Works matching AU Kunkel, Thomas A

Results: 101

Polymerase δ replicates both strands after homologous recombination-dependent fork restart.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 11, p. 932, doi. 10.1038/nsmb.3100

By:

Miyabe, Izumi;
Mizuno, Ken'Ichi;
Keszthelyi, Andrea;
Daigaku, Yasukazu;
Skouteri, Meliti;
Mohebi, Saed;
Kunkel, Thomas A;
Murray, Johanne M;
Carr, Antony M

Publication type:

Article

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 4, p. 291, doi. 10.1038/nsmb.2989

By:

Williams, Jessica S;
Clausen, Anders R;
Lujan, Scott A;
Marjavaara, Lisette;
Clark, Alan B;
Burgers, Peter M;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 3, p. 185, doi. 10.1038/nsmb.2957

By:

Clausen, Anders R;
Lujan, Scott A;
Burkholder, Adam B;
Orebaugh, Clinton D;
Williams, Jessica S;
Clausen, Maryam F;
Malc, Ewa P;
Mieczkowski, Piotr A;
Fargo, David C;
Smith, Duncan J;
Kunkel, Thomas A

Publication type:

Article

Delivering nonidentical twins.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 649, doi. 10.1038/nsmb.2852

By:

Kunkel, Thomas A;
Burgers, Peter M

Publication type:

Article

Sustained active site rigidity during synthesis by human DNA polymerase μ.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 3, p. 253, doi. 10.1038/nsmb.2766

By:

Moon, Andrea F;
Pryor, John M;
Ramsden, Dale A;
Kunkel, Thomas A;
Bebenek, Katarzyna;
Pedersen, Lars C

Publication type:

Article

Template strand scrunching during DNA gap repair synthesis by human polymerase λ.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 9, p. 967, doi. 10.1038/nsmb.1654

By:

Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Larrea, Andres A.;
Havener, Jody M.;
Perera, Lalith;
Krahn, Joseph M.;
Pedersen, Lars C.;
Ramsden, Dale A.;
Kunkel, Thomas A.

Publication type:

Article

Corrigendum: Structural insight into the substrate specificity of DNA Polymerase μ.

Published in:

2007

By:

Moon, Andrea F.;
Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Davis, Bryan J.;
Xuejun Zhong;
Ramsden, Dale A.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Correction Notice

Structural insight into the substrate specificity of DNA Polymerase μ.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 1, p. 45, doi. 10.1038/nsmb1180

By:

Moon, Andrea F.;
Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Davis, Bryan J.;
Zhong, Xuejun;
Ramsden, Dale A.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Article

Structural Insights into the Specificity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Family X DNA Polymerases.

Published in:

Genes, 2022, v. 13, n. 1, p. 15, doi. 10.3390/genes13010015

By:

Kaminski, Andrea M.;
Kunkel, Thomas A.;
Pedersen, Lars C.;
Bebenek, Katarzyna

Publication type:

Article

Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging.

Published in:

Genome Biology, 2020, v. 21, n. 1, p. N.PAG, doi. 10.1186/s13059-020-02138-5

By:

Lujan, Scott A.;
Longley, Matthew J.;
Humble, Margaret H.;
Lavender, Christopher A.;
Burkholder, Adam;
Blakely, Emma L.;
Alston, Charlotte L.;
Gorman, Grainne S.;
Turnbull, Doug M.;
McFarland, Robert;
Taylor, Robert W.;
Kunkel, Thomas A.;
Copeland, William C.

Publication type:

Article

Cadmium is a mutagen that acts by inhibiting mismatch repair.

Published in:

Nature Genetics, 2003, v. 34, n. 3, p. 326, doi. 10.1038/ng1172

By:

Jin, Yong Hwan;
Clark, Alan B;
Slebos, Robbert J C;
Al-Refai, Hanan;
Taylor, Jack A;
Kunkel, Thomas A;
Resnick, Michael A;
Gordenin, Dmitry A

Publication type:

Article

Response 1 to 'Smaller role for pol η?'.

Published in:

Nature Immunology, 2001, v. 2, n. 11, p. 983, doi. 10.1038/ni1101-983

By:

Rogozin, Igor B.;
Pavlov, Youri I.;
Kunkel, Thomas A.

Publication type:

Article

Somatic mutation hotspots correlate with DNA polymerase η error spectrum.

Published in:

Nature Immunology, 2001, v. 2, n. 6, p. 530, doi. 10.1038/88732

By:

Rogozin, Igor B.;
Pavlov, Youri I.;
Bebenek, Katarzyna;
Matsuda, Toshiro;
Kunkel, Thomas A.

Publication type:

Article

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31278-4

By:

Kaminski, Andrea M.;
Chiruvella, Kishore K.;
Ramsden, Dale A.;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Article

Biological asymmetries and the fidelity of eukaryotic DNA replication.

Published in:

BioEssays, 1992, v. 14, n. 5, p. 303, doi. 10.1002/bies.950140503

By:

Kunkel, Thomas A.

Publication type:

Article

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ.

Published in:

PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007290

By:

Terrados, Gloria;
Capp, Jean-Pascal;
Canitrot, Yvan;
García-Díaz, Miguel;
Bebenek, Katarzyna;
Kirchhoff, Tomas;
Villanueva, Alberto;
Boudsocq, François;
Bergoglio, Valé rie;
Cazaux, Christophe;
Kunkel, Thomas A.;
Hoffmann, Jean-Sébastien;
Blanco, Luis

Publication type:

Article

Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.

Published in:

EMBO Journal, 2017, v. 36, n. 3, p. 361, doi. 10.15252/embj.201592426

By:

Huang, Shar‐yin N;
Williams, Jessica S;
Arana, Mercedes E;
Kunkel, Thomas A;
Pommier, Yves

Publication type:

Article

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations.

Published in:

BMC Biology, 2004, v. 2, p. 11, doi. 10.1186/1741-7007-2-11

By:

Pavlov, Youri I.;
Maki, Satoko;
Maki, Hisaji;
Kunkel, Thomas A.

Publication type:

Article

A closed conformation for the Pol?catalytic cycle.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 97, doi. 10.1038/nsmb876

By:

Garcia-Diaz, Miguel;
Bebenek, Katarzyna;
Krahn, Joseph M.;
Kunkel, Thomas A.;
Pedersen, Lars C.

Publication type:

Article

DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae.

Published in:

Environmental & Molecular Mutagenesis, 2012, v. 53, n. 9, p. 777, doi. 10.1002/em.21728

By:

Stone, Jana E.;
Lujan, Scott A.;
Kunkel, Thomas A.

Publication type:

Article

Recurrence of secondary angiosarcoma in a patient with post-radiated breast for breast cancer.

Published in:

Archives of Gynecology & Obstetrics, 2008, v. 278, n. 5, p. 497, doi. 10.1007/s00404-008-0605-8

By:

Kunkel, Thomas;
Mylonas, Ioannis;
Mayr, Doris;
Friese, Klaus;
Sommer, Harald L.

Publication type:

Article

Stimulation of Chromosomal Rearrangements by Ribonucleotides.

Published in:

Genetics, 2015, v. 201, n. 3, p. 951, doi. 10.1534/genetics.115.181149

By:

Conover, Hailey N.;
Lujan, Scott A.;
Chapman, Mary J.;
Cornelio, Deborah A.;
Sharif, Rabab;
Williams, Jessica S.;
Clark, Alan B.;
Camilo, Francheska;
Kunkel, Thomas A.;
Argueso, Juan Lucas

Publication type:

Article

MLH1 Mutations Differentially Affect Meiotic Functions in Saccharomyces cerevisiae.

Published in:

Genetics, 2003, v. 163, n. 2, p. 515, doi. 10.1093/genetics/163.2.515

By:

Hoffmann, Eva R.;
Shcherbakova, Polina V.;
Kunkel, Thomas A.;
Borts, Rhona H.

Publication type:

Article

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Published in:

Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-05024-8

By:

Kaminski, Andrea M.;
Tumbale, Percy P.;
Schellenberg, Matthew J.;
Williams, R. Scott;
Williams, Jason G.;
Kunkel, Thomas A.;
Pedersen, Lars C.;
Bebenek, Katarzyna

Publication type:

Article

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03270-4

By:

Garbacz, Marta A.;
Lujan, Scott A.;
Burkholder, Adam B.;
Cox, Phillip B.;
Qiuqin Wu;
Zhi-Xiong Zhou;
Haber, James E.;
Kunkel, Thomas A.

Publication type:

Article

A Search Engine for the Investment Community: www.investmentseek.com.

Published in:

Journal of Alternative Investments, 2004, v. 7, n. 1, p. 102, doi. 10.3905/jai.2004.419609

By:

Kunkel, Thomas

Publication type:

Article

Fusing faculty development and student learning to address rapid curricular change.

Published in:

Journal of Dental Education, 2024, v. 88, p. 1820, doi. 10.1002/jdd.13446

By:

Horvath, Zsuzsa;
Kunkel, Thomas C.;
Potluri, Anitha

Publication type:

Article

Push and pull of base flipping.

Published in:

Nature, 1996, v. 384, n. 6604, p. 25, doi. 10.1038/384025a0

By:

Kunkel, Thomas A.;
Wilson, Samuel H.

Publication type:

Article

Slippery DNA and diseases.

Published in:

Nature, 1993, v. 365, n. 6443, p. 207, doi. 10.1038/365207a0

By:

Kunkel, Thomas A.

Publication type:

Article

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ.

Published in:

EMBO Reports, 2008, v. 9, n. 5, p. 459, doi. 10.1038/embor.2008.33

By:

Bebenek, Katarzyna;
Garcia-Diaz, Miguel;
Foley, Meredith C;
Pedersen, Lars C;
Schlick, Tamar;
Kunkel, Thomas A

Publication type:

Article

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20800-1

By:

Williams, Jessica S.;
Tumbale, Percy P.;
Arana, Mercedes E.;
Rana, Julian A.;
Williams, R. Scott;
Kunkel, Thomas A.

Publication type:

Article

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18506-5

By:

Kaminski, Andrea M.;
Pryor, John M.;
Ramsden, Dale A.;
Kunkel, Thomas A.;
Pedersen, Lars C.;
Bebenek, Katarzyna

Publication type:

Article

Arranging eukaryotic nuclear DNA polymerases for replication.

Published in:

BioEssays, 2017, v. 39, n. 8, p. n/a, doi. 10.1002/bies.201700070

By:

Kunkel, Thomas A.;
Burgers, Peter M. J.

Publication type:

Article

Passing the baton in base excision repair.

Published in:

Nature Structural Biology, 2000, v. 7, n. 3, p. 176

By:

Wilson, Samuel H.;
Kunkel, Thomas A.

Publication type:

Article

Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes.

Published in:

BMC Immunology, 2005, v. 6, p. 10, doi. 10.1186/1471-2172-6-10

By:

Mayorov, Vladimir I.;
Rogozin, Igor B.;
Adkison, Linda R.;
Frahm, Christin;
Kunkel, Thomas A.;
Pavlov, Youri I.

Publication type:

Article

Ribonucleotide incorporation into DNA during DNA replication and its consequences.

Published in:

2021

By:

Zhou, Zhi-Xiong;
Williams, Jessica S.;
Lujan, Scott A.;
Kunkel, Thomas A.

Publication type:

Literature Review

Eukaryotic genome instability in light of asymmetric DNA replication.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2016, v. 51, n. 1, p. 43, doi. 10.3109/10409238.2015.1117055

By:

Lujan, Scott A.;
Williams, Jessica S.;
Kunkel, Thomas A.

Publication type:

Article

Biochemical Basis of DNA Replication Fidelity.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 1993, v. 28, n. 2, p. 83, doi. 10.3109/10409239309086792

By:

Goodman, Myron F.;
Creighton, Steven;
Bloom, Linda B.;
Petruska, John;
Kunkel, Thomas A.

Publication type:

Article

The Multiple Biological Roles of the 3' → 5' Exonuclease of Saccharomyces cerevisiae DNA Polymerase S Require Switching between the Polymerase and Exonuclease Domains.

Published in:

Molecular & Cellular Biology, 2005, v. 25, n. 1, p. 461, doi. 10.1128/MCB.25.1.461-471.2005

By:

Yong Hwan Jin;
Garg, Pane;
Stith, Carrie M. W.;
Al-Refai, Hanan;
Sterling, Joan F.;
Murray, Laura J. W.;
Kunkel, Thomas A.;
Resnick, Michael A.;
Burger, Peter M.;
Gordeni, Dmitry A.

Publication type:

Article

A simple but profound mutation in mouse DNA polymerase ε drives tumorigenesis.

Published in:

2018

By:

Kunkel, Thomas A.

Publication type:

journal article

DNA replication and repair reactions relevant to the AHS.

Published in:

Journal of Biochemical & Molecular Toxicology, 2005, v. 19, n. 3, p. 190, doi. 10.1002/jbt.20082

By:

Kunkel, Thomas A.

Publication type:

Article

High fidelity DNA ligation prevents single base insertions in the yeast genome.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53063-1

By:

Williams, Jessica S.;
Lujan, Scott. A.;
Arana, Mercedes E.;
Burkholder, Adam B.;
Tumbale, Percy P.;
Williams, R. Scott;
Kunkel, Thomas A.

Publication type:

Article

Preferential cis-syn thymine dimer bypass by DNA polymerase ? occurs with biased fidelity.

Published in:

Nature, 2004, v. 428, n. 6978, p. 97, doi. 10.1038/nature02352

By:

McCulloch, Scott D.;
Kokoska, Robert J.;
Masutani, Chikahide;
Iwai, Shigenori;
Hanaoka, Fumio;
Kunkel, Thomas A.

Publication type:

Article

Instability throughout the Saccharomyces cerevisiae genome resulting from Pms1 endonuclease deficiency.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 16, p. 9574, doi. 10.1093/nar/gkae616

By:

Lujan, Scott A;
Garbacz, Marta A;
Liberti, Sascha E;
Burkholder, Adam B;
Kunkel, Thomas A

Publication type:

Article

Pif1 family helicases promote mutation avoidance during DNA replication.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 22, p. 12844, doi. 10.1093/nar/gkac1127

By:

Zhou, Zhi-Xiong;
Follonier, Cindy;
Lujan, Scott A;
Burkholder, Adam B;
Zakian, Virginia A;
Kunkel, Thomas A

Publication type:

Article

Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 2, p. 962, doi. 10.1093/nar/gkab1255

By:

Dahl, Joseph M;
Thomas, Natalie;
Tracy, Maxwell A;
Hearn, Brady L;
Perera, Lalith;
Kennedy, Scott R;
Herr, Alan J;
Kunkel, Thomas A

Publication type:

Article

The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 10, p. 5623, doi. 10.1093/nar/gkab371

By:

Kiktev, Denis A;
Dominska, Margaret;
Zhang, Tony;
Dahl, Joseph;
Stepchenkova, Elena I;
Mieczkowski, Piotr;
Burgers, Peter M;
Lujan, Scott;
Burkholder, Adam;
Kunkel, Thomas A;
Petes, Thomas D

Publication type:

Article

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2′-guanosine.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 17, p. 9410, doi. 10.1093/nar/gkz680

By:

Kaminski, Andrea M;
Chiruvella, Kishore K;
Ramsden, Dale A;
Kunkel, Thomas A;
Bebenek, Katarzyna;
Pedersen, Lars C

Publication type:

Article

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 8, p. 3986, doi. 10.1093/nar/gkz048

By:

Garbacz, Marta A;
Cox, Phillip B;
Sharma, Sushma;
Lujan, Scott A;
Chabes, Andrei;
Kunkel, Thomas A

Publication type:

Article

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00271-7

By:

Jamsen, Joonas A.;
Beard, William A.;
Pedersen, Lars C.;
Shock, David D.;
Moon, Andrea F.;
Krahn, Juno M.;
Bebenek, Katarzyna;
Kunkel, Thomas A.;
Wilson, Samuel H.

Publication type:

Article