Works by Laeremans, Toon

Results: 15

Development of Generic G Protein Peptidomimetics Able to Stabilize Active State G<sub>s</sub> Protein‐Coupled Receptors for Application in Drug Discovery.
Published in:
Angewandte Chemie, 2021, v. 133, n. 18, p. 10335, doi. 10.1002/ange.202100180
By:
- Mannes, Morgane;
- Martin, Charlotte;
- Triest, Sarah;
- Pia Dimmito, Marilisa;
- Mollica, Adriano;
- Laeremans, Toon;
- Menet, Christel J.;
- Ballet, Steven
Publication type:
Article
Propagation of conformational changes during μ-opioid receptor activation.
Published in:
Nature, 2015, v. 524, n. 7565, p. 375, doi. 10.1038/nature14680
By:
- Sounier, Rémy;
- Mas, Camille;
- Steyaert, Jan;
- Laeremans, Toon;
- Manglik, Aashish;
- Huang, Weijiao;
- Kobilka, Brian K.;
- Déméné, Héléne;
- Granier, Sébastien
Publication type:
Article
Structural insights into µ-opioid receptor activation.
Published in:
Nature, 2015, v. 524, n. 7565, p. 315, doi. 10.1038/nature14886
By:
- Huang, Weijiao;
- Manglik, Aashish;
- Venkatakrishnan, A. J.;
- Laeremans, Toon;
- Feinberg, Evan N.;
- Sanborn, Adrian L.;
- Kato, Hideaki E.;
- Livingston, Kathryn E.;
- Thorsen, Thor S.;
- Kling, Ralf C.;
- Granier, Sébastien;
- Gmeiner, Peter;
- Husbands, Stephen M.;
- Traynor, John R.;
- Weis, William I.;
- Steyaert, Jan;
- Dror, Ron O.;
- Kobilka, Brian K.
Publication type:
Article
The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.868579
By:
- D'Uonnolo, Giulia;
- Reynders, Nathan;
- Meyrath, Max;
- Abboud, Dayana;
- Uchański, Tomasz;
- Laeremans, Toon;
- Volkman, Brian F.;
- Janji, Bassam;
- Hanson, Julien;
- Szpakowska, Martyna;
- Chevigné, Andy
Publication type:
Article
Development by genetic immunization of Monovalent antibodies against human Vasoactive intestinal Peptide receptor 1 (VPac1), new innovative, and Versatile Tools to study VPac1 receptor Function.
Published in:
Frontiers in Endocrinology, 2018, p. 1, doi. 10.3389/fendo.2018.00153
By:
- Peyrassol, Xavier;
- Laeremans, Toon;
- Lahura, Vannessa;
- Debulpaep, Maja;
- El Hassan, Hassan;
- Steyaert, Jan;
- Parmentier, Marc;
- Langer, Ingrid
Publication type:
Article
Structure of a bacterial type IV secretion core complex at subnanometre resolution.
Published in:
EMBO Journal, 2013, v. 32, n. 8, p. 1195, doi. 10.1038/emboj.2013.58
By:
- Rivera‐Calzada, Angel;
- Fronzes, Rémi;
- Savva, Christos G;
- Chandran, Vidya;
- Lian, Pei W;
- Laeremans, Toon;
- Pardon, Els;
- Steyaert, Jan;
- Remaut, Han;
- Waksman, Gabriel;
- Orlova, Elena V
Publication type:
Article
Development of Generic G Protein Peptidomimetics Able to Stabilize Active State G<sub>s</sub> Protein‐Coupled Receptors for Application in Drug Discovery.
Published in:
Angewandte Chemie International Edition, 2021, v. 60, n. 18, p. 10247, doi. 10.1002/anie.202100180
By:
- Mannes, Morgane;
- Martin, Charlotte;
- Triest, Sarah;
- Pia Dimmito, Marilisa;
- Mollica, Adriano;
- Laeremans, Toon;
- Menet, Christel J.;
- Ballet, Steven
Publication type:
Article
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.
Published in:
Science Translational Medicine, 2016, v. 8, n. 366, p. 1, doi. 10.1126/scitranslmed.aaf8463
By:
- Danquah, Welbeck;
- Meyer-Schwesinger, Catherine;
- Rissiek, Björn;
- Pinto, Carolina;
- Serracant-Prat, Arnau;
- Amadi, Miriam;
- Iacenda, Domenica;
- Knop, Jan-Hendrik;
- Hammel, Anna;
- Bergmann, Philine;
- Schwarz, Nicole;
- Assunção, Joana;
- Rotthier, Wendy;
- Haag, Friedrich;
- Tolosa, Eva;
- Bannas, Peter;
- Boué-Grabot, Eric;
- Magnus, Tim;
- Laeremans, Toon;
- Stortelers, Catelijne
Publication type:
Article
A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.
Published in:
International Journal of Cancer, 2011, v. 129, n. 8, p. 2013, doi. 10.1002/ijc.26145
By:
- Roovers, Rob C.;
- Vosjan, Maria J.W.D.;
- Laeremans, Toon;
- el Khoulati, Rachid;
- de Bruin, Renée C.G.;
- Ferguson, Kathryn M.;
- Verkleij, Arie J.;
- van Dongen, Guus A.M.S.;
- van Bergen en Henegouwen, Paul M.P.
Publication type:
Article
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10714-y
By:
- Sigoillot, Maud;
- Overtus, Marie;
- Grodecka, Magdalena;
- Scholl, Daniel;
- Garcia-Pino, Abel;
- Laeremans, Toon;
- He, Lihua;
- Pardon, Els;
- Hildebrandt, Ellen;
- Urbatsch, Ina;
- Steyaert, Jan;
- Riordan, John R.;
- Govaerts, Cedric
Publication type:
Article
A general protocol for the generation of Nanobodies for structural biology.
Published in:
Nature Protocols, 2014, v. 9, n. 3, p. 674, doi. 10.1038/nprot.2014.039
By:
- Pardon, Els;
- Laeremans, Toon;
- Triest, Sarah;
- Rasmussen, Søren G. F.;
- Wohlkönig, Alexandre;
- Ruf, Armin;
- Muyldermans, Serge;
- Hol, Wim G. J.;
- Kobilka, Brian K.;
- Steyaert, Jan
Publication type:
Article
Nanobody‐Enabled Reverse Pharmacology on G‐Protein‐Coupled Receptors.
Published in:
Angewandte Chemie, 2018, v. 130, n. 19, p. 5390, doi. 10.1002/ange.201712581
By:
- Pardon, Els;
- Betti, Cecilia;
- Laeremans, Toon;
- Chevillard, Florent;
- Guillemyn, Karel;
- Kolb, Peter;
- Ballet, Steven;
- Steyaert, Jan
Publication type:
Article
Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies.
Published in:
Cancer Immunology, Immunotherapy, 2007, v. 56, n. 3, p. 303, doi. 10.1007/s00262-006-0180-4
By:
- Roovers, Rob;
- Laeremans, Toon;
- Huang, Lieven;
- Taeye, Severine;
- Verkleij, Arie;
- Revets, Hilde;
- Haard, Hans;
- Bergen en Henegouwen, Paul M.
Publication type:
Article
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops.
Published in:
mAbs, 2016, v. 8, n. 6, p. 1126, doi. 10.1080/19420862.2016.1189050
By:
- van der Woning, Bas;
- De Boeck, Gitte;
- Blanchetot, Christophe;
- Bobkov, Vladimir;
- Klarenbeek, Alex;
- Saunders, Michael;
- Waelbroeck, Magali;
- Laeremans, Toon;
- Steyaert, Jan;
- Hultberg, Anna;
- De Haard, Hans
Publication type:
Article
Nanobody‐Enabled Reverse Pharmacology on G‐Protein‐Coupled Receptors.
Published in:
Angewandte Chemie International Edition, 2018, v. 57, n. 19, p. 5292, doi. 10.1002/anie.201712581
By:
- Pardon, Els;
- Betti, Cecilia;
- Laeremans, Toon;
- Chevillard, Florent;
- Guillemyn, Karel;
- Kolb, Peter;
- Ballet, Steven;
- Steyaert, Jan
Publication type:
Article