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PERK activation mitigates tau pathology in vitro and in vivo.
Published in:
EMBO Molecular Medicine, 2017, v. 9, n. 3, p. 371, doi. 10.15252/emmm.201606664
By:
- Bruch, Julius;
- Xu, Hong;
- Rösler, Thomas W;
- De Andrade, Anderson;
- Kuhn, Peer‐Hendrik;
- Lichtenthaler, Stefan F;
- Arzberger, Thomas;
- Winklhofer, Konstanze F;
- Müller, Ulrich;
- Höglinger, Günter U
Publication type:
Article
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
Published in:
EMBO Molecular Medicine, 2016, v. 8, n. 5, p. 458, doi. 10.15252/emmm.201505952
By:
- Kretner, Benedikt;
- Trambauer, Johannes;
- Fukumori, Akio;
- Mielke, Janina;
- Kuhn, Peer‐Hendrik;
- Kremmer, Elisabeth;
- Giese, Armin;
- Lichtenthaler, Stefan F;
- Haass, Christian;
- Arzberger, Thomas;
- Steiner, Harald
Publication type:
Article
Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain.
Published in:
Glia, 2019, v. 67, n. 2, p. 393, doi. 10.1002/glia.23550
By:
- Heiland, Tina;
- Zeitschel, Ulrike;
- Puchades, Maja A.;
- Kuhn, Peer‐Hendrik;
- Lichtenthaler, Stefan F.;
- Bjaalie, Jan G.;
- Hartlage‐Rübsamen, Maike;
- Roßner, Steffen;
- Höfling, Corinna
Publication type:
Article
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.12748
By:
- Kuhn, Peer-Hendrik;
- Colombo, Alessio Vittorio;
- Schusser, Benjamin;
- Dreymueller, Daniela;
- Wetzel, Sebastian;
- Schepers, Ute;
- Herber, Julia;
- Ludwig, Andreas;
- Kremmer, Elisabeth;
- Montag, Dirk;
- Müller, Ulrike;
- Schweizer, Michaela;
- Saftig, Paul;
- Bräse, Stefan;
- Lichtenthaler, Stefan F.
Publication type:
Article
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Published in:
EMBO Journal, 2020, v. 39, n. 15, p. 1, doi. 10.15252/embj.2019103457
By:
- Pigoni, Martina;
- Hsia, Hung‐En;
- Hartmann, Jana;
- Rudan Njavro, Jasenka;
- Shmueli, Merav D;
- Müller, Stephan A;
- Güner, Gökhan;
- Tüshaus, Johanna;
- Kuhn, Peer‐Hendrik;
- Kumar, Rohit;
- Gao, Pan;
- Tran, Mai Ly;
- Ramazanov, Bulat;
- Blank, Birgit;
- Hipgrave Ederveen, Agnes L;
- Von Blume, Julia;
- Mulle, Christophe;
- Gunnersen, Jenny M;
- Wuhrer, Manfred;
- Rammes, Gerhard
Publication type:
Article
Therapeutic potential of BACE1/beta-secretase: Proteome-wide identification of physiological BACE1 substrates in primary neurons and mouse brain
Published in:
2012
By:
- Lichtenthaler, Stefan;
- Dislich, Bastian;
- Hogl, Sebastian;
- Colombo, Alessio;
- Zeitschel, Ulrike;
- Willem, Michael;
- Haass, Christian;
- Volbracht, Christiane;
- Roßner, Steffen;
- Kuhn, Peer-Hendrik
Publication type:
Abstract
Systematic identification of proteases with alpha-secretase activity
Published in:
2009
By:
- Lichtenthaler, Stefan F.;
- Dislich, Bastian;
- Wang, Huanhuan;
- Zeitschel, Ulrike;
- Rossner, Steffen;
- Haass, Christian;
- Kuhn, Peer-Hendrik
Publication type:
Abstract
P3-233: Interleukin-1 receptor II undergoes a similar set of proteolytic cleavages as the amyloid precursor protein
Published in:
2006
By:
- Kuhn, Peer-Hendrik;
- Haass, Christian;
- Lichtenthaler, Stefan F.
Publication type:
Abstract
P3-233: Interleukin-1 receptor II undergoes a similar set of proteolytic cleavages as the amyloid precursor protein
Published in:
2006
By:
- Kuhn, Peer-Hendrik;
- Haass, Christian;
- Lichtenthaler, Stefan F.
Publication type:
Abstract
The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control.
Published in:
PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0135618
By:
- Hadjipanayi, Ektoras;
- Kuhn, Peer-Hendrik;
- Moog, Philipp;
- Bauer, Anna-Theresa;
- Kuekrek, Haydar;
- Mirzoyan, Lilit;
- Hummel, Anja;
- Kirchhoff, Katharina;
- Salgin, Burak;
- Isenburg, Sarah;
- Dornseifer, Ulf;
- Ninkovic, Milomir;
- Machens, Hans-Günther;
- Schilling, Arndt F.
Publication type:
Article
Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and &ggr;-Secretase.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021337
By:
- Hogl, Sebastian;
- Kuhn, Peer-Hendrik;
- Colombo, Alessio;
- Lichtenthaler, Stefan F.
Publication type:
Article
An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.
Published in:
Proteomics, 2017, v. 17, n. 5, p. 1, doi. 10.1002/pmic.201600423
By:
- Serdaroglu, Alperen;
- Müller, Stephan A.;
- Schepers, Ute;
- Bräse, Stefan;
- Weichert, Wilko;
- Lichtenthaler, Stefan F.;
- Kuhn, Peer‐Hendrik
Publication type:
Article
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Published in:
Proteomics, 2013, v. 13, n. 9, p. 1519, doi. 10.1002/pmic.201200582
By:
- Hogl, Sebastian;
- Bebber, Frauke;
- Dislich, Bastian;
- Kuhn, Peer‐Hendrik;
- Haass, Christian;
- Schmid, Bettina;
- Lichtenthaler, Stefan F.
Publication type:
Article
The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.
Published in:
Cancer Immunology, Immunotherapy, 2021, v. 70, n. 6, p. 1679, doi. 10.1007/s00262-020-02813-3
By:
- Willvonseder, Barbara;
- Stögbauer, Fabian;
- Steiger, Katja;
- Jesinghaus, Moritz;
- Kuhn, Peer-Hendrik;
- Brambs, Christine;
- Engel, Jutta;
- Bronger, Holger;
- Schmidt, Georg Philipp;
- Haller, Bernhard;
- Weichert, Wilko;
- Keller, Gisela;
- Noske, Aurelia;
- Pfarr, Nicole;
- Boxberg, Melanie
Publication type:
Article
Non‐cell‐autonomous function of DR6 in Schwann cell proliferation.
Published in:
EMBO Journal, 2018, v. 37, n. 7, p. 1, doi. 10.15252/embj.201797390
By:
- Colombo, Alessio;
- Hsia, Hung‐En;
- Wang, Mengzhe;
- Kuhn, Peer‐Hendrik;
- Brill, Monika S.;
- Canevazzi, Paolo;
- Feederle, Regina;
- Taveggia, Carla;
- Misgeld, Thomas;
- Lichtenthaler, Stefan F.
Publication type:
Article
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
Published in:
EMBO Journal, 2016, v. 35, n. 21, p. 2350, doi. 10.15252/embj.201694221
By:
- Schwenk, Benjamin M;
- Hartmann, Hannelore;
- Serdaroglu, Alperen;
- Schludi, Martin H;
- Hornburg, Daniel;
- Meissner, Felix;
- Orozco, Denise;
- Colombo, Alessio;
- Tahirovic, Sabina;
- Michaelsen, Meike;
- Schreiber, Franziska;
- Haupt, Simone;
- Peitz, Michael;
- Brüstle, Oliver;
- Küpper, Clemens;
- Klopstock, Thomas;
- Otto, Markus;
- Ludolph, Albert C;
- Arzberger, Thomas;
- Kuhn, Peer‐Hendrik
Publication type:
Article
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 ( SPPL3) regulates cellular N-glycosylation.
Published in:
EMBO Journal, 2014, v. 33, n. 24, p. 2890, doi. 10.15252/embj.201488375
By:
- Voss, Matthias;
- Künzel, Ulrike;
- Higel, Fabian;
- Kuhn, Peer‐Hendrik;
- Colombo, Alessio;
- Fukumori, Akio;
- Haug‐Kröper, Martina;
- Klier, Bärbel;
- Grammer, Gudula;
- Seidl, Andreas;
- Schröder, Bernd;
- Obst, Reinhard;
- Steiner, Harald;
- Lichtenthaler, Stefan F;
- Haass, Christian;
- Fluhrer, Regina
Publication type:
Article
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Published in:
EMBO Journal, 2012, v. 31, n. 14, p. 3157, doi. 10.1038/emboj.2012.173
By:
- Kuhn, Peer-Hendrik;
- Koroniak, Katarzyna;
- Hogl, Sebastian;
- Colombo, Alessio;
- Zeitschel, Ulrike;
- Willem, Michael;
- Volbracht, Christiane;
- Schepers, Ute;
- Imhof, Axel;
- Hoffmeister, Albrecht;
- Haass, Christian;
- Roßner, Steffen;
- Bräse, Stefan;
- Lichtenthaler, Stefan F
Publication type:
Article
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons.
Published in:
EMBO Journal, 2010, v. 29, n. 17, p. 3020, doi. 10.1038/emboj.2010.167
By:
- Kuhn, Peer-Hendrik;
- Wang, Huanhuan;
- Dislich, Bastian;
- Colombo, Alessio;
- Zeitschel, Ulrike;
- Ellwart, Joachim W;
- Kremmer, Elisabeth;
- Roßner, Steffen;
- Lichtenthaler, Stefan F
Publication type:
Article
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45298-6
By:
- Bartels, Martin;
- Weckbecker, Daniel;
- Kuhn, Peer-Hendrik;
- Ryazanov, Sergey;
- Leonov, Andrei;
- Griesinger, Christian;
- Lichtenthaler, Stefan F.;
- Bötzel, Kai;
- Giese, Armin
Publication type:
Article
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production.
Published in:
Nature Cell Biology, 2006, v. 8, n. 8, p. 843, doi. 10.1038/ncb1440
By:
- Friedmann, Elena;
- Hauben, Ehud;
- Maylandt, Kerstin;
- Schleeger, Simone;
- Vreugde, Sarah;
- Lichtenthaler, Stefan F.;
- Kuhn, Peer-Hendrik;
- Stauffer, Daniela;
- Rovelli, Giorgio;
- Martoglio, Bruno
Publication type:
Article
Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.
Published in:
FASEB Journal, 2020, v. 34, n. 2, p. 2465, doi. 10.1096/fj.201902347R
By:
- Rudan Njavro, Jasenka;
- Klotz, Jakob;
- Dislich, Bastian;
- Wanngren, Johanna;
- Shmueli, Merav D.;
- Herber, Julia;
- Kuhn, Peer‐Hendrik;
- Kumar, Rohit;
- Koeglsperger, Thomas;
- Conrad, Marcus;
- Wurst, Wolfgang;
- Feederle, Regina;
- Vlachos, Andreas;
- Michalakis, Stylianos;
- Jedlicka, Peter;
- Müller, Stephan A.;
- Lichtenthaler, Stefan F.
Publication type:
Article
γ-secretase directly sheds the survival receptor BCMA from plasma cells.
Published in:
Nature Communications, 2015, v. 6, n. 6, p. 7333, doi. 10.1038/ncomms8333
By:
- Laurent, Sarah A.;
- Hoffmann, Franziska S.;
- Kuhn, Peer-Hendrik;
- Cheng, Qingyu;
- Chu, Yuanyuan;
- Schmidt-Supprian, Marc;
- Hauck, Stefanie M.;
- Schuh, Elisabeth;
- Krumbholz, Markus;
- Rübsamen, Heike;
- Wanngren, Johanna;
- Khademi, Mohsen;
- Olsson, Tomas;
- Alexander, Tobias;
- Hiepe, Falk;
- Pfister, Hans-Walter;
- Weber, Frank;
- Jenne, Dieter;
- Wekerle, Hartmut;
- Hohlfeld, Reinhard
Publication type:
Article
QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain.
Published in:
Frontiers in Neuroinformatics, 2019, v. 13, p. 1, doi. 10.3389/fninf.2019.00075
By:
- Yates, Sharon C.;
- Groeneboom, Nicolaas E.;
- Coello, Christopher;
- Lichtenthaler, Stefan F.;
- Kuhn, Peer-Hendrik;
- Demuth, Hans-Ulrich;
- Hartlage-Rübsamen, Maike;
- Roßner, Steffen;
- Leergaard, Trygve;
- Kreshuk, Anna;
- Puchades, Maja A.;
- Bjaalie, Jan G.
Publication type:
Article
Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma.
Published in:
2020
By:
- Jesinghaus, Moritz;
- Steiger, Katja;
- Stögbauer, Fabian;
- Haller, Bernhard;
- Kolk, Andreas;
- Straßen, Ulrich;
- Pickhard, Anja;
- Wirth, Markus;
- Silva, Miguel;
- Budczies, Jan;
- Becker von Rose, Aaron;
- Konukiewitz, Björn;
- Kuhn, Peer;
- Klinghammer, Konrad;
- Dapper, Hendrik;
- Münch, Stefan;
- Combs, Stephanie E.;
- Weichert, Wilko;
- Boxberg, Melanie
Publication type:
journal article
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
Published in:
Journal of Neurochemistry, 2014, v. 130, n. 1, p. 4, doi. 10.1111/jnc.12715
By:
- Vassar, Robert;
- Kuhn, Peer‐Hendrik;
- Haass, Christian;
- Kennedy, Matthew E.;
- Rajendran, Lawrence;
- Wong, Philip C.;
- Lichtenthaler, Stefan F.
Publication type:
Article
Important functional role of residue x of the presenilin Gx GD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
Published in:
Journal of Neurochemistry, 2013, v. 125, n. 1, p. 144, doi. 10.1111/jnc.12124
By:
- Kretner, Benedikt;
- Fukumori, Akio;
- Kuhn, Peer‐Hendrik;
- Pérez‐Revuelta, Blanca Isabel;
- Lichtenthaler, Stefan F.;
- Haass, Christian;
- Steiner, Harald
Publication type:
Article
Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU.
Published in:
Diagnostics (2075-4418), 2024, v. 14, n. 3, p. 294, doi. 10.3390/diagnostics14030294
By:
- Lahmer, Tobias;
- Weirich, Gregor;
- Porubsky, Stefan;
- Rasch, Sebastian;
- Kammerstetter, Florian A.;
- Schustetter, Christian;
- Schüffler, Peter;
- Erber, Johanna;
- Dibos, Miriam;
- Delbridge, Claire;
- Kuhn, Peer Hendrik;
- Jeske, Samuel;
- Steinhardt, Manuel;
- Chaker, Adam;
- Heim, Markus;
- Heemann, Uwe;
- Schmid, Roland M.;
- Weichert, Wilko;
- Stock, Konrad Friedrich;
- Slotta-Huspenina, Julia
Publication type:
Article
Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease.
Published in:
Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00137
By:
- Höfling, Corinna;
- Shehabi, Emira;
- Kuhn, Peer-Hendrik;
- Lichtenthaler, Stefan F.;
- Hartlage-Rübsamen, Maike;
- Roßner, Steffen
Publication type:
Article
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0134-z
By:
- Pigoni, Martina;
- Wanngren, Johanna;
- Kuhn, Peer-Hendrik;
- Munro, Kathryn M.;
- Gunnersen, Jenny M.;
- Takeshima, Hiroshi;
- Feederle, Regina;
- Voytyuk, Iryna;
- De Strooper, Bart;
- Levasseur, Mikail D.;
- Hrupka, Brian J.;
- Müller, Stephan A.;
- Lichtenthaler, Stefan F.
Publication type:
Article
Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.
Published in:
Molecules, 2018, v. 23, n. 4, p. 924, doi. 10.3390/molecules23040924
By:
- Hartlage-Rübsamen, Maike;
- Bluhm, Alexandra;
- Piechotta, Anke;
- Linnert, Miriam;
- Rahfeld, Jens-Ulrich;
- Demuth, Hans-Ulrich;
- Lues, Inge;
- Kuhn, Peer-Hendrik;
- Lichtenthaler, Stefan F.;
- Roßner, Steffen;
- Höfling, Corinna;
- Schilling, Stephan
Publication type:
Article
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Published in:
PLoS ONE, 2018, p. 1, doi. 10.1371/journal.pone.0200344
By:
- Causevic, Mirsada;
- Dominko, Kristina;
- Malnar, Martina;
- Vidatic, Lea;
- Cermak, Stjepko;
- Pigoni, Martina;
- Kuhn, Peer-Hendrik;
- Colombo, Alessio;
- Havas, Daniel;
- Flunkert, Stefanie;
- McDonald, Jessica;
- Gunnersen, Jenny M.;
- Hutter-Paier, Birgit;
- Tahirovic, Sabina;
- Windisch, Manfred;
- Krainc, Dimitri;
- Lichtenthaler, Stefan F.;
- Hecimovic, Silva
Publication type:
Article
Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies.
Published in:
Aging Cell, 2016, v. 15, n. 5, p. 953, doi. 10.1111/acel.12508
By:
- Höfling, Corinna;
- Morawski, Markus;
- Zeitschel, Ulrike;
- Zanier, Elisa R.;
- Moschke, Katrin;
- Serdaroglu, Alperen;
- Canneva, Fabio;
- Hörsten, Stephan;
- De Simoni, Maria‐Grazia;
- Forloni, Gianluigi;
- Jäger, Carsten;
- Kremmer, Elisabeth;
- Roßner, Steffen;
- Lichtenthaler, Stefan F.;
- Kuhn, Peer‐Hendrik
Publication type:
Article
Loss of PAFAH1B2 Reduces Amyloid-β Generation by Promoting the Degradation of Amyloid Precursor Protein C-Terminal Fragments.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 50, p. 18204, doi. 10.1523/JNEUROSCI.2681-12.2012
By:
- Page, Richard M.;
- Münch, Anna;
- Horn, Thomas;
- Kuhn, Peer-Hendrik;
- Colombo, Alessio;
- Reiner, Orly;
- Boutros, Michael;
- Steiner, Harald;
- Lichtenthaler, Stefan F.;
- Haass, Christian
Publication type:
Article
Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.
Published in:
BMC Medical Genetics, 2012, v. 13, n. 1, p. 35, doi. 10.1186/1471-2350-13-35
By:
- Augustin, Regina;
- Endres, Kristina;
- Reinhardt, Sven;
- Kuhn, Peer-Hendrik;
- Lichtenthaler, Stefan F.;
- Hansen, Jens;
- Wurst, Wolfgang;
- Tr�mbach, Dietrich
Publication type:
Article

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