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Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53758-5
By:
- Altıntaş, Umut Berkay;
- Seo, Ji-Heui;
- Giambartolomei, Claudia;
- Ozturan, Dogancan;
- Fortunato, Brad J.;
- Nelson, Geoffrey M.;
- Goldman, Seth R.;
- Adelman, Karen;
- Hach, Faraz;
- Freedman, Matthew L.;
- Lack, Nathan A.
Publication type:
Article
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35135-2
By:
- Kneppers, Jeroen;
- Severson, Tesa M.;
- Siefert, Joseph C.;
- Schol, Pieter;
- Joosten, Stacey E. P.;
- Yu, Ivan Pak Lok;
- Huang, Chia-Chi Flora;
- Morova, Tunç;
- Altıntaş, Umut Berkay;
- Giambartolomei, Claudia;
- Seo, Ji-Heui;
- Baca, Sylvan C.;
- Carneiro, Isa;
- Emberly, Eldon;
- Pasaniuc, Bogdan;
- Jerónimo, Carmen;
- Henrique, Rui;
- Freedman, Matthew L.;
- Wessels, Lodewyk F. A.;
- Lack, Nathan A.
Publication type:
Article
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Published in:
Cell Communication & Signaling, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12964-023-01335-6
By:
- Ozyerli-Goknar, Ezgi;
- Kala, Ezgi Yagmur;
- Aksu, Ali Cenk;
- Bulut, Ipek;
- Cingöz, Ahmet;
- Nizamuddin, Sheikh;
- Biniossek, Martin;
- Seker-Polat, Fidan;
- Morova, Tunc;
- Aztekin, Can;
- Kung, Sonia H. Y.;
- Syed, Hamzah;
- Tuncbag, Nurcan;
- Gönen, Mehmet;
- Philpott, Martin;
- Cribbs, Adam P.;
- Acilan, Ceyda;
- Lack, Nathan A.;
- Onder, Tamer T.;
- Timmers, H. T. Marc
Publication type:
Article
Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer.
Published in:
Cancers, 2021, v. 13, n. 14, p. 3488, doi. 10.3390/cancers13143488
By:
- Ban, Fuqiang;
- Leblanc, Eric;
- Cavga, Ayse Derya;
- Huang, Chia-Chi Flora;
- Flory, Mark R.;
- Zhang, Fan;
- Chang, Matthew E. K.;
- Morin, Hélène;
- Lallous, Nada;
- Singh, Kriti;
- Gleave, Martin E.;
- Mohammed, Hisham;
- Rennie, Paul S.;
- Lack, Nathan A.;
- Cherkasov, Artem
Publication type:
Article
5‐Fluoro/(trifluoromethoxy)‐2‐indolinone derivatives with anti‐interleukin‐1 activity.
Published in:
Archiv der Pharmazie, 2023, v. 356, n. 12, p. 1, doi. 10.1002/ardp.202300217
By:
- Soylu‐Eter, Özge;
- Sevinçli, Zekiye Şeyma;
- Ersoy, Betül;
- Hasanusta, Bahar;
- Gatfar, Uğur;
- Lack, Nathan A.;
- Erman, Burak;
- Gül, Ahmet;
- Orer, Hakan S.;
- Karalı, Nilgün
Publication type:
Article
Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo.
Published in:
Advanced Science, 2022, v. 9, n. 27, p. 1, doi. 10.1002/advs.202201294
By:
- Kayabolen, Alisan;
- Akcan, Ugur;
- Özturan, Doğancan;
- Ulbegi‐Polat, Hivda;
- Sahin, Gizem Nur;
- Pinarbasi‐Degirmenci, Nareg;
- Bayraktar, Canan;
- Soyler, Gizem;
- Sarayloo, Ehsan;
- Nurtop, Elif;
- Ozer, Berna;
- Guney‐Esken, Gulen;
- Barlas, Tayfun;
- Yildirim, Ismail Selim;
- Dogan, Ozlem;
- Karahuseyinoglu, Sercin;
- Lack, Nathan A.;
- Kaya, Mehmet;
- Albayrak, Cem;
- Can, Fusun
Publication type:
Article
A CD74-dependent MHC class I endolysosomal cross-presentation pathway.
Published in:
Nature Immunology, 2012, v. 13, n. 3, p. 237, doi. 10.1038/ni.2225
By:
- Basha, Genc;
- Omilusik, Kyla;
- Chavez-Steenbock, Ana;
- Reinicke, Anna T;
- Lack, Nathan;
- Choi, Kyung Bok;
- Jefferies, Wilfred A
Publication type:
Article
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Published in:
Nature Communications, 2015, v. 6, n. 1, p. 6025, doi. 10.1038/ncomms7025
By:
- Küçük, Can;
- Jiang, Bei;
- Hu, Xiaozhou;
- Zhang, Wenyan;
- Chan, John K. C.;
- Xiao, Wenming;
- Lack, Nathan;
- Alkan, Can;
- Williams, John C.;
- Avery, Kendra N.;
- Kavak, Pınar;
- Scuto, Anna;
- Sen, Emel;
- Gaulard, Philippe;
- Staudt, Lou;
- Iqbal, Javeed;
- Zhang, Weiwei;
- Cornish, Adam;
- Gong, Qiang;
- Yang, Qunpei
Publication type:
Article
Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3′-diindolylmethane (Ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells.
Published in:
Prostate, 2011, v. 71, n. 13, p. 1401, doi. 10.1002/pros.21356
By:
- Abdelbaqi, Khalil;
- Lack, Nathan;
- Guns, Emma Tomlinson;
- Kotha, Leela;
- Safe, Stephen;
- Sanderson, J. Thomas
Publication type:
Article
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Published in:
2017
By:
- Ryan, Ali;
- Polycarpou, Elena;
- Lack, Nathan A;
- Evangelopoulos, Dimitrios;
- Sieg, Christian;
- Halman, Alice;
- Bhakta, Sanjib;
- Eleftheriadou, Olga;
- McHugh, Timothy D;
- Keany, Sebastian;
- Lowe, Edward D;
- Ballet, Romain;
- Abuhammad, Areej;
- Jacobs, William R;
- Ciulli, Alessio;
- Sim, Edith;
- Jacobs, William R Jr
Publication type:
journal article
EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities.
Published in:
Cell Death & Disease, 2022, v. 13, n. 8, p. 1, doi. 10.1038/s41419-022-05146-4
By:
- Yedier-Bayram, Ozlem;
- Gokbayrak, Bengul;
- Kayabolen, Alisan;
- Aksu, Ali Cenk;
- Cavga, Ayse Derya;
- Cingöz, Ahmet;
- Kala, Ezgi Yagmur;
- Karabiyik, Goktug;
- Günsay, Rauf;
- Esin, Beril;
- Morova, Tunc;
- Uyulur, Fırat;
- Syed, Hamzah;
- Philpott, Martin;
- Cribbs, Adam P.;
- Kung, Sonia H. Y.;
- Lack, Nathan A.;
- Onder, Tamer T.;
- Bagci-Onder, Tugba
Publication type:
Article
Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene.
Published in:
Mammalian Genome, 2007, v. 18, n. 4, p. 270, doi. 10.1007/s00335-007-9010-z
By:
- Wakefield, Larissa;
- Long, Hilary;
- Lack, Nathan;
- Sim, Edith
Publication type:
Article
Androgen Receptor-Mediated Transcription in Prostate Cancer.
Published in:
Cells (2073-4409), 2022, v. 11, n. 5, p. 898, doi. 10.3390/cells11050898
By:
- Özturan, Doğancan;
- Morova, Tunç;
- Lack, Nathan A.
Publication type:
Article
Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours.
Published in:
Frontiers in Pharmacology, 2023, p. 01, doi. 10.3389/fphar.2023.1119620
By:
- Ellis, Samantha L. S.;
- Dada, Sarah;
- Nohara, Lilian L.;
- Saranchova, Iryna;
- Munro, Lonna;
- Pfeifer, Cheryl G.;
- Eyford, Brett A.;
- Morova, Tunc;
- Williams, David E.;
- Ping Cheng;
- Lack, Nathan A.;
- Andersen, Raymond J.;
- Jefferies, Wilfred A.
Publication type:
Article
Optimized high-throughput screening of non-coding variants identified from genome-wide association studies.
Published in:
Nucleic Acids Research, 2023, v. 51, n. 3, p. e18, doi. 10.1093/nar/gkac1198
By:
- Morova, Tunc;
- Ding, Yi;
- Huang, Chia-Chi F;
- Sar, Funda;
- Schwarz, Tommer;
- Giambartolomei, Claudia;
- Baca, Sylvan C;
- Grishin, Dennis;
- Hach, Faraz;
- Gusev, Alexander;
- Freedman, Matthew L;
- Pasaniuc, Bogdan;
- Lack, Nathan A
Publication type:
Article
Histologically benign PI‐RADS 4 and 5 lesions contain cancer‐associated epigenetic alterations.
Published in:
Prostate, 2022, v. 82, n. 1, p. 145, doi. 10.1002/pros.24255
By:
- Şeref, Ceren;
- Acar, Ömer;
- Kılıç, Mert;
- Vural, Metin;
- Sağlıcan, Yeşim;
- Saraç, Hilal;
- Coşkun, Bilgen;
- İnce, Ümit;
- Esen, Tarık;
- Lack, Nathan A.
Publication type:
Article
Association of B7‐H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer.
Published in:
Cancer (0008543X), 2022, v. 128, n. 12, p. 2269, doi. 10.1002/cncr.34190
By:
- Mendes, Adrianna A.;
- Lu, Jiayun;
- Kaur, Harsimar B.;
- Zheng, Siqun L.;
- Xu, Jianfeng;
- Hicks, Jessica;
- Weiner, Adam B.;
- Schaeffer, Edward M.;
- Ross, Ashley E.;
- Balk, Steven P.;
- Taplin, Mary‐Ellen;
- Lack, Nathan A.;
- Tekoglu, Emirhan;
- Maynard, Janielle P.;
- De Marzo, Angelo M.;
- Antonarakis, Emmanuel S.;
- Sfanos, Karen S.;
- Joshu, Corinne E.;
- Shenderov, Eugene;
- Lotan, Tamara L.
Publication type:
Article
Determining the origin of synchronous multifocal bladder cancer by exome sequencing.
Published in:
2015
By:
- Acar, Ömer;
- Özkurt, Ezgi;
- Demir, Gulfem;
- Saraç, Hilal;
- Alkan, Can;
- Esen, Tarık;
- Somel, Mehmet;
- Lack, Nathan A.
Publication type:
journal article
Impact of the ST101 clone on fatality among patients with colistin-resistant Klebsiella pneumoniae infection.
Published in:
2018
By:
- Can, Fusun;
- Menekse, Sirin;
- Ispir, Pelin;
- Atac, Nazlı;
- Albayrak, Ozgur;
- Demir, Tuana;
- Karaaslan, Doruk Can;
- Karahan, Salih Nafiz;
- Kapmaz, Mahir;
- Azap, Ozlem Kurt;
- Timurkaynak, Funda;
- Yavuz, Serap Simsek;
- Basaran, Seniha;
- Yoruk, Fugen;
- Azap, Alpay;
- Koculu, Safiye;
- Benzonana, Nur;
- Lack, Nathan A.;
- Gönen, Mehmet;
- Ergonul, Onder
Publication type:
journal article
DeepCOP: deep learning-based approach to predict gene regulating effects of small molecules.
Published in:
Bioinformatics, 2020, v. 36, n. 3, p. 813, doi. 10.1093/bioinformatics/btz645
By:
- Woo, Godwin;
- Fernandez, Michael;
- Hsing, Michael;
- Lack, Nathan A;
- Cavga, Ayse Derya;
- Cherkasov, Artem
Publication type:
Article
Androgen receptor-binding sites are highly mutated in prostate cancer.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14644-y
By:
- Morova, Tunç;
- McNeill, Daniel R.;
- Lallous, Nada;
- Gönen, Mehmet;
- Dalal, Kush;
- Wilson III, David M.;
- Gürsoy, Attila;
- Keskin, Özlem;
- Lack, Nathan A.
Publication type:
Article
Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.
Published in:
2013
By:
- Bowdish, Dawn M. E.;
- Sakamoto, Kaori;
- Lack, Nathan A.;
- Hill, Philip C.;
- Sirugo, Giorgio;
- Newport, Melanie J.;
- Gordon, Siamon;
- Hill, Adrian V. S.;
- Vannberg, Fredrick O.
Publication type:
Case Study
New Therapeutics to Treat Castrate-Resistant Prostate Cancer.
Published in:
Scientific World Journal, 2013, p. 1, doi. 10.1155/2013/379641
By:
- Acar, Ömer;
- Esen, Tarık;
- Lack, Nathan A.
Publication type:
Article

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