Works by LENZEN, Sigurd

Results: 68

Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes.

Published in:

2020

By:

Jörns, Anne;
Wedekind, Dirk;
Jähne, Joachim;
Lenzen, Sigurd;
Jörns A J, Anne;
Wedekind D W, Dirk;
Jähne J J, Joachim;
Lenzen S L, Sigurd

Publication type:

journal article

Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues.

Published in:

Journal of Diabetes Research, 2017, p. 1, doi. 10.1155/2017/2309630

By:

Teraoku, Hiroki;
Lenzen, Sigurd

Publication type:

Article

Mechanisms of lipotoxicity‐induced dysfunction and death of human pancreatic beta cells under obesity and type 2 diabetes conditions.

Published in:

Obesity Reviews, 2024, v. 25, n. 5, p. 1, doi. 10.1111/obr.13703

By:

Plötz, Thomas;
Lenzen, Sigurd

Publication type:

Article

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

Published in:

BMC Biology, 2017, v. 15, p. 1, doi. 10.1186/s12915-017-0367-5

By:

Melo, Eduardo Pinho;
Lopes, Carlos;
Gollwitzer, Peter;
Lortz, Stephan;
Lenzen, Sigurd;
Mehmeti, Ilir;
Kaminski, Clemens F.;
Ron, David;
Avezov, Edward

Publication type:

Article

The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells.

Published in:

Archives of Toxicology, 2022, v. 96, n. 7, p. 1915, doi. 10.1007/s00204-022-03282-6

By:

Lenzen, Sigurd;
Lushchak, Volodymyr I.;
Scholz, Fritz

Publication type:

Article

Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.

Published in:

BMC Research Notes, 2014, v. 7, n. 1, p. 1, doi. 10.1186/1756-0500-7-273

By:

Naujok, Ortwin;
Lentes, Jana;
Diekmann, Ulf;
Davenport, Claudia;
Lenzen, Sigurd

Publication type:

Article

Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species.

Published in:

Bioscience Reports, 2016, v. 36, n. 2, p. 1, doi. 10.1042/BSR20150193

By:

Rebiger, Lars;
Lenzen, Sigurd;
Mehmeti, Ilir

Publication type:

Article

An editorial on the article ‘Patents in the Diabetes Area in the Years 2008-2016’.

Published in:

2018

By:

Lenzen, Sigurd

Publication type:

Editorial

Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells.

Published in:

Lipids, 1994, v. 29, n. 10, p. 685, doi. 10.1007/BF02538912

By:

Rustenbeck, Ingo;
Matthies, Alexander;
Lenzen, Sigurd

Publication type:

Article

Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1 -iddm Rat, an Animal Model of Human Type 1 Diabetes.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1541, doi. 10.3390/ijms23031541

By:

Baskal, Svetlana;
Tsikas, Stefanos A.;
Begou, Olga;
Bollenbach, Alexander;
Lenzen, Sigurd;
Jörns, Anne;
Tsikas, Dimitrios

Publication type:

Article

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells.

Published in:

Biochemical Journal, 2012, v. 446, n. 1, p. 349, doi. 10.1042/BJ20111920

By:

HANZELKA, Katarzyna;
SKALNIAK, Lukasz;
JURA, Jolanta;
LENZEN, Sigurd;
GURGUL-CONVEY, Ewa

Publication type:

Article

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells.

Published in:

Biochemical Journal, 2012, v. 445, n. 3, p. 349, doi. 10.1042/BJ20111920

By:

HANZELKA, Katarzyna;
SKALNIAK, Lukasz;
JURA, Jolanta;
LENZEN, Sigurd;
GURGUL-CONVEY, Ewa

Publication type:

Article

Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study.

Published in:

Pediatric Diabetes, 2018, v. 19, n. 5, p. 963, doi. 10.1111/pedi.12671

By:

Fitas, Ana Laura;
Martins, Catarina;
Borrego, Luís Miguel;
Lopes, Lurdes;
Jörns, Anne;
Lenzen, Sigurd;
Limbert, Catarina

Publication type:

Article

Toxicity of fatty acid profiles of popular edible oils in human EndoC-βH1 beta-cells.

Published in:

Nutrition & Diabetes, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41387-020-0108-7

By:

von Hanstein, Anna-Sophie;
Lenzen, Sigurd;
Plötz, Thomas

Publication type:

Article

Dimer interface rearrangement of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase rat liver isoenzyme by cAMP-dependent Ser-32 phosphorylation

Published in:

FEBS Letters, 2012, v. 586, n. 10, p. 1419, doi. 10.1016/j.febslet.2012.03.066

By:

Langer, Sara;
Okar, David A.;
Schultz, Julia;
Lenzen, Sigurd;
Baltrusch, Simone

Publication type:

Article

Comment on Binhai Ren et al. (2013; 15: 28-41): long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.

Published in:

Journal of Gene Medicine, 2013, v. 15, n. 8/9, p. 306, doi. 10.1002/jgm.2725

By:

Elsner, Matthias;
Naujok, Ortwin;
Jörns, Anne;
Lenzen, Sigurd

Publication type:

Article

Comment on the role of interferons in the pathology of beta cell destruction in type 1 diabetes.

Published in:

2024

By:

Lenzen, Sigurd

Publication type:

Letter

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines.

Published in:

Diabetologia, 2016, v. 59, n. 10, p. 2125, doi. 10.1007/s00125-016-4060-y

By:

Gurgul-Convey, Ewa;
Mehmeti, Ilir;
Plötz, Thomas;
Jörns, Anne;
Lenzen, Sigurd

Publication type:

Article

A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm- iddm rat, an animal model of human type 1 diabetes.

Published in:

Diabetologia, 2015, v. 58, n. 12, p. 2800, doi. 10.1007/s00125-015-3757-7

By:

Arndt, Tanja;
Wedekind, Dirk;
Jörns, Anne;
Tsiavaliaris, Georgios;
Cuppen, Edwin;
Hedrich, Hans-Jürgen;
Lenzen, Sigurd

Publication type:

Article

Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy.

Published in:

Amino Acids, 2020, v. 52, n. 1, p. 103, doi. 10.1007/s00726-019-02811-5

By:

Bollenbach, Alexander;
Tsikas, Dimitrios;
Lenzen, Sigurd;
Jörns, Anne

Publication type:

Article

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings.

Published in:

Amino Acids, 2018, v. 50, n. 7, p. 799, doi. 10.1007/s00726-018-2573-z

By:

Tsikas, Dimitrios;
Hanff, Erik;
Bollenbach, Alexander;
Kruger, Ruan;
Pham, Vu Vi;
Chobanyan-Jürgens, Kristine;
Wedekind, Dirk;
Arndt, Tanja;
Jörns, Anne;
Berbée, Jimmy F. P.;
Princen, Hans M. G.;
Lücke, Thomas;
Mariotti, François;
Huneau, Jean-François;
Ückert, Stefan;
Frölich, Jürgen C.;
Lenzen, Sigurd

Publication type:

Article

Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral Transduction.

Published in:

Molecular Therapy, 2012, v. 20, n. 5, p. 918, doi. 10.1038/mt.2012.8

By:

Elsner, Matthias;
Terbish, Taivankhuu;
Jörns, Anne;
Naujok, Ortwin;
Wedekind, Dirk;
Hedrich, Hans-Jürgen;
Lenzen, Sigurd

Publication type:

Article

Insulin-producing Surrogate β-cells From Embryonic Stem Cells: Are We There Yet?

Published in:

Molecular Therapy, 2011, v. 19, n. 10, p. 1759, doi. 10.1038/mt.2011.165

By:

Naujok, Ortwin;
Burns, Chris;
Jones, Peter M;
Lenzen, Sigurd

Publication type:

Article

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Published in:

Journal of Cell Biology, 2015, v. 211, n. 2, p. 253, doi. 10.1083/jcb.201506123

By:

Tasuku Konno;
Pinho Melo, Eduardo;
Lopes, Carlos;
Mehmeti, Ilir;
Lenzen, Sigurd;
Ron, David;
Avezov, Edward

Publication type:

Article

Monoamine Oxidase in Rat and Bovine Endocrine.

Published in:

Journal of Neurochemistry, 1987, v. 49, n. 4, p. 1183, doi. 10.1111/j.1471-4159.1987.tb10009.x

By:

Lenzen, Tissues Sigurd;
Freisinger-Treichel, Marion;
Panten, Uwe

Publication type:

Article

Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes.

Published in:

2020

By:

Jörns, Anne;
Ishikawa, Daichi;
Teraoku, Hiroki;
Yoshimoto, Toshiaki;
Wedekind, Dirk;
Lenzen, Sigurd

Publication type:

journal article

Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches.

Published in:

Journal of Molecular Medicine, 2024, v. 102, n. 12, p. 1451, doi. 10.1007/s00109-024-02494-w

By:

Lenzen, Sigurd;
Jörns, Anne

Publication type:

Article

Correction to: Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat.

Published in:

2021

By:

Jörns, Anne;
Arndt, Tanja;
Yamada, Shinichiro;
Ishikawa, Daichi;
Yoshimoto, Toshiaki;
Terbish, Taivankhuu;
Wedekind, Dirk;
van der Meide, Peter H.;
Lenzen, Sigurd

Publication type:

Correction Notice

Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat.

Published in:

Journal of Molecular Medicine, 2020, v. 98, n. 8, p. 1125, doi. 10.1007/s00109-020-01941-8

By:

Jörns, Anne;
Arndt, Tanja;
Yamada, Shinichiro;
Ishikawa, Daichi;
Yoshimoto, Toshiaki;
Terbish, Taivankhuu;
Wedekind, Dirk;
van der Meide, Peter H.;
Lenzen, Sigurd

Publication type:

Article

Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1- iddm rat model of type 1 diabetes.

Published in:

Journal of Molecular Medicine, 2014, v. 92, n. 7, p. 743, doi. 10.1007/s00109-014-1137-2

By:

Jörns, Anne;
Akin, Muharrem;
Arndt, Tanja;
Terbish, Taivankhuu;
Vilsendorf, Andreas;
Wedekind, Dirk;
Hedrich, Hans-Jürgen;
Lenzen, Sigurd

Publication type:

Article

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria.

Published in:

Journal of Molecular Medicine, 2011, v. 89, n. 8, p. 785, doi. 10.1007/s00109-011-0747-1

By:

Gurgul-Convey, Ewa;
Mehmeti, Ilir;
Lortz, Stephan;
Lenzen, Sigurd

Publication type:

Article

Potentiation of Lipotoxicity in Human EndoC‐βH1 β‐Cells by Glucose is Dependent on the Structure of Free Fatty Acids.

Published in:

Molecular Nutrition & Food Research, 2023, v. 67, n. 5, p. 1, doi. 10.1002/mnfr.202200582

By:

von Hanstein, Anna‐Sophie;
Tsikas, Dimitrios;
Lenzen, Sigurd;
Jörns, Anne;
Plötz, Thomas

Publication type:

Article

TNF-α Antibody Therapy in Combination With the T-Cell-Specific Antibody Anti-TCR Reverses the Diabetic Metabolic State in the LEW.1AR1-iddm Rat.

Published in:

Diabetes, 2015, v. 64, n. 8, p. 2880, doi. 10.2337/db14-1866

By:

Jörns, Anne;
Ertekin, Ümüs Gül;
Arndt, Tanja;
Terbish, Taivankhuu;
Wedekind, Dirk;
Lenzen, Sigurd

Publication type:

Article

Antidiabetic Effect of Interleukin-1[beta] Antibody Therapy Through [beta]-Cell Protection in the Cohen Diabetes-Sensitive Rat.

Published in:

2015

By:

Aharon-Hananel, Genya;
Jörns, Anne;
Lenzen, Sigurd;
Raz, Itamar;
Weksler-Zangen, Sarah

Publication type:

Journal Article

Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat.

Published in:

Diabetes, 2015, v. 64, n. 5, p. 1780, doi. 10.2337/db14-1018

By:

Aharon-Hananel, Genya;
Jörns, Anne;
Lenzen, Sigurd;
Raz, Itamar;
Weksler-Zangen, Sarah

Publication type:

Article

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells.

Published in:

Diabetes, 2011, v. 60, n. 1, p. 200, doi. 10.2337/db09-1401

By:

Elsner, Matthias;
Gehrmann, Wiebke;
Lenzen, Sigurd

Publication type:

Article

Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat.

Published in:

Diabetes, 2008, v. 57, n. 2, p. 279, doi. 10.2337/db07-0520

By:

Weksler-Zangen, Sarah;
Raz, Itamar;
Lenzen, Sigurd;
Jörns, Anne;
Ehrenfeld, Shira;
Amir, Gail;
Oprescu, Andrei;
Yagil, Yoram;
Yagil, Chana;
Zangen, David H.;
Kaiser, Nurit

Publication type:

Article

Novel Insights Into the Regulation of the Bound and Diffusible Glucokinase in MIN6 β-Cells.

Published in:

Diabetes, 2007, v. 56, n. 5, p. 1305, doi. 10.2337/db06-0894

By:

Baltrusch, Simone;
Lenzen, Sigurd

Publication type:

Article

Mechanisms of Pancreatic Β-cell Death in Type 1 and Type 2 Diabetes.

Published in:

Diabetes, 2005, v. 54, p. S97, doi. 10.2337/diabetes.54.suppl_2.S97

By:

Cnop, Miriam;
Welsh, Nils;
Jonas, Jean-Christophe;
Jörns, Anne;
Lenzen, Sigurd;
Eizirik, Decio L.

Publication type:

Article

Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme.

Published in:

2005

By:

Baltrusch, Simone;
Francini, Flavio;
Lenzen, Sigurd;
Tiedge, Markus

Publication type:

journal article

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

Published in:

2005

By:

Jörns A;
Günther A;
Hedrich H;
Wedekind D;
Tiedge M;
Lenzen S;
Jörns, Anne;
Günther, Armin;
Hedrich, Hans-Jürgen;
Wedekind, Dirk;
Tiedge, Markus;
Lenzen, Sigurd

Publication type:

journal article

Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat.

Published in:

Diabetes, 2005, v. 54, n. 7, p. 2041, doi. 10.2337/diabetes.54.7.2041

By:

Jörns, Anne;
Günther, Armin;
Hedrich, Hans-Jürgen;
Wedekind, Dirk;
Tiedge, Markus;
Lenzen, Sigurd

Publication type:

Article

Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

Published in:

2004

By:

Gurgul, Ewa;
Lortz, Stephan;
Tiedge, Markus;
Jörns, Anne;
Lenzen, Sigurd;
Jörns, Anne

Publication type:

journal article

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.

Published in:

2004

By:

Massa, Laura;
Baltrusch, Simone;
Okar, David A.;
Lange, Alex J.;
Lenzen, Sigurd;
Tiedge, Markus

Publication type:

journal article

Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

Published in:

2003

By:

Azevedo-Martins, Anna Karenina;
Lortz, Stephan;
Lenzen, Sigurd;
Curi, Rui;
Eizirik, Decio L.;
Tiedge, Markus

Publication type:

journal article

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

Published in:

2000

By:

Lortz, Stephan;
Tiedge, Markus;
Nachtwey, Thomas;
Karlsen, Allan E.;
Nerup, Jorn;
Lenzen, Sigurd;
Lortz, S;
Tiedge, M;
Nachtwey, T;
Karlsen, A E;
Nerup, J;
Lenzen, S

Publication type:

journal article

Metabolic regulation, activity state, and intracellular binding of glucokinase in insulin-secreting cells.

Published in:

1999

By:

Tiedge, Markus;
Steffeck, Heike;
Elsner, Matthias;
Lenzen, Sigurd;
Tiedge, M;
Steffeck, H;
Elsner, M;
Lenzen, S

Publication type:

journal article

Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.

Published in:

1998

By:

Tiedge, Markus;
Lortz, Stephan;
Munday, Rex;
Lenzen, Sigurd;
Tiedge, M;
Lortz, S;
Munday, R;
Lenzen, S

Publication type:

journal article

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.

Published in:

1997

By:

Tiedge, Markus;
Lortz, Stephan;
Drinkgern, Jens;
Lenzen, Sigurd;
Tiedge, M;
Lortz, S;
Drinkgern, J;
Lenzen, S

Publication type:

journal article

Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes.

Published in:

2017

By:

Lenzen, Sigurd

Publication type:

journal article