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Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01079-1
By:
- Wojtas, Aleksandra M.;
- Carlomagno, Yari;
- Sens, Jonathon P.;
- Kang, Silvia S.;
- Jensen, Tanner D.;
- Kurti, Aishe;
- Baker, Kelsey E.;
- Berry, Taylor J.;
- Phillips, Virginia R.;
- Castanedes, Monica Casey;
- Awan, Ayesha;
- DeTure, Michael;
- De Castro, Cristhoper H. Fernandez;
- Librero, Ariston L.;
- Yue, Mei;
- Daughrity, Lillian;
- Jansen-West, Karen R.;
- Cook, Casey N.;
- Dickson, Dennis W.;
- Petrucelli, Leonard
Publication type:
Article
P4‐065: APOE4 CONDITIONALLY EXPRESSED IN CEREBROVASCULATURE IMPAIRS ENDOTHELIAL FUNCTIONS AND INDUCES COGNITIVE DEFICITS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1457, doi. 10.1016/j.jalz.2018.06.2468
By:
- Yamazaki, Yu;
- Liu, Chia-Chen;
- Oue, Hiroshi;
- Kurti, Aishe;
- Yamazaki, Akari;
- Fryer, John D.;
- Kanekiyo, Takahisa;
- Bu, Guojun
Publication type:
Article
APOE2 is associated with longevity independent of Alzheimer's disease.
Published in:
eLife, 2020, p. 1, doi. 10.7554/eLife.62199
By:
- Mitsuru Shinohara;
- Takahisa Kanekiyo;
- Masaya Tachibana;
- Kurti, Aishe;
- Motoko Shinohara;
- Yuan Fu;
- Jing Zhao;
- Xianlin Han;
- Sullivan, Patrick M.;
- Rebeck, G. William;
- Fryer, John D.;
- Heckman, Michael G.;
- Guojun Bu
Publication type:
Article
THE MOLECULAR CHAPERONE BRICHOS INHIBITS Aβ AGGREGATION AND OTHER NEUROPATHOLOGICAL PHENOTYPES IN A MOUSE MODEL OF Aβ AMYLOIDOSIS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1304, doi. 10.1016/j.jalz.2017.06.1991
By:
- Kim, Jungsu;
- Kim, Chaeyoung;
- Dolfe, Lisa;
- Belmonte, Krystal;
- Flores, Luis;
- Kurti, Aishe;
- Fryer, John D.;
- Presto, Jenny;
- Johansson, Jan
Publication type:
Article
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice.
Published in:
EMBO Reports, 2020, v. 21, n. 10, p. 1, doi. 10.15252/embr.202050197
By:
- Zhou, Xiaolai;
- Brooks, Mieu;
- Jiang, Peizhou;
- Koga, Shunsuke;
- Zuberi, Aamir R;
- Baker, Matthew C;
- Parsons, Tammee M;
- Castanedes‐Casey, Monica;
- Phillips, Virginia;
- Librero, Ariston L;
- Kurti, Aishe;
- Fryer, John D;
- Bu, Guojun;
- Lutz, Cathleen;
- Dickson, Dennis W;
- Rademakers, Rosa
Publication type:
Article
Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.
Published in:
Acta Neuropathologica Communications, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40478-019-0661-2
By:
- Carlomagno, Yari;
- Chung, Dah-eun Chloe;
- Yue, Mei;
- Kurti, Aishe;
- Avendano, Nicole M.;
- Castanedes-Casey, Monica;
- Hinkle, Kelly M.;
- Jansen-West, Karen;
- Daughrity, Lillian M.;
- Tong, Jimei;
- Phillips, Virginia;
- Rademakers, Rosa;
- DeTure, Michael;
- Fryer, John D.;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Cook, Casey
Publication type:
Article
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of <italic>C9ORF72</italic>-repeat induced toxicity.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0545-x
By:
- Nicholson, Alexandra M.;
- Zhou, Xiaolai;
- Perkerson, Ralph B.;
- Parsons, Tammee M.;
- Chew, Jeannie;
- Brooks, Mieu;
- DeJesus-Hernandez, Mariely;
- Finch, NiCole A.;
- Matchett, Billie J.;
- Kurti, Aishe;
- Jansen-West, Karen R.;
- Perkerson, Emilie;
- Daughrity, Lillian;
- Castanedes-Casey, Monica;
- Rousseau, Linda;
- Phillips, Virginia;
- Hu, Fenghua;
- Gendron, Tania F.;
- Murray, Melissa E.;
- Dickson, Dennis W.
Publication type:
Article
Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain.
Published in:
Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0455-3
By:
- Delenclos, Marion;
- Faroqi, Ayman H.;
- Mei Yue;
- Kurti, Aishe;
- Castanedes-Casey, Monica;
- Rousseau, Linda;
- Phillips, Virginia;
- Dickson, Dennis W.;
- Fryer, John D.;
- McLean, Pamela J.
Publication type:
Article
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06783-0
By:
- Zhao, Na;
- Liu, Chia-Chen;
- Van Ingelgom, Alexandra J.;
- Linares, Cynthia;
- Kurti, Aishe;
- Knight, Joshua A.;
- Heckman, Michael G.;
- Diehl, Nancy N.;
- Shinohara, Mitsuru;
- Martens, Yuka A.;
- Attrebi, Olivia N.;
- Petrucelli, Leonard;
- Fryer, John D.;
- Wszolek, Zbigniew K.;
- Graff-Radford, Neill R.;
- Caselli, Richard J.;
- Sanchez-Contreras, Monica Y.;
- Rademakers, Rosa;
- Murray, Melissa E.;
- Koga, Shunsuke
Publication type:
Article
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.
Published in:
Science Translational Medicine, 2020, v. 12, n. 529, p. 1, doi. 10.1126/scitranslmed.aay1809
By:
- Zhao, Na;
- Attrebi, Olivia N.;
- Ren, Yingxue;
- Qiao, Wenhui;
- Sonustun, Berkiye;
- Martens, Yuka A.;
- Meneses, Axel D.;
- Li, Fuyao;
- Shue, Francis;
- Zheng, Jiaying;
- Van Ingelgom, Alexandra J.;
- Davis, Mary D.;
- Kurti, Aishe;
- Knight, Joshua A.;
- Linares, Cynthia;
- Chen, Yixing;
- Delenclos, Marion;
- Liu, Chia-Chen;
- Fryer, John D.;
- Asmann, Yan W.
Publication type:
Article
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
Published in:
Brain Pathology, 2021, v. 31, n. 3, p. 1, doi. 10.1111/bpa.12945
By:
- Rademakers, Rosa;
- Nicholson, Alexandra M.;
- Ren, Yingxue;
- Koga, Shunsuke;
- Nguyen, Hung Phuoc;
- Brooks, Mieu;
- Qiao, Wenhui;
- Quicksall, Zachary S.;
- Matchett, Billie;
- Perkerson, Ralph B.;
- Kurti, Aishe;
- Castanedes‐Casey, Monica;
- Phillips, Virginia;
- Librero, Ariston L;
- Fernandez De Castro, Cristhoper H.;
- Baker, Matthew C.;
- Roemer, Shanu F.;
- Murray, Melissa E.;
- Asmann, Yan;
- Fryer, John D.
Publication type:
Article
APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology.
Published in:
Annals of Neurology, 2023, v. 93, n. 4, p. 830, doi. 10.1002/ana.26580
By:
- Meneses, Axel D.;
- Koga, Shunsuke;
- Li, Zonghua;
- O'Leary, Justin;
- Li, Fuyao;
- Chen, Kai;
- Murakami, Aya;
- Qiao, Wenhui;
- Kurti, Aishe;
- Heckman, Michael G.;
- White, Launia;
- Xie, Manling;
- Chen, Yixing;
- Finch, Nicole A.;
- Lim, Melina J.;
- Delenclos, Marion;
- DeTure, Michael A.;
- Linares, Cynthia;
- Martin, Nicholas B.;
- Ikezu, Tadafumi C.
Publication type:
Article
Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.
Published in:
Human Molecular Genetics, 2018, v. 27, n. 2, p. 211, doi. 10.1093/hmg/ddx366
By:
- Kang, Silvia S.;
- Kurti, Aishe;
- Baker, Kelsey E.;
- Chia-Chen Liu;
- Colonna, Marco;
- Ulrich, Jason D.;
- Holtzman, David M.;
- Guojun Bu;
- Fryer, John D.
Publication type:
Article
Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.
Published in:
Human Molecular Genetics, 2016, v. 25, n. 16, p. 3467, doi. 10.1093/hmg/ddw188
By:
- Kang, Silvia S.;
- Kurti, Aishe;
- Wojtas, Aleksandra;
- Baker, Kelsey E.;
- Liu, Chia-Chen;
- Kanekiyo, Takahisa;
- Deming, Yuetiva;
- Cruchaga, Carlos;
- Estus, Steven;
- Bu, Guojun;
- Fryer, John D.
Publication type:
Article
Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 21, p. 6198, doi. 10.1093/hmg/ddv336
By:
- Cook, Casey;
- Kang, Silvia S.;
- Carlomagno, Yari;
- Wen-Lang Lin;
- Mei Yue;
- Aishe Kurti;
- Mitsuru Shinohara;
- Jansen-West, Karen;
- Perkerson, Emilie;
- Castanedes-Casey, Monica;
- Rousseau, Linda;
- Phillips, Virginia;
- Guojun Bu;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Fryer, John D.
Publication type:
Article
Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models.
Published in:
Biomedicines, 2023, v. 11, n. 10, p. 2863, doi. 10.3390/biomedicines11102863
By:
- Lim, Melina J.;
- Boschen, Suelen L.;
- Kurti, Aishe;
- Castanedes Casey, Monica;
- Phillips, Virginia R.;
- Fryer, John D.;
- Dickson, Dennis;
- Jansen-West, Karen R.;
- Petrucelli, Leonard;
- Delenclos, Marion;
- McLean, Pamela J.
Publication type:
Article
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring.
Published in:
Journal of Neuroinflammation, 2014, v. 11, n. 1, p. 1, doi. 10.1186/s12974-014-0156-9
By:
- Kang, Silvia S.;
- Kurti, Aishe;
- Fair, Damien A.;
- Fryer, John D.
Publication type:
Article
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring.
Published in:
2014
By:
- Kang, Silvia S;
- Kurti, Aishe;
- Fair, Damien A;
- Fryer, John D
Publication type:
journal article
Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.
Published in:
2023
By:
- Qiao, Wenhui;
- Chen, Yixing;
- Zhong, Jun;
- Madden, Benjamin J.;
- Charlesworth, Cristine M.;
- Martens, Yuka A.;
- Liu, Chia-Chen;
- Knight, Joshua;
- Ikezu, Tadafumi C.;
- Aishe, Kurti;
- Zhu, Yiyang;
- Meneses, Axel;
- Rosenberg, Cassandra L.;
- Kuchenbecker, Lindsey A.;
- Vanmaele, Lucy K.;
- Li, Fuyao;
- Chen, Kai;
- Shue, Francis;
- Dacquel, Maxwell V.;
- Fryer, John
Publication type:
Correction Notice
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.
Published in:
Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00599-3
By:
- Qiao, Wenhui;
- Chen, Yixing;
- Zhong, Jun;
- Madden, Benjamin J.;
- Charlesworth, Cristine M.;
- Martens, Yuka A.;
- Liu, Chia-Chen;
- Knight, Joshua;
- Ikezu, Tadafumi C.;
- Aishe, Kurti;
- Zhu, Yiyang;
- Meneses, Axel;
- Rosenberg, Cassandra L.;
- Kuchenbecker, Lindsey A.;
- Vanmaele, Lucy K.;
- Li, Fuyao;
- Chen, Kai;
- Shue, Francis;
- Dacquel, Maxwell V.;
- Fryer, John
Publication type:
Article
Astrocyte-derived clusterin suppresses amyloid formation in vivo.
Published in:
Molecular Neurodegeneration, 2020, v. 15, n. 1, p. N.PAG, doi. 10.1186/s13024-020-00416-1
By:
- Wojtas, Aleksandra M.;
- Sens, Jonathon P.;
- Kang, Silvia S.;
- Baker, Kelsey E.;
- Berry, Taylor J.;
- Kurti, Aishe;
- Daughrity, Lillian;
- Jansen-West, Karen R.;
- Dickson, Dennis W.;
- Petrucelli, Leonard;
- Bu, Guojun;
- Liu, Chia-Chen;
- Fryer, John D.
Publication type:
Article
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy.
Published in:
Molecular Neurodegeneration, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s13024-019-0310-z
By:
- Chew, Jeannie;
- Cook, Casey;
- Gendron, Tania F.;
- Jansen-West, Karen;
- del Rosso, Giulia;
- Daughrity, Lillian M.;
- Castanedes-Casey, Monica;
- Kurti, Aishe;
- Stankowski, Jeannette N.;
- Disney, Matthew D.;
- Rothstein, Jeffrey D.;
- Dickson, Dennis W.;
- Fryer, John D.;
- Zhang, Yong-Jie;
- Petrucelli, Leonard
Publication type:
Article
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 13, p. 3848, doi. 10.1523/JNEUROSCI.3757-15.2016
By:
- Sakae, Nobutaka;
- Chia-Chen Liu;
- Shinohara, Mitsuru;
- Frisch-Daiello, Jessica;
- Li Ma;
- Yu Yamazaki;
- Tachibana, Masaya;
- Younkin, Linda;
- Kurti, Aishe;
- Carrasquillo, Minerva M.;
- Zou, Fanggeng;
- Sevlever, Daniel;
- Bisceglio, Gina;
- Gan, Ming;
- Fol, Romain;
- Knight, Patrick;
- Miao Wang;
- Xianlin Han;
- Fryer, John D.;
- Fitzgerald, Michael L.
Publication type:
Article

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