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Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 3, p. 1637, doi. 10.1002/alz.13569
By:
- Kotah, Janssen M.;
- Kater, Mandy S. J.;
- Brosens, Niek;
- Lesuis, Sylvie L.;
- Tandari, Roberta;
- Blok, Thomas M.;
- Marchetto, Luca;
- Yusaf, Ella;
- Koopmans, Frank T. W.;
- Smit, August B.;
- Lucassen, Paul J.;
- Krugers, Harm J.;
- Verheijen, Mark H. G.;
- Korosi, Aniko
Publication type:
Article
Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077781
By:
- Carrigan, Maria;
- Van der Lee, Sven J;
- van Loenhoud, Anna C.;
- Bocancea, Diana I.;
- Groot, Colin;
- Barkhof, Frederik;
- Krugers, Harm J.;
- Lucassen, Paul J.;
- van der Flier, Wiesje M.;
- Ossenkoppele, Rik
Publication type:
Article
Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077781
By:
- Carrigan, Maria;
- Van der Lee, Sven J;
- van Loenhoud, Anna C.;
- Bocancea, Diana I.;
- Groot, Colin;
- Barkhof, Frederik;
- Krugers, Harm J.;
- Lucassen, Paul J.;
- van der Flier, Wiesje M.;
- Ossenkoppele, Rik
Publication type:
Article
Calbindin-D28K and Parvalbumin Immunoreactivity in the Rat Hippocampus following Adrenalectomy and Corticosterone Treatment.
Published in:
Annals of the New York Academy of Sciences, 1994, v. 746, n. 1, p. 463, doi. 10.1111/j.1749-6632.1994.tb39286.x
By:
- KRUGERS, HARM J.;
- MEDEMA, RIKJE M.;
- POSTEMA, FOLKERT;
- KORF, JAKOB
Publication type:
Article
Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve.
Published in:
Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0422-7
By:
- Lesuis, Sylvie L.;
- Hoeijmakers, Lianne;
- Korosi, Aniko;
- de Rooij, Susanne R.;
- Swaab, Dick F.;
- Kessels, Helmut W.;
- Lucassen, Paul J.;
- Krugers, Harm J.
Publication type:
Article
LTP after Stress: Up or Down?
Published in:
Neural Plasticity, 2007, v. 2007, p. 1, doi. 10.1155/2007/93202
By:
- Joëls, Marian;
- Krugers, Harm J.
Publication type:
Article
EARLY LIFE STRESS ACCELERATES AMYLOID PATHOLOGY AND COGNITIVE DECLINE IN APPSWE/PS1DE9 MICE, BUT CAN BE RESCUED BY BRIEFLY BLOCKING GLUCOCORTICOID RECEPTORS AT MIDDLE AGE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1479, doi. 10.1016/j.jalz.2017.07.555
By:
- Lucassen, Paul J.;
- Lesuis, Sylvie L.;
- Weggen, Sascha;
- Baches, Sandra;
- Krugers, Harm J.
Publication type:
Article
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
Published in:
Nature Genetics, 2002, v. 32, n. 1, p. 116, doi. 10.1038/ng954
By:
- Hoogenraad, Casper C.;
- Koekkoek, Bas;
- Akhmanova, Anna;
- Krugers, Harm;
- Dortland, Bjorn;
- Miedema, Marja;
- van Alphen, Arjan;
- Kistler, Werner M.;
- Jaegle, Martine;
- Koutsourakis, Manoussos;
- Van Camp, Nadja;
- Verhoye, Marleen;
- van der Linden, Annemie;
- Kaverina, Irina;
- Grosveld, Frank;
- De Zeeuw, Chris I.;
- Galjart, Niels
Publication type:
Article
Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145706
By:
- Kanatsou, Sofia;
- Fearey, Brenna C.;
- Kuil, Laura E.;
- Lucassen, Paul J.;
- Harris, Anjanette P.;
- Seckl, Jonathan R.;
- Krugers, Harm;
- Joels, Marian
Publication type:
Article
Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity.
Published in:
PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0142012
By:
- Kanatsou, Sofia;
- Fearey, Brenna C.;
- Kuil, Laura E.;
- Lucassen, Paul J.;
- Harris, Anjanette P.;
- Seckl, Jonathan R.;
- Krugers, Harm;
- Joels, Marian
Publication type:
Article
Mineralocorticoid Receptors Guide Spatial and Stimulus-Response Learning in Mice.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086236
By:
- Arp, J. Marit;
- ter Horst, Judith P.;
- Kanatsou, Sofia;
- Fernández, Guillén;
- Joëls, Marian;
- Krugers, Harm J.;
- Oitzl, Melly S.
Publication type:
Article
Dendritic Morphology of Hippocampal and Amygdalar Neurons in Adolescent Mice Is Resilient to Genetic Differences in Stress Reactivity.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038971
By:
- Pillai, Anup G.;
- Danielle de Jong;
- Kanatsou, Sofia;
- Krugers, Harm;
- Knapman, Alana;
- Heinzmann, Jan-Michael;
- Holsboer, Florian;
- Landgraf, Rainer;
- Joëls, Marian;
- Touma, Chadi
Publication type:
Article
Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037820
By:
- Van Hasselt, Felisa N.;
- De Visser, Leonie;
- Tieskens, Jacintha M.;
- Cornelisse, Sandra;
- Baars, Annemarie M.;
- Lavrijsen, Marla;
- Krugers, Harm J.;
- Van den Bos, Ruud;
- Joëls, Marian
Publication type:
Article
Blocking Mineralocorticoid Receptors prior to Retrieval Reduces Contextual Fear Memory in Mice.
Published in:
PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026220
By:
- Ming Zhou;
- Kindt, Merel;
- Joëls, Marian;
- Krugers, Harm J.
Publication type:
Article
Opposite Effects of Early Maternal Deprivation on Neurogenesis in Male versus Female Rats.
Published in:
PLoS ONE, 2009, v. 4, n. 1, p. 1, doi. 10.1371/journal.pone.0003675
By:
- Oomen, Charlotte A.;
- Girardi, Carlos E. N.;
- Cahyadi, Rudy;
- Verbeek, Eva C.;
- Krugers, Harm;
- Joëls, Marian;
- Lucassen, Paul J.
Publication type:
Article
Postischemic Steroid Modulation: Effects on Hippocampal Neuronal Integrity and Synaptic Plasticity.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 1999, v. 19, n. 10, p. 1072, doi. 10.1097/00004647-199910000-00003
By:
- Krugers, Harm J;
- Maslam, Suharti;
- Van Vuuren, Sandra M;
- Korf, Jakob;
- Joëls, Marian
Publication type:
Article
Metyrapone Reduces Rat Brain Damage and Seizures After Hypoxia-Ischemia: An Effect Independent of Modulation of Plasma Corticosterone Levels?
Published in:
Journal of Cerebral Blood Flow & Metabolism, 1998, v. 18, n. 4, p. 386, doi. 10.1097/00004647-199804000-00006
By:
- Krugers, Harm J;
- Kemper, Richard H A;
- Korf, Jakob;
- Ter Horst, Gert J;
- Knollema, Siert
Publication type:
Article
The Subjective Experience of Ageism: The Perceived Ageism Questionnaire (PAQ).
Published in:
International Journal of Environmental Research & Public Health, 2022, v. 19, n. 14, p. 8792, doi. 10.3390/ijerph19148792
By:
- Brinkhof, Lotte P.;
- de Wit, Sanne;
- Murre, Jaap M. J.;
- Krugers, Harm J.;
- Ridderinkhof, K. Richard
Publication type:
Article
Early life stress lastingly alters the function and AMPA‐receptor composition of glutamatergic synapses in the hippocampus of male mice.
Published in:
Journal of Neuroendocrinology, 2023, v. 35, n. 12, p. 1, doi. 10.1111/jne.13346
By:
- Brosens, Niek;
- Simon, Carla;
- Kessels, Helmut W.;
- Lucassen, Paul J.;
- Krugers, Harm J.
Publication type:
Article
Glucocorticoid and β‐adrenergic regulation of hippocampal dendritic spines.
Published in:
Journal of Neuroendocrinology, 2020, v. 32, n. 1, p. N.PAG, doi. 10.1111/jne.12811
By:
- Lesuis, Sylvie L.;
- Timmermans, Wendy;
- Lucassen, Paul J.;
- Hoogenraad, Casper C.;
- Krugers, Harm J.
Publication type:
Article
Overexpression of Mineralocorticoid Receptors in the Mouse Forebrain Partly Alleviates the Effects of Chronic Early Life Stress on Spatial Memory, Neurogenesis and Synaptic Function in the Dentate Gyrus.
Published in:
Frontiers in Cellular Neuroscience, 2017, p. 1, doi. 10.3389/fncel.2017.00132
By:
- Kanatsou, Sofia;
- Karst, Henk;
- Kortesidou, Despoina;
- van den Akker, Rachelle A.;
- den Blaauwen, Jan;
- Harris, Anjanette P.;
- Seckl, Jonathan R.;
- Krugers, Harm J.;
- Joels, Marian
Publication type:
Article
Psychological Coping and Behavioral Adjustment Among Older Adults in Times of COVID-19: Exploring the Protective Role of Working Memory and Habit Propensity.
Published in:
Journal of Adult Development, 2022, v. 29, n. 3, p. 240, doi. 10.1007/s10804-022-09404-9
By:
- Brinkhof, Lotte P.;
- Ridderinkhof, K. Richard;
- van de Vijver, Irene;
- Murre, Jaap M. J.;
- Krugers, Harm J.;
- de Wit, Sanne
Publication type:
Article
Severe Early Life Stress Hampers Spatial Learning and Neurogenesis, but Improves Hippocampal Synaptic Plasticity and Emotional Learning under High-Stress Conditions in Adulthood.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 19, p. 6635, doi. 10.1523/JNEUROSCI.0247-10.2010
By:
- Oomen, Charlotte A.;
- Soeters, Heleen;
- Audureau, Nathalie;
- Vermunt, Lisa;
- Hasselt, Felisa N. van;
- Manders, Erik M. M.;
- Joës, Marian;
- Lucassen, Paul J.;
- Krugers, Harm
Publication type:
Article
Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress.
Published in:
Journal of Neuroscience, 2008, v. 28, n. 23, p. 6037, doi. 10.1523/JNEUROSCI.0526-08.2008
By:
- Champagne, Danielle L.;
- Bagot, Rosemary C.;
- van Hasselt, Felisa;
- Ramakers, Ger;
- Meaney, Michael J.;
- de Kloet, E. Ronald;
- Joëls, Marian;
- Krugers, Harm
Publication type:
Article
Improved Long-Term Potentiation and Memory in Young Tau-P301L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy.
Published in:
Journal of Neuroscience, 2006, v. 26, n. 13, p. 3514, doi. 10.1523/JNEUROSCI.5425-05.2006
By:
- Boekhoorn, Karin;
- Terwel, Dick;
- Biemans, Barbara;
- Borghgraef, Peter;
- Wiegert, Olof;
- Ramakers, Ger J. A.;
- De Vos, Koos;
- Krugers, Harm;
- Tomiyama, Takami;
- Mori, Hiroshi;
- Joels, Marian;
- Van Leuven, Fred;
- Lucassen, Paul J.
Publication type:
Article
Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum.
Published in:
Neuropsychopharmacology, 2015, v. 40, n. 4, p. 947, doi. 10.1038/npp.2014.271
By:
- Vogel, Susanne;
- Klumpers, Floris;
- Fernández, Guillén;
- Krugers, Harm J;
- Oitzl, Melly S;
- Fang, Zhou;
- Oplaat, Krista T;
- Joëls, Marian
Publication type:
Article
Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice.
Published in:
Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0101-2
By:
- Lesuis, Sylvie L;
- Weggen, Sascha;
- Baches, Sandra;
- Lucassen, Paul J;
- Krugers, Harm J
Publication type:
Article
Are older individuals predisposed to habitual control more resilient?
Published in:
Current Psychology, 2024, v. 43, n. 9, p. 7826, doi. 10.1007/s12144-023-04982-7
By:
- Brinkhof, Lotte P.;
- Ridderinkhof, K. Richard;
- Bieleke, Maik;
- Murre, Jaap M. J.;
- Krugers, Harm J.;
- de Wit, Sanne
Publication type:
Article
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats.
Published in:
Psychopharmacology, 2011, v. 214, n. 1, p. 249, doi. 10.1007/s00213-010-1922-8
By:
- Oomen, Charlotte;
- Soeters, Heleen;
- Audureau, Nathalie;
- Vermunt, Lisa;
- Hasselt, Felisa;
- Manders, Erik;
- Joëls, Marian;
- Krugers, Harm;
- Lucassen, Paul
Publication type:
Article
An emerging role for microglia in stress‐effects on memory.
Published in:
European Journal of Neuroscience, 2022, v. 55, n. 9/10, p. 2491, doi. 10.1111/ejn.15188
By:
- Sanguino‐Gómez, Jeniffer;
- Buurstede, Jacobus C.;
- Abiega, Oihane;
- Fitzsimons, Carlos P.;
- Lucassen, Paul J.;
- Eggen, Bart J. L.;
- Lesuis, Sylvie L.;
- Meijer, Onno C.;
- Krugers, Harm J.
Publication type:
Article
Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice.
Published in:
FASEB Journal, 2007, v. 21, n. 9, p. 2149, doi. 10.1096/fj.06-7735com
By:
- Sennvik, Kristina;
- Boekhoorn, Karin;
- Lasrado, Reena;
- Terwel, Dick;
- Verhaeghe, Steven;
- Korr, Hubert;
- Schmitz, Christoph;
- Tomiyama, Takami;
- Mori, Hiroshi;
- Krugers, Harm;
- Joels, Marian;
- Ramakers, Ger J. A.;
- Lucassen, Paul J.;
- Leuven, Fred Van
Publication type:
Article
Induction of glial fibrillary acidic protein immunoreactivity in the rat dentate gyrus after adrenalectomy: Comparison with neurodegenerative changes using silver impregnation.
Published in:
Hippocampus, 1994, v. 4, n. 3, p. 307, doi. 10.1002/hipo.450040314
By:
- Krugers, Harm J.;
- Medema, Rikje M.;
- Postema, Folkert;
- Korf, Jakob
Publication type:
Article
The Interplay Between Quality of Life and Resilience Factors in Later Life: A Network Analysis.
Published in:
Frontiers in Psychology, 2021, v. 12, p. 1, doi. 10.3389/fpsyg.2021.752564
By:
- Brinkhof, Lotte P.;
- Huth, Karoline B. S.;
- Murre, Jaap M. J.;
- de Wit, Sanne;
- Krugers, Harm J.;
- Ridderinkhof, K. Richard
Publication type:
Article
Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 2, p. 268, doi. 10.1093/hmg/ddr457
By:
- Ramakers, Ger J.A.;
- Wolfer, David;
- Rosenberger, Georg;
- Kuchenbecker, Kerstin;
- Kreienkamp, Hans-Jürgen;
- Prange-Kiel, Janine;
- Rune, Gabriele;
- Richter, Karin;
- Langnaese, Kristina;
- Masneuf, Sophie;
- Bösl, Michael R.;
- Fischer, Klaus-Dieter;
- Krugers, Harm J.;
- Lipp, Hans-Peter;
- van Galen, Elly;
- Kutsche, Kerstin
Publication type:
Article
Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro.
Published in:
European Journal of Neuroscience, 2003, v. 17, n. 9, p. 1928, doi. 10.1046/j.1460-9568.2003.02622.x
By:
- Alfarez, Deborah N.;
- Joëls, Marian;
- Krugers, Harm J.
Publication type:
Article
Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats.
Published in:
PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164551
By:
- Derks, Nienke A. V.;
- Krugers, Harm J.;
- Hoogenraad, Casper C.;
- Joëls, Marian;
- Sarabdjitsingh, R. Angela
Publication type:
Article
Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area.
Published in:
European Journal of Neuroscience, 2009, v. 30, n. 8, p. 1559, doi. 10.1111/j.1460-9568.2009.06951.x
By:
- Zhou, Ming;
- Conboy, Lisa;
- Sandi, Carmen;
- Joëls, Marian;
- Krugers, Harm J.
Publication type:
Article
Rat Hippocampal Lactate Efflux During Electroconvulsive Shock or Stress Is Differently Dependent on Entorhinal Cortex and Adrenal Integrity.
Published in:
Journal of Neurochemistry, 1992, v. 58, n. 3, p. 826, doi. 10.1111/j.1471-4159.1992.tb09331.x
By:
- Krugers, Harm J.;
- Jaarsma, Dick;
- Korf, Jakob
Publication type:
Article
Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus.
Published in:
Hippocampus, 2016, v. 26, n. 7, p. 848, doi. 10.1002/hipo.22567
By:
- Xiong, Hui;
- Cassé, Frédéric;
- Zhou, Ming;
- Xiong, Zhi‐Qi;
- Joels, Marian;
- Martin, Stéphane;
- Krugers, Harm J.
Publication type:
Article
Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life.
Published in:
Hippocampus, 2012, v. 22, n. 2, p. 255, doi. 10.1002/hipo.20892
By:
- van Hasselt, Felisa N.;
- Cornelisse, Sandra;
- Yuan Zhang, Tie;
- Meaney, Michael J.;
- Velzing, Els H.;
- Krugers, Harm J.;
- Joëls, Marian
Publication type:
Article
Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons.
Published in:
Hippocampus, 2009, v. 19, n. 9, p. 828, doi. 10.1002/hipo.20566
By:
- Alfarez, Deborah N.;
- De Simoni, Anna;
- Velzing, Els H.;
- Bracey, Ed;
- Joëls, Marian;
- Edwards, Frances A.;
- Krugers, Harm J.
Publication type:
Article
Corticosterone shifts different forms of synaptic potentiation in opposite directions.
Published in:
Hippocampus, 2005, v. 15, n. 6, p. 697, doi. 10.1002/hipo.20092
By:
- Krugers, Harm J.;
- Alfarez, Deborah N.;
- Karst, Henk;
- Parashkouhi, Keyvan;
- van Gemert, Neeltje;
- Joëls, Marian
Publication type:
Article
Exposure to chronic psychosocial stress and corticosterone in the rat: Effects on spatial discrimination learning and hippocampal protein kinase Cγ immunoreactivity.
Published in:
Hippocampus, 1997, v. 7, n. 4, p. 427, doi. 10.1002/(SICI)1098-1063(1997)7:4<427::AID-HIPO8>3.0.CO;2-F
By:
- Krugers, Harm J.;
- Douma, Bas R.K.;
- Andringa, Gerda;
- Bohus, Béla;
- Korf, Jakob;
- Luiten, Paul G.M.
Publication type:
Article
Pharmacotherapy in the Aftermath of Trauma; Opportunities in the 'Golden Hours'.
Published in:
Current Psychiatry Reports, 2014, v. 16, n. 7, p. 1, doi. 10.1007/s11920-014-0455-y
By:
- Vermetten, Eric;
- Zhohar, Joseph;
- Krugers, Harm
Publication type:
Article
Improving goal striving and resilience in older adults through a personalized metacognitive self-help intervention: a protocol paper.
Published in:
BMC Psychology, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40359-023-01259-3
By:
- Brinkhof, Lotte P.;
- Ridderinkhof, K. Richard;
- Murre, Jaap M. J.;
- Krugers, Harm J.;
- de Wit, Sanne
Publication type:
Article
Corrigendum: The interplay between quality of life and resilience factors in later life: a network analysis.
Published in:
Frontiers in Psychology, 2023, p. 1, doi. 10.3389/fpsyg.2023.1264753
By:
- Brinkhof, Lotte P.;
- Huth, Karoline B. S.;
- Murre, Jaap M. J.;
- de Wit, Sanne;
- Krugers, Harm J.;
- Ridderinkhof, K. Richard
Publication type:
Article
Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility.
Published in:
Frontiers in Human Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnhum.2022.815759
By:
- Ridderinkhof, K. Richard;
- Krugers, Harm J.
Publication type:
Article
Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons.
Published in:
Journal of Psychopharmacology, 2012, v. 26, n. 4, p. 516, doi. 10.1177/0269881111424930
By:
- Zhou, Ming;
- Hoogenraad, Casper C;
- Joëls, Marian;
- Krugers, Harm J
Publication type:
Article

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