
Jarman, James;
Higgins, Brendan D.;
Morrison, John J.;
Laffey, John G.

Publication type:

Article

Development and assessment of the performance of a shared ventilatory system that uses clinically available components to individualize tidal volumes.

Published in:

BMC Anesthesiology, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12871-023-02200-2

By:

Hannon, David M.;
Jones, Tim;
Conolly, Jack;
Judge, Conor;
Iqbal, Talha;
Shahzad, Atif;
Madden, Michael;
Kirrane, Frank;
Conneely, Peter;
Harte, Brian H.;
O'Halloran, Martin;
Laffey, John G.

Publication type:

Article

Mesenchymal Stem Cell Trials for Pulmonary Diseases.

Published in:

Journal of Cellular Biochemistry, 2014, v. 115, n. 6, p. 1023, doi. 10.1002/jcb.24783

By:

Antunes, Mariana A.;
Laffey, John G.;
Pelosi, Paolo;
Rocco, Patricia R.M.

Publication type:

Article

β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application.

Published in:

Journal of Fungi, 2020, v. 6, n. 4, p. 1, doi. 10.3390/jof6040356

By:

Murphy, Emma J.;
Rezoagli, Emanuele;
Major, Ian;
Rowan, Neil J.;
Laffey, John G.

Publication type:

Article

Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study.

Published in:

Annals of Intensive Care, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13613-022-01015-7

By:

Rezoagli, Emanuele;
McNicholas, Bairbre A.;
Madotto, Fabiana;
Pham, Tài;
Bellani, Giacomo;
Laffey, John G.

Publication type:

Article

Relationship between growth of food-spoilage yeast in high-sugar environments and sensitivity to high-intensity pulsed UV light irradiation.

Published in:

International Journal of Food Science & Technology, 2012, v. 47, n. 9, p. 1925, doi. 10.1111/j.1365-2621.2012.03052.x

By:

Hayes, Jennifer C.;
Laffey, John G.;
McNeil, Brian;
Rowan, Neil J.

Publication type:

Article

Oxygen targets in critically ill patients: from pathophysiology to population enrichment strategies.

Published in:

Medical Gas Research, 2025, v. 15, n. 3, p. 409, doi. 10.4103/mgr.MEDGASRES-D-24-00120

By:

Ripa, Claudio;
Munshi, Laveena;
Kuebler, Wolfgang M.;
Magliocca, Aurora;
Taccone, Fabio S.;
Ware, Lorraine B.;
Citerio, Giuseppe;
Laffey, John G.;
Rezoagli, Emanuele

Publication type:

Article

Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model.

Published in:

Stem Cell Research & Therapy, 2023, v. 14, n. 1, p. 1, doi. 10.1186/s13287-023-03385-6

By:

Gonzalez, Hector;
McCarthy, Sean;
Masterson, Claire;
Byrnes, Declan;
Sallent, Ignacio;
Horan, Emma;
Elliman, Stephen J.;
Vella, Gabriele;
Mello, Adriele P.;
Silva, Johnatas D.;
Krasnodembskaya, Anna D.;
MacLoughlin, Ronan;
Laffey, John G.;
O'Toole, Daniel

Publication type:

Article

Awake prone positioning in acute hypoxaemic respiratory failure.

Published in:

European Respiratory Review, 2023, v. 32, n. 168, p. 1, doi. 10.1183/16000617.0245-2022

By:

McNicholas, Bairbre A.;
Ibarra-Estrada, Miguel;
Perez, Yonatan;
Jie Li;
Pavlov, Ivan;
Kharat, Aileen;
Vines, David L.;
Roca, Oriol;
Cosgrave, David;
Guerin, Claude;
Ehrmann, Stephan;
Laffey, John G.

Publication type:

Article

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research.

Published in:

European Respiratory Review, 2021, v. 30, n. 159, p. 1, doi. 10.1183/16000617.0317-2020

By:

Bos, Lieuwe D. J.;
Artigas, Antonio;
Constantin, Jean-Michel;
Hagens, Laura A.;
Heijnen, Nanon;
Laffey, John G.;
Meyer, Nuala;
Papazian, Laurent;
Pisani, Lara;
Schultz, Marcus J.;
Shankar-Hari, Manu;
Smit, Marry R.;
Summers, Charlotte;
Ware, Lorraine B.;
Scala, Raffaele;
Calfee, Carolyn S.

Publication type:

Article

Tracheostomy procedures in the intensive care unit: an international survey.

Published in:

Critical Care, 2015, v. 19, n. 1, p. 1, doi. 10.1186/s13054-015-1013-7

By:

Vargas, Maria;
Sutherasan, Yuda;
Antonelli, Massimo;
Brunetti, Iole;
Corcione, Antonio;
Laffey, John G.;
Putensen, Christian;
Servillo, Giuseppe;
Pelosi, Paolo

Publication type:

Article

Tracheostomy procedures in the intensive care unit: an international survey.

Published in:

Critical Care, 2015, v. 19, n. 1, p. 291, doi. 10.1186/s13054-015-1013-7

By:

Vargas, Maria;
Sutherasan, Yuda;
Antonelli, Massimo;
Brunetti, Iole;
Corcione, Antonio;
Laffey, John G.;
Putensen, Christian;
Servillo, Giuseppe;
Pelosi, Paolo

Publication type:

Article

Acidosis in the critically ill -- balancing risks and benefits to optimize outcome.

Published in:

Critical Care, 2014, v. 18, n. 2, p. 129, doi. 10.1186/cc13815

By:

Curley, Gerard F.;
Laffey, John G.

Publication type:

Article

Acidosis in the critically ill - balancing risks and benefits to optimize outcome.

Published in:

2014

By:

Curley, Gerard F;
Laffey, John G

Publication type:

journal article

Natural language processing in critical care: opportunities, challenges, and future directions.

Published in:

Intensive Care Medicine, 2025, v. 51, n. 3, p. 585, doi. 10.1007/s00134-024-07776-y

By:

McNicholas, Bairbre A.;
Madden, Michael G.;
Laffey, John G.

Publication type:

Article

Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study.

Published in:

Intensive Care Medicine, 2025, v. 51, n. 2, p. 318, doi. 10.1007/s00134-025-07808-1

By:

Robba, Chiara;
Giardiello, Daniele;
Almondo, Chiara;
Asehnoune, Karim;
Badenes, Rafael;
Cinotti, Raphael;
Elhadi, Muhammed;
Graziano, Francesca;
Helbok, Raimund;
Jiang, Lidan;
Chen, Wenjin;
Laffey, John G.;
Messina, Antonio;
Putensen, Christian;
Schultz, Marcus J.;
Wahlster, Sarah;
Rebora, Paola;
Galimberti, Stefania;
Taccone, Fabio Silvio;
Citerio, Giuseppe

Publication type:

Article

Assessing the usefulness of a large language model to query and summarize unstructured medical notes in intensive care.

Published in:

Intensive Care Medicine, 2023, v. 49, n. 8, p. 1018, doi. 10.1007/s00134-023-07128-2

By:

Madden, Michael G.;
McNicholas, Bairbre A.;
Laffey, John G.

Publication type:

Article

Awake prone positioning.

Published in:

Intensive Care Medicine, 2022, v. 48, n. 12, p. 1793, doi. 10.1007/s00134-022-06893-w

By:

McNicholas, Bairbre A.;
Ehrmann, Stephan;
Laffey, John G.

Publication type:

Article

Protective ventilation.

Published in:

Intensive Care Medicine, 2022, v. 48, n. 11, p. 1629, doi. 10.1007/s00134-022-06820-z

By:

Juffermans, Nicole P.;
Rocco, Patricia R. M.;
Laffey, John G.

Publication type:

Article

Emerging pharmacological therapies for ARDS: COVID-19 and beyond.

Published in:

Intensive Care Medicine, 2020, v. 46, n. 12, p. 2265, doi. 10.1007/s00134-020-06141-z

By:

Horie, Shahd;
McNicholas, Bairbre;
Rezoagli, Emanuele;
Pham, Tài;
Curley, Ger;
McAuley, Danny;
O'Kane, Cecilia;
Nichol, Alistair;
dos Santos, Claudia;
Rocco, Patricia R. M.;
Bellani, Giacomo;
Laffey, John G.

Publication type:

Article

Missed or delayed diagnosis of ARDS: a common and serious problem.

Published in:

2020

By:

Bellani, Giacomo;
Pham, Tài;
Laffey, John G.

Publication type:

journal article

Validation of a tool for estimating clinician recognition of ARDS using data from the international LUNG SAFE study.

Published in:

PLoS Digital Health, 2023, v. 2, n. 8, p. 1, doi. 10.1371/journal.pdig.0000325

By:

Bechel, Meagan A.;
Madotto, Fabiana;
Pah, Adam R.;
Bellani, Giacomo;
Laffey, John G.;
Pham, Tài;
Amaral, Luís A. Nunes;
Weiss, Curtis H.

Publication type:

Article

The role of microRNAs in muscle wasting and recovery during critical illness: a systematic review.

Published in:

JCSM Rapid Communications, 2023, v. 6, n. 2, p. 68, doi. 10.1002/rco2.80

By:

Borja‐Gonzalez, Maria;
Coyne, Sarah;
Fagan, Sarah;
Casas‐Martinez, Jose C.;
Sannicandro, Anthony J.;
McNicholas, Bairbre;
O'Connell, Kevin;
Laffey, John G.;
O'Caoimh, Rónán;
McDonagh, Brian;
Goljanek‐Whysall, Katarzyna

Publication type:

Article

Towards a biological definition of ARDS: are treatable traits the solution?

Published in:

Intensive Care Medicine Experimental, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40635-022-00435-w

By:

Bos, Lieuwe D. J.;
Laffey, John G.;
Ware, Lorraine B.;
Heijnen, Nanon F. L.;
Sinha, Pratik;
Patel, Brijesh;
Jabaudon, Matthieu;
Bastarache, Julie A.;
McAuley, Daniel F.;
Summers, Charlotte;
Calfee, Carolyn S.;
Shankar-Hari, Manu

Publication type:

Article

Role of the adaptive immune response in sepsis.

Published in:

Intensive Care Medicine Experimental, 2020, v. 8, p. 1, doi. 10.1186/s40635-020-00309-z

By:

Brady, Jack;
Horie, Shahd;
Laffey, John G.

Publication type:

Article

The importance of discovery science in the development of therapies for the critically ill.

Published in:

2020

By:

Juffermans, Nicole P.;
Radermacher, Peter;
Laffey, John G.

Publication type:

Letter

In vitro characterization of PrismaLung+: a novel ECCO2R device.

Published in:

Intensive Care Medicine Experimental, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40635-020-00301-7

By:

Hospach, Ingeborg;
Goldstein, Jacques;
Harenski, Kai;
Laffey, John G.;
Pouchoulin, Dominique;
Raible, Manuela;
Votteler, Stefanie;
Storr, Markus

Publication type:

Article

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism.

Published in:

Intensive Care Medicine Experimental, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40635-020-0295-5

By:

Horie, Shahd;
Gaynard, Sean;
Murphy, Mary;
Barry, Frank;
Scully, Michael;
O'Toole, Daniel;
Laffey, John G.

Publication type:

Article

Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns.

Published in:

Intensive Care Medicine Experimental, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40635-019-0235-4

By:

Masterson, Claire H.;
Curley, Gerard F.;
Laffey, John G.

Publication type:

Article

Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns.

Published in:

Intensive Care Medicine Experimental, 2019, v. 7, p. 1, doi. 10.1186/s40635-019-0235-4

By:

Masterson, Claire H.;
Curley, Gerard F.;
Laffey, John G.

Publication type:

Article

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Published in:

2016

By:

Bellani, Giacomo;
Laffey, John G.;
Tài Pham;
Fan, Eddy;
Brochard, Laurent;
Esteban, Andres;
Gattinoni, Luciano;
van Flaren, Frank;
Larsson, Anders;
McAuley, Daniel F.;
Ranieri, Marco;
Rubenfeld, Gordon;
Thompson, B. Taylor;
Wrigge, Flermann;
Slutsky, Arthur S.;
Pesenti, Antonio;
Pham, Tài;
van Haren, Frank;
Wrigge, Hermann;
LUNG SAFE Investigators and the ESICM Trials Group

Publication type:

journal article

Prone positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients.

Published in:

BMC Research Notes, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13104-020-05426-2

By:

Clarke, Jennifer;
Geoghegan, Pierce;
McEvoy, Natalie;
Boylan, Maria;
Ní Choileáin, Orna;
Mulligan, Martin;
Hogan, Grace;
Keogh, Aoife;
McElvaney, Oliver J.;
McElvaney, Oisín F.;
Bourke, John;
McNicholas, Bairbre;
Laffey, John G.;
McElvaney, Noel G.;
Curley, Gerard F.

Publication type:

Article

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis.

Published in:

Critical Care, 2022, v. 26, n. 1, p. 1, doi. 10.1186/s13054-022-03983-5

By:

Li Bassi, Gianluigi;
Gibbons, Kristen;
Suen, Jacky Y.;
Dalton, Heidi J.;
White, Nicole;
Corley, Amanda;
Shrapnel, Sally;
Hinton, Samuel;
Forsyth, Simon;
Laffey, John G.;
Fan, Eddy;
Fanning, Jonathon P.;
Panigada, Mauro;
Bartlett, Robert;
Brodie, Daniel;
Burrell, Aidan;
Chiumello, Davide;
Elhazmi, Alyaa;
Esperatti, Mariano;
Grasselli, Giacomo

Publication type:

Article

Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial.

Published in:

Critical Care, 2022, v. 26, n. 1, p. 1, doi. 10.1186/s13054-022-03950-0

By:

Ibarra-Estrada, Miguel;
Li, Jie;
Pavlov, Ivan;
Perez, Yonatan;
Roca, Oriol;
Tavernier, Elsa;
McNicholas, Bairbre;
Vines, David;
Marín-Rosales, Miguel;
Vargas-Obieta, Alexandra;
García-Salcido, Roxana;
Aguirre-Díaz, Sara A.;
López-Pulgarín, José A.;
Chávez-Peña, Quetzalcóatl;
Mijangos-Méndez, Julio C.;
Aguirre-Avalos, Guadalupe;
Ehrmann, Stephan;
Laffey, John G.

Publication type:

Article

Dangers of hyperoxia.

Published in:

2021

By:

Singer, Mervyn;
Young, Paul J.;
Laffey, John G.;
Asfar, Pierre;
Taccone, Fabio Silvio;
Skrifvars, Markus B.;
Meyhoff, Christian S.;
Radermacher, Peter

Publication type:

journal article