Found: 29
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Haploinsufficiency of progranulin causes cell type specific impairments in PINK1/Parkin mitophagy.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.064195
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- Article
Haploinsufficiency of progranulin causes impairments in PINK/PARKIN mitophagy: Molecular and cell biology/TDP‐43.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042104
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- Article
N‐terminal phosphorylation of Fused in Sarcoma (FUS) protein results in distinct changes to the cellular proteome that differ from the P525L model of pathology: Developing topics.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047681
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- Article
Network analysis of the brain proteome of GRN knockout mice reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations: Developing topics.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047569
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- Article
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
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- Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40478-020-01037-x
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- Article
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.
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- Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.00033
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- Article
P4‐511: A NOVEL ROLE FOR THE FTD‐CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1509, doi. 10.1016/j.jalz.2019.08.057
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- Article
O2‐11‐03: PROGRANULIN LOSS DYSREGULATES SPLENIC AND PERIPHERAL BLOOD IMMUNE CELL POPULATIONS AND MAY CONTRIBUTE TO NEUROINFLAMMATION AND NEURODEGENERATION IN FRONTOTEMPORAL DEMENTIA.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P647, doi. 10.1016/j.jalz.2018.06.2702
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- Article
Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity.
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- Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 9, p. 1759, doi. 10.1002/pro.3212
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- Article
GRANULINS ARE STABLE LYSOSOMAL PROTEINS: IMPLICATIONS FOR THE ROLE OF PROGRANULIN IN ALZHEIMER’S DISEASE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P556, doi. 10.1016/j.jalz.2017.07.160
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- Article
TDP-43 PATHOLOGY DISRUPTS NUCLEAR PORE COMPLEXES AND NUCLEOCYTOPLASMIC TRANSPORT IN ALS/FTD.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P602, doi. 10.1016/j.jalz.2017.07.247
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- Article
Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
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- Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0114-3
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- Article
FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage.
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- Journal of Neuroscience, 2014, v. 34, n. 23, p. 7802, doi. 10.1523/JNEUROSCI.0172-14.2014
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- Article
Steroids as γ-secretase modulators.
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- FASEB Journal, 2013, v. 27, n. 9, p. 3775, doi. 10.1096/fj.12-225649
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- Article
Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells.
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- Journal of Neuroscience, 2013, v. 33, n. 21, p. 9202, doi. 10.1523/JNEUROSCI.5336-12.2013
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- Article
Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 39, doi. 10.1186/1750-1326-7-39
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- Article
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 53, doi. 10.1186/1750-1326-7-53
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Insight into the mechanism of gamma-secretase cleavage: Juxtamembrane amino acids are key to the length of secreted amyloid beta peptide
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- 2010
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- Abstract
IC-P3-212: Mapping the binding site of gamma-secretase modulators by small (and not so small) organic molecules
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- 2008
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- Abstract
P1-052: Somatic brain transgenic TDP-43 mice
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- 2008
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- Abstract
P2-338: Substrate-targeting gamma-secretase modulators
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- 2008
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- Abstract
P2-461: Selective modulation of gamma-secretase cleavage of the amyloid precursor family of proteins
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- 2008
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- Abstract
Substrate-targeting γ-secretase modulators.
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- Nature, 2008, v. 453, n. 7197, p. 925, doi. 10.1038/nature07055
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- Article
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
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- BMC Neuroscience, 2007, v. 8, p. 54, doi. 10.1186/1471-2202-8-54
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- Article
Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
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- FASEB Journal, 2006, v. 20, n. 10, p. 1671, doi. 10.1096/fj.06-5762com
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- Article
P4-289: Mechanistic insights into the in vitro and in vivo modulation of Aβ42 levels and amyloid pathology by NSAIDS and related compounds
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- 2006
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- Abstract
P4-289: Mechanistic insights into the in vitro and in vivo modulation of Aβ42 levels and amyloid pathology by NSAIDS and related compounds
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- 2006
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- Abstract
Inhibitors of Rho-kinase modulate amyloid-β (Aβ) secretion but lack selectivity for Aβ42.
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- Journal of Neurochemistry, 2006, v. 96, n. 2, p. 355, doi. 10.1111/j.1471-4159.2005.03553.x
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- Article
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aß42 production.
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- Nature Medicine, 2005, v. 11, n. 5, p. 545, doi. 10.1038/nm1235
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- Article