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Tumor budding assessed according to the criteria of the International Tumor Budding Consensus Conference determines prognosis in resected esophageal adenocarcinoma.
Published in:
Virchows Archiv: European Journal of Pathology, 2021, v. 478, n. 3, p. 393, doi. 10.1007/s00428-020-02897-3
By:
- Lohneis, Philipp;
- Hieggelke, Lena;
- Gebauer, Florian;
- Ball, Markus;
- Bruns, Christiane;
- Büttner, Reinhard;
- Löser, Heike;
- Quaas, Alexander
Publication type:
Article
GATA binding protein 6 (GATA6) is co-amplified with PIK3CA in patients with esophageal adenocarcinoma and is linked to neoadjuvant therapy.
Published in:
Journal of Cancer Research & Clinical Oncology, 2021, v. 147, n. 4, p. 1031, doi. 10.1007/s00432-020-03486-2
By:
- Plum, Patrick Sven;
- Löser, Heike;
- Zander, Thomas;
- Essakly, Ahlem;
- Bruns, Christiane J.;
- Hillmer, Axel M.;
- Alakus, Hakan;
- Schröder, Wolfgang;
- Büttner, Reinhard;
- Gebauer, Florian;
- Quaas, Alexander
Publication type:
Article
Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma.
Published in:
Journal of Cancer Research & Clinical Oncology, 2020, v. 146, n. 9, p. 2319, doi. 10.1007/s00432-020-03295-7
By:
- Gebauer, Florian;
- Krämer, Max;
- Bruns, Christiane;
- Schlößer, Hans A.;
- Thelen, Martin;
- Lohneis, Philipp;
- Schröder, Wolfgang;
- Zander, Thomas;
- Alakus, Hakan;
- Buettner, Reinhard;
- Loeser, Heike;
- Quaas, Alexander
Publication type:
Article
Upregulation of insulin-like growth factor II mRNA-binding protein 3 (IMP3) has negative prognostic impact on early invasive (pT1) adenocarcinoma of the esophagus.
Published in:
Journal of Cancer Research & Clinical Oncology, 2018, v. 144, n. 9, p. 1731, doi. 10.1007/s00432-018-2698-1
By:
- Plum, Patrick Sven;
- Ulase, Dita;
- Bollschweiler, Elfriede;
- Chon, Seung-Hun;
- Berlth, Felix;
- Zander, Thomas;
- Alakus, Hakan;
- Hölscher, Arnulf H.;
- Bruns, Christiane J.;
- Schallenberg, Simon;
- Quaas, Alexander;
- Loeser, Heike
Publication type:
Article
Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma.
Published in:
2020
By:
- Loeser, Heike;
- Kraemer, Max;
- Gebauer, Florian;
- Bruns, Christiane;
- Schröder, Wolfgang;
- Zander, Thomas;
- Alakus, Hakan;
- Hoelscher, Arnulf;
- Buettner, Reinhard;
- Lohneis, Philipp;
- Quaas, Alexander
Publication type:
journal article
Integrin beta1 (ITGB1) as a prognostic marker in esophageal adenocarcinoma.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-25071-y
By:
- Damanakis, Alexander I.;
- Wahler, Isabell;
- Fuchs, Hans;
- Löser, Heike;
- Schröder, Wolfgang;
- Zander, Thomas;
- Chon, Seung-Hun;
- Bruns, Christiane;
- Quaas, Alexander;
- Gebauer, Florian
Publication type:
Article
Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma.
Published in:
Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1249172
By:
- Maria Raters, Verena;
- Gebauer, Florian;
- Löser, Heike;
- Schröder, Wolfgang;
- Schlösser, Hans Anton;
- Fuchs, Hans;
- Bruns, Christiane;
- Quaas, Alexander;
- Zander, Thomas
Publication type:
Article
Long-Term Outcome After Histopathological Complete Response with and Without Nodal Metastases Following Multimodal Treatment of Esophageal Cancer.
Published in:
Annals of Surgical Oncology: An Oncology Journal for Surgeons, 2022, v. 29, n. 7, p. 4419, doi. 10.1245/s10434-022-11700-3
By:
- Schroeder, Wolfgang;
- Ghadimi, Markus P. H.;
- Schloesser, Hans;
- Loeser, Heike;
- Schiller, Petra;
- Zander, Thomas;
- Gebauer, Florian;
- Fuchs, Hans;
- Quaas, Alexander;
- Bruns, Christiane J.
Publication type:
Article
Concurrent KRAS p.G12C mutation and ANK3::RET fusion in a patient with metastatic colorectal cancer: a case report.
Published in:
Diagnostic Pathology, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13000-024-01478-1
By:
- Bedau, Tillmann;
- Heydt, Carina;
- Siebolts, Udo;
- Zander, Thomas;
- Kraemer, Max;
- Loeser, Heike;
- Buettner, Reinhard;
- Quaas, Alexander
Publication type:
Article
Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas.
Published in:
2020
By:
- Rehkaemper, Jan;
- Korenkov, Michael;
- Quaas, Alexander;
- Rueschoff, Josef;
- Pamuk, Aylin;
- Zander, Thomas;
- Hillmer, Axel M.;
- Buettner, Reinhard;
- Hoelscher, Arnulf Heinrich;
- Bruns, Christiane Josephine;
- Loeser, Heike;
- Alakus, Hakan;
- Schoemig-Markiefka, Birgid
Publication type:
journal article
Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.
Published in:
2020
By:
- Schallenberg, Simon;
- Bork, Julian;
- Essakly, Ahlem;
- Alakus, Hakan;
- Buettner, Reinhard;
- Hillmer, Axel M.;
- Bruns, Christiane;
- Schroeder, Wolfgang;
- Zander, Thomas;
- Loeser, Heike;
- Gebauer, Florian;
- Quaas, Alexander
Publication type:
journal article
Mesothelin expression in esophageal adenocarcinoma and squamous cell carcinoma and its possible impact on future treatment strategies.
Published in:
Therapeutic Advances in Medical Oncology, 2020, v. 12, p. 1, doi. 10.1177/1758835920917571
By:
- Moentenich, Valeska;
- Comut, Erdem;
- Gebauer, Florian;
- Tuchscherer, Armin;
- Bruns, Christiane;
- Schroeder, Wolfgang;
- Buettner, Reinhard;
- Alakus, Hakan;
- Loeser, Heike;
- Zander, Thomas;
- Quaas, Alexander
Publication type:
Article
Immune profile and immunosurveillance in treatment-naive and neoadjuvantly treated esophageal adenocarcinoma.
Published in:
Cancer Immunology, Immunotherapy, 2020, v. 69, n. 4, p. 523, doi. 10.1007/s00262-019-02475-w
By:
- Wagener-Ryczek, Svenja;
- Schoemmel, Max;
- Kraemer, Max;
- Bruns, Christiane;
- Schroeder, Wolfgang;
- Zander, Thomas;
- Gebauer, Florian;
- Alakus, Hakan;
- Merkelbach-Bruse, Sabine;
- Buettner, Reinhard;
- Loeser, Heike;
- Thelen, Martin;
- Schlößer, Hans A.;
- Quaas, Alexander
Publication type:
Article
Expression of Immune Checkpoint Regulators IDO, VISTA, LAG3, and TIM3 in Resected Pancreatic Ductal Adenocarcinoma.
Published in:
Cancers, 2021, v. 13, n. 11, p. 2689, doi. 10.3390/cancers13112689
By:
- Popp, Felix C.;
- Capino, Ingracia;
- Bartels, Joana;
- Damanakis, Alexander I.;
- Li, Jiahui;
- Datta, Rabi R.;
- Löser, Heike;
- Zhao, Yue;
- Quaas, Alexander;
- Lohneis, Philipp;
- Bruns, Christiane J.
Publication type:
Article
Y Chromosome Loss Is a Frequent Event in Barrett's Adenocarcinoma and Associated with Poor Outcome.
Published in:
Cancers, 2020, v. 12, n. 7, p. 1743, doi. 10.3390/cancers12071743
By:
- Loeser, Heike;
- Wölwer, Christina B.;
- Alakus, Hakan;
- Chon, Seung-Hun;
- Zander, Thomas;
- Buettner, Reinhard;
- Hillmer, Axel M.;
- Bruns, Christiane J.;
- Schroeder, Wolfgang;
- Gebauer, Florian;
- Quaas, Alexander
Publication type:
Article
Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma.
Published in:
Cancers, 2020, v. 12, n. 2, p. 451, doi. 10.3390/cancers12020451
By:
- Schiffmann, Lars M.;
- Loeser, Heike;
- Jacob, Anne Sophie;
- Maus, Martin;
- Fuchs, Hans;
- Zhao, Yue;
- Tharun, Lars;
- Essakly, Ahlem;
- Iannos Damanakis, Alexander;
- Zander, Thomas;
- Büttner, Reinhard;
- Schröder, Wolfgang;
- Bruns, Christiane;
- Quaas, Alexander;
- Gebauer, Florian
Publication type:
Article
Cell type‐specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics.
Published in:
Molecular Oncology, 2020, v. 14, n. 6, p. 1170, doi. 10.1002/1878-0261.12680
By:
- Krämer, Max;
- Plum, Patrick S.;
- Velazquez Camacho, Oscar;
- Folz‐Donahue, Kat;
- Thelen, Martin;
- Garcia‐Marquez, Isabel;
- Wölwer, Christina;
- Büsker, Sören;
- Wittig, Jana;
- Franitza, Marek;
- Altmüller, Janine;
- Löser, Heike;
- Schlößer, Hans;
- Büttner, Reinhard;
- Schröder, Wolfgang;
- Bruns, Christiane J.;
- Alakus, Hakan;
- Quaas, Alexander;
- Chon, Seung‐Hun;
- Hillmer, Axel M.
Publication type:
Article
Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center.
Published in:
Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.569475
By:
- Quaas, Alexander;
- Rehkaemper, Jan;
- Rueschoff, Josef;
- Pamuk, Aylin;
- Zander, Thomas;
- Hillmer, Axel;
- Siemanowski, Janna;
- Wittig, Jana;
- Buettner, Reinhard;
- Plum, Patrick;
- Popp, Felix;
- Gebauer, Florian;
- Bruns, Christiane Josephine;
- Loeser, Heike;
- Alakus, Hakan;
- Schoemig-Markiefka, Birgid
Publication type:
Article
Somatic BRCA1-associated protein 1 (BAP1) loss is an early and rare event in esophageal adenocarcinoma.
Published in:
Molecular & Clinical Oncology, 2017, v. 7, n. 2, p. 225, doi. 10.3892/mco.2017.1286
By:
- LOESER, HEIKE;
- WALDSCHMIDT, DIRK;
- KUETTING, FABIAN;
- SCHALLENBERG, SIMON;
- ZANDER, THOMAS;
- BOLLSCHWEILER, ELFRIEDE;
- HOELSCHER, ARNULF;
- WECKERMANN, KATHARINA;
- PLUM, PATRICK;
- ALAKUS, HAKAN;
- BUETTNER, REINHARD;
- QUAAS, ALEXANDER
Publication type:
Article
Copy-number variation and protein expression of DOT1L in pancreatic adenocarcinoma as a potential drug target.
Published in:
Molecular & Clinical Oncology, 2017, v. 6, n. 5, p. 639, doi. 10.3892/mco.2017.1194
By:
- LOESER, HEIKE;
- WALDSCHMIDT, DIRK;
- KUETTING, FABIAN;
- HEYDT, CARINA;
- ZANDER, THOMAS;
- PLUM, PATRICK;
- ALAKUS, HAKAN;
- BUETTNER, REINHARD;
- QUAAS, ALEXANDER
Publication type:
Article
Vimentin 3, the New Hope, Differentiating RCC versus Oncocytoma.
Published in:
Disease Markers, 2015, p. 1, doi. 10.1155/2015/368534
By:
- von Brandenstein, Melanie;
- Puetz, Katharina;
- Schlosser, Monika;
- Löser, Heike;
- Kallinowski, Joachim P.;
- Gödde, Daniel;
- Buettner, Reinhard;
- Störkel, Stefan;
- Fries, Jochen W. U.
Publication type:
Article
Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma.
Published in:
2019
By:
- Schiffmann, Lars M.;
- Göbel, Heike;
- Löser, Heike;
- Schorn, Fabian;
- Werthenbach, Jan Paul;
- Fuchs, Hans F.;
- Plum, Patrick S.;
- Bludau, Marc;
- Zander, Thomas;
- Schröder, Wolfgang;
- Bruns, Christiane J.;
- Kashkar, Hamid;
- Quaas, Alexander;
- Gebauer, Florian
Publication type:
journal article
HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma.
Published in:
2019
By:
- Plum, Patrick Sven;
- Gebauer, Florian;
- Krämer, Max;
- Alakus, Hakan;
- Berlth, Felix;
- Chon, Seung-Hun;
- Schiffmann, Lars;
- Zander, Thomas;
- Büttner, Reinhard;
- Hölscher, Arnulf Heinrich;
- Bruns, Christiane Josephine;
- Quaas, Alexander;
- Loeser, Heike
Publication type:
journal article
First reported case of a collision tumor composed of pancreatic adenocarcinoma and retroperitoneal liposarcoma: a case report.
Published in:
2018
By:
- Buchner, Denise;
- Hieggelke, Lena;
- Löser, Heike;
- Bruns, Christiane Josephine;
- Quaas, Alexander;
- Ghadimi, Markus Philipp Hussein
Publication type:
journal article
PS02.197: UPREGULATION OF IMP3 HAS A NEGATIVE PROGNOSTIC IMPACT IN EARLY INVASIVE ESOPHAGEAL ADENOCARCINOMA.
Published in:
Diseases of the Esophagus, 2018, v. 31, n. 13, p. 178, doi. 10.1093/dote/doy089.PS02.197
By:
- Plum, Patrick;
- Ulase, Dita;
- Chon, Seung-Hun;
- Berlth, Felix;
- Zander, Thomas;
- Alakus, Hakan;
- Bollschweiler, Elfriede;
- Hölscher, Arnulf;
- Bruns, Christiane;
- Quaas, Alexander;
- Löser, Heike
Publication type:
Article
PS02.092: HER2 EXPRESSION AND GENE AMPLIFICATION CORRELATES WITH BETTER SURVIVAL IN ESOPHAGEAL ADENOCARCINOMA.
Published in:
Diseases of the Esophagus, 2018, v. 31, n. 13, p. 146, doi. 10.1093/dote/doy089.PS02.092
By:
- Loeser, Heike;
- Plum, Patrick;
- Zander, Thomas;
- Kraemer, Max;
- Alakus, Hakan;
- Buettner, Reinhard;
- Bruns, Christiane;
- Gebauer, Florian;
- Quaas, Alexander
Publication type:
Article
PS02.058: EXTENSIVE ANALYSIS OF IMMUNECHECKPOINT RECEPTORS AND TUMOR INFILTRATING T-CELLS WITH RESPECT TO THEIR PROGNOSTIC RELEVANCE IN ESOPHAGEAL ADENOCARCINOMA.
Published in:
Diseases of the Esophagus, 2018, v. 31, n. 13, p. 137, doi. 10.1093/dote/doy089.PS02.058
By:
- Gebauer, Florian;
- Loeser, Heike;
- Fuchs, Hans;
- Leers, Jessica;
- Schroeder, Wolfgang;
- Quaas, Alexander;
- Bruns, Christiane
Publication type:
Article
Integrin alpha V (ITGAV) expression in esophageal adenocarcinoma is associated with shortened overall-survival.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-75085-7
By:
- Loeser, Heike;
- Scholz, Matthias;
- Fuchs, Hans;
- Essakly, Ahlem;
- Damanakis, Alexander Iannos;
- Zander, Thomas;
- Büttner, Reinhard;
- Schröder, Wolfgang;
- Bruns, Christiane;
- Quaas, Alexander;
- Gebauer, Florian
Publication type:
Article
Varioliform gastritis: an unusual endoscopic finding.
Published in:
2018
By:
- Kasper, Philipp;
- Loeser, Heike;
- Goeser, Tobias
Publication type:
Case Study
Predicting the HER2 status in oesophageal cancer from tissue microarrays using convolutional neural networks.
Published in:
British Journal of Cancer, 2023, v. 128, n. 7, p. 1369, doi. 10.1038/s41416-023-02143-y
By:
- Pisula, Juan I.;
- Datta, Rabi R.;
- Valdez, Leandra Börner;
- Avemarg, Jan-Robert;
- Jung, Jin-On;
- Plum, Patrick;
- Löser, Heike;
- Lohneis, Philipp;
- Meuschke, Monique;
- dos Santos, Daniel Pinto;
- Gebauer, Florian;
- Quaas, Alexander;
- Walch, Axel;
- Bruns, Christiane J.;
- Lawonn, Kai;
- Popp, Felix C.;
- Bozek, Katarzyna
Publication type:
Article
Optimized PD-L1 scoring of gastric cancer.
Published in:
Gastric Cancer, 2021, v. 24, n. 5, p. 1115, doi. 10.1007/s10120-021-01195-4
By:
- Schoemig-Markiefka, Birgid;
- Eschbach, Jana;
- Scheel, Andreas H.;
- Pamuk, Aylin;
- Rueschoff, Josef;
- Zander, Thomas;
- Buettner, Reinhard;
- Schroeder, Wolfgang;
- Bruns, Christiane J.;
- Loeser, Heike;
- Alakus, Hakan;
- Quaas, Alexander
Publication type:
Article
Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma.
Published in:
Gastric Cancer, 2021, v. 24, n. 6, p. 1213, doi. 10.1007/s10120-021-01197-2
By:
- Quaas, Alexander;
- Pamuk, Aylin;
- Klein, Sebastian;
- Quantius, Jennifer;
- Rehkaemper, Jan;
- Barutcu, Atakan G.;
- Rueschoff, Josef;
- Zander, Thomas;
- Gebauer, Florian;
- Hillmer, Axel;
- Buettner, Reinhard;
- Schroeder, Wolfgang;
- Bruns, Christiane J.;
- Löser, Heike;
- Schoemig-Markiefka, Birgid;
- Alakus, Hakan
Publication type:
Article
ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
Published in:
American Journal of Nephrology, 2015, v. 41, n. 3, p. 191, doi. 10.1159/000381272
By:
- Loeser, Heike;
- von Brandenstein, Melanie;
- Herschung, angela;
- Schlosser, Monika;
- Büttner, Reinhard;
- Fries, Jochen W.U.
Publication type:
Article
ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity?
Published in:
2015
By:
- Loeser, Heike;
- von Brandenstein, Melanie;
- Herschung, Angela;
- Schlosser, Monika;
- Büttner, Reinhard;
- Fries, Jochen W U
Publication type:
journal article
Junger Patient mit ungewöhnlicher Raumforderung am Unterlid.
Published in:
Der Ophthalmologe, 2020, v. 117, n. 1, p. 73, doi. 10.1007/s00347-019-00948-y
By:
- Rokohl, Alexander C.;
- Löser, Heike;
- Mor, Joel M.;
- Loreck, Niklas;
- Koch, Konrad R.;
- Heindl, Ludwig M.
Publication type:
Article
Claudin 18.2 expression in esophageal adenocarcinoma and its potential impact on future treatment strategies.
Published in:
Oncology Letters, 2020, v. 19, n. 6, p. 3665, doi. 10.3892/ol.2020.11520
By:
- MOENTENICH, VALESKA;
- GEBAUER, FLORIAN;
- COMUT, ERDEM;
- TUCHSCHERER, ARMIN;
- BRUNS, CHRISTIANE;
- SCHROEDER, WOLFGANG;
- BUETTNER, REINHARD;
- ALAKUS, HAKAN;
- LOESER, HEIKE;
- ZANDER, THOMAS;
- QUAAS, ALEXANDER
Publication type:
Article

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