Works by Lütjohann, Dieter

Results: 130

The Interpretation of Cholesterol Balance Derived Synthesis Data and Surrogate Noncholesterol Plasma Markers for Cholesterol Synthesis under Lipid Lowering Therapies.

Published in:

2017

By:

Stellaard, Frans;
Lütjohann, Dieter;
Lütjohann, Dieter

Publication type:

journal article

Influence of the SLCO1B11b and 5 haplotypes on pravastatin’s cholesterol lowering capabilities and basal sterol serum levels.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006, v. 373, n. 1, p. 45, doi. 10.1007/s00210-006-0053-6

By:

Gerloff, Thomas;
Schaefer, Melanie;
Mwinyi, Jessica;
Johne, Andreas;
Sudhop, Thomas;
Lütjohann, Dieter;
Roots, Ivar;
von Bergmann, Klaus

Publication type:

Article

Cerebral Accumulation of Dietary Derivable Plant Sterols does not Interfere with Memory and Anxiety Related Behavior in Abcg5−/− Mice.

Published in:

Plant Foods for Human Nutrition, 2011, v. 66, n. 2, p. 149, doi. 10.1007/s11130-011-0219-3

By:

Vanmierlo, Tim;
Rutten, Kris;
Zee, Leonie;
Friedrichs, Silvia;
Bloks, Vincent;
Blokland, Arjan;
Ramaekers, Frans;
Sijbrands, Eric;
Steinbusch, Harry;
Prickaerts, Jos;
Kuipers, Folkert;
Lütjohann, Dieter;
Mulder, Monique

Publication type:

Article

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.01906

By:

Snodgrass, Ryan G.;
Zezina, Ekaterina;
Namgaladze, Dmitry;
Gupta, Sahil;
Angioni, Carlo;
Geisslinger, Gerd;
Lütjohann, Dieter;
Brüne, Bernhard

Publication type:

Article

Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24−/− Mice.

Published in:

Neurochemical Research, 2009, v. 34, n. 6, p. 1167

By:

Maria Ledesma;
Lucie Kalvodova;
Alicia Smith;
Arames Crameri;
Fabienne Skaanes-Brunner;
Karin Thelen;
Luka Kulic;
Dieter Lütjohann;
Frank Heppner;
Roger Nitsch

Publication type:

Article

Cholesterol Absorption and Synthesis in Vegetarians and Omnivores.

Published in:

Molecular Nutrition & Food Research, 2018, v. 62, n. 6, p. 1, doi. 10.1002/mnfr.201700689

By:

Lütjohann, Dieter;
Meyer, Sven;
von Bergmann, Klaus;
Stellaard, Frans

Publication type:

Article

Variations in dietary intake and plasma concentrations of plant sterols across plant-based diets among North American adults.

Published in:

Molecular Nutrition & Food Research, 2017, v. 61, n. 8, p. n/a, doi. 10.1002/mnfr.201600828

By:

Jaceldo‐Siegl, Karen;
Lütjohann, Dieter;
Sirirat, Rawiwan;
Mashchak, Andrew;
Fraser, Gary E.;
Haddad, Ella

Publication type:

Article

Sex‐opposed inflammatory effects of 27‐hydroxycholesterol are mediated via differences in estrogen signaling.

Published in:

Journal of Pathology, 2020, v. 251, n. 4, p. 429, doi. 10.1002/path.5477

By:

Houben, Tom;
Bitorina, Albert V;
Oligschlaeger, Yvonne;
Jeurissen, Mike LJ;
Rensen, Sander;
Köhler, S Eleonore;
Westerterp, Marit;
Lütjohann, Dieter;
Theys, Jan;
Romano, Andrea;
Plat, Jogchum;
Shiri‐Sverdlov, Ronit

Publication type:

Article

The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo.

Published in:

EMBO Journal, 2006, v. 25, n. 2, p. 432, doi. 10.1038/sj.emboj.7600938

By:

Crameri, Arames;
Biondi, Elisa;
Kuehnle, Katrin;
Lütjohann, Dieter;
Thelen, Karin M.;
Perga, Simona;
Dotti, Carlos G.;
Nitsch, Roger M.;
Ledesma, Maria Dolores;
Mohajeri, M. Hasan

Publication type:

Article

CNS cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

Published in:

2011

By:

Popp, Julius;
Lewczuk, Piotr;
Kölsch, Heike;
Giannakopoulos, Panteleimon;
Maier, Wolfgang;
Kornhuber, Johannes;
Jessen, Frank;
Lütjohann, Dieter

Publication type:

Abstract

Lecithin: Cholesterol Acyltransferase (LCAT) is required for normal brain apoE metabolism in mice

Published in:

2009

By:

Hirsch-Reinshagen, Veronica;
Donkin, James;
Stukas, Sophie;
Fan, Jianjia;
Parks, John S.;
Kuivenhoven, Jan Albert;
Lütjohann, Dieter;
Pritchard, Haydn;
Wellington, Cheryl L.

Publication type:

Abstract

P4-190: Role of gamma-secretase in lipoprotein endocytosis

Published in:

2008

By:

Walter, Jochen;
Thelen, Karin;
Lütjohann, Dieter;
DeWachter, Ilse;
van Leuven, Fred;
Sisodia, Sangram S.;
St. George-Hyslop, Peter;
Thal, Dietmar;
Tamboli, Irfan

Publication type:

Abstract

P1-048: DHA-enriched diet and cholesterol containing Typical Western Diet influence Alzheimer-like pathology, cognition and the cerebral vasculature in APPSwe/PS1dE9 mice

Published in:

2008

By:

Hooijmans, Carlijn R.;
van der Zee, C.E.E.M.;
Dederen, Pieter J.;
Reijmer, Yael D.;
Brouwer, Katrien M.;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Heerschap, Arend;
Kiliaan, Amanda J.

Publication type:

Abstract

P2-153: Alterations of brain cholesterol metabolism: Relevance of desmosterol in Alzheimer’s disease and vascular dementia

Published in:

2006

By:

Kölsch, Heike;
Heun, Reinhard;
Jessen, Frank;
Popp, Julius;
Maier, Wolfgang;
Lütjohann, Dieter

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

O3-03-05: Involvement of presenilin-dependent γ-secretase activity in the transcriptional control of cellular cholesterol biosynthesis

Published in:

2006

By:

Walter, Jochen;
Thelen, Karin;
Lütjohann, Dieter;
Kukoc-Zivojnov, Natasa;
Prager, Kai;
Tamboli, Irfan Y.

Publication type:

Abstract

P2-153: Alterations of brain cholesterol metabolism: Relevance of desmosterol in Alzheimer’s disease and vascular dementia

Published in:

2006

By:

Kölsch, Heike;
Heun, Reinhard;
Jessen, Frank;
Popp, Julius;
Maier, Wolfgang;
Lütjohann, Dieter

Publication type:

Abstract

P1-026: Changes in cerebral hemodynamics and Alzheimer’s pathology in aged APP/PS1 mice supplemented with docosahexanoic acid (DHA) and cholesterol enriched diets

Published in:

2006

By:

Hooijmans, Carlijn R.;
Rutters, Femke;
Dederen, Pieter J.;
Heerschap, Arend;
Tanila, Heikki;
van Groen, Thomas;
Broersen, Laus M.;
Lütjohann, Dieter;
Kiliaan, Amanda J.

Publication type:

Abstract

O3-03-05: Involvement of presenilin-dependent γ-secretase activity in the transcriptional control of cellular cholesterol biosynthesis

Published in:

2006

By:

Walter, Jochen;
Thelen, Karin;
Lütjohann, Dieter;
Kukoc-Zivojnov, Natasa;
Prager, Kai;
Tamboli, Irfan Y.

Publication type:

Abstract

AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARγ.

Published in:

Cardiovascular Diabetology, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1475-2840-12-30

By:

Tiyerili, Vedat;
Becher, Ulrich M.;
Aksoy, Adem;
Lütjohann, Dieter;
Wassmann, Sven;
Nickenig, Georg;
Mueller, Cornelius F. H.

Publication type:

Article

Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease.

Published in:

BMC Gastroenterology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-230X-13-30

By:

Renner, Olga;
Lütjohann, Dieter;
Richter, Dominique;
Strohmeyer1, André;
Schimmel, Silke;
Müller, Oliver;
Stange, Eduard F.;
Harsch, Simone

Publication type:

Article

Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease.

Published in:

2013

By:

Renner, Olga;
Lütjohann, Dieter;
Richter, Dominique;
Strohmeyer, André;
Schimmel, Silke;
Müller, Oliver;
Stange, Eduard F;
Harsch, Simone

Publication type:

journal article

AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model.

Published in:

Acta Neuropathologica, 2023, v. 146, n. 2, p. 353, doi. 10.1007/s00401-023-02579-9

By:

Deng, Ruizhi;
Medico-Salsench, Eva;
Nikoncuk, Anita;
Ramakrishnan, Reshmi;
Lanko, Kristina;
Kühn, Nikolas A.;
van der Linde, Herma C.;
Lor-Zade, Sarah;
Albuainain, Fatimah;
Shi, Yuwei;
Yousefi, Soheil;
Capo, Ivan;
van den Herik, Evita Medici;
van Slegtenhorst, Marjon;
van Minkelen, Rick;
Geeven, Geert;
Mulder, Monique T.;
Ruijter, George J. G.;
Lütjohann, Dieter;
Jacobs, Edwin H.

Publication type:

Article

A Transient Inflammatory Response Induced by Lipopolysaccharide Infusion Lowers Markers of Endogenous Cholesterol and Bile Acid Synthesis in Healthy Normocholesterolemic Young Men.

Published in:

Biomedicines, 2023, v. 11, n. 1, p. 126, doi. 10.3390/biomedicines11010126

By:

Mashnafi, Sultan;
Baumgartner, Sabine;
Mensink, Ronald P.;
Perlee, Desiree;
van Vught, Lonneke A.;
Lütjohann, Dieter;
Plat, Jogchum

Publication type:

Article

Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation.

Published in:

Biomedicines, 2021, v. 9, n. 5, p. 518, doi. 10.3390/biomedicines9050518

By:

Magro dos Reis, Inês;
Houben, Tom;
Gijbels, Marion J. J.;
Lütjohann, Dieter;
Plat, Jogchum;
Shiri-Sverdlov, Ronit;
Barresi, Valeria

Publication type:

Article

Cholesterol Crystal Dissolution Rate of Serum Predicts Outcomes in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

Published in:

Journal of the American Heart Association, 2024, v. 13, n. 3, p. 1, doi. 10.1161/JAHA.123.031997

By:

Al-Kassou, Baravan;
Al-Kassou, Lara;
Mahn, Thorsten;
Lütjohann, Dieter;
Shamekhi, Jasmin;
Willemsen, Nicola;
Niepmann, Sven Thomas;
Baldus, Stephan;
Kelm, Malte;
Nickenig, Georg;
Latz, Eicke;
Zimmer, Sebastian

Publication type:

Article

Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.

Published in:

Multiple Sclerosis Journal, 2018, v. 24, n. 3, p. 279, doi. 10.1177/1352458517696595

By:

Mailleux, Jo;
Vanmierlo, Tim;
Bogie, Jeroen F. J.;
Wouters, Elien;
Hendriks, Jerome J. A.;
Lütjohann, Dieter;
van Horssen, Jack

Publication type:

Article

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes.

Published in:

European Journal of Nutrition, 2020, v. 59, n. 5, p. 2039, doi. 10.1007/s00394-019-02052-y

By:

Nascimento, Emmani B. M.;
Konings, Maurice;
Schaart, Gert;
Groen, Albert K.;
Lütjohann, Dieter;
van Marken Lichtenbelt, Wouter D.;
Schrauwen, Patrick;
Plat, Jogchum

Publication type:

Article

Total Plasma Homocysteine and Related Amino Acids in End-Stage Renal Disease (ESRD) Patients Measured by Gas Chromatography-Mass Spectrometry - Comparison with the Abbott IMx Homocysteine Assay and the HPLC Method.

Published in:

Clinical Chemistry & Laboratory Medicine, 2001, v. 39, n. 8, p. 681

By:

Sigit, Joseph I.;
Hages, Monika;
Brensing, Karl A.;
Frotscher, Ulrich;
Pietrzik, Klaus;
Bergmann, Klaus von;
Lütjohann, Dieter

Publication type:

Article

Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels.

Published in:

2012

By:

Tansley, Gavin;
Holmes, Daniel T;
Lütjohann, Dieter;
Head, Elizabeth;
Wellington, Cheryl L

Publication type:

Journal Article

Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels.

Published in:

Current Gerontology & Geratrics Research, 2012, p. 1, doi. 10.1155/2012/179318

By:

Tansley, Gavin;
Holmes, Daniel T.;
Lütjohann, Dieter;
Head, Elizabeth;
Wellington, Cheryl L.

Publication type:

Article

Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

Published in:

Bipolar Disorders, 2005, v. 7, n. 5, p. 449, doi. 10.1111/j.1399-5618.2005.00239.x

By:

Beasley, Clare L;
Honer, William G;
Bergmann, Klaus;
Falkai, Peter;
Lütjohann, Dieter;
Bayer, Thomas A

Publication type:

Article

Monocytic microparticles promote atherogenesis by modulating inflammatory cells in mice.

Published in:

Journal of Cellular & Molecular Medicine, 2012, v. 16, n. 11, p. 2777, doi. 10.1111/j.1582-4934.2012.01595.x

By:

Hoyer, Friedrich Felix;
Giesen, Meike Kristin;
Nunes França, Carolina;
Lütjohann, Dieter;
Nickenig, Georg;
Werner, Nikos

Publication type:

Article

RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism.

Published in:

Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 3, p. 589, doi. 10.1111/j.1582-4934.2009.00383.x

By:

Kölsch, Heike;
Lütjohann, Dieter;
Jessen, Frank;
Popp, Julius;
Hentschel, Frank;
Kelemen, Peter;
Friedrichs, Silvia;
Wolfgang Maier, T. A.;
Reinhard Heun

Publication type:

Article

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.

Published in:

Annals of Neurology, 2002, v. 52, n. 3, p. 346, doi. 10.1002/ana.10292

By:

Simons, Mikael;
Schwärzler, Frank;
Lütjohann, Dieter;
Von Bergmann, Klaus;
Beyreuther, Konrad;
Dichgans, Johannes;
Wormstall, Henning;
Hartmann, Tobias;
Schulz, Jörg B.

Publication type:

Article

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.

Published in:

FASEB Journal, 2008, v. 22, n. 4, p. 1073, doi. 10.1096/fj.07-9944com

By:

Nan Wang;
Yvan-Charvet, Laurent;
Lütjohann, Dieter;
Mulder, Monique;
Vanmierlo, Tim;
Tae-Wan Kim;
Tall, Alan R.

Publication type:

Article

High-Dose Statin Treatment Does Not Alter Plasma Marker for Brain Cholesterol Metabolism in Patients With Moderately Elevated Plasma Cholesterol Levels.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 7, p. 812, doi. 10.1177/0091270006289851

By:

Thelen, Karin M.;
Laaksonen, Reijo;
Päivä, Hannu;
Lehtimäki, Terho;
Lütjohann, Dieter

Publication type:

Article

High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System.

Published in:

Journal of NeuroImmune Pharmacology, 2014, v. 9, n. 2, p. 209, doi. 10.1007/s11481-013-9502-4

By:

Timmermans, Silke;
Bogie, Jeroen;
Vanmierlo, Tim;
Lütjohann, Dieter;
Stinissen, Piet;
Hellings, Niels;
Hendriks, Jerome

Publication type:

Article

Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice.

Published in:

Brain Structure & Function, 2014, v. 219, n. 5, p. 1841, doi. 10.1007/s00429-013-0606-7

By:

Jansen, Diane;
Zerbi, Valerio;
Janssen, Carola;
Rooij, Daan;
Zinnhardt, Bastian;
Dederen, Pieter;
Wright, Alan;
Broersen, Laus;
Lütjohann, Dieter;
Heerschap, Arend;
Kiliaan, Amanda

Publication type:

Article

Cholesterol Synthesis Is Associated with Hepatic Lipid Content and Dependent on Fructose/Glucose Intake in Healthy Humans.

Published in:

Experimental Diabetes Research, 2012, p. 1, doi. 10.1155/2012/361863

By:

Silbernagel, Guenther;
Lütjohann, Dieter;
Machann, Juergen;
Meichsner, Sabrina;
Kantartzis, Konstantinos;
Schick, Fritz;
Häring, Hans-Ulrich;
Stefan, Norbert;
Fritsche, Andreas

Publication type:

Article

Common variant p.D19H of the hepatobiliary sterol transporter ABCG8 increases the risk of gallstones in children.

Published in:

Liver International, 2022, v. 42, n. 7, p. 1585, doi. 10.1111/liv.15186

By:

Krawczyk, Marcin;
Niewiadomska, Olga;
Jankowska, Irena;
Jankowski, Krzysztof;
Więckowski, Sebastian;
Lebensztejn, Dariusz;
Więcek, Sabina;
Gozdowska, Jolanta;
Kułaga, Zbigniew;
Weber, Susanne N.;
Lütjohann, Dieter;
Lammert, Frank;
Socha, Piotr

Publication type:

Article

Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice.

Published in:

Liver International, 2011, v. 31, n. 1, p. 52, doi. 10.1111/j.1478-3231.2010.02361.x

By:

Amigo, Ludwig;
Husche, Constanze;
Zanlungo, Silvana;
Lütjohann, Dieter;
Arrese, Marco;
Miquel, Juan Francisco;
Rigotti, Attilio;
Nervi, Flavio

Publication type:

Article

The mitochondrial protease PARL is required for spermatogenesis.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-023-05703-3

By:

Schumacher, Sarah;
Klose, Laura;
Lambertz, Jessica;
Lütjohann, Dieter;
Biemann, Ronald;
Kuerten, Stefanie;
Fester, Lars

Publication type:

Article

Brain cholesterol and suicidal behaviourSee Lalovic et al. (this issue). Cholesterol content in brains of suicide completers.

Published in:

International Journal of Neuropsychopharmacology, 2007, v. 10, n. 2, p. 153

By:

Dieter Lütjohann

Publication type:

Article

Phytosterol-Enriched Dietary Supplements for Lowering Plasma LDL-Cholesterol: Yes or No?

Published in:

Nutrients, 2025, v. 17, n. 4, p. 654, doi. 10.3390/nu17040654

By:

Stellaard, Frans;
Lütjohann, Dieter

Publication type:

Article

Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model.

Published in:

Nutrients, 2024, v. 16, n. 11, p. 1614, doi. 10.3390/nu16111614

By:

Martens, Nikita;
Zhan, Na;
Yam, Sammie C.;
Leijten, Frank P. J.;
Palumbo, Marcella;
Caspers, Martien;
Tiane, Assia;
Friedrichs, Silvia;
Li, Yanlin;
van Vark-van der Zee, Leonie;
Voortman, Gardi;
Zimetti, Francesca;
Jaarsma, Dick;
Verschuren, Lars;
Jonker, Johan W.;
Kuipers, Folkert;
Lütjohann, Dieter;
Vanmierlo, Tim;
Mulder, Monique T.

Publication type:

Article

Association between Serum Phytosterols and Lipid Levels in a Population-Based Study.

Published in:

Nutrients, 2024, v. 16, n. 6, p. 775, doi. 10.3390/nu16060775

By:

Stanasila, Laura;
Lütjohann, Dieter;
Popp, Julius;
Marques-Vidal, Pedro

Publication type:

Article

Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?

Published in:

Nutrients, 2023, v. 15, n. 13, p. 3004, doi. 10.3390/nu15133004

By:

Martens, Nikita;
Zhan, Na;
Voortman, Gardi;
Leijten, Frank P. J.;
van Rheenen, Connor;
van Leerdam, Suzanne;
Geng, Xicheng;
Huybrechts, Michiel;
Liu, Hongbing;
Jonker, Johan W.;
Kuipers, Folkert;
Lütjohann, Dieter;
Vanmierlo, Tim;
Mulder, Monique T.

Publication type:

Article

Measurement of Serum Low Density Lipoprotein Cholesterol and Triglyceride-Rich Remnant Cholesterol as Independent Predictors of Atherosclerotic Cardiovascular Disease: Possibilities and Limitations.

Published in:

Nutrients, 2023, v. 15, n. 9, p. 2202, doi. 10.3390/nu15092202

By:

Lütjohann, Dieter;
Klör, Hans-Ulrich;
Stellaard, Frans

Publication type:

Article

Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases—A German Expert Panel Statement †.

Published in:

Nutrients, 2023, v. 15, n. 4, p. 828, doi. 10.3390/nu15040828

By:

Windler, Eberhard;
Beil, Frank-Ulrich;
Berthold, Heiner K.;
Gouni-Berthold, Ioanna;
Kassner, Ursula;
Klose, Gerald;
Lorkowski, Stefan;
März, Winfried;
Parhofer, Klaus G.;
Plat, Jogchum;
Silbernagel, Günter;
Steinhagen-Thiessen, Elisabeth;
Weingärtner, Oliver;
Zyriax, Birgit-Christiane;
Lütjohann, Dieter

Publication type:

Article