Found: 17

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  • Development of CDK2 and CDK5 Dual Degrader TMX‐2172.

    Published in:
    Angewandte Chemie, 2020, v. 132, n. 33, p. 13969, doi. 10.1002/ange.202004087
    By:
    • Teng, Mingxing;
    • Jiang, Jie;
    • He, Zhixiang;
    • Kwiatkowski, Nicholas P.;
    • Donovan, Katherine A.;
    • Mills, Caitlin E.;
    • Victor, Chiara;
    • Hatcher, John M.;
    • Fischer, Eric S.;
    • Sorger, Peter K.;
    • Zhang, Tinghu;
    • Gray, Nathanael S.
    Publication type:
    Article

  • A kinase-independent role for CDK8 in BCR-ABL1<sup>+</sup> leukemia.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12656-x
    By:
    • Menzl, Ingeborg;
    • Zhang, Tinghu;
    • Berger-Becvar, Angelika;
    • Grausenburger, Reinhard;
    • Heller, Gerwin;
    • Prchal-Murphy, Michaela;
    • Edlinger, Leo;
    • Knab, Vanessa M.;
    • Uras, Iris Z.;
    • Grundschober, Eva;
    • Bauer, Karin;
    • Roth, Mareike;
    • Skucha, Anna;
    • Liu, Yao;
    • Hatcher, John M.;
    • Liang, Yanke;
    • Kwiatkowski, Nicholas P.;
    • Fux, Daniela;
    • Hoelbl-Kovacic, Andrea;
    • Kubicek, Stefan
    Publication type:
    Article

  • CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09703-y
    By:
    • Krajewska, Malgorzata;
    • Dries, Ruben;
    • Grassetti, Andrew V.;
    • Dust, Sofia;
    • Gao, Yang;
    • Huang, Hao;
    • Sharma, Bandana;
    • Day, Daniel S.;
    • Kwiatkowski, Nicholas;
    • Pomaville, Monica;
    • Dodd, Oliver;
    • Chipumuro, Edmond;
    • Zhang, Tinghu;
    • Greenleaf, Arno L.;
    • Yuan, Guo-Cheng;
    • Gray, Nathanael S.;
    • Young, Richard A.;
    • Geyer, Matthias;
    • Gerber, Scott A.;
    • George, Rani E.
    Publication type:
    Article

  • Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma.

    Published in:
    Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2021.773186
    By:
    • Gao, Yang;
    • Volegova, Marina;
    • Nasholm, Nicole;
    • Das, Sanjukta;
    • Kwiatkowski, Nicholas;
    • Abraham, Brian J.;
    • Zhang, Tinghu;
    • Gray, Nathanael S.;
    • Gustafson, Clay;
    • Krajewska, Malgorzata;
    • George, Rani E.
    Publication type:
    Article

  • Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes.

    Published in:
    Nature Communications, 2017, v. 8, n. 6, p. 15797, doi. 10.1038/ncomms15797
    By:
    • Abraham, Brian J.;
    • Hnisz, Denes;
    • Weintraub, Abraham S.;
    • Kwiatkowski, Nicholas;
    • Li, Charles H.;
    • Li, Zhaodong;
    • Weichert-Leahey, Nina;
    • Rahman, Sunniyat;
    • Liu, Yu;
    • Etchin, Julia;
    • Li, Benshang;
    • Shen, Shuhong;
    • Lee, Tong Ihn;
    • Zhang, Jinghui;
    • Look, A. Thomas;
    • Mansour, Marc R.;
    • Young, Richard A.
    Publication type:
    Article

  • Small genomic insertions form enhancers that misregulate oncogenes.

    Published in:
    Nature Communications, 2017, v. 8, n. 2, p. 14385, doi. 10.1038/ncomms14385
    By:
    • Abraham, Brian J.;
    • Hnisz, Denes;
    • Weintraub, Abraham S.;
    • Kwiatkowski, Nicholas;
    • Li, Charles H.;
    • Li, Zhaodong;
    • Weichert-Leahey, Nina;
    • Rahman, Sunniyat;
    • Liu, Yu;
    • Etchin, Julia;
    • Li, Benshang;
    • Shen, Shuhong;
    • Lee, Tong Ihn;
    • Zhang, Jinghui;
    • Look, A. Thomas;
    • Mansour, Marc R.;
    • Young, Richard A.
    Publication type:
    Article

  • Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.

    Published in:
    Nature Communications, 2017, v. 8, n. 2, p. 14747, doi. 10.1038/ncomms14747
    By:
    • Cayrol, Florencia;
    • Praditsuktavorn, Pannee;
    • Fernando, Tharu M.;
    • Kwiatkowski, Nicholas;
    • Marullo, Rossella;
    • Calvo-Vidal, M. Nieves;
    • Phillip, Jude;
    • Pera, Benet;
    • Yang, Shao Ning;
    • Takpradit, Kaipol;
    • Roman, Lidia;
    • Gaudiano, Marcello;
    • Crescenzo, Ramona;
    • Ruan, Jia;
    • Inghirami, Giorgio;
    • Zhang, Tinghu;
    • Cremaschi, Graciela;
    • Gray, Nathanael S;
    • Cerchietti, Leandro
    Publication type:
    Article

  • THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 14290, doi. 10.1038/ncomms14290
    By:
    • Cayrol, Florencia;
    • Praditsuktavorn, Pannee;
    • Fernando, Tharu M.;
    • Kwiatkowski, Nicholas;
    • Marullo, Rosella;
    • Calvo-Vidal, M. Nieves;
    • Phillip, Jude;
    • Pera, Benet;
    • Yang, Shao Ning;
    • Takpradit, Kaipol;
    • Roman, Lidia;
    • Gaudiano, Marcello;
    • Crescenzo, Ramona;
    • Ruan, Jia;
    • Inghirami, Giorgio;
    • Zhang, Tinghu;
    • Cremaschi, Graciela;
    • Gray, Nathanael S.;
    • Cerchietti, Leandro
    Publication type:
    Article

  • P-099: Perturbation of CDK7 and super-enhancer driven transcriptional programs synergistically halts multiple myeloma cell proliferation.

    Published in:
    Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S93, doi. 10.1016/S2152-2650(21)02233-3
    By:
    • Yao Yao;
    • Park, Woojun D.;
    • Morelli, Eugenio;
    • Samur, Mehmet K.;
    • Kwiatkowski, Nicholas;
    • Yan Xu;
    • Nabet, Behnam;
    • Chakraborty, Chandraditya;
    • Chesi, Marta;
    • Gray, Nathaniel;
    • Young, Rick;
    • Anderson, Kenneth;
    • Lin, Charles;
    • Munshi, Nikhil C.;
    • Fulciniti, Mariateresa
    Publication type:
    Article

  • Development of CDK2 and CDK5 Dual Degrader TMX‐2172.

    Published in:
    Angewandte Chemie International Edition, 2020, v. 59, n. 33, p. 13865, doi. 10.1002/anie.202004087
    By:
    • Teng, Mingxing;
    • Jiang, Jie;
    • He, Zhixiang;
    • Kwiatkowski, Nicholas P.;
    • Donovan, Katherine A.;
    • Mills, Caitlin E.;
    • Victor, Chiara;
    • Hatcher, John M.;
    • Fischer, Eric S.;
    • Sorger, Peter K.;
    • Zhang, Tinghu;
    • Gray, Nathanael S.
    Publication type:
    Article

  • Release of Mps1 from kinetochores is crucial for timely anaphase onset.

    Published in:
    Journal of Cell Biology, 2010, v. 191, n. 2, p. 281, doi. 10.1083/jcb.201003038
    By:
    • Jelluma, Nannette;
    • Dansen, Tobias B.;
    • Sliedrecht, Tale;
    • Kwiatkowski, Nicholas P.;
    • Kops, Geert J. P. L.
    Publication type:
    Article

  • Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.

    Published in:
    eLife, 2022, p. 1, doi. 10.7554/eLife.78810
    By:
    • Mengyang Fan;
    • Wenchao Lu;
    • Jianwei Che;
    • Kwiatkowski, Nicholas P.;
    • Yang Gao;
    • Hyuk-Soo Seo;
    • Ficarro, Scott B.;
    • Gokhale, Prafulla C.;
    • Yao Liu;
    • Geffken, Ezekiel A.;
    • Lakhani, Jimit;
    • Kijun Song;
    • Miljan Kuljanin;
    • Wenzhi Ji;
    • Jie Jiang;
    • Zhixiang He;
    • Tse, Jason;
    • Boghossian, Andrew S.;
    • Rees, Matthew G.;
    • Ronan, Melissa M.
    Publication type:
    Article

  • Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

    Published in:
    Nature, 2014, v. 511, n. 7511, p. 616, doi. 10.1038/nature13393
    By:
    • Kwiatkowski, Nicholas;
    • Zhang, Tinghu;
    • Rahl, Peter B.;
    • Abraham, Brian J.;
    • Reddy, Jessica;
    • Ficarro, Scott B.;
    • Dastur, Anahita;
    • Amzallag, Arnaud;
    • Ramaswamy, Sridhar;
    • Tesar, Bethany;
    • Jenkins, Catherine E.;
    • Hannett, Nancy M.;
    • McMillin, Douglas;
    • Sanda, Takaomi;
    • Sim, Taebo;
    • Kim, Nam Doo;
    • Look, Thomas;
    • Mitsiades, Constantine S.;
    • Weng, Andrew P.;
    • Brown, Jennifer R.
    Publication type:
    Article

  • Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

    Published in:
    Nature Chemical Biology, 2010, v. 6, n. 5, p. 359, doi. 10.1038/nchembio.345
    By:
    • Kwiatkowski, Nicholas;
    • Jelluma, Nannette;
    • Filippakopoulos, Panagis;
    • Soundararajan, Meera;
    • Manak, Michael S.;
    • Kwon, Mijung;
    • Choi, Hwan Geun;
    • Sim, Taebo;
    • Deveraux, Quinn L.;
    • Rottmann, Sabine;
    • Pellman, David;
    • Shah, Jagesh V.;
    • Kops, Geert J. P. L.;
    • Knapp, Stefan;
    • Gray, Nathanael S
    Publication type:
    Article

  • Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.

    Published in:
    2013
    By:
    • Tannous, Bakhos A;
    • Kerami, Mariam;
    • Van der Stoop, Petra M;
    • Kwiatkowski, Nicholas;
    • Wang, Jinhua;
    • Zhou, Wenjun;
    • Kessler, Almuth F;
    • Lewandrowski, Grant;
    • Hiddingh, Lotte;
    • Sol, Nik;
    • Lagerweij, Tonny;
    • Wedekind, Laurine;
    • Niers, Johanna M;
    • Barazas, Marco;
    • Nilsson, R Jonas A;
    • Geerts, Dirk;
    • De Witt Hamer, Philip C;
    • Hagemann, Carsten;
    • Vandertop, W Peter;
    • Van Tellingen, Olaf
    Publication type:
    journal article

  • Effects of the Selective MPSI Inhibitor MPSI-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs.

    Published in:
    JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 17, p. 1322, doi. 10.1093/jnci/djt168
    By:
    • Tannous, Bakhos A.;
    • Kerami, Mariam;
    • Van der Stoop, Petra M.;
    • Kwiatkowski, Nicholas;
    • Jinhua Wang;
    • Wenjun Zhou;
    • Kessler, Almuth F.;
    • Lewandrowski, Grant;
    • Hiddingh, Lotte;
    • Sol, Nik;
    • Lagerweij, Tonny;
    • Wedekind, Laurine;
    • Niers, Johanna M.;
    • Barazas, Marco;
    • Nilsson, R. Jonas A.;
    • Geerts, Dirk;
    • DeWitt Hamer^, Philip C.;
    • Hagemann, Carsten;
    • Vandertop, W. Peter;
    • Van Tellingen, Olaf
    Publication type:
    Article

  • Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines.

    Published in:
    Molecular Oncology, 2015, v. 9, n. 1, p. 260, doi. 10.1016/j.molonc.2014.08.011
    By:
    • Calles, Antonio;
    • Kwiatkowski, Nicholas;
    • Cammarata, Bernard K.;
    • Ercan, Dalia;
    • Gray, Nathanael S.;
    • Jänne, Pasi A.
    Publication type:
    Article