Works by Kunkel, Thomas A

Results: 102

Marginal Fit Comparison of CAD/CAM Crowns Milled from Two Different Materials.

Published in:

Journal of Prosthodontics (John Wiley & Sons, Inc.), 2018, v. 27, n. 5, p. 421, doi. 10.1111/jopr.12683

By:

Azarbal, Atousa;
Azarbal, Mohsen;
Engelmeier, Robert L.;
Kunkel, Thomas C.

Publication type:

Article

Push and pull of base flipping.

Published in:

Nature, 1996, v. 384, n. 6604, p. 25, doi. 10.1038/384025a0

By:

Kunkel, Thomas A.;
Wilson, Samuel H.

Publication type:

Article

Slippery DNA and diseases.

Published in:

Nature, 1993, v. 365, n. 6443, p. 207, doi. 10.1038/365207a0

By:

Kunkel, Thomas A.

Publication type:

Article

Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity.

Published in:

Nucleic Acids Research, 2010, v. 38, n. 10, p. 3233, doi. 10.1093/nar/gkq048

By:

Takata, Kei-ichi;
Arana, Mercedes E.;
Seki, Mineaki;
Kunkel, Thomas A.;
Wood, Richard D.

Publication type:

Article

Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase ζ.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 11, p. 3774, doi. 10.1093/nar/gkp238

By:

Stone, Jana E.;
Kissling, Grace E.;
Lujan, Scott A.;
Rogozin, Igor B.;
Stith, Carrie M.;
Burgers, Peter M. J.;
Kunkel, Thomas A.

Publication type:

Article

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases δ and η.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 9, p. 2830, doi. 10.1093/nar/gkp103

By:

McCulloch, Scott D.;
Kokoska, Robert J.;
Garg, Parie;
Burgers, Peter M.;
Kunkel, Thomas A.

Publication type:

Article

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 7, p. 2174, doi. 10.1093/nar/gkn062

By:

Pursell, Zachary F.;
McDonald, J. Tyson;
Mathews, Christopher K.;
Kunkel, Thomas A.

Publication type:

Article

Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 12, p. 3892, doi. 10.1093/nar/gkn312

By:

Zhong, Xuejun;
Pedersen, Lars C.;
Kunkel, Thomas A.

Publication type:

Article

Low-fidelity DNA synthesis by human DNA polymerase theta.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 11, p. 3847, doi. 10.1093/nar/gkn310

By:

Arana, Mercedes E.;
Seki, Mineaki;
Wood, Richard D.;
Rogozin, Igor B.;
Kunkel, Thomas A.

Publication type:

Article

Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase λ in human nuclear extracts.

Published in:

Nucleic Acids Research, 2008, v. 36, n. 9, p. 2895, doi. 10.1093/nar/gkn126

By:

Zhou, Rui-Zhe;
Blanco, Luis;
Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Povirk, Lawrence F.

Publication type:

Article

Multiple functions for the N-terminal region of Msh6.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 12, p. 4114, doi. 10.1093/nar/gkm409

By:

Clark, Alan B.;
Deterding, Leesa;
Tomer, Kenneth B.;
Kunkel, Thomas A.

Publication type:

Article

Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase ε.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 9, p. 3076, doi. 10.1093/nar/gkm132

By:

Pursell, Zachary F.;
Isoz, Isabelle;
Lundström, Else-Britt;
Johansson, Erik;
Kunkel, Thomas A.

Publication type:

Article

The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 17, p. 4731, doi. 10.1093/nar/gkl465

By:

Zhong, Xuejun;
Garg, Parie;
Stith, Carrie M.;
McElhinny, Stephanie A. Nick;
Kissling, Grace E.;
Burgers, Peter M. J.;
Kunkel, Thomas A.

Publication type:

Article

RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase δ.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 16, p. 4335, doi. 10.1093/nar/gkl403

By:

Fortune, John M.;
Stith, Carrie M.;
Kissling, Grace E.;
Burgers, Peter M. J.;
Kunkel, Thomas A.

Publication type:

Article

Promiscuous mismatch extension by human DNA polymerase lambda.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 11, p. 3259, doi. 10.1093/nar/gkl377

By:

Picher, Angel J.;
García-Díaz, Miguel;
Bebenek, Katarzyna;
Pedersen, Lars C.;
Kunkel, Thomas A.;
Blanco, Luis

Publication type:

Article

Enzymatic switching for efficient and accurate translesion DNA replication.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 15, p. 4665, doi. 10.1093/nar/gkh777

By:

McCulloch, Scott D.;
Kokoska, Robert J.;
Chilkova, Olga;
Welch, Carrie M.;
Johansson, Erik;
Burgers, Peter M. J.;
Kunkel, Thomas A.

Publication type:

Article

Roles of Saccharomyces cerevisiae DNA polymerases Polη and Polζ in response to irradiation by simulated sunlight.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 15, p. 4541, doi. 10.1093/nar/gkg489

By:

Kozmin, Stanislav G.;
Pavlov, Youri I.;
Kunkel, Thomas A.;
Sage, Evelyne

Publication type:

Article

DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 8, p. 2025, doi. 10.1093/nar/gkg324

By:

Hall, Mark C.;
Shcherbakova, Polina V.;
Fortune, John M.;
Borchers, Christoph H.;
Dial, J. Michael;
Tomer, Kenneth B.;
Kunkel, Thomas A.

Publication type:

Article

Deletion errors generated during replication of CAG repeats.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 17, p. 3481, doi. 10.1093/nar/27.17.3481

By:

Kroutil, Lisa C.;
Kunkel, Thomas A.

Publication type:

Article

Functional analysis of human MutSα and MutSβ complexes in yeast.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 3, p. 736, doi. 10.1093/nar/27.3.736

By:

Clark, Alan B.;
Cook, Molly E.;
Tran, Hiep T.;
Gordenin, Dmitry A.;
Resnick, Michael A.;
Kunkel, Thomas A.

Publication type:

Article

Efficiency, Fidelity and Enzymatic Switching During Translesion DNA Synthesis.

Published in:

Cell Cycle, 2004, v. 3, n. 5, p. 580, doi. 10.4161/cc.3.5.893

By:

McCulloch, Scott D.;
Kokoska, Robert J.;
Kunkel, Thomas A.

Publication type:

Article

Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.

Published in:

EMBO Journal, 2015, v. 34, n. 13, p. 1829, doi. 10.15252/embj.201489865

By:

Liu, Songbai;
Lu, Guojun;
Ali, Shafat;
Liu, Wenpeng;
Zheng, Li;
Dai, Huifang;
Li, Hongzhi;
Xu, Hong;
Hua, Yuejin;
Zhou, Yajing;
Ortega, Janice;
Li, Guo‐Min;
Kunkel, Thomas A;
Shen, Binghui

Publication type:

Article

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases.

Published in:

Cell Research, 2008, v. 18, n. 1, p. 148, doi. 10.1038/cr.2008.4

By:

McCulloch, Scott D.;
Kunkel, Thomas A.

Publication type:

Article

Polymerase δ replicates both strands after homologous recombination-dependent fork restart.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 932, doi. 10.1038/nsmb.3100

By:

Miyabe, Izumi;
Mizuno, Ken'Ichi;
Keszthelyi, Andrea;
Daigaku, Yasukazu;
Skouteri, Meliti;
Mohebi, Saed;
Kunkel, Thomas A;
Murray, Johanne M;
Carr, Antony M

Publication type:

Article

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 4, p. 291, doi. 10.1038/nsmb.2989

By:

Williams, Jessica S;
Clausen, Anders R;
Lujan, Scott A;
Marjavaara, Lisette;
Clark, Alan B;
Burgers, Peter M;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 3, p. 185, doi. 10.1038/nsmb.2957

By:

Clausen, Anders R;
Lujan, Scott A;
Burkholder, Adam B;
Orebaugh, Clinton D;
Williams, Jessica S;
Clausen, Maryam F;
Malc, Ewa P;
Mieczkowski, Piotr A;
Fargo, David C;
Smith, Duncan J;
Kunkel, Thomas A

Publication type:

Article

Delivering nonidentical twins.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 649, doi. 10.1038/nsmb.2852

By:

Kunkel, Thomas A;
Burgers, Peter M

Publication type:

Article

Sustained active site rigidity during synthesis by human DNA polymerase μ.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 3, p. 253, doi. 10.1038/nsmb.2766

By:

Moon, Andrea F;
Pryor, John M;
Ramsden, Dale A;
Kunkel, Thomas A;
Bebenek, Katarzyna;
Pedersen, Lars C

Publication type:

Article

Template strand scrunching during DNA gap repair synthesis by human polymerase λ.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 9, p. 967, doi. 10.1038/nsmb.1654

By:

Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Larrea, Andres A.;
Havener, Jody M.;
Perera, Lalith;
Krahn, Joseph M.;
Pedersen, Lars C.;
Ramsden, Dale A.;
Kunkel, Thomas A.

Publication type:

Article

Corrigendum: Structural insight into the substrate specificity of DNA Polymerase μ.

Published in:

2007

By:

Moon, Andrea F.;
Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Davis, Bryan J.;
Xuejun Zhong;
Ramsden, Dale A.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Correction Notice

Structural insight into the substrate specificity of DNA Polymerase μ.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 1, p. 45, doi. 10.1038/nsmb1180

By:

Moon, Andrea F.;
Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Davis, Bryan J.;
Zhong, Xuejun;
Ramsden, Dale A.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Article

A closed conformation for the Pol?catalytic cycle.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 97, doi. 10.1038/nsmb876

By:

Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Krahn, Joseph M.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Article

Complementation of an hMSH2 defect in human colorectal carcinoma cells by human chromosome 2 transfer.

Published in:

Molecular Carcinogenesis, 2000, v. 29, n. 1, p. 37, doi. 10.1002/1098-2744(200009)29:1<37::AID-MC5>3.0.CO;2-2

By:

Watanabe, Yoh;
Haugen-Strano, Astrid;
Umar, Asad;
Yamada, Kanae;
Hemmi, Hiromichi;
Kikuchi, Yoshinori;
Takano, Shoichi;
Shibata, Yoichiro;
Barrett, J. Carl;
Kunkel, Thomas A.;
Koi, Minoru

Publication type:

Article

Survival choices.

Published in:

Nature Cell Biology, 2006, v. 8, n. 6, p. 547, doi. 10.1038/ncb0606-547

By:

Kunkel, Thomas A.;
Van Houten, Bennett

Publication type:

Article

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Published in:

Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-05024-8

By:

Kaminski, Andrea M.;
Tumbale, Percy P.;
Schellenberg, Matthew J.;
Williams, R. Scott;
Williams, Jason G.;
Kunkel, Thomas A.;
Pedersen, Lars C.;
Bebenek, Katarzyna

Publication type:

Article

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03270-4

By:

Garbacz, Marta A.;
Lujan, Scott A.;
Burkholder, Adam B.;
Cox, Phillip B.;
Qiuqin Wu;
Zhi-Xiong Zhou;
Haber, James E.;
Kunkel, Thomas A.

Publication type:

Article

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00271-7

By:

Jamsen, Joonas A.;
Beard, William A.;
Pedersen, Lars C.;
Shock, David D.;
Moon, Andrea F.;
Krahn, Juno M.;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Wilson, Samuel H.

Publication type:

Article

Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.

Published in:

EMBO Journal, 2017, v. 36, n. 3, p. 361, doi. 10.15252/embj.201592426

By:

Huang, Shar‐yin N;
Williams, Jessica S;
Arana, Mercedes E;
Kunkel, Thomas A;
Pommier, Yves

Publication type:

Article

Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes.

Published in:

BMC Immunology, 2005, v. 6, p. 10, doi. 10.1186/1471-2172-6-10

By:

Mayorov, Vladimir I.;
Rogozin, Igor B.;
Adkison, Linda R.;
Frahm, Christin;
Kunkel, Thomas A.;
Pavlov, Youri I.

Publication type:

Article

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations.

Published in:

BMC Biology, 2004, v. 2, p. 11, doi. 10.1186/1741-7007-2-11

By:

Pavlov, Youri I.;
Maki, Satoko;
Maki, Hisaji;
Kunkel, Thomas A.

Publication type:

Article

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

Published in:

Nature, 2011, v. 474, n. 7350, p. 230, doi. 10.1038/nature10155

By:

Jirawatnotai, Siwanon;
Yiduo Hu;
Michowski, Wojciech;
Elias, Joshua E.;
Becks, Lisa;
Bienvenu, Frederic;
Zagozdzon, Agnieszka;
Goswami, Tapasree;
Yaoyu E. Wang;
Clark, Alan B.;
Kunkel, Thomas A.;
van Harn, Tanja;
Bing Xia;
Correll, Mick;
Quackenbush, John;
Livingston, David M.;
Gygi, Steven P.;
Sicinski, Piotr

Publication type:

Article

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ.

Published in:

EMBO Reports, 2008, v. 9, n. 5, p. 459, doi. 10.1038/embor.2008.33

By:

Bebenek, Katarzyna;
Garcia-Diaz, Miguel;
Foley, Meredith C;
Pedersen, Lars C;
Schlick, Tamar;
Kunkel, Thomas A

Publication type:

Article

High fidelity DNA ligation prevents single base insertions in the yeast genome.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53063-1

By:

Williams, Jessica S.;
Lujan, Scott. A.;
Arana, Mercedes E.;
Burkholder, Adam B.;
Tumbale, Percy P.;
Williams, R. Scott;
Kunkel, Thomas A.

Publication type:

Article

Cadmium is a mutagen that acts by inhibiting mismatch repair.

Published in:

Nature Genetics, 2003, v. 34, n. 3, p. 326, doi. 10.1038/ng1172

By:

Jin, Yong Hwan;
Clark, Alan B;
Slebos, Robbert J C;
Al-Refai, Hanan;
Taylor, Jack A;
Kunkel, Thomas A;
Resnick, Michael A;
Gordenin, Dmitry A

Publication type:

Article

Muver, a computational framework for accurately calling accumulated mutations.

Published in:

BMC Genomics, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s12864-018-4753-3

By:

Burkholder, Adam B.;
Lujan, Scott A.;
Lavender, Christopher A.;
Grimm, Sara A.;
Kunkel, Thomas A.;
Fargo, David C.

Publication type:

Article

Stimulation of Chromosomal Rearrangements by Ribonucleotides.

Published in:

Genetics, 2015, v. 201, n. 3, p. 951, doi. 10.1534/genetics.115.181149

By:

Conover, Hailey N.;
Lujan, Scott A.;
Chapman, Mary J.;
Cornelio, Deborah A.;
Sharif, Rabab;
Williams, Jessica S.;
Clark, Alan B.;
Camilo, Francheska;
Kunkel, Thomas A.;
Argueso, Juan Lucas

Publication type:

Article

MLH1 Mutations Differentially Affect Meiotic Functions in Saccharomyces cerevisiae.

Published in:

Genetics, 2003, v. 163, n. 2, p. 515, doi. 10.1093/genetics/163.2.515

By:

Hoffmann, Eva R.;
Shcherbakova, Polina V.;
Kunkel, Thomas A.;
Borts, Rhona H.

Publication type:

Article

In Vivo Consequences of Putative Active Site Mutations in Yeast DNA Polymerases...

Published in:

Genetics, 2001, v. 159, n. 1, p. 47, doi. 10.1093/genetics/159.1.47

By:

Pavlov, Youri I.;
Shcherbakova, Polina V.;
Kunkel, Thomas A.

Publication type:

Article

Functional overlap in mismatch repair by human MSH3 and MSH6.

Published in:

Genetics, 1998, v. 148, n. 4, p. 1637, doi. 10.1093/genetics/148.4.1637

By:

Umar, Asad;
Risinger, John I.;
Glaab, Warren E.;
Tindall, Kenneth R.;
Barrett, J. Carl;
Kunkel, Thomas A.

Publication type:

Article

Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11995-z

By:

Zhou, Zhi-Xiong;
Lujan, Scott A.;
Burkholder, Adam B.;
Garbacz, Marta A.;
Kunkel, Thomas A.

Publication type:

Article