Works by Kvaratskhelia, Mamuka

Results: 33

LENACAPAVIR INHIBITS VIRION MATURATION BY BLOCKING FORMATION OF CAPSID PENTAMERS.

Published in:

Topics in Antiviral Medicine, 2023, v. 31, n. 2, p. 42

By:

Szu-Wei Huang;
Briganti, Lorenzo;
Wei, Guochao;
Annamalai, Arun;
Bester, Stephanie;
Shkriabai, Nikoloz;
Kvaratskhelia, Mamuka

Publication type:

Article

Multimodal Functionalities of HIV-1 Integrase.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 5, p. 926, doi. 10.3390/v14050926

By:

Engelman, Alan N.;
Kvaratskhelia, Mamuka

Publication type:

Article

ATR prevents Ca<sup>2+</sup> overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.

Published in:

FASEB Journal, 2021, v. 35, n. 5, p. 1, doi. 10.1096/fj.202001636RRR

By:

Zhengke Li;
Hui Wang-Heaton;
Cartwright, Brian M.;
Makinwa, Yetunde;
Hilton, Benjamin A.;
Musich, Phillip R.;
Shkriabai, Nikolozi;
Kvaratskhelia, Mamuka;
Shengheng Guan;
Qian Chen;
Xiaochun Yu;
Yue Zou

Publication type:

Article

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 6, p. 3924, doi. 10.1093/nar/gkt074

By:

Eidahl, Jocelyn O.;
Crowe, Brandon L.;
North, Justin A.;
McKee, Christopher J.;
Shkriabai, Nikoloz;
Feng, Lei;
Plumb, Matthew;
Graham, Robert L.;
Gorelick, Robert J.;
Hess, Sonja;
Poirier, Michael G.;
Foster, Mark P.;
Kvaratskhelia, Mamuka

Publication type:

Article

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 22, p. 11518, doi. 10.1093/nar/gks913

By:

Wang, Hao;
Jurado, Kellie A.;
Wu, Xiaolin;
Shun, Ming-Chieh;
Li, Xiang;
Ferris, Andrea L.;
Smith, Steven J.;
Patel, Pratiq A.;
Fuchs, James R.;
Cherepanov, Peter;
Kvaratskhelia, Mamuka;
Hughes, Stephen H.;
Engelman, Alan

Publication type:

Article

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 20, p. 9009, doi. 10.1093/nar/gkr581

By:

Kessl, Jacques J.;
Li, Min;
Ignatov, Michael;
Shkriabai, Nikolozi;
Eidahl, Jocelyn O.;
Feng, Lei;
Musier-Forsyth, Karin;
Craigie, Robert;
Kvaratskhelia, Mamuka

Publication type:

Article

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 18, p. 8237, doi. 10.1093/nar/gkr381

By:

Ditzler, Mark A.;
Bose, Debojit;
Shkriabai, Nikolozi;
Marchand, Bruno;
Sarafianos, Stefan G.;
Kvaratskhelia, Mamuka;
Burke, Donald H.

Publication type:

Article

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 18, p. 5157, doi. 10.1093/nar/gkl667

By:

Marchand, Christophe;
Krajewski, Krzysztof;
Lee, Hsiu-Fang;
Antony, Smitha;
Johnson, Allison A.;
Amin, Ronak;
Roller, Peter;
Kvaratskhelia, Mamuka;
Pommier, Yves

Publication type:

Article

A new structural insight into XPA-DNA interactions.

Published in:

Bioscience Reports, 2014, v. 34, n. 6, p. 831, doi. 10.1042/BSR20140158

By:

Hilton, Benjamin;
Shkriabai, Nick;
Musich, Phillip R.;
Kvaratskhelia, Mamuka;
Shell, Steven;
Yue Zou

Publication type:

Article

The Pleiotropic Effects of YBX1 on HTLV-1 Transcription.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13119, doi. 10.3390/ijms241713119

By:

Smith, Susan;
Seth, Jaideep;
Midkiff, Amanda;
Stahl, Rachel;
Syu, Yu-Ci;
Shkriabai, Nikoloz;
Kvaratskhelia, Mamuka;
Musier-Forsyth, Karin;
Jain, Pooja;
Green, Patrick L.;
Panfil, Amanda R.

Publication type:

Article

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

Published in:

Frontiers in Microbiology, 2018, p. 1, doi. 10.3389/fmicb.2018.00080

By:

Panfil, Amanda R.;
Al-Saleem, Jacob;
Howard, Cory M.;
Shkriabai, Nikoloz;
Kvaratskhelia, Mamuka;
Green, Patrick L.

Publication type:

Article

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33662-6

By:

Wei, Guochao;
Iqbal, Naseer;
Courouble, Valentine V.;
Francis, Ashwanth C.;
Singh, Parmit K.;
Hudait, Arpa;
Annamalai, Arun S.;
Bester, Stephanie;
Huang, Szu-Wei;
Shkriabai, Nikoloz;
Briganti, Lorenzo;
Haney, Reed;
KewalRamani, Vineet N.;
Voth, Gregory A.;
Engelman, Alan N.;
Melikyan, Gregory B.;
Griffin, Patrick R.;
Asturias, Francisco;
Kvaratskhelia, Mamuka

Publication type:

Article

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 11, p. 1911, doi. 10.1002/pro.2997

By:

Deng, Nanjie;
Hoyte, Ashley;
Mansour, Yara E.;
Mohamed, Mosaad S.;
Fuchs, James R.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Levy, Ronald

Publication type:

Article

HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio.

Published in:

Retrovirology, 2021, v. 18, n. 1, p. 1, doi. 10.1186/s12977-021-00582-0

By:

Liu, Shuohui;
Koneru, Pratibha C.;
Li, Wen;
Pathirage, Chathuri;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Musier-Forsyth, Karin

Publication type:

Article

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase.

Published in:

PLoS Pathogens, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.ppat.1004171

By:

Sharma, Amit;
Slaughter, Alison;
Jena, Nivedita;
Feng, Lei;
Kessl, Jacques J.;
Fadel, Hind J.;
Malani, Nirav;
Male, Frances;
Wu, Li;
Poeschla, Eric;
Bushman, Frederic D.;
Fuchs, James R.;
Kvaratskhelia, Mamuka

Publication type:

Article

HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1.

Published in:

PLoS ONE, 2019, v. 14, n. 3, p. 1, doi. 10.1371/journal.pone.0214059

By:

Al-Saleem, Jacob;
Dirksen, Wessel P.;
Martinez, Michael P.;
Shkriabai, Nikoloz;
Kvaratskhelia, Mamuka;
Ratner, Lee;
Green, Patrick L.

Publication type:

Article

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.

Published in:

PLoS Pathogens, 2025, v. 21, n. 1, p. 1, doi. 10.1371/journal.ppat.1012862

By:

Huang, Szu-Wei;
Briganti, Lorenzo;
Annamalai, Arun S.;
Greenwood, Juliet;
Shkriabai, Nikoloz;
Haney, Reed;
Armstrong, Michael L.;
Wempe, Michael F.;
Singh, Satya Prakash;
Francis, Ashwanth C.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka

Publication type:

Article

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 11, p. 5344, doi. 10.1093/nar/gkw391

By:

Tien-Hao Chen;
Akiko Tanimoto;
Shkriabai, Nikoloz;
Mamuka Kvaratskhelia;
Wysocki, Vicki;
Gopalan, Venkat

Publication type:

Article

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 9, p. 5917, doi. 10.1093/nar/gku175

By:

Aiyer, Sriram;
Swapna, G. V. T.;
Malani, Nirav;
Aramini, James M.;
Schneider, William M.;
Plumb, Matthew R.;
Ghanem, Mustafa;
Larue, Ross C.;
Sharma, Amit;
Studamire, Barbara;
Kvaratskhelia, Mamuka;
Bushman, Frederic D.;
Montelione, Gaetano T.;
Roth, Monica J.

Publication type:

Article

Molecular mechanisms of retroviral integration site selection.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 16, p. 10209, doi. 10.1093/nar/gku769

By:

Kvaratskhelia, Mamuka;
Sharma, Amit;
Larue, Ross C.;
Serrao, Erik;
Engelman, Alan

Publication type:

Article

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 9, p. 5917, doi. 10.1093/nar/gku175

By:

Aiyer, Sriram;
Swapna, G.V.T.;
Malani, Nirav;
Aramini, James M.;
Schneider, William M.;
Plumb, Matthew R.;
Ghanem, Mustafa;
Larue, Ross C.;
Sharma, Amit;
Studamire, Barbara;
Kvaratskhelia, Mamuka;
Bushman, Frederic D.;
Montelione, Gaetano T.;
Roth, Monica J.

Publication type:

Article

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 8, p. 4868, doi. 10.1093/nar/gku135

By:

Larue, Ross C.;
Plumb, Matthew R.;
Crowe, Brandon L.;
Shkriabai, Nikoloz;
Sharma, Amit;
DiFiore, Julia;
Malani, Nirav;
Aiyer, Sriram S.;
Roth, Monica J.;
Bushman, Frederic D.;
Foster, Mark P.;
Kvaratskhelia, Mamuka

Publication type:

Article

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.

Published in:

PLoS Pathogens, 2024, v. 20, n. 3, p. 1, doi. 10.1371/journal.ppat.1011830

By:

Layish, Bailey;
Goli, Ram;
Flick, Haley;
Huang, Szu-Wei;
Zhang, Robert Z.;
Kvaratskhelia, Mamuka;
Kane, Melissa

Publication type:

Article

Identification and Characterization of HTLV-1 HBZ Post-Translational Modifications.

Published in:

PLoS ONE, 2014, v. 9, n. 11, p. 1, doi. 10.1371/journal.pone.0112762

By:

Dissinger, Nathan;
Shkriabai, Nikoloz;
Hess, Sonja;
Al-Saleem, Jacob;
Kvaratskhelia, Mamuka;
Green, Patrick L.

Publication type:

Article

BET proteins target murine leukemia virus integration to transcription start sites.

Published in:

2013

By:

Sharma, Amit;
Larue, Ross;
Plumb, Matthew;
Malani, Nirav;
Male, Frances;
Slaughter, Alison;
Kessl, Jacques;
Shkriabai, Nikoloz;
Coward, Elizabeth;
Aiyer, Sriram;
Green, Patrick;
Li Wu;
Roth, Monica;
Bushman, Frederic;
Kvaratskhelia, Mamuka

Publication type:

Abstract

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses.

Published in:

Retrovirology, 2012, v. 9, n. 1, p. 64, doi. 10.1186/1742-4690-9-64

By:

Doueiri, Rami;
Anupam, Rajaneesh;
Kvaratskhelia, Mamuka;
Green, Kari B.;
Lairmore, Michael D.;
Green, Patrick L.

Publication type:

Article

Human T-lymphotropic virus type 1 p30 interacts with REGγ and ATM (Ataxia Telangiectasia Mutated) to promote cell survival.

Published in:

2011

By:

Anupam, Rajaneesh;
Datta, Antara;
Bowden, Nadine;
Shkriabai, Nikolozi;
Kvaratskhelia, Mamuka;
Lairmore, Michael

Publication type:

Abstract

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4<sup>+</sup> cells.

Published in:

Retrovirology, 2010, v. 7, p. 66, doi. 10.1186/1742-4690-7-66

By:

Raghavendra, Nidhanapati K.;
Shkriabai, Nikolozi;
Graham, Robert L. J.;
Hess, Sonja;
Kvaratskhelia, Mamuka;
Li Wu

Publication type:

Article

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.54311

By:

Elliott, Jennifer L.;
Eschbach, Jenna E.;
Koneru, Pratibha C.;
Wen Li;
Puray-Chavez, Maritza;
Townsend, Dana;
Lawson, Dana Q.;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Kutluay, Sebla B.

Publication type:

Article

HIV-1 Integrase-DNA Recognition Mechanisms.

Published in:

Viruses (1999-4915), 2009, v. 1, n. 3, p. 713, doi. 10.3390/v1030713

By:

Kessl, Jacques J.;
McKee, Christopher J.;
Eidahl, Jocelyn O.;
Shkriabai, Nikolozi;
Katz, Ari;
Kvaratskhelia, Mamuka

Publication type:

Article

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.

Published in:

PLoS Pathogens, 2021, v. 17, n. 7, p. 1, doi. 10.1371/journal.ppat.1009671

By:

Maehigashi, Tatsuya;
Ahn, Seohyun;
Kim, Uk-Il;
Lindenberger, Jared;
Oo, Adrian;
Koneru, Pratibha C.;
Mahboubi, Bijan;
Engelman, Alan N.;
Kvaratskhelia, Mamuka;
Kim, Kyungjin;
Kim, Baek

Publication type:

Article

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.

Published in:

Molecules, 2018, v. 23, n. 8, p. 1858, doi. 10.3390/molecules23081858

By:

Aquaro, Stefano;
Zhao, Xue Zhi;
Burke, Terrence R.;
Métifiot, Mathieu;
Kiselev, Evgeny;
Maddali, Kasthuraiah;
Marchand, Christophe;
Pommier, Yves;
Kessl, Jacques J.;
Kvaratskhelia, Mamuka

Publication type:

Article

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins.

Published in:

Scientific Reports, 2016, p. 32499, doi. 10.1038/srep32499

By:

Kudryashova, Elena;
Koneru, Pratibha C.;
Kvaratskhelia, Mamuka;
Strömstedt, Adam A.;
Lu, Wuyuan;
Kudryashov, Dmitri S.

Publication type:

Article